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牛兴东从肝脾论治功能性便秘经验浅谈

中国民间疗法 2024年第11期32卷 33-35页

作者：韩普超莫日根魏玉霞内蒙古医科大学内蒙古呼和浩特010000 内蒙古自治区中医医院内蒙古呼和浩特010020 内蒙古自治区精神卫生中心内蒙古呼和浩特010010

功能性便秘是一种常见的消化系统疾病,现代医学对功能性便秘的治疗效果不佳,且病情易反复发作。牛兴东教授在治疗功能性便秘方面有丰富的临床经验,认为功能性便秘主要是由肝郁脾虚所致,故治疗主要以疏肝理气、健脾益气为治法,且提倡重... 详细信息

功能性便秘是一种常见的消化系统疾病,现代医学对功能性便秘的治疗效果不佳,且病情易反复发作。牛兴东教授在治疗功能性便秘方面有丰富的临床经验,认为功能性便秘主要是由肝郁脾虚所致,故治疗主要以疏肝理气、健脾益气为治法,且提倡重视功能性便秘患者的日常调护。该文主要介绍牛兴东教授治疗功能性便秘临床经验及特色,以便更好地传承和发展名中医的学术思想及临证经验。

关键词：功能性便秘肝脾中医药肝郁脾虚牛兴东

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广西男男性行为者rush poppers使用情况及相关因素研究

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中国艾滋病性病 2024年第1期30卷 23-28页

作者：刘露刘君辉阮玉华江宇裴恒妍黄腾达韦玉霞戴学宾茹梦陈世文谢艺红广西医科大学公共卫生学院南宁530021 南宁市疾病预防控制中心南宁530023 传染病预防控制国家重点实验室北京102206 中国疾病预防控制中心性病艾滋病预防控制中心北京102206

目的了解广西MSM中rush poppers的使用情况及相关因素,为制定有针对性的干预措施提供科学依据。方法于2022年3-7月通过多种途径招募MSM开展面对面问卷调查。采用多因素Logistic回归模型分析rush pop⁃pers使用情况的影响因素及其与高危... 详细信息

目的了解广西MSM中rush poppers的使用情况及相关因素,为制定有针对性的干预措施提供科学依据。方法于2022年3-7月通过多种途径招募MSM开展面对面问卷调查。采用多因素Logistic回归模型分析rush pop⁃pers使用情况的影响因素及其与高危性行为的关系。结果共调查1006名MSM,18~24岁占34.0%,本科及以上文化程度占40.0%,近6个月男性性伴数≥2人占64.3%,近1个月发生过无保护肛交占30.6%(308/1006),近1年rush poppers使用比例为35.7%。多因素分析显示,影响rush poppers使用的主要因素包括:年龄18~24岁和25~39岁[vs.≥40岁,aOR(95%CI)分别为2.93(1.66~5.14)和4.52(2.71~7.53)]、少数民族(vs.汉族,aOR=1.37,95%CI:1.03~1.83)、首次发生男男性行为的年龄<20岁(vs.≥20岁,aOR=1.80,95%CI:1.30~2.51)、近6个月男性性伴数为2~5人和≥6人[vs.≤1人,aOR(95%CI)分别为3.08(2.22~4.28)和4.59(2.91~7.23)]、近1个月有固定男性性伴(vs.无固定男性性伴,aOR=1.69,95%CI:1.23~2.31)、近1个月发生无保护被动肛交(vs.未发生过无保护被动肛交,aOR=1.84,95%CI:1.30~2.62)、近1年使用过其他娱乐性药物(vs.未使用过其他娱乐性药物,aOR=4.21,95%CI:2.29~7.73)。结论广西MSM使用rush poppers的比例较高,其使用与年龄、民族、以及多性伴、无保护被动肛交等高危性行为有关。今后应进一步加强rush poppers获取途径的调查并加强监管,充分利用网络平台加强健康宣教,提升MSM尤其是青壮年和少数民族MSM对rush poppers危害性的认知。

关键词：男男性行为者 rush poppers 使用情况高危性行为相关因素

Trace Pd alloyed with Au to boost Au/uncalcined TS-1 catalyzed propane hydro-oxidation to acetone

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Nano Research 2024年第8期17卷 7182-7193页

作者： Jinwei Sun Zhihua Zhang Erchuan Yang wei Du Fan Liu Kesheng Xu yuxia Zhong Xuezhi Duan Xinggui Zhou State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

Selective oxidation of propane to acetone(AC)with H_(2)and O_(2)provides a direct route to convert low-cost propane into valueadded ***,the catalytic activity of conventional Au/Ti-based catalysts is constrained by the high energy barrier for H_(2)***,uncalcined TS-1 supported Au-Pd bimetallic catalysts were prepared,and the relationship between the active-site structure and corresponding performance in the selective oxidation of propane with H_(2)and O_(2)in the gas phase was systematically *** contrast to the liquid-phase reaction,trace Pd alloyed with Au triggered an increase in both catalytic activity and selectivity,in which Au_(20)-Pd_(1)/TS-1-B catalyst exhibited excellent activity(170 gAC·h^(−1)·kgcat^(−1))and AC selectivity(90.6%),much higher than those of the Au/TS-1-B catalyst(AC formation rate of 100 gAC·h^(−1)·kgcat^(−1)and AC selectivity of 86.3%).It was found that Pd was gradually isolated into monomers with the increase of Au/Pd molar ratio,and the synergy between Pd single atoms and Au improved the catalytic performance via enhancing hydrogen dissociation and modulating the electronic structure of ***,the reaction conditions were optimized based on the kinetics studies and the Au_(20)-Pd_(1)/TS-1-B catalyst exhibited enhanced H_(2)selectivity(45%)and long-term stability(over 130 h).The insights gained here can offer valuable guidance for the design of Au-Pd catalysts applicable to other gas-phase oxidation reactions.

关键词： propane selective oxidation acetone hydrogen dissociation Au-Pd alloy synergy

Associations of muscle mass,strength,and quality with all-cause mortality in China:a population-based cohort study

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Chinese Medical Journal 2022年第11期135卷 1358-1368页

作者： Man Wu yuxia wei Jun Lv Yu Guo Pei Pei Jiachen Li Huaidong Du Ling Yang Yiping Chen Xiaohui Sun Hua Zhang Junshi Chen Zhengming Chen Canqing Yu Liming Li 无 Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences Ministry of EducationPeking UniversityBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Responses Beijing 100191China National Coordinating Center of China Kadoorie Biobank Chinese Academy of Medical SciencesBeijing 102308China Medical Research Council Population Health Research Unit the University of OxfordOxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK NCDs Prevention and Control Department Qingdao CDCQingdaoShandong 266033China NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100022China. on behalf of the China Kadoorie Biobank Collaborative Group

Background It remains unclear about the association of muscle mass,strength,and quality with death in the general Chinese population of diverse economical and geographical *** present study aimed to comprehensively examine such associations across different regions in *** Based on the China Kadoorie Biobank study,the present study included 23,290 participants who were aged 38 to 88 years and had no prevalent cardiovascular diseases or *** mass and grip strength were measured using calibrated *** muscle quality was defined as the ratio of grip strength to arm muscle *** muscle mass,grip strength,and arm muscle quality were defined as the sex-specific lowest quintiles of muscle mass index,grip strength,and arm muscle quality,*** proportional hazards models yielded hazard ratios(HRs)and 95%confidence intervals(CIs)for risks of all-cause mortality in relation to muscle mass,strength,and *** During a median follow-up of 3.98 years,739 participants *** HR(95%CI)of all-cause mortality risk was 1.28(1.08–1.51)for low appendicular muscle mass index,1.38(1.16–1.62)for low total muscle mass index,1.68(1.41–2.00)for low grip strength,and 1.41(1.20–1.66)for low arm muscle quality in models adjusted for sociodemographic characteristics,lifestyle factors,and medical *** Low muscle mass,grip strength,and arm muscle quality are all associated with short-term increased risks of mortality,indicating the importance of maintaining normal muscle mass,strength,and quality for general Chinese adults.

关键词： Muscle All-cause mortality Chinese Prospective Muscle mass Muscle strength Muscle quality

Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice

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Journal of Environmental Sciences 2024年第3期137卷 553-566页

作者： Xingpei Fan Xiaoyan Li Jiaxin Li yuxia Zhang Xiangjuan wei Hailong Hu Boya Zhang Haining Du Meimei Zhao Ruijiao Zhu Daqian Yang Yuri Oh Ning Gu School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150006China Department of Medicine Renal Electrolyte and Hypertension DivisionDepartment of GeneticsPerelman School of MedicineUniversity of PennsylvaniaPhiladelphia 19104USA Faculty of Education Wakayama UniversityWakayama 640-8441Japan

Nanoplastics-induced developmental and reproductive toxicity,neurotoxicity and immunotoxicity are a focus of widespread ***,the effects of nanoplastics(NPs)on glycolipid metabolism and the precise underlying mechanisms are unclear at ***,we showed that oral administration of polystyrene nanoparticles(PS-NPs)disrupts glycolipid metabolism,with reactive oxygen species(ROS)identified as a potential key signaling *** PS-NPs treatment,excessive production of ROS induced the infammatory response and activated the antioxidant pathway through nuclear factor-erythroid factor 2-related factor *** activation of nuclear factor-κB(NFκB)signaling pathway induced the phosphorylation of the mitogen-activated protein kinases(MAPK)signaling pathway,which induced the activation of extracellular regulated kinases(ERK)and *** activation of the MAPK signaling proteins induced high continued phosphorylation of insulin receptor substrate-1,in turn,leading to decreased protein kinase B(Akt)activity,which weakened the sensitivity of liver cells to insulin signals and induced insulin *** parallel,phosphorylation of Akt led to loss of control of Fo XO1,a key gene of gluconeogenesis,activating transcription of glucose-6-phosphatase(G6PC)and phosphoenolpyruvate carboxykinase(PEPCK)in a manner dependent on PGC1α.Moreover,the activated ERK promoted lipid accumulation through ERK-PPARγ***,sterol regulatory element-binding protein-1 and levels of its downstream lipogenic enzymes,ACC-1,were *** treatment with the antioxidant resveratrol,PS-NPs-induced glucose and lipid metabolic disorders were improved by inhibiting ROS-induced activation of NFκB and MAPK signaling pathway in *** on above,PS-NPs exposure disrupts glycolipid metabolism in mice,with ROS identified as a potential key signaling molecule.

关键词： Nanoplastics Resveratrol Hyperglycemia Lipid metabolism Infammatory response Reactive oxygen species(ROS)

Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 544-547页

作者： Min Dong Rui Tang Jing Li Jiajia Zhao Yu Wang Lin Ouyang wei Lu Jun Tao Meng Dang yuxia Tang Zhaogang Teng Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Post and TelecommunicationsNanjing 210023China Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Radiology The 909th HospitalSoutheast HospitalSchool of MedicineXiamen UniversityZhangzhou 363000China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China

Photodynamic therapy(PDT)is an effective treatment method for *** the specifically accumulated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of ***,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and *** confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of *** revealed the modification of CTPP significantly improves the targeting ability of the *** vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60μg/mL JPMO-Pt-CTPP-ZnPc was only 3%.Simultaneously,compared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.

关键词： Mesoporous materials Janus particle Photodynamic therapy Mitochondria targeting Tumor treatment

Peak compression technique in high-performance liquid chromatography

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Chinese Science Bulletin 2009年第16期54卷 2805-2809页

作者： wei yuxia WANG Lin XIAO ShengYuan QING Hong ZHU Yong HU GaoFei DENG YuLin School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China

Peak compression technique based on the difference of the solute migration velocity in two different mobile phases was described theoretically and confirmed using benzaldehyde and 4-hydroxyquinoline (4-HQ) as model compounds. After peak compression, the peak compression factors (the ratio of peak width at half-height under non-compression and that under compression condition) of benzaldehyde and 4-HQ were 0.19 and 0.13, respectively. By this application of the peak compression technique to the mixture, both enhanced peak height and good separation were obtained in one run cycle. This peak compression technique was introduced to determine benzaldehyde from semicarbazide-sensitive amine oxidase-catalyzed enzymetic reaction in order to illustrate the applicability of this technique to the real sample. As a result, the peak was compressed effectively, and 4.94-fold, 19.3-fold and 5.74-fold enhancement in peak height, plate number and signal to noise ratio were also achieved, respectively.

关键词：压缩技术高效液相色谱模型化合物脲甲醛迁移速度羟基喹啉压缩条件运行周期

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基于水质的鄱阳湖流域总磷排放限值制订研究

给水排水 2023年第4期49卷 37-43页

作者：魏玉霞陈焰蔡木林中国环境科学研究院北京100012

通过对鄱阳湖流域总磷主要排放源进行识别,确定了主要排放控制行业,采用基于鄱阳湖流域水环境容量的方法推导基于水质的总磷排放限值。对在线监测浓度数据采用对数正态分布模型统计不同排放时间周期浓度值的波动变异系数,根据基于排放... 详细信息

通过对鄱阳湖流域总磷主要排放源进行识别,确定了主要排放控制行业,采用基于鄱阳湖流域水环境容量的方法推导基于水质的总磷排放限值。对在线监测浓度数据采用对数正态分布模型统计不同排放时间周期浓度值的波动变异系数,根据基于排放负荷分配的排放浓度限值WLA、长期浓度值LTA和日均浓度值ADL之间的变异系数计算流域污染物的日均排放浓度限值,并采用分区分类思路确立了不同区域的排放限值。通过与我国排放标准中基于技术的总磷排放限值进行对比,并从经济技术可行性对基于水质的排放限值进行了评估,得出鄱阳湖流域基于水质的总磷排放限值具有合理可行性,可产生一定的环境效益。

关键词：鄱阳湖流域排放标准水质总磷排放限值

The Significance of Minimally Invasive Core Needle Biopsy and Immunohistochemistry Analysis in 235 Cases with Breast Lesions

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Chinese Journal of Clinical Oncology 2009年第1期6卷 36-41页

作者： Yun Niu Tieju Liu Xuchen Cao Xiumin Ding Li wei yuxia Gao Jun Liu Key Laboratory of Breast Cancer Preventionand Therapy National Ministry of Educationand Key Laboratory of Cancer Prevention andTherapy Tianjin Medical University CancerInstitute & Hospital Tianjin 300060 China.

OBJECTIVE To evaluate core needle biopsy (CNB) as a mini-mally invasive method to examine breast lesions and discuss theclinical significance of subsequent immunohistochemistry (IHC)*** The clinical data and pathological results of 235 pa-tients with breast lesions, who received CNB before surgery, wereanalyzed and compared. Based on the results of CNB done beforesurgery, 87 out of 204 patients diagnosed as invasive carcinomawere subjected to immunodetection for p53, c-erbB-2, ER and *** morphological change of cancer tissues in response to chemo-therapy was also *** In total of 235 cases receiving CNB examination, 204were diagnosed as invasive carcinoma, reaching a 100% consistentrate with the surgical diagnosis. Sixty percent of the cases diag-nosed as non-invasive carcinoma by CNB was identified to havethe presence of invading elements in surgical specimens, and simi-larly, 50% of the cases diagnosed as atypical ductal hyperplasia byCNB was confirmed to be carcinoma by the subsequent result ofexcision biopsy. There was no significant difference between theCNB biopsy and regular surgical samples in positive rate of im-munohistochemistry analysis (p53, c-erbB-2, ER and PR; P >0.05).However, there was significant difference in the expression rate ofp53 and c-erbB-2 between the cases with and without morphologi-cal change in response to chemotherapy (P < 0.05). In most caseswith p53 and c-erbB-2 positive, there was no obvious morphologi-cal change after *** CNB is a cost-effective diagnostic method withminimal invasion for breast lesions, although it still has some limi-tations. Immunodetection on CNB tissue is expected to have greatsignificance in clinical applications.

关键词：免疫组织化学分析定位穿刺活检乳腺病变微创 p53基因氯硝基苯 erbB 临床应用价值