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Reduced serum high-density lipoprotein cholesterol levels and aberrantly expressed cholesterol metabolism genes in colorectal cancer

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World Journal of Clinical Cases 2022年第14期10卷 4446-4459页

作者： Jin-Hua Tao Xiao-Tong Wang Wei Yuan Jia-Nan Chen Zhi-Jie Wang yun-bin ma Fu-Qiang Zhao Liu-Yuan Zhang Jie ma Qian Liu Department of Colorectal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Clinical Immunology CenterNational Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Abodominal Surgery Beijing Sanhuan Cancer HospitalBeijing 100122China

BACKGROUND Colorectal cancer(CRC)is a common malignant tumor of the gastrointestinal *** metabolism,as an important part of material and energy circulation,is well known to play a crucial role in *** To explore the relationship between serum lipids and CRC development and identify aberrantly expressed cholesterol metabolism genes in *** We retrospectively collected 843 patients who had confirmed CRC and received surgical resection from 2013 to 2015 at the Cancer Hospital of the Chinese Academy of Medical Sciences as our research *** levels of serum total cholesterol(TC),triglycerides,low-density lipoprotein cholesterol(LDL-C),highdensity lipoprotein cholesterol(HDL-C),LDL-C/HDL-C and clinical features were collected and statistically analyzed by ***,we used the data from Oncomine to screen the differentially expressed genes(DEGs)of the cholesterol metabolism pathway in CRC and used Gene Expression Profiling Interactive Analysis to confirm the candidate *** was used to analyze the prognostic value of the DEGs,and Search Tool for the Retrieval of Interacting Genes was used to construct the protein-protein interaction network of *** The serum HDL-C level in CRC patients was significantly correlated with tumor size,and patients whose tumor size was more than 5 cm had a lower serum HDL-C level(1.18±0.41 mmol/L vs 1.25±0.35 mmol/L,P<0.01)than their *** addition,TC/HDL(4.19±1.33 vs 3.93±1.26,P<0.01)and LDL-C/HDL-C(2.83±1.10 vs 2.61±0.96,P<0.01)were higher in patients with larger *** levels of HDL-C(P<0.05),TC/HDL-C(P<0.01)and LDL-C/HDL-C(P<0.05)varied in different stages of CRC patients,and the differences were *** screened 14 differentially expressed genes(DEGs)of the cholesterol metabolism pathway in CRC and confirmed that lipoprotein receptor-related protein 8(LRP8),PCSK9,low-density lipoprotein receptor(LDLR),MBTPS2 and FDXR are upregulated,while ABCA1 and OSBPL1A are downregulated in

关键词： Colorectal cancer High-density lipoprotein cholesterol Cholesterol metabolism Prognosis

Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals

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World Journal of Gastroenterology 2019年第34期25卷 5197-5209页

作者： Zhi-Jie Wang Ke An Rui Li Wei Shen man-Dula Bao Jin-Hua Tao Jia-Nan Chen Shi-Wen Mei Hai-Yu Shen yun-bin ma Fu-Qiang Zhao Fang-Ze Wei Qian Liu Department of Colorectal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of General Surgery Beijing HospitalBeijing 100730China Department of Orthopedics Lanzhou University Second HospitalLanzhou 730030China Department of Colorectal Surgery University of Chinese Academy of Sciences Zhejiang Cancer HospitalHangzhou 310022China

BACKGROUND Colorectal high-grade neuroendocrine neoplasms(HGNENs)are rare and constitute less than 1%of all colorectal *** on their morphological differentiation and proliferation identity,these neoplasms present heterogeneous clinicopathologic *** regarding treatment strategies for and improvement of the clinical outcomes of these patients remain *** To delineate the clinicopathologic features of and explore the prognostic factors for this rare *** This observational study reviewed the data of 72 consecutive patients with colorectal HGNENs from three Chinese hospitals between 2000 and *** clinicopathologic characteristics and follow-up data were carefully collected from their medical records,outpatient reexaminations,and telephone interviews.A survival analysis was conducted to evaluate their outcomes and to identify the prognostic factors for this *** According to the latest recommendations for the classification and nomenclature of colorectal HGNENs,61(84.7%)patients in our cohort had poorly differentiated neoplasms,which were categorized as high-grade neuroendocrine carcinomas(HGNECs),and the remaining 11(15.3%)patients had well differentiated neoplasms,which were categorized as high-grade neuroendocrine tumors(HGNETs).Most of the neoplasms(63.9%)were located at the *** than half of the patients(51.4%)presented with distant metastasis at the date of *** patients were followed for a median duration of 15.5 *** the entire cohort,the median survival time was 31 mo,and the 3-year and 5-year survival rates were 44.3%and 36.3%,*** the univariate and multivariate analyses demonstrated that increasing age,HGNEC type,and distant metastasis were risk factors for poor clinical *** Colorectal HGNENs are rare and aggressive malignancies with poor clinical ***,patients with younger age,good morphological differentiation,and without metastat

关键词： Colon Rectum Neuroendocrine Neoplasm Metastasis Prognosis

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： bin Xie Yuanhui Guo yun Chen Hao Zhang Jiawei Xiao maoxiang Hou Huilong Liu Li ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang bin Wang Ju-yun ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

采前喷钙对金陵黄露桃钙吸收及细胞超微结构的影响

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江苏农业学报 2016年第5期32卷 1171-1176页

作者：廖亚运张斌斌马瑞娟俞明亮南京农业大学园艺学院江苏南京210095 江苏省农业科学院园艺研究所.江苏省高效园艺作物遗传改良重点实验室江苏南京210014

以鲜食黄肉桃品种金陵黄露为材料,在盛花后30 d(幼果期)、55 d(果实膨大期)、80 d(成熟前期),分3次对果实和叶片喷施不同形态的钙,研究了喷钙对叶片、果皮、果肉钙含量及果肉细胞超微结构的影响。结果表明,采前喷钙增加了金陵黄露桃叶... 详细信息

以鲜食黄肉桃品种金陵黄露为材料,在盛花后30 d(幼果期)、55 d(果实膨大期)、80 d(成熟前期),分3次对果实和叶片喷施不同形态的钙,研究了喷钙对叶片、果皮、果肉钙含量及果肉细胞超微结构的影响。结果表明,采前喷钙增加了金陵黄露桃叶片、果皮、果肉的钙含量,整个发育期以幼果期喷钙效果最为显著,0.015 mol/L螯合钙处理在3个测定时期(花后55 d、80 d、87 d)钙含量最高。此外,在果实贮藏25 d后,观察其果肉细胞超微结构,发现经喷钙处理的果肉细胞中钙主要分布于细胞壁、细胞膜、液泡膜,而且细胞结构较清晰完整,0.020 mol/L和0.015 mol/L螯合钙处理的清晰程度较好;而喷施清水对照的果肉细胞中仅发现少量的钙,其细胞壁扭曲变形、断裂,细胞分室作用消失,细胞结构异常,细胞膜系统的结构和功能受到损伤。可见,在桃生长发育过程中叶片和果实表面喷施不同浓度的钙溶液能增加果实钙含量,使细胞结构和功能得到有效保护,其中以0.015 mol/L螯合钙处理效果较为明显。

关键词：桃钙含量细胞超微结构

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Confident Estimation for Density of a Biological Population Based on Line Transect Sampling

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Acta mathematicae Applicatae Sinica 2010年第1期26卷 79-92页

作者： Ren-bin Gong yun-bei ma Yong Zhou Research Institute of Petroleum Exploration and Development Northwest Gansu 730020 China Academy of mathematics and System Science. Chinese Academy of Science Beijing 100190 China Department of Statistics Shanghai University of Finance and Economics Shanghai 200433 China

Line transect sampling is a very useful method in survey of wildlife population. Confident interval estimation for density D of a biological population is proposed based on a sequential design. The survey area is occupied by the population whose size is unknown. A stopping rule is proposed by a kernel-based estimator of density function of the perpendicular data at a distance. With this stopping rule, we construct several confidence intervals for D by difference procedures. Some bias reduction techniques are used to modify the confidence intervals. These intervals provide the desired coverage probability as the bandwidth in the stopping rule approaches zero. A simulation study is also given to illustrate the performance of this proposed sequential kernel procedure.

关键词： Line transect sampling Confident interval estimation Stopping rule Bias reduction

Static Recrystallization Kinetics Model After Hot Deformation of Low-Alloy Steel Q345B

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Journal of Iron and Steel Research International 2010年第8期17卷 61-66页

作者： ma Bo PENG Yan JIA bin LIU yun-fei State Key Laboratory of Metastable materials Science and Technology Engineering Research Center of Rolling Equipmentand Complete Technology of Ministry of EducationYanshan UniversityQinhuangdao 066004HebeiChina

The static recrystallization behavior of low-alloy steel Q345B during double-pass hot compression deformation tests was investigated in the temperature range of 900-1000 ℃,the true strain range of 0.15-0.25 and the interpass time range of 0.5-50 s on Gleeble-3500 thermo-simulation *** results show that static recrystallization during the interpass time is *** the deformation temperature and strain increase,softening caused by static recrystallization is *** to the analysis and calculation of thermo-simulation data,the static recrystallization activation energy was obtained and static recrystallization kinetics model was ***,the error analysis of static recrystallization kinetics model proved that the model had good ***,this model provides a theoretical basis for static recrystallization（SRX）and will contribute to the development of multipass hot rolling process,in order to control the rolling process more accurately.

关键词： Gleeble-3500 low-alloy steel static recrystallization activation energy kinetics model

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen Shen Xiaoming Xiao Zhichao Li Qi Zhou Wei Yang bin Jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 ma cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 ma cm-2and exhibited high structural robustness,maintaining stability at 1000 ma cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting