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生成式人工智能与“三教”改革--驱动、路径与挑战

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晋城职业技术学院学报 2024年第2期17卷 23-26,33页

作者：谭玉林江西财经职业学院江西九江332000

生成式人工智能的快速发展,对“三教”改革带来了深刻影响,成为职业教育“三教”改革的重要驱动力。研究认为,生成式人工智能有助于实现教育的个性化、教学内容的创新性、教师角色的转变等,从而促进“三教”改革向更加适应未来发展的方... 详细信息

生成式人工智能的快速发展,对“三教”改革带来了深刻影响,成为职业教育“三教”改革的重要驱动力。研究认为,生成式人工智能有助于实现教育的个性化、教学内容的创新性、教师角色的转变等,从而促进“三教”改革向更加适应未来发展的方向深化。同时,在利用生成式人工智能推进“三教”改革过程中,需要关注教育与人工智能的有效结合,重视教师能力的提升,完善教学资源建设,并建立科学的教学效果评估体系。

关键词：生成式人工智能职业教育 “三教”改革个性化学习

FOLFOX-肝动脉灌注化疗联合程序性死亡受体-1抑制剂和靶向药物治疗中国肝癌分期Ⅲa期肝细胞癌

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中国介入影像与治疗学 2024年第7期21卷 393-397页

作者：吴迪祝子祎范龙飞谭玉林蚌埠医科大学第一附属医院介入科安徽蚌埠233000

目的观察FOLFOX-肝动脉灌注化疗(HAIC)联合程序性死亡受体-1(PD-1)抑制剂和靶向药物治疗中国肝癌分期(CNLC)Ⅲa期肝细胞癌(HCC)的价值。方法回顾性分析61例接受PD-1抑制剂+靶向药物治疗的CNLCⅢa期HCC患者,根据是否接受联合FOLFOX-HAIC... 详细信息

目的观察FOLFOX-肝动脉灌注化疗(HAIC)联合程序性死亡受体-1(PD-1)抑制剂和靶向药物治疗中国肝癌分期(CNLC)Ⅲa期肝细胞癌(HCC)的价值。方法回顾性分析61例接受PD-1抑制剂+靶向药物治疗的CNLCⅢa期HCC患者,根据是否接受联合FOLFOX-HAIC治疗将其归入观察组(n=30)及对照组(n=31);比较组间一般资料、治疗方案、不良反应及疗效,分析观察组方案的治疗价值。结果组间患者一般资料及PD-1抑制剂+靶向药物方案差异均无统计学意义(P均>0.05);1~2级不良反应中,观察组恶心、呕吐及腹痛发生率均高于对照组(P均0.05)。观察组客观缓解率(ORR)、无进展生存期(PFS)及总生存期(OS)均高于对照组(P均<0.05)。结论FOLFOX-HAIC联合PD-1抑制剂+靶向药物治疗CNLCⅢa期HCC疗效较佳而安全性尚可。

关键词：癌,肝细胞程序性细胞死亡受体-1 化学疗法癌症局部灌注

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促进高职学生深度学习的混合式合作学习研究

柳州职业技术学院学报 2024年第1期24卷 60-67页

作者：谭玉林梅建安江西财经职业学院江西九江332000

为进一步深化教育信息技术的应用,推动高职院校教育教学改革,提高人才培养质量,研究构建了促进高职学生深度学习的混合式合作学习框架。依据深度学习要求和高职学生特点,分析混合式合作学习对学生的认知、能力和情感三个维度的促进效果... 详细信息

为进一步深化教育信息技术的应用,推动高职院校教育教学改革,提高人才培养质量,研究构建了促进高职学生深度学习的混合式合作学习框架。依据深度学习要求和高职学生特点,分析混合式合作学习对学生的认知、能力和情感三个维度的促进效果。研究表明,混合式合作学习对高职学生的知识水平和能力水平有显著的促进效应,对思维水平和积极情感体验有明显的提升作用。

关键词：高职学生深度学习混合式合作学习

肝动脉化疗栓塞术联合卡瑞利珠及阿帕替尼治疗中晚期肝癌的安全性及临床疗效观察

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蚌埠医学院学报 2024年第1期49卷 51-54,58页

作者：梅琪袁牧钱景瑜刘若宇谭玉林蚌埠医科大学第一附属医院介入科安徽蚌埠233004

目的:探讨肝动脉化疗栓塞术(TACE)联合卡瑞利珠及阿帕替尼治疗中晚期肝癌的临床疗效。方法:回顾性分析中晚期肝癌病人40例的临床资料,观察组20例行TACE联合卡瑞利珠及阿帕替尼治疗,对照组20例行TACE联合阿帕替尼治疗。分析2组近、远期... 详细信息

目的:探讨肝动脉化疗栓塞术(TACE)联合卡瑞利珠及阿帕替尼治疗中晚期肝癌的临床疗效。方法:回顾性分析中晚期肝癌病人40例的临床资料,观察组20例行TACE联合卡瑞利珠及阿帕替尼治疗,对照组20例行TACE联合阿帕替尼治疗。分析2组近、远期疗效及不良反应发生情况。结果:治疗3个月后复查肝脏增强CT或MRI,观察组客观缓解率为50.0%(10/20),高于对照组的20.0%(4/20)(P0.05)。随访6~16个月,生存分析显示,观察组无进展生存期均值和中位无进展生存期分别为9.49、8.00个月,对照组分别为7.33、6.00个月,2组差异有统计学意义(P<0.05)。病人常见不良反应包括继发性高血压、手足综合征、肝肾功能损害、骨髓抑制、心脏毒性等,均经药物减量及对症治疗缓解。结论:TACE联合卡瑞利珠及阿帕替尼治疗中晚期肝癌安全可控,可有效延长病人生存期,值得临床推广。

关键词：肝肿瘤肝动脉化疗栓塞术卡瑞利珠阿帕替尼

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基于生物信息学构建胃癌免疫相关LncRNA预后风险模型

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中国免疫学杂志 2024年第6期40卷 1203-1209页

作者：姜华基丁蔚谭玉林壮麟奚诚徐逸昕王一波徐学忠江苏大学附属武进医院徐州医科大学武进临床学院普外科常州213017

目的:基于生物信息学筛选出新的胃癌预后免疫相关LncRNAs,进一步构建免疫相关LncRNAs预后风险模型,以期作为胃癌早期诊断及判断预后状态的新指标。方法:从多重数据平台中下载胃癌转录组数据及相应的临床预后资料,运用生物信息学方法筛... 详细信息

目的:基于生物信息学筛选出新的胃癌预后免疫相关LncRNAs,进一步构建免疫相关LncRNAs预后风险模型,以期作为胃癌早期诊断及判断预后状态的新指标。方法:从多重数据平台中下载胃癌转录组数据及相应的临床预后资料,运用生物信息学方法筛选出胃癌免疫相关LncRNAs。采用Cox回归分析筛选胃癌免疫预后相关LncRNAs,确定具有独立预后意义的免疫预后相关LncRNAs构建预后风险模型,计算每例患者的风险评分,根据截断值将患者分为低风险组和高风险组,采用Kaplan-Meier分析法进行生存分析并绘制生存曲线,绘制列线图并进行内部验证,同时单因素和多因素Cox回归分析风险评分和临床病理特征与胃癌患者生存预后的关系。结果:通过Cox回归分析确定3个免疫预后相关LncRNAs(UCA1、MIR4435-1HG、RP11-617F23.1),并构建预测评分模型,根据预后评分将患者分为高风险组和低风险组,生存曲线显示两组患者预后差异有统计学意义(P<0.05),多因素Cox回归分析风险评分为胃癌预后的独立危险因素,列线图内部验证显示可信度良好。结论:胃癌中免疫相关的LncRNAs与胃癌患者预后显著相关,基于其构建的预测评分模型可以有效预测预后,可作为其独立的预后生物标志物。

关键词：胃癌 LncRNA 免疫预后

Effect of temperature and time on the precipitation ofκ-carbides in Fe-28Mn-10Al-0.8C low-density steels:Aging mechanism and its impact on material properties

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2189-2198页

作者： yulin Gao Min Zhang Rui Wang Xinxin Zhang Zhunli tan Xiaoyu Chong School of Mechanical Electronic and Control EngineeringMaterials Science and Engineering Research CenterBeijing Jiaotong UniversityBeijing 100044China Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

In low-density steel,κ-carbides primarily precipitate in the form of nanoscale particles within austenite ***,their precipitation within ferrite matrix grains has not been comprehensively explored,and the second-phase evolution mechanism during aging remains *** this study,the crystallographic characteristics and morphological evolution ofκ-carbides in Fe-28Mn-10Al-0.8C(wt%)low-density steel at different aging temperatures and times and the impacts of these changes on the steels’microhardness and properties were comprehensively *** different heat treatment conditions,intragranularκ-carbides exhibited various morpho-logical and crystallographic characteristics,such as acicular,spherical,and short rod-like *** the initial stage of aging,acicularκ-carbides primarily precipitated,accompanied by a few spherical carbides.κ-Carbides grew and coarsened with aging time,the spherical carbides were considerably reduced,and rod-like carbides *** hardness testing demonstrated that the material’s hardness was affected by the volume fraction,morphology,and size ofκ-*** aging at higher temperatures led to an increase in carbide size and volume fraction,resulting in a gradual rise in *** deformation,the primary mechanisms for strengthening were dislocation strengthening and second-phase *** on these findings,potential strategies for improving material strength are proposed.

关键词： low-density steel κ-carbide solution-aging treatment hardness

Calcium channel blockers and Alzheimer's disease

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Neural Regeneration Research 2012年第2期7卷 137-140页

作者： Yi tan yulin Deng Hong Qing School of Life Science Beijing Institute of Technology Beijing 100081 China

Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer＇s disease. Calcium channel blockers are effective therapeutics for treating Alzheimer＇s disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer＇s disease theraov.

关键词： Alzheimer's disease caic-ium channel calcium homeostasis Alzheimer's diseasepathogenesis β-amyloid calcium channel blocker

Togni-ⅡReagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes

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Chinese Journal of Chemistry 2021年第12期39卷 3429-3434页

作者： Shuang Teng Lingkui Meng Bingbing Xu Guangsheng Tu Peng Wu Zhiwen Liao yulin tan Jian Guo Jing Zeng Qian Wan Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyHuazhong University of Science and Technology13 Hangkong RoadWuhanHubei 430030China Institute of Brain Research Huazhong University of Science and Technology13 Hangkong RoadWuhanHubei 430030China

Based on the redox reactions of Togni-Ⅱreagent and thiols,a thiol-tuned selective functionalization of unactivated olefins was *** combination with aryl thiols,stoichiometric amount of Togni-Ⅱreagent prompted a hydrotrifluoromethylation of alkenes,in which,aryl thiols played as reductant and hydrogen source;while by utilization of alkyl thiols,catalytic amount of Togni-Ⅱreagent initiated thiol-ene and thiol-yne *** reported applications are characterized by their operational simplicity and wide functional group tolerance.

关键词： Togni-Ⅱreagent Hydrotriflupromethylation Thiol-ene reaction Alkenes Radical reactions

Puerarin mediated miR-30b-5p targeting fibroblast activation protein against oral submucous fibrosis

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BIOCELL 2024年第4期48卷 591-599页

作者： SAIFEI XIE HUI XIE JINCAI GUO JIN tan yulin YU MINYI ZHANG SHANG WEN Department of Periodontal Mucosa Hunan University of Chinese MedicineChangshaChina Department of Periodontal Mucosa Changsha Stomatology HospitalChangshaChina Department of Pharmacy Changsha Stomatology HospitalChangshaChina Department of Stomatology The First Hospital of Hunan University of Chinese MedicineChangshaChina

Background:Puerarin(Pue)has been reported to be a natural active ingredient with multiple antiﬁbrotic *** work aimed at exploring the function of Pue in oral submucousﬁbrosis(OSF)***:Human oral mucosaﬁbroblasts(hOMF)were induced with transforming growth factor beta1(TGF-β1)and intervened with *** ofﬁbrosis-related markers were analyzed by Western blot and IF *** viability was characterized by the CCK-8 *** of miR-30 family members were quantiﬁed by *** correlation betweenﬁbroblast activation protein(FAP)and miR-30 family expression was evaluated by the Pearson correlation coefﬁ*** prediction and dual-luciferase reporter assay were employed to verify the regulation between FAP and *** speciﬁc mechanism of Pue on OSF was explored through the promotion or inhibition of ***:After induction by TGF-β1,hOMF showed upregulated Collagen I,Collagen III,and FAP expressions,while miR-30 family expression was downregulated with miR-30b-5p being the most signiﬁ*** intervention inhibited the excessive proliferation of TGF-β1-induced hOMF,downregulated FAP,collagen type 3(COL3A1),collagen type 1(COL1A1),matrix metalloproteinase 1(MMP1),and matrix metalloproteinase 3(MMP3)expressions,and restored miR-30 family *** prediction and dual-luciferase reporter assay revealed that miR-30b-5p selectively inhibited FAP ***,miR-30b-5p mimic suppressed the excessive proliferation of TGF-β1-induced hOMF and declinedﬁbrosis *** intervention signiﬁcantly reversed the promotion of TGF-β1-induced OSF by miR-30b-5p ***:Pue mediated miR-30b-5p targeting FAP against OSF,which provided a theoretical basis for the pathogenesis research and Pue application in OSF.

关键词： Puerarin miR-30b-5p FAP Oral submucous fibrosis