Short-term exposure to ambient ozone associated with cardiac arrhythmias in healthy adults

作     者：Lingyan Liu Yutong Zhu Hongbing Xu Yang Wang Tong Wang Qian Zhao Yi Zhang Jie Chen Shengcong Liu Tieci Yi Rongshan Wu Shuo Liu Xiaoming Song Jianping Li Wei Huang Lingyan Liu;Yutong Zhu;Hongbing Xu;Yang Wang;Tong Wang;Qian Zhao;Yi Zhang;Jie Chen;Shengcong Liu;Tieci Yi;Rongshan Wu;Shuo Liu;Xiaoming Song;Jianping Li;Wei Huang

作者机构：Department of Occupational and Environmental Health SciencesSchool of Public HealthPeking UniversityBeijing 100191China Peking University Institute of Environmental MedicinePeking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences of Ministry of EducationHealth Science CenterPeking UniversityBeijing 100191China Department of Prevention and Health CareHospital of Health Science CenterPeking UniversityBeijing 100191 China Institute for Risk Assessment SciencesUniversity Medical Centre UtrechtUniversity of UtrechtP.O.Box 801253508 TC Utrechtthe Netherlands Department of CardiologyPeking University First HospitalBeijing 100034China 

出 版 物：《Global Health Journal》 (全球健康杂志（英文）)

年 卷 期：2022年第6卷第1期

页      面：6-18页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by China Postdoctoral Science Foundation(2021M690249) Michigan Medicine-PKUHSC Joint Institute for Translational and Clinical Research(BMU20140467) 

主　　题：Ozone Cardiac arrhythmias Cardiac autonomic function Myocardial injury Panel study 

摘      要：Objective The exact biological mechanism whereby exposure to ambient ozone(O3)may contribute to clinical onset of cardiovascular events remains *** this study,we aim to examine the impacts of O3 exposure on cardiac arrhythmias and potential pathways involved through autonomic dysfunction and myocardial *** Seventy-three non-smoking healthy adults were followed with 4 repeated measurements of 24-hour ambulatory arrhythmias,heart rate variability,ST-segment deviation,and blood pressure(BP)in Beijing,China,2014‒*** additive mixed models coupled with distributed lag nonlinear models were constructed to evaluate the associations and potential interlinks between O3 exposure and outcome *** During the study period,24-hour average concentrations of ambient O3 were 47.4µg/m3(ranging from 1.0 to 165.9µg/m3).Increased risks of premature ventricular contraction and ventricular tachycardia were associated with interquartile range increases in O3 exposure during the last 5 days before each participant s clinic visit,with relative risks of 2.14(95%confidence interval[CI]:1.95 to 2.32)and 5.47(95%CI:3.51 to 7.43),*** analyses further showed that sympathetic activation,parasympathetic inhibition,and elevated BP levels,as well as heightened risks of ST-segment depression could mediate up to 47.74%of the risks of arrhythmias attributable to O3 *** Our results suggest that short-term exposure to ambient O3 could prompt the genesis of arrhythmias partially through worsening autonomic function and myocardial burden.