Togni-ⅡReagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes

作     者：Shuang Teng Lingkui Meng Bingbing Xu Guangsheng Tu Peng Wu Zhiwen Liao Yulin Tan Jian Guo Jing Zeng Qian Wan Shuang Teng;Lingkui Meng;Bingbing Xu;Guangsheng Tu;Peng Wu;Zhiwen Liao;Yulin Tan;Jian Guo;Jing Zeng;Qian Wan

作者机构：Hubei Key Laboratory of Natural Medicinal Chemistry and Resource EvaluationSchool of PharmacyHuazhong University of Science and Technology13 Hangkong RoadWuhanHubei 430030China Institute of Brain ResearchHuazhong University of Science and Technology13 Hangkong RoadWuhanHubei 430030China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第12期

页      面：3429-3434页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Financial support from the National Natural Science Foundation of China(21877043,21702068,22025102) Wuhan Creative Talent Development Fund,and Fundamental Research Funds for the Central Universities(2017KFYXJJ150)is greatly appreciated We also thank Analytical and Testing Center of HUST for NMR tests 

主　　题：Togni-Ⅱreagent Hydrotriflupromethylation Thiol-ene reaction Alkenes Radical reactions 

摘      要：Based on the redox reactions of Togni-Ⅱreagent and thiols,a thiol-tuned selective functionalization of unactivated olefins was *** combination with aryl thiols,stoichiometric amount of Togni-Ⅱreagent prompted a hydrotrifluoromethylation of alkenes,in which,aryl thiols played as reductant and hydrogen source;while by utilization of alkyl thiols,catalytic amount of Togni-Ⅱreagent initiated thiol-ene and thiol-yne *** reported applications are characterized by their operational simplicity and wide functional group tolerance.