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Enhancement of norfloxacin solubility via inclusion complexation with β-cyclodextrin and its derivative hydroxypropyl-β-cyclodextrin

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Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 536-546页

作者： Gabriel Onn Kit Loh yvonne tze fung tan Kok-Khiang Peh School of Pharmaceutical Sciences Universiti Sains Malaysia

The objectives of the study were to investigate the effects of β-cyclodextrin(βCD) and hydroxypropyl-β-cyclodextrin(HPβCD) on the solubility and dissolution rate of norfloxacin prepared using three different methods, at drug to cyclodextrin weight ratios of 1:1, 1:2, 1:4 and 1:8. All the methods increased the solubility and dissolution rate of norfloxacin via inclusion complexation with βCD and HPβCD. Norfloxacin was converted from crystalline to amorphous form through inclusion complexation. Solvent evaporation method was the most effective method in terms of norfloxacin solubilisation, while inclusion complex of HPβCD has higher solubility than βCD complex when prepared using the same procedure.

关键词： Norfloxacin Inclusion complexation Cyclodextrins Solubility Dissolution

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Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients

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中华医学杂志(英文版) 2005年第20期000卷 5-11页

作者： LAU tze Kin,LEUNG Tak Yeung,fung Tak Yuen,Daljit S SAHOTA,LEUNG Tse Ngong Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China

Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedur

关键词： chorionic villus sampling · postoperative complication · pregnancy outcome

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Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients

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Chinese Medical Journal 2005年第20期118卷 1675-1681页

作者： LAU tze Kin LEUNG Tak Yeung fung Tak Yuen CHAN Lin Wai Daljit S SAHOTA LEUNG Tse Ngong Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spitalChinese University of Hong KongShatinHong Kong SARChina

Background The true risk of choronic villus sampling(CVS)is poorly *** objective of this study was to review the clinical outcome of transabdominal CVS performed in a university teaching unit,with an emphasis on the complication *** A comprehensive audit database was maintained for 1351 pregnant women,including 17 sets ot twin pregnancies,who had a *** and outcome of all CVSs made in the unit between May 1996 and May 2004 were *** CVSs were performed by one of 5 operators using the identical *** All procedures were performed transabdominally.A total of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 *** mean gestation at CVS was(11.8+0.7)weeks,and 97.3%of the procedures were performed between 11 and 13 completed *** majority(96.2%)required only 1 puncture to achieve correct needle *** procedure failed to obtain an adequate sample in 4 subjects(0.30%).A total of 1351 chromosomal studies were requested and there was 1 case(0.07%)of culture *** results of chromosomal studies were available within 14 days in 36.7%of the cases and within 21 days in 94.0%.Overall,77 chromosomal abnormalities(5.7%)and 5 cases of thalassemia major were *** outcome was unknown in only 13 singleton subjects(0.96%).In the remaining 1355 fetuses,there were 76 pregnancy terminations(5.56%),10 fetal losses with obvious obstetric causes(0.73%),and 21 potentially procedure-related fetal losses(1.54%).In the last group,the majority had one or more co-existing obstetric *** background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%.Therefore,the procedure-related fetal loss rate was estimated to be at the maximum of 0.74%.Conclusions In experienced hands,first trimester transabdominal CVS is an accurate and safe invasive prenatal diagnostic *** should be one of the treatment options available to pregn

关键词： chorionic villus sampling postoperative complication pregnancy outcome

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