Acute Toxicity Test of Abrus cantoniensis Hance Extract

作     者：Xuankai HU Haichun LONG Qiao WEI Yuxia WEI Jinli HUANG Tingshu LI Zhidong LEI Suoyi HUANG 

作者机构：Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of Guangxi’s Colleges for the Study of Characteristic Ethnic Medicine in Youjiang River BasinBaise 533000China 

出 版 物：《Medicinal Plant》 (药用植物：英文版)

年 卷 期：2019年第10卷第6期

页      面：32-34页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Construction Project of China State Administration of Traditional Chinese Medicine on Key Discipline of Traditional Chinese Medicine—Chemistry of Traditional Chinese Medicine during the"Twelfth Five-Year Plan"Period[Guo Zhong Yi Yao Ren Jiao Fa(2012)32] Key R&D Project in Guangxi,China(GuiKe AB18221095) Guangxi Natural Science Foundation of China(2017GXNSFAA198031) 2017 College Students’Innovation and Entrepreneurship Training Program in Guangxi Zhuang Autonomous Region,China(201710599055) 

主　　题：Abrus cantoniensis Hance Acute toxicity Maximum dosage 

摘      要：[Objectives]To investigate the acute toxicity of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract to mice.[Methods]The medium lethal dose(LD50)in mice could not be determined,so the maximum dose method was used for *** were not fed but allowed to drink water for 16 h before the *** were 74 SPF Kunming Mice,half male and half female,and it was divided into extract group and blank control *** toxicity and death were recorded after intragastric administration and regular close *** any mice died,the dead mice were *** changes of heart,liver,spleen,lung,kidney,brain,stomach,small intestine and other organs were observed with the naked *** the end of the 14 d observation period,the surviving mice in each group were killed and *** gross pathological changes of the main organs were observed with the naked eye according to the same method mentioned above.[Results]There were no obvious toxic symptoms and no death in the mice.[Conclusions]The maximum doses of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract in mice were 1.61,1.71,1.65 and 1.79 g/L,*** it was found that the quarterly tests of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract suggested that the medicine was safe.