Correlation between diabetic retinopathy and Helicobacter pylori infection: a cross-sectional retrospective study

作     者：Zhen-Rong Liu Ting Bao Gui-Jun Xue Qiao-Yun Xu Yun-Xia Gao Ming Zhang 

作者机构：Health Management CenterGeneral Practice Medical CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of OphthalmologyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2023年第16卷第8期

页      面：1260-1267页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by The Project of National Key Research and Development(No.2018YFC1106103) 

主　　题：diabetic retinopathy Helicobacter pylori physical examination population correlation 

摘      要：AIM:To explore the correlation between diabetic retinopathy(DR)and Helicobacter pylori(Hp)infection,based on data from a physical examination ***:This cross-sectional retrospective analysis included data of 73824 health examination participants from December 2018 to December *** were divided into the diabetic group and non-diabetic group,nondiabetic retinopathy(NDR)group,non-proliferative diabetic retinopathy(NPDR)group,proliferative diabetic retinopathy(PDR)group,and Hp infection ***,age,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting plasma glucose(FPG),glycated hemoglobin A1c(HbA1c),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and Hp data were recorded to compare the degree of DR lesions and Hp *** regression analysis was used to evaluate the correlation between DR and Hp ***:There was a statistically significant difference between the diabetic and non-diabetic group(χ2=94.17,P0.0001).Logistic regression analysis showed that male sex,age,BMI,SBP,TG,LDL-C,and Hp infection were independent risk factors for *** was no correlation between the degree of DR lesions and Hp infection(ρ=-0.00339,P=0.7753).Age[odds ratio(OR)=1.035,95%CI:1.024,1.046,P0.0001]and SBP(OR=1.009,95%CI:1.004,1.015,P=0.0013)were independent risk factors for the degree of ***:There is a significant correlation between DR and Hp infection in the physical examination *** infection is a risk factor for DR,and there is no significant difference between Hp infection and DR of different pathological *** eradicating Hp may be of help to prevent DR.