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Study on the vertical deformations induced by terrestrial water storage changes in huang-Huai-Hai river basin

Geodesy and Geodynamics 2024年第4期15卷 352-365页

作者： Liansheng Deng yugang Xiao Qusen Chen Feifei Liao Zhao Li School of Electrical and Electronic Information Engineering Hubei Polytechnic University Hubei Luojia Laboratory GNSS Research Center Wuhan University Changjiang Spatial Information Technology Engineering Co. Ltd.

Terrestrial water storage(TWS) variations are associated with water mass movements, which may cause the deformation displacements of the Global Navigation Satellite System(GNSS) stations. This study investigates the spatio-temporal TWS variations and addresses the relationship between deformation variations observed in the huang-Huai-Hai River Basin(HHHRB) and local hydrological features. Results indicate that the vertical velocities at the GNSS stations induced by TWS changes are relatively small, and the impacts of the terrestrial water storage changes are mainly reflected in the changes of seasonal characteristics. Although there is a downward TWS trend from 2011 to 2022 in most HHHRB areas,velocities from the vertical displacements of both Gravity Recovery and Climate Experiment(GRACE) and GRACE Follow-On(GFO) and the GNSS reflect that the HHHRB is undergoing an uplift process, while the magnitude of the GRACE/GFO derived velocities is much smaller than that of the GNSS solutions.Common hydrological deformations estimated from GRACE/GFO and GNSS measurements reveal that the TWS-derived displacements can explain 54.5% of the GNSS seasonal variations, with the phases of terrestrial water storage advancing by about one month relative to GNSS common signal phases.Moreover, the decrease of the groundwater storage in the HHHRB has been accelerating since 2008. After reaching its lowest level around mid-2020, it began to rise rapidly, which might be closely related to the implementation of the South-North Water Transfer Central Project.

关键词： Terrestrial water storage GRACE GNSS Vertical deformations huang-Huai-Hai river basin

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Prussian blue nanosphere-embedded in situ hydrogel for photothermal therapy by peritumoral administration

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Acta Pharmaceutica Sinica B 2019年第3期9卷 604-614页

作者： Jijun Fu Bo Wu Minyan Wei yugang huang Yi Zhou Qiang Zhang Lingran Du The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou Medical UniversityGuangzhou510700China Key Laboratory of Molecular Target&Clinical Pharmacology School of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou511436China Center of Pharmaceutical Research and Development School of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou511436China

To establish an injectable hydrogel containing Prussian blue(PB) nanospheres for photothermal therapy against cancer, PB nanospheres were prepared by one-pot synthesis and the thermosensitive Pluronic F127 was used as the hydrogel matrix. The PB nanospheres and the hydrogel were characterized by shape, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation, as well as the rheological features. The effect of the PB nanospheres and the hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast cancer cells. The retention,photothermal efficacy, therapeutic effects and systemic toxicity of the hydrogel were assessed in a tumor-bearing mouse model. The PB nanospheres had a diameter of about 150 nm and exhibited satisfactory serum stability, photo-heat convert ability and repeated laser exposure stability. The hydrogel encapsulation did not negatively influence the above features of the photothermal agent. The nanospherecontaining hydrogel showed a phase transition at body temperature and, as a result, a long retention time in vivo. The photothermal agent-embedded hydrogel displayed promising photothermal therapeutic effects in the tumor-bearing mouse model with little-to-no systemic toxicity after peritumoral administration.

关键词： Prussian blue Nanospheres Hydrogel Thermosensitive Injectable In situ Photothermal

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Signaling cascades in the failing heart and emerging therapeutic strategies

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1519-1554页

作者： Xin He Tailai Du Tianxin Long Xinxue Liao yugang Dong Zhan-Peng huang Department of Cardiology Center for Translational MedicineInstitute of Precision MedicineThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University) GuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China

Chronic heart failure is the end stage of cardiac diseases.With a high prevalence and a high mortality rate worldwide,chronic heart failure is one of the heaviest health-related burdens.In addition to the standard neurohormonal blockade therapy,several medications have been developed for chronic heart failure treatment,but the population-wide improvement in chronic heart failure prognosis over time has been modest,and novel therapies are still needed.

关键词： mortality cardiac prognosis

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Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

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Bone Research 2022年第3期10卷 509-523页

作者： Yiqi Yang Yixuan Lin Minqi Wang Kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai huang yugang Wang Hanjun Li Tingting Tang Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Bone and Joint Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics Shanghai Jiangong HospitalShanghaiChina Department of Trauma Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Stem Cell Research Center Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChin

Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment.

关键词： peroxidation osteoporosis diabetic

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acSB:Anti-Collision Selective-Based Broadcast Protocol in CRAdHocs

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Computers, Materials & Continua 2018年第7期56卷 35-46页

作者： Yueyue Li Zhong huang yugang Ma Guangjun Wen Univeristy of Electronic Science and Technology of China Qingshuihe CampusNo.2006Xiyuan AveWest Hi-Tech ZoneChengduSichuan611731China Institute for Infocomm Research A*STAR1 Fusionopolis Way#21-01 Connexis(South Tower)138632Singapore

As a fundamental operation in ad hoc networks,broadcast could achieve efficient message propagations.Particularl y in the cognitive radio ad hoc network where unlicensed users have different sets of available channels,broadcasts are carried out on multiple channels.Accordingly,channel selection and collision avoidance are challenging issues to balance the efficiency against the reliability of broadcasting.In this paper,an anticollision selective broadcast protocol,called acSB,is proposed.A channel selection algorithm based on limited neighbor information is considered to maximize success rates of transmissions once the sender and receiver have the same channel.Moreover,an anticollision scheme is adopted to avoid simultaneous rebroadcasts.Consequently,the proposed broadcast acSB outperforms other approaches in terms of smaller transmission delay,higher message reach rate and fewer broadcast collisions evaluated by simulations under different scenarios.

关键词： Broadcast protocol selective protocol collision avoidance distributed data dissemination cognitive radio ad hoc network

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Multivalent Display of Lipophilic DNA Binders for Dual-Selective Anti-Mycobacterium Peptidomimetics with Binary Mechanism of Action

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CCS Chemistry 2022年第11期4卷 3573-3586页

作者： Jianxue Wang Junfeng Song Xianhui Chen Rey-Ting Guo Yingjie Wang Guopu huang Nan Zheng Peilei Hu Xinxin Feng yugang Bai State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical BiologySchool of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082 State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhanHubei 430062 Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhenGuangdong 518055 Department of Polymer Science and Engineering School of Chemical EngineeringDalian University of TechnologyDalianLiaoning 116024 Hunan Institute for Tuberculosis Control Hunan Chest HospitalChangshaHunan 410013

We made oligoamidine-based peptidomimetics highly specific for mycobacteria eradication by introducing and arraying lipophilic DNA binding motifs on macromolecular backbones.The short poly(amidino-phenylindole)(PAPI)structures feature an alternating amphiphilic structure with cationic,lipophilic DNA-binding moieties,enabling fast and selective eradication of mycobacteria through binary,membrane-and DNA-selective mechanisms of action.More importantly,PAPIs address the primary treatment challenge by combating mycobacteria in eukaryotic cells and working as a sensitizer for conventional antibiotics,in bothways promoting more thorough removal of pathogens and reducing the mycobacteria’s resistance generation rate during treatment.Structural optimizationwas achieved to counter specific pathogens,including Mycobacterium tuberculosis,in the Mycobacterium genus.One of the hit peptidomimetics was evaluated in a zebrafish-based aquatic infection model using Mycobacterium fortuitum and a mice tail infection model using Mycobacterium marinum,both revealing excellent in vivo performance.

关键词： peptidomimetic mycobacteria antimicrobial membrane disruption DNA binding

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药厂孵化室的设计与施工

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洁净与空调技术 2024年第2期 75-78页

作者：邢军吴铮王国栋黄仁杰喻志明牛振敏杨鹏举毛玉刚中国电子系统工程第四建设有限公司

讲述药厂孵化室的两种设计方案,着重的解析非常规设计的原因和观点以及此方案的安装施工,希望可以为以后类似项目提供参考。

关键词：孵化室保温水平单向流

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量子级联技术研究进展:从光源到探测

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遥测遥控 2024年第3期45卷 1-23页

作者：杨超李泰澎黄宝玉李愽乐张盛楠黄彦王兆刚史青尹玉刚彭泳卿李晓干北京遥测技术研究所北京100076 大连理工大学集成电路学院大连116024

量子级联技术基于多量子阱或超晶格结构中的子带跃迁和共振隧穿理论,既可以产生光源,又可以探测光信号,是量子级联激光器(QCL)和量子级联探测器(QCD)的理论基石,在检测、遥感、通信、雷达等领域具有广泛的应用前景。经过最近三十年的研... 详细信息

量子级联技术基于多量子阱或超晶格结构中的子带跃迁和共振隧穿理论,既可以产生光源,又可以探测光信号,是量子级联激光器(QCL)和量子级联探测器(QCD)的理论基石,在检测、遥感、通信、雷达等领域具有广泛的应用前景。经过最近三十年的研究,量子级联技术在基础研究、产品性能以及应用系统研发和场景试验方面都取得了重大进展。本文首先简要介绍了量子级联技术的原理和发展历史,随后阐述了量子级联器件子带能级结构和电子输运动力学计算思路,接着重点综述了量子级联技术的研究进展,包括中远红外高功率QCL、中远红外宽调谐QCL、太赫兹QCL、高性能QCD,以及QCL和QCD的单芯片光子集成方面的内容,最后介绍了QCL和QCD的产品与应用情况。

关键词：量子级联激光器探测器集成进展

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Optimal dose of zinc supplementation for preventing aluminum-induced neurotoxicity in rats

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Neural Regeneration Research 2013年第29期8卷 2754-2762页

作者： Hao Lu Jianyang Hu Jing Li Wei Pang Yandan Hu Hongpeng Yang Wenjie Li Chengyu huang Mingman Zhang yugang Jiang Department of Nutrition and Food Hygiene West China School of Public HealthSichuan University Department of Nutrition Institute of Health & Environmental MedicineAcademy of Military Medical Sciences Department of Hepatobiliary Surgery Children's HospitalChongqing Medical University Department of Nutrition and Food Hygiene College of Public HealthZhengzhou University

Zinc supplementation can help maintain learning and memory function in rodents. In this study, we hypothesized that zinc supplementation could antagonize the neurotoxicity induced by aluminum in rats. Animals were fed a diet containing different doses of zinc （50, 100, 200 mg/kg） for 9 weeks, and orally administered aluminum chloride （300 mg/kg daily） from the third week for 7 consecutive weeks. Open-field behavioral test results showed that the number of rearings in the group given the 100 mg/kg zinc supplement was significantly increased compared with the group given the 50 mg/kg zinc supplement. Malondialdehyde content in the cerebrum was significantly decreased, while dopamine and 5-hydroxytryptamine levels were increased in the groups given the diet sup- plemented with 100 and 200 mg/kg zinc, compared with the group given the diet supplemented with 50 mg/kg zinc. The acetylcholinesterase activity in the cerebrum was significantly decreased in the group given the 100 mg/kg zinc supplement. Hematoxylin-eosin staining revealed evident patho- logical damage in the hippocampus of rats in the group given the diet supplemented with 50 mg/kg zinc, but the damage was attenuated in the groups given the diet supplemented with 100 and 200 mg/kg zinc. Our findings suggest that zinc is a potential neuroprotective agent against alumi-num-induced neurotoxicity in rats, and the optimal dosages are 100 and 200 mg/kg.

关键词： neural regeneration brain injury aluminum zinc trace elements behavior pathology cerebrummalondialdehyde superoxide dismutase acetylcholinesterase dopamine grants-supported paperneuroregeneration

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Enhancement of refresh time in quasi-nonvolatile memory by the density of states engineering

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Journal of Semiconductors 2021年第2期42卷 100-107页

作者： Zhaowu Tang Chunsen Liu Senfeng Zeng Xiaohe huang Liwei Liu Jiayi Li yugang Jiang David Wei Zhang Peng Zhou State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China School of Computer Science Fudan UniversityShanghai 200433China

The recently reported quasi-nonvolatile memory based on semi-floating gate architecture has attracted extensive attention thanks to its potential to bridge the large gap between volatile and nonvolatile memory.However,the further extension of the refresh time in quasi-nonvolatile memory is limited by the charge leakage through the p-n junction.Here,based on the density of states engineered van der Waals heterostructures,the leakage of electrons from the floating gate to the channel is greatly suppressed.As a result,the refresh time is effectively extended to more than 100 s,which is the longest among all previously reported quasi-nonvolatile memories.This work provides a new idea to enhance the refresh time of quasi-nonvolatile memory by the density of states engineering and demonstrates great application potential for high-speed and low-power memory technology.

关键词： quasi-nonvolatile memory refresh time density of states engineering

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