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Effect of nourishing Yin and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 95-102页

作者： SUN Yanyan xue yuanyuan SUN Wen WANG Yonghong YU Jian Department of Traditional Chinese Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Zibo Central HospitalZibo 255000China

OBJECTIVE:To elucidate the mechanism of the nourishing Yin and purging fire Chinese herbal mixture(NYPF)in delaying light-induced premature puberty in ***:Twenty-one days old female SpragueDawley rats were randomly assigned to normal group(N),long light exposure group(L),NYPF and normal saline group(NS).Rats in the L,NYPF and NS groups were exposed to 16 h:350 lux light/8 h:dark,while rats in the N group were exposed to 12 h:50 lux light/12 h:*** and normal saline was administered to the rats in the NYPF group or NS group,respectively,from day *** rats in every group were sacrificed at 9 *** day 28(P28),on the day when rat's vulva opened in the L group(L-VO),on the day when the first estrous interphase occurred in rats of L group(L-E1),and on the day when the second estrous interphase occurred in rats of L group(L-E2),***:On day 34,all rats in the L group,80%of rats in the NS group,40%of rats in the N group,and 20%of rats in the NYPF group showed complete opening of the *** P28,m RNA level of hypothalamic kisspeptin(Kiss-1)in the L group was significantly higher than that in the N group(P<0.05).The rats in the L and NS groups had significantly lower hypothalamic argininephenylalanine-amide(RFamide)-related peptide 3(RFRP-3)m RNA levels than those in the N group(P<0.05),whereas RFRP-3 m RNA level was significantly higher in the NYPF group than that in the L group(P<0.05).At L-VO,the ovarian index of the L and NS groups was significantly higher than that of the N group(P<0.05)and estradiol(E2)level of the NYPF group was significantly lower than that of the N and NS groups(P<0.05);hypothalamic Kiss-1 m RNA level in the L and NS groups was significantly higher than that in the N and NYPF groups(P<0.05),whereas hypothalamic RFRP-3 m RNA level in the L,NYPF,and NS groups was significantly lower than that in the N group(P<0.05).At L-E1,E2 level of the L and NS groups was significantly higher than that of the N group(P<0.01),wher

关键词： light puberty precocious kisspeptins RFRP-3 melatonin Nourishing Yin and Purging Fire

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MOF-Derived Co and Fe Species Loaded on N-Doped Carbon Networks as Efficient Oxygen Electrocatalysts for Zn-Air Batteries

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Nano-Micro Letters 2022年第10期14卷 136-147页

作者： yuanyuan xue Yibo Guo Qinming Zhang Zhaojun Xie Jinping Wei Zhen Zhou School of Materials Science and Engineering Institute of New Energy Material ChemistryKey Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)Renewable Energy Conversion and Storage Center(ReCast)Nankai UniversityTianjin 300350People’s Republic of China School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Searching for cheap,efficient,and stable oxygen electrocatalysts is vital to promote the practical performance of Zn-air batteries with high theoretic energy ***,a series of Co nanoparticles and highly dispersed Fe loaded on N-doped porous carbon substrates are pre-pared through a“double-solvent”method with in situ doped metal-organic frameworks as *** optimized catalysts exhibit excellent performance for oxygen reduction and evolution ***,rechargeable Zn-air bat-teries with designed catalysts demonstrate higher peak power density and better cycling stability than those with commercial Pt/C+RuO_(2).According to structure characterizations and electrochemical tests,the interaction of Co nanoparticles and highly dispersed Fe contributes to the superior performance for oxygen *** addition,large specific surface areas,porous struc-tures and interconnected three-dimensional carbon networks also play important roles in improving oxygen *** work provides inspiration for rational design of advanced oxygen electrocatalysts and paves a way for the practical application of rechargeable Zn-air batteries.

关键词： Oxygen reduction reaction Oxygen evolution reaction Zn-air batteries Bifunctional catalysts Metal-organic frameworks

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Research on proton radiation effects on CMOS image sensors with experimental and particle transport simulation methods

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Science China(Information Sciences) 2017年第12期60卷 114-116页

作者： yuanyuan xue Zujun WANG Minbo LIU Baoping HE Zhibin YAO Jiangkun SHENG Wuying MA Guantao DONG Junshan JIN State Key Laboratory of Intense Pulsed Irradiation Simulation and Effect Northwest Institute of Nuclear Technology

Recently,complementary metal-oxide semiconductor image sensors(CISs)have become a key element of the imaging instrument and have been widely used in many scientific applications[1,2]such as space remote sensing,medical imaging,and nuclear power plant ***,CISs used in these harsh radiation environments are susceptible to damage by particles or rays.

关键词： TID Research on proton radiation effects on CMOS image sensors with experimental and particle transport simulation methods CIS SCR

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Modeling dark signal of CMOS image sensors irradiated by reactor neutron using Monte Carlo method

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Science China(Information Sciences) 2018年第6期61卷 209-218页

作者： yuanyuan xue Zujun WANG Wei CHEN Baoping HE Zhibin YAO Minbo LIU Jiangkun SHENG Wuying MA Guantao DONG Junshan JIN State Key Laboratory of Intense Pulsed Irradiation Simulation and Effect Northwest Institute of Nuclear Technology

The dark signal degradation of the CMOS image sensor(CIS) was induced by neutron radiation,and it was modeled by Geant4, which is a three-dimensional Monte Carlo code. The simplified model of the CIS array was established according to the actual pixel geometry, material, and doping concentration. Nuclear elastic interaction and capture interaction were included in the physical processes, and the displacement damage dose in the space charge region of the pixel was calculated. The mean dark signal and dark signal distribution were modeled using Geant4, and the physical mechanisms were analyzed. The modeling results were in good agreement with the experimental and theoretical results.

关键词： modeling CIS neutron radiation dark signal Geant4

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Analysis of displacement damage effects on bipolar transistors irradiated by spallation neutrons

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Chinese Physics B 2019年第6期28卷 372-377页

作者： Yan Liu Wei Chen Chaohui He Chunlei Su Chenhui Wang Xiaoming Jin Junlin Li yuanyuan xue School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect(Northwest Institute of Nuclear Technology) Xi’an 710024China

Displacement damage induced by neutron irradiation in China Spallation Neutron Source(CSNS) is studied on bipolar transistors with lateral PNP, substrate PNP, and vertical NPN configurations, respectively. Comparison of the effects on different type transistors is conducted based on displacement damage factor, and the differences are analyzed through minority carrier lifetime calculation and structure analysis. The influence of CSNS neutrons irradiation on the lateral PNP transistors is analyzed by the gate-controlled method, including the oxide charge accumulation, surface recombine velocity,and minority carrier lifetime. The results indicate that the total ionizing dose in CSNS neutron radiation environment is negligible in this study. The displacement damage factors based on 1-MeV equivalent neutron flux of different transistors are consistent between Xi’an pulse reactor(XAPR) and CSNS.

关键词： displacement damage China Spallation Neutron Source(CSNS) reactor neutrons bipolar transistors

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Comparison of the dark signal degradation induced by Gamma ray, proton, and neutron radiation in pinned photodiode CMOS image sensors

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Science China(Information Sciences) 2019年第6期62卷 174-176页

作者： Zujun WANG yuanyuan xue Wei CHEN Rui XU Hao NING Baoping HE Zhibin YAO Minbo LIU Jiangkun SHENG Wuying MA Guantao DONG State Key Laboratory of Intense Pulsed Irradiation Simulation and Effect Northwest Institute of Nuclear Technology School of Materials Science and Engineering Xiangtan University

Dear editor,CMOS image sensors (CISs) present numerous advantages and have become feasible alternatives for CCDs (charge coupled devices) in satellite imaging system, nuclear industry, and particle detection [1–3]. However, CISs used in these applications are often operated under harsh radiation environments and are susceptible to total ionizing dose (TID) and displacement damage.

关键词： proton Figure Comparison of the dark signal degradation induced by Gamma ray and neutron radiation in pinned photodiode CMOS image sensors

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PFA-fixed Hsp6Osp-loaded dendritic cells as a vaccine for the control of mouse experimental allergic encephalomyelitis

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Cellular & Molecular Immunology 2014年第2期11卷 169-174页

作者： Feng Liu Hui Zheng yuanyuan Qi xue Wang Jianjun Yang Miaomiao Han Hart Zhang Hong Jiang These authors contributed equally to this work.

We have shown that Hsp6Osp-loaded immature dendritic cells （DC/sp） can protect mice from the induction of experimental allergic encephalomyelitis （EAE） by inducing Qa-l-restricted CD8＋ T regulatory （Treg） cells. The binding half-life between Qa-1 and Hsp6Osp is particularly short and leads to an unstable Qa- l/peptide complex that significantly decreases the efficacy of this vaccination. To prevent Qa-l/Hsp6Osp complex dissociation, we utilized paraformaldehyde （PFA） fixation to stabilize the formation of the Qa-l/Hsp6Osp complex and maximize the function of DC/sp as a vaccine to control autoimmune diseases. Compared with the non-fixed DC/sp, the fixed DC/sp （FDC/sp） showed an enhanced ability to activate Qa-l-restricted Hsp6Osp-specific CD8＋T cells in vitro and prevented EAE in vivo. Importantly, the FDC/sp maintained immune activity following cryopreservation for I week or after storage for 72 h at 4 ~C. These results indicate that PFA fixation can sustain or increase the efficacy of DC/sp by improving the stability of the Qa-l/Hsp6Osp complex on the surface of the DC/sp. In addition, PFA fixation creates a time window for DC/sp storage, transport and application. Our d^tn ~u^p__~t ~ nnt^nti^l clinic^l ..~e nf FDCI^n ~ ~ vnccine fnr the nr^v~ntinn and treatment of autnimm.n~_ di_~_~__

关键词： autoimmune disease dendritic cells Hsp6Osp PFA fixation Qa-l-restricted CD8+ T cells

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基于激光雷达扫描的密集城区建筑物自动检测

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光学技术 2022年第2期48卷 223-228页

作者：薛媛媛山西工程科技职业大学建筑设计学院山西晋中030619

为改善城区建筑物自动检测的准确性,结合激光雷达扫描与光学成像提出一种新的城区建筑物自动检测技术。将激光雷达扫描产生的点云送入自编码器进行下采样与特征提取,将光学图像像素送入自编码器进行空间特征提取,构建特征图模型来融合... 详细信息

为改善城区建筑物自动检测的准确性,结合激光雷达扫描与光学成像提出一种新的城区建筑物自动检测技术。将激光雷达扫描产生的点云送入自编码器进行下采样与特征提取,将光学图像像素送入自编码器进行空间特征提取,构建特征图模型来融合不同的特征集。然后,设计了基于卷积神经网络的半监督分类器,识别城区的建筑物、地面以及绿植等不同区域。实验结果表明,所提技术可准确地检测城区的建筑物区域,为建设智慧城市提供基础。

关键词：智慧城市激光雷达光学图像城市测量卷积神经网络深度自编码器

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The rising zebrafish research in China：Meeting report of the 3rd Chinese Zebrafish Principal Investigator Meeting ＆ the Inaugural Meeting of China Zebrafish Society

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Journal of Genetics and Genomics 2016年第10期43卷 617-620页

作者： Dongyuan Ma yuanyuan xue Yifan Zhang Yonghua Sun Anming Meng Feng Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Freshwater Ecology and Biotechnology China Zebrafish Resource CenterInstitute of HydrobiologyChinese Academy of SciencesWuhan 430072China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

The zebrafish has become a very important animal model,not only for developmental biology and genetics,but also for disease modeling and drug *** the year of 2000,zebrafish research has been rapidly growing in China,and the laboratories using zebrafish as the main subject have been increasing dramatically（Xie et al.,2015）.For example,the number of participants who attended the Chinese Zebrafish Principle Investigator （PI） Meeting series is 80 in 2012, 150 in 2014, and over 200 this year.

关键词： the Inaugural Meeting of China Zebrafish Society The rising zebrafish research in China

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Compounding effects of human activities and climatic changes on coexistence of oasis-desert ecosystems:Prioritizing resilient decision-making for a riskier world

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Research in Cold and Arid Regions 2023年第5期15卷 219-229页

作者： XinWei Yin Wei Liu Meng Zhu JuTao Zhang Qi Feng HaiYang Xi LinShan Yang Tuo Han WenJu Cheng YingQing Su BaiTing Zhang yuanyuan xue ZeXia Chen LingGe Wang Key Laboratory of Ecohydrology of Inland River Basin Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100049China College of Geography and Environment Science Northwest Normal UniversityLanzhouGansu 730070China

Water-salt balance is critical for the stable coexistence of salt-affected and groundwater-fed oasis-desert ecosystems. Yet, a comprehensive investigation of how soil salinization and groundwater degradation threaten the coexistence of oasis-desert ecosystems is still scarce, especially under the compounding effects of human activities and climatic changes. Here, we assessed the impacts of irrigated agriculture on hydrological regimes in oasisdesert systems, investigated the spatio-temporal variations of soil salinization in irrigated cropland, and evaluated the implications of the interplays of soil salinization and groundwater degradation on the coexistence of oasis-desert ecosystems in northwestern China, based on meaningful modelling approaches and comprehensive measurements over 1995–2020. The results showed that the irrigation return flow coefficient decreased sharply from 0.21 ± 0.09 in the traditional irrigation period to 0.09 ± 0.01 in the water-saving irrigation period. The continuous drop in groundwater tables and significant degradation of groundwater quality are occurring throughout this watershed. The eco-environmental flows are reaching to their limit with watershed closures(i.e.,the drainage from the oasis region into the desert region is being weakened or even eliminated), although these progressions were largely hidden by regional precipitation and streamflow variability. The process of salt migration and accumulation across different landscapes in oasis-desert system is being reshaped, and soil salinization in water-saving agricultural irrigated lands is accelerating with a regional average annual growth rate of18%. The vegetation in this watershed is degrading, and anthropogenic disturbance accelerates this trend. Our results highlight that environmental stress adaptation strategies must account for resilience maintenance to avoid accelerating catastrophic transitions in oasis-desert ecosystems. Determining the optimal oasis scales and formulatin

关键词： Oasis-desert ecosystems Hydrological regimes Soil salinization Vegetation dynamics Resilient decision-making

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