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Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic Therapy

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Nano-Micro Letters 2019年第4期11卷 196-214页

作者： Xiaomin Li Yang Liu Fei Fu Mingbo Cheng yutong Liu Licheng Yu wei Wang Yeda Wan Zhi Yuan Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071People’s Republic of China Department of Radiology Tianjin HospitalTianjin 300210People’s Republic of China

Inconvenient dual-laser irradiation and tumor hypoxic environment as well as limited judgment of treating region have impeded the development of combined photothermal and photodynamic therapies(PTT and PDT).Herein,Bi2Se3@AIPH nanoparticles(NPs)are facilely developed to overcome these *** a one-step method,free radical generator(AIPH)and phase transition material(lauric acid,LA,44-46°C)are encapsulated in hollow bismuth selenide nanoparticles(Bi2Se3 NPs).Under a single 808-nm laser irradiation at the tumor area,hyperthermia produced by Bi2Se3 not only directly leads to cell death,but also promotes AIPH release by melting LA and triggers free radical generation,which could further eradicate tumor cells in hypoxic ***,Bi2Se3 with high X-ray attenuation coefficient endows the NPs with high computed tomography(CT)imaging capability,which is important for treating area *** results exhibit that Bi2Se3@AIPH NPs possesses 31.2%photothermal conversion efficiency for enhanced PTT,ideal free radical generation for oxygen-independent PDT,and 37.77 HU mL mg?1 X-ray attenuation coefficient for CT imaging with high *** importantly,the tumor growth inhibition rate by synergistic PTT,PDT,and following immunotherapy is 99.6%,and even one tumor disappears completely,which demonstrates excellent cascaded synergistic effect of Bi2Se3@AIPH NPs for the tumor therapy.

关键词： Bi2Se3 Free radical Oxygen-independent Photothermal Photodynamic

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隐空间转换的混合样本图像去雾

计算机工程与应用 2023年第9期59卷 225-236页

作者：郑玉彤孙昊英宋伟中央民族大学信息工程学院北京100081 自然资源部海洋环境探测技术与应用重点实验室广州510310 国家语言资源监测与研究少数民族语言中心北京100081

深度学习从数据集中学习样本的内在规律,数据集的质量一定程度上决定了模型的表现。在去雾任务的公开数据集中,由于缺少成对真实数据,合成的成对数据难以模拟真实环境等问题,可能导致训练出的模型在实际环境中表现不佳。为此,提出混合... 详细信息

深度学习从数据集中学习样本的内在规律,数据集的质量一定程度上决定了模型的表现。在去雾任务的公开数据集中,由于缺少成对真实数据,合成的成对数据难以模拟真实环境等问题,可能导致训练出的模型在实际环境中表现不佳。为此,提出混合样本学习问题,利用合成的成对数据和真实数据(混合样本)同时训练模型,通过隐空间的转换实现混合样本间的转换。算法利用变分自编码器和生成对抗网络(VAE-GAN)将混合样本分别编码到隐空间,利用对抗损失将真实数据的隐空间向合成雾图的隐空间对齐,利用含特征自适应融合(MFF)模块的映射网络学习成对数据隐空间之间的转换,从而建立起从真实雾图域到清晰图像域之间的去雾数据通路。实验结果表明,该算法相比其他去雾算法在真实雾图上的去雾结果更加清晰,对于较厚的雾图也有突出的效果,且该算法的峰值信噪比高于对比算法。

关键词：单幅图像去雾隐空间转换混合样本变分自编码器(VAE) 生成对抗网络(GAN)

Short-term exposure to ambient ozone associated with cardiac arrhythmias in healthy adults

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Global Health Journal 2022年第1期6卷 6-18页

作者： Lingyan Liu yutong Zhu Hongbing Xu Yang Wang Tong Wang Qian Zhao Yi Zhang Jie Chen Shengcong Liu Tieci Yi Rongshan Wu Shuo Liu Xiaoming Song Jianping Li wei Huang Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Peking University Institute of Environmental Medicine Peking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science CenterPeking UniversityBeijing 100191China Department of Prevention and Health Care Hospital of Health Science CenterPeking UniversityBeijing 100191 China Institute for Risk Assessment Sciences University Medical Centre UtrechtUniversity of UtrechtP.O.Box 801253508 TC Utrechtthe Netherlands Department of Cardiology Peking University First HospitalBeijing 100034China

Objective The exact biological mechanism whereby exposure to ambient ozone(O3)may contribute to clinical onset of cardiovascular events remains *** this study,we aim to examine the impacts of O3 exposure on cardiac arrhythmias and potential pathways involved through autonomic dysfunction and myocardial *** Seventy-three non-smoking healthy adults were followed with 4 repeated measurements of 24-hour ambulatory arrhythmias,heart rate variability,ST-segment deviation,and blood pressure(BP)in Beijing,China,2014‒*** additive mixed models coupled with distributed lag nonlinear models were constructed to evaluate the associations and potential interlinks between O3 exposure and outcome *** During the study period,24-hour average concentrations of ambient O3 were 47.4µg/m3(ranging from 1.0 to 165.9µg/m3).Increased risks of premature ventricular contraction and ventricular tachycardia were associated with interquartile range increases in O3 exposure during the last 5 days before each participant's clinic visit,with relative risks of 2.14(95%confidence interval[CI]:1.95 to 2.32)and 5.47(95%CI:3.51 to 7.43),*** analyses further showed that sympathetic activation,parasympathetic inhibition,and elevated BP levels,as well as heightened risks of ST-segment depression could mediate up to 47.74%of the risks of arrhythmias attributable to O3 *** Our results suggest that short-term exposure to ambient O3 could prompt the genesis of arrhythmias partially through worsening autonomic function and myocardial burden.

关键词： Ozone Cardiac arrhythmias Cardiac autonomic function Myocardial injury Panel study

Incidence and mortality of laryngeal cancer in China, 2015

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Chinese Journal of Cancer Research 2020年第1期32卷 10-17页

作者： yutong He Di Liang Daojuan Li Baoen Shan Rongshou Zheng Siwei Zhang Wenqiang wei Jie He Cancer Institute the Fourth Hospital of Hebei Medical University/the Tumor Hospital of Hebei ProvinceShijiazhuang 050011China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China

Objective: Using data from cancer registries to estimate laryngeal cancer incidence and mortality in China, ***: Data submitted from 501 cancer registries were checked and evaluated according to the criteria of data quality control and 368 registries’ data were qualified for the final analysis. Data were stratified by area(urban/rural), sex, age group and combined with national population data to estimate laryngeal cancer incidence and mortality in China, 2015. China population census in 2000 and Segi’s population were used for ***: The percentage of cases morphological verified(MV%) of laryngeal cancer was 74.18%. The percentage of death certificate-only cases(DCO%) was 2.10%. And the mortality to incidence(M/I) ratio was *** 25,300 new cases of laryngeal cancer were diagnosed in 2015 and 13,700 deaths were reported. The crude rate of laryngeal cancer was 1.84 per 100,000(males and females were 3.20 and 0.42 per 100,000, respectively).Age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 1.18 and 1.19 per 100,000, respectively. The cumulative incidence rate(0-74 years old) was 0.15%.The crude mortality rate was 1.00 per 100,000. Age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 0.61 and 0.61 per 100,000, respectively, with the cumulative rate(0-74 years old) was 0.07%. Incidence and mortality of laryngeal cancer in males were higher than those in females. And the rates in urban areas were higher than those in rural ***: The incidence and mortality of laryngeal cancer in China were low. And the rates were significantly higher in males than in females. Risk factor control and targeted prevention should be strengthened.

关键词： China laryngeal cancer incidence mortality

深部煤炭地下气化制氢碳排放核算及碳减排潜力分析

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煤炭科学技术 2023年第1期51卷 531-541页

作者：刘淑琴刘欢纪雨彤郭巍中国矿业大学(北京)化学与环境工程学院北京100083

创新煤炭开发利用技术以降低煤炭从生产到利用全生命周期内的碳排放,是符合我国能源禀赋特点的煤基清洁能源路线。地下气化是深部煤炭原位开采的潜力方式之一,耦合CCS/CCUS(碳捕集与封存/碳捕集、利用及封存)的深部煤炭地下气化制氢技... 详细信息

创新煤炭开发利用技术以降低煤炭从生产到利用全生命周期内的碳排放,是符合我国能源禀赋特点的煤基清洁能源路线。地下气化是深部煤炭原位开采的潜力方式之一,耦合CCS/CCUS(碳捕集与封存/碳捕集、利用及封存)的深部煤炭地下气化制氢技术路线不仅可以利用丰富的深部煤炭资源,而且有望成为一种理想的煤基低成本制氢路线。基于世界上唯一的千米级深部煤炭地下气化试验数据,结合Aspen Plus过程模拟,开展了深部煤炭地下气化制氢碳排放核算及碳减排潜力分析。与商业化的Lurgi煤炭地面气化制氢路线作对比,利用生命周期评价方法建立了2种工艺的全生命周期碳排放计算模型,比较了2种制氢路线的生命周期碳排放。评估了深部煤炭地下气化制氢的CCS/CCUS路径及碳减排潜力。研究结果表明,在氢气生产能力为12亿Nm3/a情形下,深部煤炭地下气化制氢和Lurgi煤炭地面气化制氢生命周期内的碳排放分别为3.29×10^(6)t CO_(2)-eq (当量二氧化碳)和3.93×10^(6)t CO_(2)-eq,其中以废气形式直接排放进入大气的二氧化碳量分别为2.09×10^(6)t和2.24×10^(6)t。在氢气生产阶段的主要碳排放源为废气,包括酸性气体脱除单元排出的废气和甲烷重整单元排出的烟气。深部煤炭地下气化制氢工艺所带来的高甲烷含量特征导致生产1 kg氢气时,甲烷重整单元烟气贡献的CO_(2)排放量达到8.84 kg。间接排放方面,由于深部煤炭地下气化直接采用液态水作为气化剂而不需要消耗外界蒸汽,因此蒸汽消耗带来的碳排放低于地面气化。Lurgi煤炭地面气化上游包含煤炭采选及煤炭运输阶段,尽管这两阶段的碳排放占比只有6.7%,但仍然会带来2.63×105t CO_(2)-eq的碳排放。若深部煤炭地下气化空腔在地质安全风险评估的前提下用于CO_(2)地质储存,储存量可以达到CO_(2)排放总量的61.8%,若再配套47万t/a的尿素装置,即可有效利用其余的CO_(2),形成近零排放的深部煤炭地下气化制氢及尿素联产技术路线。研究结果为深部煤炭地下气化制氢提供了碳排放定量评价的科学依据。

关键词：煤炭地下气化 Lurgi气化氢气生产碳减排碳排放核算

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针对森林背景的去雾图像优化

森林工程 2022年第4期38卷 106-112页

作者：孟宇彤赵康军赵伟东北林业大学信息与计算机工程学院哈尔滨150040 临沭县工业和信息化产业发展中心山东临沂276700

森林雾天常导致采集的图像信息质量差,为得到更为清晰完整的森林去雾图像,从而为森林监测提供更好的数据支持和保障,该文利用自适应性算法初步确定森林雾气含量以及光线强度等环境状况,再用亮暗通道融合算法对全局大气光、透射率等大气... 详细信息

森林雾天常导致采集的图像信息质量差,为得到更为清晰完整的森林去雾图像,从而为森林监测提供更好的数据支持和保障,该文利用自适应性算法初步确定森林雾气含量以及光线强度等环境状况,再用亮暗通道融合算法对全局大气光、透射率等大气模型的重要参数值进行优化,最后针对亮暗通道先验算法造成的晕轮效应进行高斯曲率滤波处理。基于自适应图像增强的亮暗通道融合去雾算法能有效改善森林图像的质量,得到细节丰富、视觉效果清晰的森林去雾图像。实验分别从主观标准和客观标准对图像效果进行科学性评价,所得到的融合改进算法对森林图像优化有良好的效果。

关键词：森林图像优化自适应图像去雾亮暗通道融合高斯曲率滤波

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基于深度条件概率密度函数的居民电力负荷预测

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电网与清洁能源 2022年第5期38卷 36-41页

作者：陈伟赵裕童国网上海市区供电公司上海200080

居民电力负荷预测主要用于电力调度工作的停电计划,以提高供电可靠度及居民用户满意度。由于电力数据量大且不确定性因素过多,对其负荷进行预测的难度较大。现有的电力负荷预测方法无法获取电力数据的自由度数值,导致负荷预测过程稳定... 详细信息

居民电力负荷预测主要用于电力调度工作的停电计划,以提高供电可靠度及居民用户满意度。由于电力数据量大且不确定性因素过多,对其负荷进行预测的难度较大。现有的电力负荷预测方法无法获取电力数据的自由度数值,导致负荷预测过程稳定性差、预测结果精度低。提出一种基于深度条件概率密度函数的居民电力负荷预测方法。引入四次方核函数,得出随时间变化下居民电力负荷数据的观测值与预测值间的变量关系;通过高斯回归方程使得预测向量值符合正态分布;利用交叉验证方法提取预测值的最优自由度,通过借自由度确定分位点,根据对比分析结果确定下一随机变量的预测数据分位点,实现居民电力负荷的预测。仿真实验证明,所提方法得出的电力负荷波动结果与实测结果相吻合,预测误差可控制在0.001~0.437 MW。说明该方法预测准确性高,可为电力决策提供有效帮助。

关键词：深度条件概率密度函数四次方核函数线性函数自由度负荷预测

Molecular imaging:design mechanism and bioapplications

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Science China Chemistry 2023年第5期66卷 1336-1383页

作者： Lanlan Chen Yifan Lyu Xuan Zhang Liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu wei Li yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing Ren Mengyi Xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and Chemomet-ricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education) College of ChemistryFuzhou UniversityFuzhou 350108China College of Chemistry Beijing University of Chemical TechnologyBeijing 100029China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Institute of Molecular Medicine(IMM) State Key Laboratory of Oncogenes and Related Genes Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China School of Chemistry and Chemical Engineering University of JinanJinan 250022China

Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of ***,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission *** this review,we summarize the development of current state-of-the-art molecular imaging *** introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided *** we discuss the perspectives and challenges in this emerging *** expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices.

关键词： molecular imaging imaging probes multimodality biomedical applications diseases diagnosis

提升设备管理严控技改大修项目精益化管理水平

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电力与能源 2018年第4期39卷 500-501,505页

作者：刘当武郑高峰李葵王筠秦丹丹刘丽许中平魏雨桐国网安徽省电力有限公司合肥230061 国网安徽省电力有限公司信息通信分公司合肥230061 北京国网信通埃森哲信息技术有限公司北京100032

为提高电力系统设备运行可靠性,确保供电质量,每年都会耗费大量投资对电力系统设备进行生产技改、生产大修,从项目管理流程角度对技改大修项目全过程及预算执行开展了大量监测分析工作,对项目进度及预算执行实现了严格把控。国网安徽电... 详细信息

为提高电力系统设备运行可靠性,确保供电质量,每年都会耗费大量投资对电力系统设备进行生产技改、生产大修,从项目管理流程角度对技改大修项目全过程及预算执行开展了大量监测分析工作,对项目进度及预算执行实现了严格把控。国网安徽电力有限公司运营监测(控)中心针对技改大修项目,以技改大修对象即电力设备为出发点,对技改大修项目的有效性及合理性开展监测分析,实现了从电力设备角度进行项目管控的突破,提高了公司的精益化管理水平。

关键词：生产技改生产大修投资控制重复废旧物资处置