检索结果-南通市图书馆

circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM_(2.5)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 527-539页

作者： Qingping Liu Yaling Zhang Bin Han Mengruo Wang Huaifang Hu Jie Ning Wentao Hu Meiyu Chen Yaxian Pang Yuanyuan Chen Lei Bao yujie niu Rong Zhang Department of Toxicology Hebei Medical UniversityShijiazhuang 050017China State Key Laboratory of Environment Health(Incubation) Key Laboratory of Environment and HealthMinistry of EducationKey Laboratory of Environment and Health(Wuhan)Ministry of Environmental ProtectionSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Occupational Health and Environmental Health Hebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Environment and Human Health Hebei Medical UniversityShijiazhuang 050017China

As an environmental pollutant,ambient fine particulate matter (PM_(2.5)) was linked to cardiovascular *** molecular mechanisms underlying PM_(2.5)-induced extrapulmonary disease has not been elucidated *** this study the ambient PM_(2.5)exposure mice model we established was to explore adverse effects of vessel and potential ***-term PM_(2.5)exposure caused reduced lung function and vascular stiffness in *** chronic PM_(2.5)induced migration and epithelial-mesenchymal transition (EMT) phenotype in BEAS-2B *** PM_(2.5)treatment,the circRNAs and mRNAs levels of exosomes released by BEAS-2B cells were detected by competing endogenous RNA (ceRNA) array,which contained 1664 differentially expressed circRNAs (DE-circRNAs) and 308 differentially expressed m RNAs (DE-mRNAs).By bioinformatics analysis on host genes of DE-circRNAs,vascular diseases and some pathways related to vascular diseases including focal adhesion,tight junction and adherens junction were ***,ceRNA network was constructed,and DE-mRNAs in ceRNA network were conducted functional enrichment analysis by Ingenuity Pathway Analysis,which indicated that hsa_circ_0012627,hsa_circ_0053261and hsa_circ_0052810 were related to vascular endothelial ***,it was verified experimentally that Exo^(PM2.5)could induce endothelial dysfunction by increased endothelial permeability and decreased relaxation in *** present study,we investigated in-depth knowledge into the molecule events related to PM_(2.5) toxicity and pathogenesis of vascular diseases.

关键词： Fine particulate matter Vascular stiffness Exosome ceRNA microarray Endothelial dysfunction

在线全文

学校读者我要写书评

暂无评论

《今年的选举》中的毛泽东民主选举思想探析

唐山学院学报 2024年第1期37卷 11-19页

作者：牛玉杰南开大学马克思主义学院天津300350

在《今年的选举》这篇报告中,毛泽东详细论述了他有关民主选举的深刻思考,其中主要包括民主选举的重大意义、民主选举的保障条件以及民主选举的重要问题三个方面,集中体现了毛泽东民主选举思想的全过程性、阶级性、人民性以及程序性,这... 详细信息

在《今年的选举》这篇报告中,毛泽东详细论述了他有关民主选举的深刻思考,其中主要包括民主选举的重大意义、民主选举的保障条件以及民主选举的重要问题三个方面,集中体现了毛泽东民主选举思想的全过程性、阶级性、人民性以及程序性,这不仅在当时具有重大的指导意义,而且在新时代也能为发展和完善民主选举提供深刻的启示,即必须坚持党的领导、坚持人民当家作主、完善相关法律法规、发展全过程人民民主以及动员群众监督政府。

关键词：毛泽东民主选举思想今年的选举

习近平关于新时代党团关系重要论述的生成逻辑、核心要义和价值意蕴

在线全文

学校读者我要写书评

暂无评论

华北水利水电大学学报（社会科学版） 2024年第1期40卷 61-67页

作者：牛玉杰南开大学马克思主义学院天津300350

亲密无间的党团关系是促进党团肌体组织共同健康发展的有力保障。习近平关于新时代党团关系的重要论述贯穿着理论根基、历史积淀、实践来源相结合的生成逻辑,蕴含着始终坚持党对共青团的领导和明确新时代共青团职责定位的二重核心要义... 详细信息

亲密无间的党团关系是促进党团肌体组织共同健康发展的有力保障。习近平关于新时代党团关系的重要论述贯穿着理论根基、历史积淀、实践来源相结合的生成逻辑,蕴含着始终坚持党对共青团的领导和明确新时代共青团职责定位的二重核心要义。具体来说,一方面,党作为共青团的缔造者,要坚持对共青团的政治领导,加强对共青团理想信念的引领以及重视对共青团组织建设的领导;另一方面,新时代共青团必须坚守党的助手与后备军、党沟通青年群体的桥梁纽带以及去“四化”与强“三性”的职责定位。习近平关于新时代党团关系重要论述不仅继承和发展了马克思主义关于党团关系的深刻认识,而且开辟了新时代党团关系健康发展的根本遵循。

关键词：新时代党团关系生成逻辑核心要义价值意蕴

2016—2022年石家庄市农田土壤镉污染变化及潜在生态风险评价

在线全文

学校读者我要写书评

暂无评论

中华疾病控制杂志 2024年第4期28卷 431-437页

作者：武瑞婷陈凤格范尉尉张荣牛玉杰河北医科大学公共卫生学院石家庄050017 河北省环境与人群健康重点实验室石家庄050017 石家庄市疾病预防控制中心公共卫生监测与评价所石家庄050011 中国疾病预防控制中心环境与健康研究基地石家庄050011

目的了解石家庄市2016—2022年农田土壤镉污染情况,评估对人群健康的潜在风险,评价《河北省农村人居环境整治“三年行动”实施方案(2018—2020年)》(“三年行动”)的实施对镉污染的改善效果。方法选择石家庄6个项目县,每个县每年采集20... 详细信息

目的了解石家庄市2016—2022年农田土壤镉污染情况,评估对人群健康的潜在风险,评价《河北省农村人居环境整治“三年行动”实施方案(2018—2020年)》(“三年行动”)的实施对镉污染的改善效果。方法选择石家庄6个项目县,每个县每年采集20份样本,并统一于每年7—8月在各县监测点处采样,采用标准限值对土壤中镉进行评价,同时采用地累积指数法和潜在生态风险指数法对其进行评估。结果共采集农田土壤840份,其中在2016年和2017年镉含量均值较大,主要集中在正定县和赞皇县;在“三年行动”后石家庄市平均镉污染水平总体有所降低。其中正定县、赞皇县、栾城区、藁城区和鹿泉区在实施后镉含量降低,无极县在“三年行动”后镉含量上升。结论石家庄市农田土壤中镉污染水平在“三年行动”后下降,表明该项目实施对降低土壤镉风险有一定效果,但仍需加强对土壤中镉污染的调查与监测,从而对潜在风险及时作出应对政策。

关键词：农田土壤镉潜在生态风险

围产期饲粮中添加异位酸对奶牛瘤胃发酵参数、瘤胃微生物和生产性能的影响

在线全文

学校读者我要写书评

暂无评论

中国畜牧兽医 2024年第4期51卷 1428-1437页

作者：马小雪龙锐牛玉杰郭红勇罗瑞卿吴妍妍张文举石河子大学动物科技学院石河子832003 重庆市畜科院重庆402460 新疆天山军垦牧业有限责任公司石河子832000

【目的】试验旨在研究围产期饲粮中添加异位酸对奶牛瘤胃微生物群、产奶量、乳脂率和乳蛋白率的影响,为异位酸添加剂在奶牛生产中的合理使用提供理论依据。【方法】选取18头第3胎次、生产日期相近的围产期中国荷斯坦奶牛,随机分为3组(每... 详细信息

【目的】试验旨在研究围产期饲粮中添加异位酸对奶牛瘤胃微生物群、产奶量、乳脂率和乳蛋白率的影响,为异位酸添加剂在奶牛生产中的合理使用提供理论依据。【方法】选取18头第3胎次、生产日期相近的围产期中国荷斯坦奶牛,随机分为3组(每组6个重复,每个重复1头):对照组(C组)饲喂基础饲粮,试验组奶牛在基础饲粮中分别添加30(A组)和60 mL/d异位酸(B组),预饲期10 d,正式试验从奶牛产前21 d开始至产后21 d结束。分别于产后10和21 d采集所有奶牛的乳样测定乳成分;产后21 d晨饲前使用瘤胃导管采集所有奶牛的瘤胃液,测定瘤胃发酵参数和微生物多样性。【结果】①A和B组奶牛的产奶量、乳脂率和乳蛋白率均显著高于C组(P0.5,P<0.05),与Firmicutes、Spirochaetota和Butyrivibrio呈显著负相关(R<-0.5,P<0.05)。【结论】在围产期奶牛饲粮中添加异位酸能够提高瘤胃中VFA含量,并增加产奶量、乳脂率和乳蛋白率,其中添加60 mL/d异位酸对于提高奶牛的瘤胃发育和生产性能更有优势。

关键词：异位酸围产期奶牛瘤胃微生物瘤胃发酵参数生产性能

在线全文

学校读者我要写书评

暂无评论

痤疮丙酸杆菌与皮肤健康的相关研究进展

中国美容医学 2024年第8期33卷 187-193页

作者：牛钰杰(综述) 马来记(综述) 杨素珍(综述) 李燕(综述) 邵丽(审校) 上海应用技术大学香料香精化妆品学部上海201418 山东福瑞达生物股份有限公司山东济南250101

痤疮丙酸杆菌(Propionibacterium acnes)是人体皮肤上的常驻菌,是毛囊皮脂腺内的主要微生物。痤疮丙酸杆菌因与痤疮发病有关,使其变得“臭名昭著”。然而,随着基因组学、蛋白组学以及代谢组学的发展,人们对痤疮丙酸杆菌有了新的认识,正... 详细信息

痤疮丙酸杆菌(Propionibacterium acnes)是人体皮肤上的常驻菌,是毛囊皮脂腺内的主要微生物。痤疮丙酸杆菌因与痤疮发病有关,使其变得“臭名昭著”。然而,随着基因组学、蛋白组学以及代谢组学的发展,人们对痤疮丙酸杆菌有了新的认识,正常生理状态下它是人体共生菌,对宿主的健康发挥着重要作用。本文就痤疮丙酸杆菌的发现历程、生物学特征以及对皮肤健康的影响方面来归纳总结痤疮丙酸杆菌与皮肤健康的关系。

关键词：痤疮丙酸杆菌基因组学炎症性皮肤病群体感应生物膜

维普期刊数据库博看期刊

MSD-Net: Pneumonia Classification Model Based on Multi-Scale Directional Feature Enhancement

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第6期79卷 4863-4882页

作者： Tao Zhou yujie Guo Caiyue Peng Yuxia niu Yunfeng Pan Huiling Lu School of Computer Science and Engineering North Minzu UniversityYinchuan750021China School of Medical Information&Engineering Ningxia Medical UniversityYinchuan750004China Key Laboratory of Image and Graphics Intelligent Processing of State Ethnic Affairs Commission North Minzu UniversityYinchuan750021China

Computer-aided diagnosis of pneumonia based on deep learning is a research ***,there are some problems that the features of different sizes and different directions are not sufficient when extracting the features in lung X-ray images.A pneumonia classification model based on multi-scale directional feature enhancement MSD-Net is proposed in this *** main innovations are as follows:Firstly,the Multi-scale Residual Feature Extraction Module(MRFEM)is designed to effectively extract multi-scale *** MRFEM uses dilated convolutions with different expansion rates to increase the receptive field and extract multi-scale features ***,the Multi-scale Directional Feature Perception Module(MDFPM)is designed,which uses a three-branch structure of different sizes convolution to transmit direction feature layer by layer,and focuses on the target region to enhance the feature ***,the Axial Compression Former Module(ACFM)is designed to perform global calculations to enhance the perception ability of global features in different *** verify the effectiveness of the MSD-Net,comparative experiments and ablation experiments are carried *** the COVID-19 RADIOGRAPHY DATABASE,the Accuracy,Recall,Precision,F1 Score,and Specificity of MSD-Net are 97.76%,95.57%,95.52%,95.52%,and 98.51%,*** the chest X-ray dataset,the Accuracy,Recall,Precision,F1 Score and Specificity of MSD-Net are 97.78%,95.22%,96.49%,95.58%,and 98.11%,*** model improves the accuracy of lung image recognition effectively and provides an important clinical reference to pneumonia Computer-Aided Diagnosis.

关键词： Pneumonia X-ray image ResNet multi-scale feature direction feature transformer

Fuzzy Privacy Decision for Context-Aware Access Personal Information

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2007年第5期12卷 941-945页

作者： ZHANG Qingsheng QI Yong ZHAO Jizhong HOU Di niu yujie School of Electronic and Information Engineering Xi＇an Jiaotong University Xi＇an 710049 Shaanxi China

A context-aware privacy protection framework was designed for context-aware services and privacy control methods about access personal information in pervasive environment. In the process of user＇s privacy decision, it can produce fuzzy privacy decision as the change of personal information sensitivity and personal information receiver trust. The uncertain privacy decision model was proposed about personal information disclosure based on the change of personal information receiver trust and personal information sensitivity. A fuzzy privacy decision information system was designed according to this model. Personal privacy control policies can be extracted from this information system by using rough set theory. It also solves the problem about learning privacy control policies of personal information disclosure.

关键词： context-aware privacy decision fuzzy objective information system rough set theory

The Bone Microenvironmental Effect in the Dormancy of Cancer

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2014年第4期5卷 315-322页

作者： Weiwei Shen yujie niu Helong Zhang Department of Oncology Tangdu Hospital Fourth Military Medical University Xi’an Shaanxi China

Tumors have already threatened human life and health for centuries, especially the recurrent of bone metastases is difficult to cure. Relapse can occur years to decades after resection of primary tumor. This phenomenon is common in many clinical cases and animal experimental studies. The effect of traditional radiotherapy and chemotherapy on relapse is very limited, and the patients’ prognosis is poor. Because the delayed occurrence of metastases, researchers put forward a new concept “dormancy”, including a single dormant tumor cell (growth-arrest) and tumor mass dormancy (equivalence of the proliferation rate and apoptosis rate). It is probable that dormant tumor cells are the resource of relapse and the main reason of chemotherapy resistance. The mechanisms mediated tumor cell dormancy are complex and poorly understood, and bone marrow microenvironment plays an important role in this process. This review focuses on the bone marrow microenvironmental effect in inducing cancer cells to dormancy uncovered by the latest researches.

关键词： Bone Marrow Tumor Metastasis Dormancy