Acute Toxicity Test of Abrus cantoniensis Hance Extract
Acute Toxicity Test of Abrus cantoniensis Hance Extract作者机构:Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of Guangxi’s Colleges for the Study of Characteristic Ethnic Medicine in Youjiang River BasinBaise 533000China
出 版 物:《Medicinal Plant》 (药用植物:英文版)
年 卷 期:2019年第10卷第6期
页 面:32-34页
学科分类:1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金:Supported by Construction Project of China State Administration of Traditional Chinese Medicine on Key Discipline of Traditional Chinese Medicine—Chemistry of Traditional Chinese Medicine during the"Twelfth Five-Year Plan"Period[Guo Zhong Yi Yao Ren Jiao Fa(2012)32] Key R&D Project in Guangxi,China(GuiKe AB18221095) Guangxi Natural Science Foundation of China(2017GXNSFAA198031) 2017 College Students’Innovation and Entrepreneurship Training Program in Guangxi Zhuang Autonomous Region,China(201710599055)
主 题:Abrus cantoniensis Hance Acute toxicity Maximum dosage
摘 要:[Objectives]To investigate the acute toxicity of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract to mice.[Methods]The medium lethal dose(LD50)in mice could not be determined,so the maximum dose method was used for *** were not fed but allowed to drink water for 16 h before the *** were 74 SPF Kunming Mice,half male and half female,and it was divided into extract group and blank control *** toxicity and death were recorded after intragastric administration and regular close *** any mice died,the dead mice were *** changes of heart,liver,spleen,lung,kidney,brain,stomach,small intestine and other organs were observed with the naked *** the end of the 14 d observation period,the surviving mice in each group were killed and *** gross pathological changes of the main organs were observed with the naked eye according to the same method mentioned above.[Results]There were no obvious toxic symptoms and no death in the mice.[Conclusions]The maximum doses of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract in mice were 1.61,1.71,1.65 and 1.79 g/L,*** it was found that the quarterly tests of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract suggested that the medicine was safe.