Computational Investigation of Cell Migration Behavior in a Confluent Epithelial Monolayer

作     者：Jie Bai Xiaowei Zeng 

作者机构：Department of Mechanical EngineeringUniversity of Texas at San AntonioSan Antonio78249USA 

出 版 物：《Computer Modeling in Engineering & Sciences》 (工程与科学中的计算机建模（英文）)

年 卷 期：2022年第131卷第5期

页      面：551-565页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work is supported by a grant from National Institutes of Health(Grant No.SC2GM112575) a grant from the John L.Santikos Charitable Foundation of the San Antonio Area Foundation 

主　　题：Epithelial monolayer cell migration cell stiffness intercellular interactions finite element simulation 

摘      要：Cell migration plays a significant role in many biological activities,yet the physical mechanisms of cell migration are still not well *** this study,a continuum physics-based epithelial monolayer model including the intercellular interaction was employed to study the cell migration behavior in a confluent epithelial monolayer at constant cell *** epithelial cell was modeled as isotropic elastic *** finite element simulation,the results revealed that themotile cellwas subjected to higher stress than the other jammed cells during the migration *** stiffness was implied to play a significant role in epithelial cell migration *** stiffness results in smaller displacement and lower migration speed.