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The Significance of Minimally Invasive Core Needle Biopsy and Immunohistochemistry Analysis in 235 Cases with Breast Lesions

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Chinese Journal of Clinical Oncology 2009年第1期6卷 36-41页

作者： Yun Niu Tieju Liu Xuchen Cao Xiumin Ding Li wei yuxia Gao Jun Liu Key Laboratory of Breast Cancer Preventionand Therapy National Ministry of Educationand Key Laboratory of Cancer Prevention andTherapy Tianjin Medical University CancerInstitute & Hospital Tianjin 300060 China.

OBJECTIVE To evaluate core needle biopsy (CNB) as a mini-mally invasive method to examine breast lesions and discuss theclinical significance of subsequent immunohistochemistry (IHC)*** The clinical data and pathological results of 235 pa-tients with breast lesions, who received CNB before surgery, wereanalyzed and compared. Based on the results of CNB done beforesurgery, 87 out of 204 patients diagnosed as invasive carcinomawere subjected to immunodetection for p53, c-erbB-2, ER and *** morphological change of cancer tissues in response to chemo-therapy was also *** In total of 235 cases receiving CNB examination, 204were diagnosed as invasive carcinoma, reaching a 100% consistentrate with the surgical diagnosis. Sixty percent of the cases diag-nosed as non-invasive carcinoma by CNB was identified to havethe presence of invading elements in surgical specimens, and simi-larly, 50% of the cases diagnosed as atypical ductal hyperplasia byCNB was confirmed to be carcinoma by the subsequent result ofexcision biopsy. There was no significant difference between theCNB biopsy and regular surgical samples in positive rate of im-munohistochemistry analysis (p53, c-erbB-2, ER and PR; P >0.05).However, there was significant difference in the expression rate ofp53 and c-erbB-2 between the cases with and without morphologi-cal change in response to chemotherapy (P < 0.05). In most caseswith p53 and c-erbB-2 positive, there was no obvious morphologi-cal change after *** CNB is a cost-effective diagnostic method withminimal invasion for breast lesions, although it still has some limi-tations. Immunodetection on CNB tissue is expected to have greatsignificance in clinical applications.

关键词： breast carcinoma breast lesions core needle biopsy immnuohistochemistry.

Acute Toxicity Test of Abrus cantoniensis Hance Extract

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Medicinal Plant 2019年第6期10卷 32-34页

作者： Xuankai HU Haichun LONG Qiao wei yuxia wei Jinli HUANG Tingshu LI Zhidong LEI Suoyi HUANG Youjiang Medical University for Nationalities Baise 533000China Key Laboratory of Guangxi’s Colleges for the Study of Characteristic Ethnic Medicine in Youjiang River Basin Baise 533000China

[Objectives]To investigate the acute toxicity of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract to mice.[Methods]The medium lethal dose(LD50)in mice could not be determined,so the maximum dose method was used for *** were not fed but allowed to drink water for 16 h before the *** were 74 SPF Kunming Mice,half male and half female,and it was divided into extract group and blank control *** toxicity and death were recorded after intragastric administration and regular close *** any mice died,the dead mice were *** changes of heart,liver,spleen,lung,kidney,brain,stomach,small intestine and other organs were observed with the naked *** the end of the 14 d observation period,the surviving mice in each group were killed and *** gross pathological changes of the main organs were observed with the naked eye according to the same method mentioned above.[Results]There were no obvious toxic symptoms and no death in the mice.[Conclusions]The maximum doses of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract in mice were 1.61,1.71,1.65 and 1.79 g/L,*** it was found that the quarterly tests of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract suggested that the medicine was safe.

关键词： Abrus cantoniensis Hance Acute toxicity Maximum dosage

内配煤用量对某难选铁矿石压块直接还原焙烧的影响

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中南大学学报（自然科学版） 2013年第4期44卷 1305-1311页

作者：魏玉霞孙体昌寇珏余文曹允业北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083

针对某种低品位复杂难选铁矿石,研究原矿压块—直接还原—磨矿磁选工艺的影响因素和机理。将矿石破碎到粒径小于4 mm后,加入一定量黏结剂C和内配煤压块,通过对压块、直接还原焙烧和磨矿磁选条件进行试验确定最佳工艺条件,采用X线衍射(X... 详细信息

针对某种低品位复杂难选铁矿石,研究原矿压块—直接还原—磨矿磁选工艺的影响因素和机理。将矿石破碎到粒径小于4 mm后,加入一定量黏结剂C和内配煤压块,通过对压块、直接还原焙烧和磨矿磁选条件进行试验确定最佳工艺条件,采用X线衍射(XRD)和扫描电子显微镜(SEM)对原矿在不同内配煤用量下压块后直接还原反应机理进行研究。研究结果表明:在原矿直接还原反应中,不仅包括铁氧化物向金属铁的还原,而且存在低价铁氧化物与原矿中脉石之间的反应,生成了铁橄榄石和铁尖晶石。提高内配煤用量,有利于铁氧化物和铁橄榄石等的还原。内配煤用量较高时焙烧块中生成的金属铁晶粒出现明显地连接和长大,与脉石矿物边缘界限明显,从而其回收率较用量低时有明显升高。得到铁品位为90.05%,回收率91.26%的直接还原铁产品。

关键词：内配煤用量难选铁矿石压块焙烧

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基于水质的鄱阳湖流域总磷排放限值制订研究

给水排水 2023年第4期49卷 37-43页

作者：魏玉霞陈焰蔡木林中国环境科学研究院北京100012

通过对鄱阳湖流域总磷主要排放源进行识别,确定了主要排放控制行业,采用基于鄱阳湖流域水环境容量的方法推导基于水质的总磷排放限值。对在线监测浓度数据采用对数正态分布模型统计不同排放时间周期浓度值的波动变异系数,根据基于排放... 详细信息

通过对鄱阳湖流域总磷主要排放源进行识别,确定了主要排放控制行业,采用基于鄱阳湖流域水环境容量的方法推导基于水质的总磷排放限值。对在线监测浓度数据采用对数正态分布模型统计不同排放时间周期浓度值的波动变异系数,根据基于排放负荷分配的排放浓度限值WLA、长期浓度值LTA和日均浓度值ADL之间的变异系数计算流域污染物的日均排放浓度限值,并采用分区分类思路确立了不同区域的排放限值。通过与我国排放标准中基于技术的总磷排放限值进行对比,并从经济技术可行性对基于水质的排放限值进行了评估,得出鄱阳湖流域基于水质的总磷排放限值具有合理可行性,可产生一定的环境效益。

关键词：鄱阳湖流域排放标准水质总磷排放限值

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蔗糖浓度和光强对姜试管苗生长和光合的影响

应用与环境生物学报 2008年第3期14卷 356-361页

作者：周明关秋竹韦玉霞张振贤中国农业大学农学与生物技术学院北京100094

研究了0%、1%、3%三个蔗糖浓度和60、120、180μmolm-2s-1三个光强梯度对河南张良姜和四川竹根姜试管苗生长和光合作用的影响.结果表明,随着蔗糖浓度的降低,两个品种试管苗的生长受到明显抑制,叶绿素和类胡萝卜素含量也随之下降,但总光... 详细信息

研究了0%、1%、3%三个蔗糖浓度和60、120、180μmolm-2s-1三个光强梯度对河南张良姜和四川竹根姜试管苗生长和光合作用的影响.结果表明,随着蔗糖浓度的降低,两个品种试管苗的生长受到明显抑制,叶绿素和类胡萝卜素含量也随之下降,但总光合速率(Pg)、净光合速率(Pn)和暗呼吸速率(Rd)却随之升高,Fv/Fm均以3%蔗糖处理最低.将光强从60μmolm-2s-1提高到120μmolm-2s-1,对试管苗生长有一定促进作用,但180μmolm-2s-1光强下其生长受到抑制.两个品种的叶绿素含量随光强增加均呈下降趋势.张良姜Pn以120μmolm-2s-1光强处理最高,竹根姜Pn随培养光强升高而升高,180μmolm-2s-1光强下达到最大值,为0.88μmolm-2s-1.180μmolm-2s-1光强下培养的张良姜试管苗Fv/Fm明显降低,发生了光抑制.竹根姜各光强处理间Fv/Fm无显著差异.张良姜试管苗的Rd随培养光强升高而增大,而竹根姜各光强处理间R差异不显著.

关键词：姜试管苗蔗糖浓度光强生长光合作用

Associations of muscle mass,strength,and quality with all-cause mortality in China:a population-based cohort study

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Chinese Medical Journal 2022年第11期135卷 1358-1368页

作者： Man Wu yuxia wei Jun Lv Yu Guo Pei Pei Jiachen Li Huaidong Du Ling Yang Yiping Chen Xiaohui Sun Hua Zhang Junshi Chen Zhengming Chen Canqing Yu Liming Li 无 Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences Ministry of EducationPeking UniversityBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Responses Beijing 100191China National Coordinating Center of China Kadoorie Biobank Chinese Academy of Medical SciencesBeijing 102308China Medical Research Council Population Health Research Unit the University of OxfordOxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK NCDs Prevention and Control Department Qingdao CDCQingdaoShandong 266033China NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100022China. on behalf of the China Kadoorie Biobank Collaborative Group

Background It remains unclear about the association of muscle mass,strength,and quality with death in the general Chinese population of diverse economical and geographical *** present study aimed to comprehensively examine such associations across different regions in *** Based on the China Kadoorie Biobank study,the present study included 23,290 participants who were aged 38 to 88 years and had no prevalent cardiovascular diseases or *** mass and grip strength were measured using calibrated *** muscle quality was defined as the ratio of grip strength to arm muscle *** muscle mass,grip strength,and arm muscle quality were defined as the sex-specific lowest quintiles of muscle mass index,grip strength,and arm muscle quality,*** proportional hazards models yielded hazard ratios(HRs)and 95%confidence intervals(CIs)for risks of all-cause mortality in relation to muscle mass,strength,and *** During a median follow-up of 3.98 years,739 participants *** HR(95%CI)of all-cause mortality risk was 1.28(1.08–1.51)for low appendicular muscle mass index,1.38(1.16–1.62)for low total muscle mass index,1.68(1.41–2.00)for low grip strength,and 1.41(1.20–1.66)for low arm muscle quality in models adjusted for sociodemographic characteristics,lifestyle factors,and medical *** Low muscle mass,grip strength,and arm muscle quality are all associated with short-term increased risks of mortality,indicating the importance of maintaining normal muscle mass,strength,and quality for general Chinese adults.

关键词： Muscle All-cause mortality Chinese Prospective Muscle mass Muscle strength Muscle quality

参与城市更新对地方国有企业全要素生产率的影响研究

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华东师范大学学报（哲学社会科学版） 2024年第1期56卷 129-145,179页

作者：张传勇王祯韦雨霞上海交通大学国际与公共事务学院上海200030 上海交通大学安泰经济与管理学院

随着我国城市发展模式从城市扩张向城市更新转变,评估城市更新项目的经济社会效应变得越来越重要。近年来,地方国有企业逐渐成为参与城市更新项目的主要力量,然而,参与城市更新对这些企业的经营效率影响如何尚未得到充分论证。有鉴于此... 详细信息

随着我国城市发展模式从城市扩张向城市更新转变,评估城市更新项目的经济社会效应变得越来越重要。近年来,地方国有企业逐渐成为参与城市更新项目的主要力量,然而,参与城市更新对这些企业的经营效率影响如何尚未得到充分论证。有鉴于此,采用多维固定效应模型和倾向匹配得分法,通过匹配地块微观交易数据和上市公司数据,评估地方国有企业参与城市更新对其全要素生产率的影响,并探讨其中可能的机制,其结果表明:相对于非国有企业,国有企业更有可能参与城市更新,并且参与城市更新显著提高了国有企业的全要素生产率;相应的影响机制包括地方政府补偿效应和国有企业自身的企业社会责任。这些结论有助于有效推进城市更新、提高地方国有企业的经营效率以及推动国有企业的发展,并为相关政策的制定提供科学依据。

关键词：城市更新地方国有企业全要素生产率地方政府补偿效应企业社会责任

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工业机器人应用与制造业企业内部控制质量

常州工学院学报 2023年第5期36卷 50-57页

作者：韦雨霞湖南工业大学经济与贸易学院湖南株洲412000

以2011—2019年沪深两市A股制造业企业为研究对象,运用双向固定效应模型,研究工业机器人应用对内部控制质量的影响和股权集中度的调节作用。结果表明:工业机器人应用对内部控制质量存在显著的促进作用,该结论经多种稳健性检验后,仍然成... 详细信息

以2011—2019年沪深两市A股制造业企业为研究对象,运用双向固定效应模型,研究工业机器人应用对内部控制质量的影响和股权集中度的调节作用。结果表明:工业机器人应用对内部控制质量存在显著的促进作用,该结论经多种稳健性检验后,仍然成立;调节效应结果表明,股权集中度对两者关系起负向调节作用;进一步异质性分析结果表明,工业机器人应用对非国有、沿海地区以及行业竞争水平高的企业的内部控制质量提升效果更为显著。

关键词：工业机器人应用内部控制质量股权集中度

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农药工业废水中特征污染物排放限值制订研究

环境污染与防治 2019年第11期41卷 1384-1386,1392页

作者：魏玉霞胡林林韩梅中国环境科学研究院环境标准研究所

中国农药工业废水中特征污染物一直未开展监测监控,导致相关数据匮乏。针对农药工业废水中特征污染物对生态环境的高毒性和对作用对象的高敏感性,首先基于非敏感水生生物保护的目的推导农药工业废水特征污染物的水质基准,然后综合多种... 详细信息

中国农药工业废水中特征污染物一直未开展监测监控,导致相关数据匮乏。针对农药工业废水中特征污染物对生态环境的高毒性和对作用对象的高敏感性,首先基于非敏感水生生物保护的目的推导农药工业废水特征污染物的水质基准,然后综合多种因素最终制定特征污染物排放限值。该方法确立的45种特征污染物排放限值,与美国、印度和世界银行组织制定的排放限值基本处于同一数量级,并且具有目标可达性和管理可行性,可为其他行业特征污染物排放限值的制订提供方法借鉴。

关键词：农药工业废水特征污染物水质基准非敏感物种