Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals
Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals作者机构：Department of Colorectal SurgeryNational Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General SurgeryChina-Japan Friendship HospitalBeijing 100029China Department of General SurgeryBeijing HospitalBeijing 100730China Department of OrthopedicsLanzhou University Second HospitalLanzhou 730030China Department of Colorectal SurgeryUniversity of Chinese Academy of Sciences Zhejiang Cancer HospitalHangzhou 310022China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2019年第25卷第34期
页 面：5197-5209页
核心收录：
基 金：Supported by the Medicine and Health Technology Innovation Project of Chinese Academy of Medical Sciences No.2017-12M-1-006
主 题：Colon Rectum Neuroendocrine Neoplasm Metastasis Prognosis
摘 要：BACKGROUND Colorectal high-grade neuroendocrine neoplasms(HGNENs)are rare and constitute less than 1%of all colorectal *** on their morphological differentiation and proliferation identity,these neoplasms present heterogeneous clinicopathologic *** regarding treatment strategies for and improvement of the clinical outcomes of these patients remain *** To delineate the clinicopathologic features of and explore the prognostic factors for this rare *** This observational study reviewed the data of 72 consecutive patients with colorectal HGNENs from three Chinese hospitals between 2000 and *** clinicopathologic characteristics and follow-up data were carefully collected from their medical records,outpatient reexaminations,and telephone interviews.A survival analysis was conducted to evaluate their outcomes and to identify the prognostic factors for this *** According to the latest recommendations for the classification and nomenclature of colorectal HGNENs,61(84.7%)patients in our cohort had poorly differentiated neoplasms,which were categorized as high-grade neuroendocrine carcinomas(HGNECs),and the remaining 11(15.3%)patients had well differentiated neoplasms,which were categorized as high-grade neuroendocrine tumors(HGNETs).Most of the neoplasms(63.9%)were located at the *** than half of the patients(51.4%)presented with distant metastasis at the date of *** patients were followed for a median duration of 15.5 *** the entire cohort,the median survival time was 31 mo,and the 3-year and 5-year survival rates were 44.3%and 36.3%,*** the univariate and multivariate analyses demonstrated that increasing age,HGNEC type,and distant metastasis were risk factors for poor clinical *** Colorectal HGNENs are rare and aggressive malignancies with poor clinical ***,patients with younger age,good morphological differentiation,and without metastat
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