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A survey on deep geometry learning:From a representation perspective

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Computational Visual Media 2020年第2期6卷 113-133页

作者： yun-peng Xiao Yu-Kun Lai Fang-Lue Zhang Chunpeng li lin Gao Institute of Computing Technology Chinese Academy of SciencesBeijingChina School of Computer Science and Informatics Cardiff UniversityWalesUK School of Engineering and Computer Science Victoria University of WellingtonWellingtonNew Zealand

Researchers have achieved great success in dealing with 2 D images using deep *** recent years,3 D computer vision and geometry deep learning have gained ever more *** advanced techniques for 3 D shapes have been proposed for different *** 2 D images,which can be uniformly represented by a regular grid of pixels,3 D shapes have various representations,such as depth images,multi-view images,voxels,point clouds,meshes,implicit surfaces,*** performance achieved in different applications largely depends on the representation used,and there is no unique representation that works well for all ***,in this survey,we review recent developments in deep learning for 3 D geometry from a representation perspective,summarizing the advantages and disadvantages of different representations for different *** also present existing datasets in these representations and further discuss future research directions.

关键词： 3D shape representation geometry learning neural networks computer graphics

Application and prospect of adipose stem cell transplantation in treating lymphedema

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World Journal of Stem Cells 2020年第7期12卷 676-687页

作者： Zhu-Jun li Elan Yang yun-Zhu li Zheng-yun liang Jiu-Zuo Huang Nan-ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Lymphedema is a chronic,debilitating and incurable disease that affects 0.13%-2%of the global *** evidence indicates that adipose-derived stem cells(ADSCs)might serve as suitable seed cells for lymphatic tissue engineering and lymphedema *** To summarize applications of ADSCs for treating lymphedema in both animal studies and clinical *** A systematic search was performed on four databases-PubMed,***,the evidence-based Cochrane library,and OVID-using the following search string:(“lymphedema”or“lymphoedema”or“lymphangiogenesis”)and(“adipose-derived stem cells”or“adipose-derived stromal cells”or“adipose-derived regenerative cells”).A manual search was performed by skimming the references of relevant *** studies and clinical trials using adipose-derived cells for the treatment of any kind of lymphedema were *** A total of eight research articles published before November 2019 were included for this *** articles focused on animal studies and another three focused on clinical *** transplantation therapy was demonstrated to be effective against lymphedema in all *** animal studies found that coadministration of ADSCs and controlled-release vascular endothelial growth factor-C or platelet-rich plasma could improve the effectiveness of ADSC *** sequential clinical trials were conducted on breast cancer-related lymphedema patients,and all showed favorable *** ADSC-based therapy is a promising option for treating ***-scale,multicenter randomized controlled trials are needed to develop more effective and durable therapeutic strategies.

关键词： Lymphedema Adipose-derived stem cells Animal model Clinical trial Vascular endothelial growth factor-C Lymphangiogenesis

Three Types of Isocoumarins with Unusual Carbon Skeletons from Artemisia dubia var. subdigitata and Their Antihepatoma Activity

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Chinese Journal of Chemistry 2024年第16期42卷 1901-1912页

作者： Ke-Xin Yang Tian-ze li yun-Bao Ma Yong-Cui Wang Feng-Jiao li Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Ten novel isocoumarins,including four pairs of enantiomers,were isolated from Artemisia dubia ***(Asteraceae).Compounds 1,2 and 3a/3b possessed a unique 6/6/6-tricyclic system comprising an unusual 1-(2-methylcyclohexyl)propan-1-one moiety fused with isocoumarin core *** 4a/4b were characterized as an unexpected 2,5-dimethylcyclohexan-1-one scaffold,and compounds 5a/5b and 6a/6b were rare 1,*** structures and absolute configurations were elucidated through spectroscopic data,X-ray crystallography,ECD and NMR calculations with DP4+*** biosynthetic pathways were proposed from the naturally occurring *** pharmacological analysis suggested that the targets of compound 1 were significantly enriched in the cell cycle and Pl3K-Akt signaling *** molecular docking revealed that compound 1 had high binding affinity with CDK2(total score:6.8717).Furthermore,compounds 1 and 2 exhibited inhibitory activity on three human hepatoma cell lines,with inhibitory ratios of 85.1% and 84.5%(HepG2),88.2% and 87.3%(Huh7),and 69.2% and 69.1%(SK-Hep-1)at 200μmol·L^(-1),respectively.

关键词： Artemisia dubia var.subdigitata Isocoumarins Antihepatoma activity Cancer Natural products X-ray diffraction

Novel Protein C6ORF120 Promotes Apoptosis through Mitochondria-dependent Pathway in CD4+ T Lymphocytes

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Biomedical and Environmental Sciences 2023年第7期36卷 639-643页

作者： liU Hui WANG Xin WANG peng WANG Yu Qi YI yun yun li Xin Department of Center of Integrated Traditional Chinese and Western Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Center of Integrated Traditional Chinese and Western Medicine Peking University Ditan Teaching HospitalBeijing 100015China

Generally,a healthy immune system should be in dynamic balance,which can be maintained by both promoting and resisting *** apoptosis is indispensable for maintaining homeostasis[1]and participates in the entire process of lymphocyte differentiation,development,maturation,and immune *** has been reported that a large amount of lymphocyte apoptosis occurs in lymphoid organs during severe trauma[2].Lymphocytes consist of T and B lymphocytes,among which CD4^(+)T cells were the focus of this ***4^(+)T lymphocytes play an important role in the innate *** of CD4^(+)T lymphocytes is an important biological process that induces CD4^(+)T cell depletion[3].Numerous studies have shown that CD4^(+)T cell apoptosis participates in many pathological processes of diseases such as HIV infection,cancer,and systemic sclerosis[4].Classical apoptosis is induced by factors that can activate several pathways,including the mitochondrial,endoplasmic reticulum,and death receptor pathways[5].The mitochondrial pathway is mainly activated by the Bcl-2 family[6].The endoplasmic reticulum(ER)pathway is affected by endoplasmic reticulum *** external factors can trigger the death receptor pathway,such as the binding of TNF-TNFR and the combination of Fas-FasL[7].Considering these pathways,it is feasible to study the specific mechanisms of lymphocyte apoptosis,primarily in CD4^(+)T cells.

关键词： Apoptosis lymphocytes organs

Dynamic observation of bone marrow suppression and chromosomal aberrations in patients with acute colchicine poisoning

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World Journal of Emergency Medicine 2022年第2期13卷 130-134页

作者： Yan-qing liu Xiao-xia Lu Kai-xun Hu Xiao-bo peng yun Jiang li-mei Han Zhi-qiang Ma Ming-fei peng Kun Wan Xi-gang Zhang ze-wu Qiu Poisoning Treatment Department Department of Hematologythe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Academy of Military Medical Sciences Academy of Military SciencesBeijing 100850China

Colchicine is a neutral lipophilic tricyclic alkaloid toxic to human cells containing tubulin,[1-2]and primarily stops the proliferation of active cells in the mitotic metaphase,such as intestinal mucosal cells and hematopoietic *** is widely used in treating gout and familial Mediterranean fever,while it is also used in establishing animal and plant experimental model.[3]In the recent study,treatment of patients affected by coronavirus disease 2019(COVID-19)with colchicine may prove a viable path.[4]The course of colchicine poisoning can be divided into three stages,[5]and most of the patients died in the second stage(2-7 d,the multiple organ injury stage).The cause of death was heart failure[6]and bone marrow hematopoietic failure in the terminal phase.[7]Hematopoiesis is a classic sign of colchicine *** cases of colchicine poisoning have been comprehensively reported,and the target organs included heart,digestive tract,muscle,lung,kidney,hematopoietic system,etc.[8-11]This study aimed to investigate the injury of bone marrow hematopoietic system after colchicine poisoning and evaluate the therapeutic effect of bone marrow hematopoietic stimulation drugs.

关键词： establishing neutral alkaloid

Hydrothermal Synthesis of Nanorods and Nanowires of Mg/Al Layered Double Hydroxides

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Chemical Research in Chinese Universities 2007年第5期23卷 622-624页

作者： ZHAO yun JIAO Qing-ze DING Xue-jia ZHANG li-qun liU Yuan-yuan School of Chemical Engineering and Environment Beijing Institute of Technology Beijing 100051 P. R. China Key Laboratory of Beifing City on Preparation and Processing of Novel Polymer Materials Beijing University of Chemical Technology Beijing 100029 P. R. China

Layered double hydroxides（LDHs） are a class of synthetic anion clays, characterized by the formula [MⅡ1-xMⅢx（OH）2]x＋（An-）x/n5yH2O（where M=metal and A=anion, usually carbonate）[1-3]. A large number of LDHs with a wide variety of MⅡ-MⅢ cation pairs including MⅠ-MⅢ（e.g., li-Al） and MⅡ-MⅣ（e.g., Co-Ti） have been reported. Thus the identities of the cations（MⅠ, MⅡ, MⅢ and MⅣ） and the interlayer anion（An-） together with the value of the stoichiometric coefficient（x） may vary widely, giving rise to a large class of isostructural materials. As a result,

关键词： Nanorod Nanowire Layered double hydroxide Hydrothermal synthesis

Homing Guidance Law with Falling Angle and Flying Time Control

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Journal of Harbin Institute of Technology(New Series) 2014年第1期21卷 55-61页

作者： peng-yun liu Rui-Sheng Sun Wei-Ming li School of Energy and Power Engineering Nanjing University of Science and Technology

In this paper,a new homing guidance method is used to control the flying time and falling angle for guided missiles. Through this approach,it finds the approximate solution to the quadratic equation of time-togo,which is used for the formula derivation of the flying time control command. In this guidance law design,the acceleration rate control command is adopted. The guidance law is composed of a PN guidance command and a flying time control command. Firstly,it obtains a desired falling angle with accurate guidance. Secondly,it introduces to satisfy the constraint of flying time. The flying time control requires an assumption on the future evolution of missile,which is called time-to-go. To cope with the time-varying speed of missiles,a method of compensating the estimation of time-to-go is presented. The new guidance law is evaluated by using a simulation of typical terminal guidance for rocket-propelled torpedo. The simulation results show that the guidance achieves excellent control performance and exhibits insensitivity to initial trajectory parameter over a widen flight envelope.

关键词： homing guidance law falling angle flying time rocket-propelled torpedo time-to-go

Pancreatic head carcinoma:clinical analysis of 189 cases

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 79-84页

作者： Hua, yun-peng liang, li-Jian peng, Bao-Gang li, Shao-Qiang Huang, Jie-Fu Sun Yat Sen Univ Affiliated Hosp 1 Dept Hepatobiliary Surg Guangzhou 510080 Guangdong Peoples R China

BACKGROUND: Pancreatic cancer is a lethal disease with an increasing incidence. We retrospectively reviewed the clinical data on diagnosis and treatment of pancreatic head carcinoma, and analyzed the factors affecting prognosis of the disease. METHODS: The data of 189 patients with pancreatic head carcinoma treated from September 1, 1995 to August 31, 2005 were reviewed retrospectively. Ninety-four patients treated from September 1, 2000 to August 31, 2005 were followed up in April 2008. The median survival time (MST) and 1- to 5-year cumulative survival rates of the patients were calculated by the life table method and the Kaplan-Meier method. Cox regression was used to screen out significant risk factors. RESULTS: 96.9% of the patients were more than 40 years old, and the male/female ratio was 1.63. The detection rate of transabdominal ultrasonography (US), computed tomography (CT), endoscopic ultrasonography (EUS), and serum tumor marker CA19-9 were 82.0%, 93.1%, 94.7% and 79.8%, respectively. The MST of patients with pancreatic head carcinoma was 360 +/- 60 days. The 1- to 5-year cumulative survival rates were 50.0%, 19.2%, 12.1%, 9.4% and 4.7%, respectively. However, patients with unresectable tumor survived for a shorter time (183 +/- 18 days). Their 1- to 2-year cumulative survival rates were 28.3% and 0.0%. Cox regression analysis showed that in pancreatic head carcinoma, the independent predictors for prognosis included tumor size, invasion of the superior mesenteric vessel, and radical resection. The MST of patients with pancreatic head carcinoma after radical resection was 510 days, significantly longer than that of patients undergoing non-specific treatment and palliative therapy (225 days). In addition, patients with slight jaundice survived for the longest time (533 +/- 51 days), compared with patients with severe jaundice (236 +/- 43 days) and without jaundice (392 +/- 109 days). CONCLUSIONS: Pancreatic head carcinoma is easily misdiagnosed, and is us

关键词： pancreatic head carcinoma surgical procedure diagnosis prognosis

A Spectroscopic Study of the SU UMa-type Dwarf Nova YZ Cnc during its 2002 Superoutburst

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Chinese Journal of Astronomy and Astrophysics 2005年第6期5卷 601-609页

作者： Ying-He Zhao Zong-yun li Xiao-An Wu Qiu-He peng Department of Astronomy Nanjing University Nanjing 210093

We report on time-resolved spectroscopic observations of the SU Ursae Majoris dwarf nova, YZ Cnc for over llh on two nights during its 2002 January superoutburst. The spectra on the first day only showed absorption-line profiles, while on the second day the lines showed “W” profiles with blue and red troughs. The radial velocity curve of the absorption troughs and emission peaks of H/3 has an amplitude of 49±10 km s^-1 and a phase offset of -0.07±0.04, which are very similar to those measured in quiescence. However, the γ velocity deviates strongly from the systemic velocity measured in quiescence, by some ±60 km s^-1. Large shifts of -70 km s^-1 in the orbital-averaged velocity and -0.09 in the phase are also found in our observations. All these features can be well explained by a precessing, eccentric disk.

关键词： accretion, accretion disks -binaries close - novae, cataclysmic variables - stars dwarf novae - stars individual (YZ Cancri)