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Acute inferior wall myocardial infarction induced by aortic dissection in a young adult with Marfan syndrome:A case report

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World Journal of Clinical Cases 2021年第4期9卷 970-975页

作者： yun-Xiao Zhang Hang yang gui-Song Wang Department of Cardiology Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing 100191China Department of Cardiac Surgery Peking University Third HospitalBeijing 100191China

BACKGROUND Aortic dissection(AD)is an emergent and life-threatening disorder,and its inhospital mortality was reported to be as high as 24.4%-27.4%.AD can mimic other more common disorders,especially acute myocardial infarction(AMI),in terms of both symptoms and electrocardiogram changes.Reperfusion for patients with AD may result in catastrophic outcomes.Increased awareness of AD can be helpful for early diagnosis,especially among younger patients.CASE SUMMARY We report a 28-year-old man with acute left side chest pain without cardiovascular risk factors.He was diagnosed with acute inferior ST-segment elevation myocardial infarction(STEMI),which,based on illness history,physical examination,and intraoperative findings,was eventually determined to be type A AD caused by Marfan syndrome.Emergent coronary angiography revealed the anomalous origin of the right coronary artery as well as eccentric stenosis of the proximal segment.Subsequently,computed tomography angiography(CTA)showed intramural thrombosis of the ascending aorta.Finally,the patient was transferred to the cardiovascular surgery department for a Bentall operation.He was discharged 13 d after the operation,and aortic CTA proved a full recovery at the 2-year follow-up.CONCLUSION It is essential and challenging to differentiate AD from AMI.Type A AD should be the primary consideration in younger STEMI patients without cardiovascular risk factors but with outstanding features of Marfan syndrome.

关键词： Aortic dissection Acute myocardial infarction Marfan syndrome Case report

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Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid-βand Prevents Alzheimer’s Disease-Type Pathology and Cognitive Deficits

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Neuroscience Bulletin 2023年第12期39卷 1775-1788页

作者： Zhi-Hao Liu Yu-Di Bai Zhong-Yuan Yu Hui-yun Li Jie Liu Cheng-Rong Tan gui-Hua Zeng yun-Feng Tu Pu-yang Sun Yu-Juan Jia Jin-Cai He Yan-Jiang Wang Xian-Le Bu Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China Institute of Brain and Intelligence Third Military Medical UniversityChongqing400042China State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical UniversityChongqing400042China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai201200China

Deficiencies in the clearance of peripheral amyloidβ(Aβ)play a crucial role in the progression of Alzheimer’s disease(AD).Previous studies have shown that the ability of blood monocytes to phagocytose Aβis decreased in AD.However,the exact mechanism of Aβclearance dysfunction in AD monocytes remains unclear.In the present study,we found that blood monocytes in AD mice exhibited decreases in energy metabolism,which was accompanied by cellular senescence,a senescence-associated secretory phenotype,and dysfunctional phagocytosis of Aβ.Improving energy metabolism rejuvenated monocytes and enhanced their ability to phagocytose Aβin vivo and in vitro.Moreover,enhancing blood monocyte Aβphagocytosis by improving energy metabolism alleviated brain Aβdeposition and neuroinflammation and eventually improved cognitive function in AD mice.This study reveals a new mechanism of impaired Aβphagocytosis in monocytes and provides evidence that restoring their energy metabolism may be a novel therapeutic strategy for AD.

关键词： Alzheimer's disease Aβclearance Monocyte Phagocytosis Energy metabolism

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Correlation between diabetic retinopathy and Helicobacter pylori infection: a cross-sectional retrospective study

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1260-1267页

作者： Zhen-Rong Liu Ting Bao gui-Jun Xue Qiao-yun Xu yun-Xia Gao Ming Zhang Health Management Center General Practice Medical CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To explore the correlation between diabetic retinopathy(DR)and Helicobacter pylori(Hp)infection,based on data from a physical examination population.METHODS:This cross-sectional retrospective analysis included data of 73824 health examination participants from December 2018 to December 2019.Participants were divided into the diabetic group and non-diabetic group,nondiabetic retinopathy(NDR)group,non-proliferative diabetic retinopathy(NPDR)group,proliferative diabetic retinopathy(PDR)group,and Hp infection group.Gender,age,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting plasma glucose(FPG),glycated hemoglobin A1c(HbA1c),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and Hp data were recorded to compare the degree of DR lesions and Hp infection.Logistic regression analysis was used to evaluate the correlation between DR and Hp infection.RESULTS:There was a statistically significant difference between the diabetic and non-diabetic group(χ2=94.17,P<0.0001).Logistic regression analysis showed that male sex,age,BMI,SBP,TG,LDL-C,and Hp infection were independent risk factors for DR.There was no correlation between the degree of DR lesions and Hp infection(ρ=-0.00339,P=0.7753).Age[odds ratio(OR)=1.035,95%CI:1.024,1.046,P<0.0001]and SBP(OR=1.009,95%CI:1.004,1.015,P=0.0013)were independent risk factors for the degree of DR.CONCLUSION:There is a significant correlation between DR and Hp infection in the physical examination population.Hp infection is a risk factor for DR,and there is no significant difference between Hp infection and DR of different pathological degrees.Actively eradicating Hp may be of help to prevent DR.

关键词： diabetic retinopathy Helicobacter pylori physical examination population correlation

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黄河(郑州段)水体中微塑料污染特征及来源分析

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中国环境科学 2024年第7期44卷 4136-4144页

作者：李和通马振芳郭宇邓正云李银月桂新马丽张发文河南省郑州生态环境监测中心河南郑州450007 河南农业大学河南郑州450046

为探究微塑料在我国黄河中下游水体中的分布情况和污染特征,以黄河(郑州段)为研究对象,选取7个具有代表性的点位采集水样,通过体视显微镜对微塑料的丰度和形貌特征进行观察,进一步借助显微红外光谱对其组成成分进行鉴定,并将统计结果与... 详细信息

为探究微塑料在我国黄河中下游水体中的分布情况和污染特征,以黄河(郑州段)为研究对象,选取7个具有代表性的点位采集水样,通过体视显微镜对微塑料的丰度和形貌特征进行观察,进一步借助显微红外光谱对其组成成分进行鉴定,并将统计结果与其他水体的微塑料污染状况进行对比分析,并探究其污染来源.结果表明:黄河(郑州段)水体中微塑料平均丰度为(16.86±4.20)n/L;以粒径小于1mm的尺寸为主,占比高达61.42%;形状中纤维状占比最高为79.31%;微塑料颜色以透明为主,占比为56.06%;微塑料聚合物类型以人造丝(Rayon)为主,同时还有聚对苯二甲酸乙二醇酯(PET)和聚丙烯(PP)等.不同点位微塑料的形貌特征和聚合物类型可在一定程度上反映其潜在污染来源.黄河(郑州段)和其他水体相比,微塑料丰度分布存在一定的差异性,粒径分布趋势则大致相同,形状、颜色以纤维状、透明为主,不同水体间的微塑料污染差异可能与水体周边生境、经济水平以及人类活动情况等因素密切相关.

关键词：微塑料污染特征黄河丰度分布

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Granulomatous prostatitis after bacille Calmette-Guérin instillation resembles prostate carcinoma:A case report and review of the literature

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World Journal of Clinical Cases 2023年第9期11卷 2051-2059页

作者： Yu Yao Jun-Jie Ji Hai-yun Wang Li-Jiang Sun gui-Ming Zhang Department of Urology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Bacille Calmette-Guérin(BCG)instillation is recommended in patients with nonmuscle-invasive bladder cancer who have intermediate-risk and high-risk tumors.However,granulomatous prostatitis is a rare complication induced by BCG instillation,which can easily be misdiagnosed as prostate cancer.Here,we report a case of granulomatous prostatitis that resembled prostate cancer.CASE SUMMARY A 64-year-old Chinese man with bladder cancer received BCG instillation.Three days later,he stopped BCG instillation and received anti-infective therapy due to the urinary tract infection.Three months after BCG restart,he had rising total prostate-specific antigen(PSA)(9.14 ng/mL)and decreasing free PSA/total PSA(0.09).T2-weighted images of magnetic resonance imaging(MRI)showed a 28 mm×20 mm diffuse low signal abnormality in the right peripheral zone,which was markedly hyperintense on high b-value diffusion-weighted MRI and hypointense on apparent diffusion coefficient map images.Considering Prostate Imaging Reporting and Data System score of 5 and possibility of prostate cancer,a prostate biopsy was conducted.Histopathology showed typical features of granulomatous prostatitis.The nucleic acid test for tuberculosis was positive.He was finally diagnosed with BCG-induced granulomatous prostatitis.Thereafter,he stopped BCG instillation and received anti-tuberculosis treatment.During 10 mo follow-up,he had no evidence of tumor recurrence or symptoms of tuberculosis.CONCLUSION Temporarily elevated PSA and high followed by low signal abnormality on diffusion-weighted MRI are important indicators of BCG-induced granulomatous prostatitis.

关键词： Granulomatous prostatitis Prostate cancer Bacille Calmette-Guérin Magnetic resonance imaging Prostate-specific antigen Case report

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Quafu-RL:The cloud quantum computers based quantum reinforcement learning

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Chinese Physics B 2024年第5期33卷 29-34页

作者：靳羽欣许宏泽王正安庄伟峰黄凯旋时运豪马卫国李天铭陈驰通许凯冯玉龙刘培陈墨李尚书杨智鹏钱辰马运恒肖骁钱鹏顾炎武柴绪丹普亚南张翼鹏魏世杰曾进峰李行龙桂鲁金贻荣于海峰范桁刘东胡孟军 Beijing Academy of Quantum Information Sciences Beijing 100193China State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Institute of Physics Chinese Academy of SciencesBeijing 100190China Frontier Science Center for Quantum Information Beijing 100184China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences Nankai UniversityTianjin 300071China

With the rapid advancement of quantum computing,hybrid quantum–classical machine learning has shown numerous potential applications at the current stage,with expectations of being achievable in the noisy intermediate-scale quantum(NISQ)era.Quantum reinforcement learning,as an indispensable study,has recently demonstrated its ability to solve standard benchmark environments with formally provable theoretical advantages over classical counterparts.However,despite the progress of quantum processors and the emergence of quantum computing clouds,implementing quantum reinforcement learning algorithms utilizing parameterized quantum circuits(PQCs)on NISQ devices remains infrequent.In this work,we take the first step towards executing benchmark quantum reinforcement problems on real devices equipped with at most 136 qubits on the BAQIS Quafu quantum computing cloud.The experimental results demonstrate that the policy agents can successfully accomplish objectives under modified conditions in both the training and inference phases.Moreover,we design hardware-efficient PQC architectures in the quantum model using a multi-objective evolutionary algorithm and develop a learning algorithm that is adaptable to quantum devices.We hope that the Quafu-RL can be a guiding example to show how to realize machine learning tasks by taking advantage of quantum computers on the quantum cloud platform.

关键词： quantum cloud platform quantum reinforcement learning evolutionary quantum architecture search

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促进烟草根系早生快发的移栽基质优化研究

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植物营养与肥料学报 2024年第3期30卷 615-626页

作者：艾栋张云贵李志宏冯文强朱经伟陈曦常乃杰边立丽刘青丽中国农业科学院农业资源与农业区划研究所北京100081 中国烟草总公司四川省公司四川成都610041 贵州省烟草科学研究院贵州贵阳550081

[目的]针对烤烟移栽苗根系前期发育迟缓等问题,研究利用廉价有机材料和腐殖酸改良幼苗移栽基质对烤烟根区水肥环境和烟苗生长的影响,为研制高效和环境友好型烟草幼苗移栽载体奠定基础。[方法]常规移栽基质一般由秸秆、椰糠、草炭以3∶1... 详细信息

[目的]针对烤烟移栽苗根系前期发育迟缓等问题,研究利用廉价有机材料和腐殖酸改良幼苗移栽基质对烤烟根区水肥环境和烟苗生长的影响,为研制高效和环境友好型烟草幼苗移栽载体奠定基础。[方法]常规移栽基质一般由秸秆、椰糠、草炭以3∶1∶1混合而成,本试验以此基质作基础处理(JYC);另设添加腐殖酸钾(JYCK)、蛭石(JYCZ)、腐殖酸钾和蛭石(JYCZK)处理,以供试土壤为空白对照(CK),当幼苗在移栽基质中生长10、30、50天时,测定土壤理化指标和烤烟生物量,在生长10与50天时,测定烟草根系形态指标。[结果]与CK处理相比,基质移栽在移栽后10天的烟草根生物量和根冠比分别增加了48.3%~62.1%和80.4%~114.4%,烟株根长度和根分支数分别提高了45.9%~128.9%和52.0%~174.3%;移栽后50天的土壤硝态氮和溶解性有机碳(DOC)含量分别提高了62.9%~147.2%和230.3%~399.8%。基于随机森林模型分析,发现移栽基质、土壤温度和溶解性有机碳含量、根长度和根尖数显著影响烤烟地上部生物量;通过相关性分析和结构方程模型分析,发现移栽基质通过改善根区环境,直接或间接影响烤烟根系形态和促进地上部生物量的积累。与CK相比,JYC、JYCK、JYCZ和JYCZK处理的土壤硝态氮含量分别提高了65.2%、147.2%、62.9%和80.0%。JYCZK处理的烤烟根长度比JYC和JYCK处理分别提高了45.0%和30.1%,根分支数分别增加了28.9%和40.8%。[结论]在基础基质中添加0.5%的腐殖酸钾和16.7%的蛭石(体积)能更有效地协调土壤氮素供应水平,优化烤烟根系形态。

关键词：移栽基质根区环境根系形态烤烟

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RING-box proteins regulate leaf senescence and stomatal closure via repression of ABA transporter gene ABCG40

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Journal of Integrative Plant Biology 2022年第5期64卷 979-994页

作者： yun Qi Wei Jun Jie Yuan Chen Chen Xiao gui Xin Li Jing Ying Yan Shao Jian Zheng Zhong Jie Ding State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Guangdong Laboratory for Lingnan Modern Agriculture College of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China College of Agronomy and Biotechnology Zhejiang UniversityHangzhou 310058China Agricultural Experimental Station Zhejiang UniversityHangzhou 310058China

Plant hormone abscisic acid(ABA)plays an indispensable role in the control of leaf senescence,during which ABA signaling depends on its biosynthesis.Nevertheless,the role of ABA transport in leaf senescence remains unknown.Here,we identified two novel RING-box protein-encoding genes UBIQUITIN LIGASE of SENESCENCE 1 and2(ULS1 and ULS2)involved in leaf senescence.Lack of ULS1 and ULS2 accelerates leaf senescence,which is specifically promoted by ABA treatment.Furthermore,the expression of senescence-related genes is significantly affected in mature leaves of uls1/uls2 double mutant(versus wild type(WT))in an ABA-dependent manner,and the ABA content is substantially increased.ULS1 and ULS2 are mainly expressed in the guard cells and aging leaves,and the expression is induced by ABA.Further RNA-seq and quantitative proteomics of ubiquitination reveal that ABA transporter ABCG40 is highly expressed in uls1/uls2 mutant versus WT,though it is not the direct target of ULS1/2.Finally,we show that the acceleration of leaf senescence,the increase of leaf ABA content,and the promotion of stomatal closure in uls1/usl2 mutant are suppressed by abcg40 loss-of-function mutation.These results indicate that ULS1 and ULS2 function in feedback inhibition of ABCG40-dependent ABA transport during ABA-induced leaf senescence and stomatal closure.

关键词： ABA Arabidopsis E3 ligase leaf senescence stomata transport

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机器学习公平性指标:现状、挑战和展望

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计算机科学 2024年第1期51卷 266-272页

作者：张文琼李云南京邮电大学计算机学院、软件学院、网络空间安全学院南京210023 江苏省大数据安全与智能处理重点实验室南京210023

随着机器学习应用的日益普及,机器学习公平性问题引起了学术界和工业界的广泛关注,成为了可信人工智能的重要组成部分。为了评估和改善机器学习应用的公平性,研究人员提出了一系列公平性指标,这些指标有助于保障机器学习模型在不同个体... 详细信息

随着机器学习应用的日益普及,机器学习公平性问题引起了学术界和工业界的广泛关注,成为了可信人工智能的重要组成部分。为了评估和改善机器学习应用的公平性,研究人员提出了一系列公平性指标,这些指标有助于保障机器学习模型在不同个体、群体间的公平决策,并为改善和优化模型提供指导。但各界对于指标之间的区别与联系仍没有形成共识,对不同场景、不同任务的公平性定义没有明确的划分,公平性指标缺乏完善的分类体系。文中对公平性指标进行了全面的整理和归类,从指标的数学定义出发,根据是否基于概率统计将公平性指标分为两类,然后分别对这两类指标进行进一步的细粒度划分和阐述。为了便于读者理解和运用,结合一个实际案例,从适用场景和实现条件等方面指出各类指标的优势和面临的挑战,还结合数学定义讨论了指标之间的关系,并对未来趋势进行了展望。

关键词：机器学习机器学习公平性可信人工智能公平性指标公平决策

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不同蔗叶生物炭施用量对甘蔗产量及养分吸收利用的影响

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南方农业学报 2024年第3期55卷 803-811页

作者：杨梦乐彭嘉宇桂意云沈小微唐新莲黄金生周柳强刘昔辉谭宏伟区惠平广西大学农学院广西南宁530004 广西农业科学院农业资源与环境研究所/广西耕地保育重点实验室广西南宁530007 广西农业科学院甘蔗研究所/广西甘蔗遗传改良重点实验室/农业农村部广西甘蔗生物技术与遗传改良重点实验室广西南宁530007

【目的】研究蔗叶源生物炭不同施用量对甘蔗产量及氮磷钾养分吸收利用的影响,以期为蔗叶生物炭在甘蔗生产中的科学施用及实现养分高效利用提供理论依据。【方法】于2021—2022年开展田间试验和15N同位素示踪桶栽试验,以桂柳05136和桂糖4... 详细信息

【目的】研究蔗叶源生物炭不同施用量对甘蔗产量及氮磷钾养分吸收利用的影响,以期为蔗叶生物炭在甘蔗生产中的科学施用及实现养分高效利用提供理论依据。【方法】于2021—2022年开展田间试验和15N同位素示踪桶栽试验,以桂柳05136和桂糖42为供试品种,设CK(对照,不施蔗叶生物炭)、T1(蔗叶生物炭用量2.7 t/ha)、T2(蔗叶生物炭用量5.4 t/ha)和T3(蔗叶生物炭用量10.8 t/ha)4个处理,对比分析不同蔗叶生物炭用量对甘蔗收获期蔗茎和蔗叶产量、氮磷钾养分含量和吸收累积量、氮肥吸收量及氮肥利用率的影响。【结果】与CK相比,施入不同用量的蔗叶生物炭对蔗叶产量无显著影响(P>0.05,下同),但均可不同程度提高甘蔗蔗茎产量,且随蔗叶生物炭施用量增加,蔗茎产量呈先升高后降低的变化趋势,在T2处理达最高,且差异达显著水平(P<0.05,下同)。施用蔗叶生物炭,蔗茎与蔗叶氮、磷含量及地上部氮、磷吸收累积量均无显著变化,T2处理显著提高2022年大田试验蔗叶磷吸收累积量及桶栽试验蔗茎氮、磷吸收累积量。大田试验下,施用蔗叶生物炭较CK显著提高蔗茎钾含量,2021年和2022年增幅分别为31.3%~38.2%和10.5%~29.5%。蔗茎钾含量T2处理与T1处理相当,并在2022年显著高于T3处理。但在桶栽试验下,施用蔗叶生物炭对蔗茎、蔗叶及尾梢钾含量均无显著影响。施用蔗叶生物炭提高了大田试验蔗茎及地上部钾吸收累积量,其中,蔗茎增幅18.2%~45.6%,地上部增幅13.5%~32.8%,且以T2处理最高。施用蔗叶生物炭对甘蔗氮、磷养分生理利用效率无显著影响,但大田试验的钾养分生理利用效率显著降低14.7%~23.1%(2021年)和6.0%~19.5%(2022年)。15N同位素示踪进一步表明,蔗茎的氮肥吸收量最高,占总吸收量的46.5%~54.2%,蔗叶和尾梢的氮肥吸收量相当,分别占总吸收量的23.3%~27.5%和22.6%~28.0%。施用不同用量蔗叶生物炭,蔗叶与尾梢的氮肥吸收量差异不显著。T2处理较其他处理显著提高蔗茎氮肥吸收量36.5%~37.5%及氮肥利用率18.1%~24.2%。【结论】施用不同用量蔗叶生物炭对氮、磷的吸收因不同年份有所差异,但有利于提高甘蔗产量及蔗茎对钾的吸收,5.4 t/ha生物炭用量下蔗茎产量及钾吸收量最高,且显著促进蔗茎对氮肥的吸收及提高氮肥利用率,可作为推荐的适宜施用量。

关键词：生物炭甘蔗产量养分吸收

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