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Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease

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Zoological Research 2024年第1期45卷 79-94页

作者： ya-Ling Zhu Lei-Lei Meng Jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang yun-Shu Tang Min Xue Mei-Zi Zhu Jin Peng Xue-Jin Lu Jian-Zhen Huang Zi-Chen Song Chong Wu Ke-Zhong Zheng Qing-Qing dai Fan Huang Hao-Shu Fang Department of Pathophysiology Anhui Medical UniversityHefeiAnhui 230032China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China College of Animal Science and Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain ***,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP ***,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory *** total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD *** on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating *** study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.

关键词： Non-alcoholic fatty liver disease C/EBPβ Lipopolysaccharide-binding protein H3K27ac Integrative analysis Enhancer

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Cultivating the uncultured:Harnessing the“sandwich agar plate”approach to isolate heme-dependent bacteria from marine sediment

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mLife 2024年第1期3卷 143-155页

作者： Jing Zhang Qi-yun Liang Da-Shuai Mu Fengbai Lian ya Gong Mengqi Ye Guan-Jun Chen Yuqi Ye Zong-Jun Du State Key Laboratory of Microbial Techlogy Insttute of Micrbial TchnoogyShandong UniversityQingdaoChina Marine College Shandong UniverstyWeihaiChina Shandong University-Weihai Research Institute of Industrial Technology WeihaiChina

In the classical microbial isolation technique,the isolation process inevitably destroys all microbial interactions and thus makes it difficult to culture the many microorganisms that rely on these interactions for *** this study,we designed a simple coculture technique named the“sandwich agar plate method,”which maintains microbial interactions throughout the isolation and pure culture *** total yield of uncultured species in sandwich agar plates based on eight helper strains was almost 10-fold that of the control *** uncultured species displayed commensal *** study found that heme was the growth-promoting factor of some marine commensal *** genomic analysis revealed that heme auxotrophies were common in various biotopes and prevalent in many uncultured microbial ***,our study supported that the survival strategies of heme auxotrophy in different habitats varied *** findings highlight that cocultivation based on the“sandwich agar plate method”could be developed and used to isolate more uncultured bacteria.

关键词： cultivation growth factors heme sandwich agar plate uncultured bacteria

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FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1803-1824页

作者： Xian-Ze Xie Lei Zuo Wei Huang Qiao-Mei Fan ya-yun Weng Wen-Dong yao Jia-Li Jiang Jia-Qi Jin Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310018Zhejiang ProvinceChina Anhui Province Huainan City Shou County Agricultural Machinery Affairs Management Center Huainan 232200Anhui ProvinceChina

BACKGROUND Stomach adenocarcinoma(STAD)is one of the main reasons for cancer-related deaths *** investigation aimed to define the connection between STAD and Cuproptosis-related genes(CRGs).Cuproptosis is a newly identified form of mitochondrial cell death triggered by *** To explore the identification of potential biomarkers for STAD disease based on *** A predictive model using Gene Ontology(GO),Least Absolute Shrinkage and Selection Operator(LASSO),Kyoto Encyclopedia of Genes and Genomes(KEGG),Gene Set Variation Analysis(GSVA),and Gene Set Enrichment Analysis analyzed gene interconnections,focusing on 3 copper-related genes and their expression in The Cancer Genome *** for mRNA-miRNA and mRNA-transcription factor interactions were *** prognostic significance of CRG scores was evaluated using time-receiver operating characteristic,Kaplan-Meier curves,and COX regression *** was conducted with datasets GSE26942,GSE54129,and *** of copper-related differ-entially expressed genes was also analyzed in various human tissues and gastric cancer subpopulations using the human protein *** Three significant genes(FDX1,LIAS,MTF1)were identified and selected via LASSO analysis to predict and classify individuals with STAD into high and low CRG score *** genes were down-regulated in both risk *** and KEGG analyses highlighted their involvement mainly in the electron transport *** validating their differential expression,FDX1 emerged as the most accurate diagnostic marker for gastric ***,the RCircos package localized FDX1 on chromosome *** Our study revealed that FDX1 could be a potential biomarker and treatment target for gastric malignancy,providing new ideas for further scientific research.

关键词： Stomach adenocarcinoma disease Copper death FDX1 prognostic biomarkers Cuproptosis-related genes

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1949年华北解放区南下干部集中整训之研究

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河北学刊 2024年第1期44卷 115-122页

作者：代雅洁南开大学马克思主义学院

抽调大批干部南下是中共中央为夺取全国胜利而制定的重大战略决策,华北解放区的干部南下工作则构成全国“南下”战略中的关键性环节。在南下干部的动员、抽调等工作完成之后,华北解放区下辖各区的南下干部分别在石家庄、武安、菏泽、威... 详细信息

抽调大批干部南下是中共中央为夺取全国胜利而制定的重大战略决策,华北解放区的干部南下工作则构成全国“南下”战略中的关键性环节。在南下干部的动员、抽调等工作完成之后,华北解放区下辖各区的南下干部分别在石家庄、武安、菏泽、威县、开平和正定等地开展了为期一个月左右的集中整训。此次集中整训目标明确,兼顾思想性与实用性,为南下干部适应从北方到南方、从老区到新区、从乡村到城市的工作实践转移奠定了基础。华北解放区南下干部集中整训过程中的组织整编、学习教育和军事训练,亦暗含着中国共产党理论与实践相结合、常规与运动相融合的干部生成与养成机制。

关键词：南下干部集中整训华北解放区

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Molecular mechanism of hypoxia and alpha-ketoglutaric acid on collagen expression in scleral fibroblasts

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1780-1790页

作者： yun Sun Zhuo-Zheng Li Jing yang ya-Ru Sha Xin-Yu Hou Hong Fu Jia-Yin Li Shu-Chang Bai Yong-Fang Xie Guo-Hui Wang School of Life Science and Technology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

AIM:To investigate the molecular mechanisms underlying the influence of hypoxia and alpha-ketoglutaric acid(α-KG)on scleral collagen ***:Meta-analysis and clinical statistics were used to prove the changes in choroidal thickness(ChT)during *** establishment of a hypoxic myopia model(HYP)for rabbit scleral fibroblasts through hypoxic culture and the effects of hypoxia andα-KG on collagen expression were demonstrated by Sirius red *** analysis was used to verify the genes and pathways that hypoxia andα-KG affect collagen ***,real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)was used for reverse ***:Meta-analysis results aligned with clinical statistics,revealing a thinning of ChT,leading to scleral *** red staining indicated lower collagen expression in the HYP group and higher collagen expression in the HYP+α-KG group,showed that hypoxia reduced collagen expression in scleral fibroblasts,whileα-KG can elevated collagen expression under HYP *** analysis unveiled the related genes and signaling pathways of hypoxia andα-KG affect scleral collagen expression and the results were verified by ***:The potential molecular mechanisms through which hypoxia andα-KG influencing myopia is unraveled and three novel genes TLCD4,TBC1D4,and EPHX3 are *** findings provide a new perspective on the prevention and treatment of myopia via regulating collagen expression.

关键词： sclera scleral collagen expression hypoxia alpha-ketoglutaric acid myopia

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拔尖创新人才培养的理论基础和实践思路

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华东师范大学学报（教育科学版） 2024年第1期42卷 1-23页

作者：戴耘纽约州立大学美国纽约州奥尔伯尼市12222

拔尖创新人才的培养是一个现实而又紧迫的话题,但关于什么是“拔尖创新人才”,如何选拔和培养这类人才,尚缺乏成熟的理论准备和实践引导。本文旨在对创新潜能、发展、成就的理论以及对应的识别、培养、文化支持等社会实践做一个系统概... 详细信息

拔尖创新人才的培养是一个现实而又紧迫的话题,但关于什么是“拔尖创新人才”,如何选拔和培养这类人才,尚缺乏成熟的理论准备和实践引导。本文旨在对创新潜能、发展、成就的理论以及对应的识别、培养、文化支持等社会实践做一个系统概要的阐述。首先,在拔尖创新人才的界定上,本文提出了创新的五种形态和创新人才的两种不同类型。第二,在创新人才的识别问题上,本文提出了基于人才动态发展观并结合“总体筛选”和“个体考察”的人才识别模式。第三,在发展和培养问题上,本文提出兼顾成长阶段和领域具体性同时突出“探索未知”和“开放性”的培养模式。第四,在创新成就的文化支持上,本文探讨了如何在创新实践中营造兼容认知多样性和鼓励自由探索的生态环境。第五,本文进一步针对现有教育体制提出了五个实践策略上的着眼点。最后,关于教育实践的政策导向,本文提出了四个基本原则和四种认知误区。

关键词：创新人才创新类型创新潜能心智发展人才识别培养模式创新文化教育政策

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3M syndrome patient with a novel mutation:A case rep

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World Journal of Clinical Cases 2024年第8期12卷 1454-1460页

作者： Ming-Ran Luo Si-Ming dai Yin Li Qian Wang Hao Liu Peng Gao Jia-yun Liu Jian Chen Shu-Jie Zhao Guo-Yong Yin Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND A rare autosomal recessive genetic disorder,3M syndrome,is characterized by severe intrauterine and postnatal growth *** with 3M syndrome typically exhibit short stature,facial deformities,long tubular bones,and high vertebral bodies but generally lack mental abnormalities or other organ *** genes associated with 3M syndrome include CUL7,OBSL1 and *** clinical and molecular characteristics of patient with 3M syn-drome are unique and serve as important diagnostic *** SUMMARY In this case,the patient displayed square shoulders,scoliosis,long slender tubular bones,and normal neurological ***,the patient did not exhibit the typical dysmorphic facial features,relative macrocephaly,or growth retardation commonly observed in individuals with 3M *** exon sequencing revealed a novel heterozygous c.56681+1G>C(Splice-3)variant and a previously reported nonsense heterozygous c.3341G>A(***1114Ter)variant of ***,it is important to note that the clinical features of 3M syndrome may not always be observable,and genetic confirmation is often ***,the identification of the c.5683+1G>C variant in OBSL1 is notewor-thy because it has not been previously reported in public *** Our study identified a new variant(c.5683+1G>C)of OBSL1 that contributes to expanding the molecular profile of 3M syndrome.

关键词： 3M syndrome CUL7 OBSL1 CCDC8 Autosomal recessive Case report

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Ocular surface in patients with different degrees of myopia

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1313-1321页

作者： yan-yun Lyu Shuang Wang Xiao-Niao Chen Zhen-Yu Wang Shan-Shan Huang yan Yuan Hong-Shuang Lu Wen-Li yang Li-ya Qiao Lei Tian Ying Jie Tongren Eye Care Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical University and Beijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Department of Ophthalmology the Third Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100039China Department of Ophthalmology and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan

AIM:To investigate the clinical features of the ocular surface in patients with different degrees of ***:A cross-sectional study was conducted involving 122 participants with myopia in Beijing Tongren Hospital from February to June,*** completing the Ocular Surface Disease Index(OSDI)score scale,measurements were taken for refraction,biometric parameters and ocular surface *** prevalence,severity and related parameters of the dry eye among different groups based on axial length(AL)were *** analysis was performed between ocular surface parameters and refraction/biometric measurement ***:Statistically significant differences were observed in refractive error,corneal thickness,anterior chamber depth,and subfoveal choroidal thickness among the groups(all P<0.05).With the increase in AL,the incidence and severity of dry eye increased significantly(P<0.05).Moreover,the tear film break-up time(BUT)shortened(P<0.05),and the corneal fluorescein staining(CFS)points increased significantly(P<0.05).OSDI scores were positively correlated with AL and spherical equivalent(SE;both P<0.05);BUT was negatively correlated with AL,SE,and corneal astigmatism(AST;all P<0.05);Schirmer I test(SIT)results were negatively correlated with AL and SE(both P<0.05).CONCLUSION:AL elongation is a risk factor for dry eye onset in myopic *** longer the AL,the more severe the dry eye is,with the increased CFS spots and tear film ***,SE and AST exhibit negative correlations with dry eye symptom scores and ocular surface parameters.

关键词： myopia axial length ocular surface dry eye

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Topological edge and corner states of valley photonic crystals with zipper-like boundary conditions

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Chinese Physics B 2024年第4期33卷 480-491页

作者：沈云峰许孝芳孙铭周文佶常雅箐 School of Mechanical Engineering Jiangsu UniversityZhenjiang 212000China School of Optical and Electronic Information Suzhou City University&Suzhou Key Laboratory of BiophotonicsSuzhou 215104China

We present a stable valley photonic crystal(VPC)unit cell with C_(3v)symmetric quasi-ring-shaped dielectric columns and realize its topological phase transition by breaking mirror *** on this unit cell structure,topological edge states(TESs)and topological corner states(TCSs)are *** obtain a new type of wave transmission mode based on photonic crystal zipper-like boundaries and apply it to a beam splitter assembled from rectangular photonic crystals(PCs).The constructed beam splitter structure is compact and possesses frequency separation *** addition,we construct a box-shaped triangular PC structures with zipper-like boundaries and discover phenomena of TCSs in the corners,comparing its corner states with those formed by other *** on this,we explore the regularities of the electric field patterns of TESs and TCSs,explain the connection between the characteristic frequencies and locality of TCSs,which helps better control photons and ensures low power consumption of the system.

关键词： valley photonic crystal topological edge states topological corner states higher-order topological insulators topological phase transition

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Overall clinical course of indeterminate dendritic cell tumor patients without skin lesions:A rare case report

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World Journal of Clinical Cases 2024年第19期12卷 4022-4028页

作者： Hao Liang yun-Fei Zhao Liu-Ping Zhang ya-Kun Wu Department of Hepatobiliary Surgery Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Pathology Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Gastrointestinal Surgery Suining Central HospitalSuining 629000Sichuan ProvinceChina

BACKGROUND Indeterminate dendritic cell tumor(IDCT)is a rare tumor of immune cells,and IDCT patients without skin lesions are rarely ***,the clinical course in this type of patient is unclear,and further research on the underlying pathological mechanisms and appropriate treatments is *** SUMMARY This study describes a female IDCT patient with bile duct *** strong mimicry of IDCT lesions confused doctors,and consequently,this patient,who had no skin lesions,was first diagnosed with ***,she presented with persistent abdominal distension without *** mesenteric lymph nodes along with massive ascites were observed in the subsequent imaging ***,no tumor cells or pathogens were found in the three subsequent ascites *** took 2 years to reach the correct diagnosis,which was eventually obtained by performing surgery for biopsy of the patient’s abdominal lymph ***,by then,she was already in a cachexic ***,she received a cycle of cyclophosphamide therapy and was advised to visit a hospital specializing in rare *** For IDCT patients without skin lesions,early biopsy is the key to obtaining a correct ***,the collective management of IDCT patients is *** histological and molecular biology studies based on human specimens are critical for understanding the pathological mechanism of dendritic cell tumors in the future.

关键词： Indeterminate dendritic cell tumor Clinical development Surgical biopsy Collective management Dendritic cell Case report

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