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河北省不同地理区域的棉铃虫种群分布

河北农业科学 2024年第1期28卷 60-65页

作者：李耀发安静杰窦亚楠张尚卿党志红李明远袁文龙郭江龙高占林河北省农林科学院植物保护研究所/河北省农业有害生物综合防治工程技术研究中心/农业农村部华北北部作物有害生物综合治理重点实验室河北保定071000 保定市蔬菜技术推广站河北保定071000 唐山市农业科学研究院河北唐山063001 河北省农业技术推广总站河北石家庄050011 河北省植保植检总站河北石家庄050011

随着黄河流域棉花种植面积的逐渐缩小,Bt棉花作为棉铃虫“诱杀陷阱”的作用逐渐减弱。为了明确河北省各作物种植结构调整后棉铃虫在不同地理区域内的种群分布特点,2018年和2019年利用性信息素诱捕技术,监测了5—9月河北省从南到北不同... 详细信息

随着黄河流域棉花种植面积的逐渐缩小,Bt棉花作为棉铃虫“诱杀陷阱”的作用逐渐减弱。为了明确河北省各作物种植结构调整后棉铃虫在不同地理区域内的种群分布特点,2018年和2019年利用性信息素诱捕技术,监测了5—9月河北省从南到北不同作物上棉铃虫成虫的种群数量。结果表明:(1)河北省棉铃虫种群发生数量大,并在多种寄主作物田中广泛分布,其中冀南地区棉田棉铃虫有4个成虫发生高峰期,高峰期诱捕虫量均达到100头/个(诱捕器)以上,最高达到了272.67头/个(诱捕器);(2)棉铃虫种群数量从南到北呈逐步递减趋势,南部、中部、北部的最高诱捕虫量分别为272.67、118.00和94.50头/个(诱捕器);(3)除棉田外,花生和玉米等作物田以及葡萄等果园的棉铃虫也需要引起足够重视。本研究结果明确了河北省新的种植结构布局下不同地理区域内棉铃虫的种群数量及其分布动态,可为华北地区不同作物布局下棉铃虫的区域性防治提供理论依据。

关键词：棉铃虫作物布局种群动态黄河流域棉花

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钝体头部边界层“逾越”型转捩机理研究

航空动力学报 2008年第1期23卷 81-86页

作者：袁湘江陆利蓬沈清涂国华中国空气动力研究与发展中心北京航空航天大学能源与动力工程学院北京100083 航天空气动力技术研究院北京100074

利用数值模拟的方法,研究了再入条件下,钝头体边界层中一种新的失稳机制.这种失稳机制无法用线性稳定性理论解释.最近的研究工作表明,流动中存在着一种与局部有限幅值扰动相关的失稳机制.它与常规的T-S波或二次失稳的过程不同.数值模拟... 详细信息

利用数值模拟的方法,研究了再入条件下,钝头体边界层中一种新的失稳机制.这种失稳机制无法用线性稳定性理论解释.最近的研究工作表明,流动中存在着一种与局部有限幅值扰动相关的失稳机制.它与常规的T-S波或二次失稳的过程不同.数值模拟了受空间模式的局部扰动影响的钝体头部超声速边界层的失稳过程.在模拟中,明确了不同扰动模型非线性相互作用的物理机制.

关键词：航空航天推进系统紧致格式非线性边界层转捩钝体

Identification of Germline Mutations in East‑Asian Young Never‑Smokers with Lung Adenocarcinoma by Whole‑Exome Sequencing

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Phenomics 2023年第2期3卷 182-189页

作者： Fangqiu Fu Xiaoting Tao Zhonglin Jiang Zhendong Gao Yue Zhao yuan Li Hong Hu Libing shen Yihua Sun Yang Zhang Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering Fudan University Shanghai Cancer Center270 Dong‑An RoadShanghai 200032China Institute of Thoracic Oncology Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Key Laboratory of Systems Biology Center for Excellence in Molecular Cell ScienceInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China International Human Phenome Institutes(Shanghai) Shanghai 200433China

Recently,an increasing number of young never-smokers are diagnosed with lung *** aim of this study is to investigate the genetic predisposition of lung cancer in these patients and discover candidate pathogenic variants for lung adenocarcinoma in young *** blood was collected from 123 never-smoking east-Asian patients diagnosed with lung adenocarcinoma before the age of ***-exome sequencing(WES)was conducted on genomic DNA extracted from peripheral blood *** a result,3,481 single nucleotide variants were *** bioinformatical tools and the published gene list associated with genetic predisposition of cancer,pathogenic variants were detected in ten germline genes:ATR,FANCD2,FANCE,GATA2,HFE,MSH2,PDGFRA,PMS2,SDHB,and *** with pathogenic variants were more likely to occur in females(9/10,90.0%)and have stage IV lung adenocarcinoma(4/10,40%).Furthermore,germline muta-tions in 17 genes(ASB18,B3GALT5,CLEC4F,COL6A6,CYP4B1,C6orf132,EXO1,GATA4,HCK,KCP,NPHP4,PIGX,PPIL2,PPP1R3G,RRBP1,SALL4,and TTC28),which occurred in at least two patients,displayed potentially pathogenic *** ontology analysis further showed that these genes with germline mutations were mainly located in nucleo-plasm and associated with DNA repair-related biological *** study provides spectrum of pathogenic variants and functional explanation for genetic predisposition of lung adenocarcinoma in young never-smokers,which sheds a light on prevention and early diagnosis of lung cancer.

关键词： Lung adenocarcinoma Germline mutation Never-smoker Young age DNA repair

A Hf0.5Zr0.5O2 ferroelectric capacitor-based half-destructive read scheme for computing-in-memory

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Science China(Information Sciences) 2023年第5期66卷 303-304页

作者： Yulin ZHAO yuan WANG Donglin ZHANG Zhongze HAN Qiao HU Xuanzhi LIU qingting DING Jinhui CHENG Wenjun ZHANG Yue CAO Ruixi ZHOU qing LUO Jianguo YANG Hangbing LV Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Microelectronics University of Science and Technology of China Zhejiang Lab

The emerging non-volatile memories (NVMs), including resistive random access memory (RRAM)[1], phase-change memory (PCM)[2], and ferroelectric random access memory (Fe RAM)[3], have broad application prospects owing to their non-volatility and near-zero static energy consumption. Compared to other NVMs, ferroelectric capacitors(Fe CAPs) ofer advantages in energy consumption and endurance. However, the destructive read operation of capacitors (e.g., DRAMs and Fe CAPs) destroys the stored data.

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Characteristics associated with falls among the elderly within aged care wards in a tertiary hospital： a retrospective case-control study

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Chinese Medical Journal 2010年第13期123卷 1668-1672页

作者： CHEN Xue-li LIU Yun-hu Daniel KY Chan shen qing Huong Van Nguyen Department of Rehabilitation Beijing Geriatric Hospital Beijing 100095 China Aged Care Bankstown-Lidcombe Hospital Sydney New South Wales Australia Faculty of Medicine University of New South Wales Sydney Anetralia

Background Falls are the most frequently reported adverse events in inpatient settings. We conducted a retrospective case-control study of inpatient falls within aged care wards in a tertiary hospital to investigate the associated characteristics of elderly patients suffering from falls and fall-related characteristics. Methods Consecutive retrospective cross-sectional design spanned July 2006 to December 2008. Patient group： Information on all aged care inpatients who suffered from 1 or more falls was extracted from Incident Information Management System （IIMS）. Further details about the particular admission（s） were obtained from patients＇ medical records, e.g., patients＇ characteristics and circumstances surrounding the falls. Randomly selected aged care patients who did not suffer from a fall and who were discharged from the hospital in the same period served control group. Characteristics among patients with single fall and recurrent falls, as well as non-railers were compared. Results Of the 438 falls evaluated, 71.9% occurred in patients＇ room and 18.9% in patients＇ bathroom/toilet. The common activities were moving/transferring and taking shower/toileting, respectively, 70.3%, 12.1% while occurring falls; and time of falls had a high peak during 9：00-11：00 a.m. Many were unassisted while falling. The common contributing factors for fall were intrinsic factors. Patients with recurrent falls were more likely to have lower Mini-Mental State Examination （MMSE） score. Logistic regression analysis showed length of stay longer than five weeks, dementia and stroke were independent risk factors for recurrent falls; and living in hostel/nursing home preadmission, needing assistance with mobility, cognitive impairment, stroke, incontinence and arthritis/osteoporosis were independent risk factors for fall. Conclusions In an aged care ward, falls are independently associated with recurrent factors. Cognitive impairment/dementia was a strong risk factor for falls, and main

关键词： falls recurrent falls inpatients the elderly

Effects of phlorizin on vascular complications in diabetes db/db mice

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Chinese Medical Journal 2012年第20期125卷 3692-3696页

作者： shen Lin YOU Bei-an GAO Hai-qing LI Bao-ying YU Fei PEI Fei Department of Geriatrics Qilu Hospital of Shandong UniversityJinanShandong 250012China

Background Diabetic macrovascular complications are important causes of cardiovascular and cerebrovascular diseases and also one of the major causes of morbidity and mortality in patients with type 2 diabetes mellitus （T2DM）. Phlorizin has been reported to be effective in reducing the blood glucose level in diabetic mellitus, while little is known about its effects on vascular complications. This study aimed to observe the effects of phlorizin on the aorta of diabetes db/db mice and explore its mechanism. Methods Diabetic db/db mice （n=16） and age-matched db/m mice （n=8） were divided into three groups： normal control group （CC group, db/m mice, n=8）, untreated diabetic group （DM group, db/db mice, n=8） and diabetic group treated by phlorizin （DMT group, db/db mice, n=8）. Phlorizin （20 mg/kg body weight） was given in normal saline solution intragastrically for 10 weeks. Animals were weighed weekly. At the 10th weekend, all mice were fasted overnight and then sacrificed. Fasting blood was collected, and the aortas were dissected. The blood samples were analyzed for fasting blood glucose （FBG）, serum advanced glycation end products （AGEs）, malondialdehyde （MDA） and superoxide dismutase （SOD） activity, the aortic ultrastructure was studied. Results The weight and serum concentration of FBG, AGEs, and MDA in the DM group were higher than that in the CC group （P 〈0.01 ）, and they were significantly lower in the DMT group （P 〈0.05）. Serum SOD activity was lower than that in the CC group （P 〈0.01）, and it is significantly higher in the DMT group （P 〈0.05）. The severity of aorta damage in the DMT group was less than that in the DM group. Conclusions Phlorizin protected the db/db mice from diabetic macrovascular complications, attributed to the decreasing of blood glucose and AGEs level, and its antioxidant potential. This study may provide a new natural medicine for treating diabetic macrovascular complications.

关键词： diabetes mellitus, type 2," phlorizin macrovascular complications db/db mice," oxidative stress

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起升动载激励下岸桥起升传动系统动态特性

东北大学学报（自然科学版） 2016年第4期37卷 526-531页

作者：刘媛媛张氢秦仙蓉孙远韬同济大学机械与能源工程学院上海200092

为研究岸桥起升传动系统在起升复杂工况下的动态特性,建立了起升机构的动力学模型,模拟了传动系统所受的起升动载.考虑传动系统中齿轮副的时变啮合刚度和支撑刚度,建立了起升传动系统平移-扭转耦合的动力学模型,得到了电机从启动到匀速... 详细信息

为研究岸桥起升传动系统在起升复杂工况下的动态特性,建立了起升机构的动力学模型,模拟了传动系统所受的起升动载.考虑传动系统中齿轮副的时变啮合刚度和支撑刚度,建立了起升传动系统平移-扭转耦合的动力学模型,得到了电机从启动到匀速最后减速到停止的起升过程中传动系统各构件的振动响应,并对不同阶段的啮合力进行了频域分析.研究表明,传动系统各构件的扭转振动与起升动载有相同的变化趋势,且由于起升速度的变化,加速和减速阶段的啮合力频谱出现了边频带现象.

关键词：岸桥起升机构齿轮传动起升动载动态特性

Research on the interaction design of somatosensory games——With the original game ＂Dream＂ in the center

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International English Education Research 2016年第12期 83-86页

作者： YANG yuan WANG Ziyan shen Jiadan FANG Yichen Sino-Korean School of Multimedia Design Shanghai University of Engineering Science Shanghai 201600 China

The emergence of the somatosensory interactive technology has changed the ways of the interaction between the users and the computers, so that people can control the computers more freely. This paper focuses on the interactive design of the somatosensory games, and combines the Kinect interactive devices with the popular Unity 3D game engines, and analyzes and designs the realization principles of the somatosensory games, the somatosensory games and the digital somatosensory interactive display. Through the design and production of the original game ＂Dream＂, the author discusses the design methods of the game interactive experience while abandoning the traditional human-comouter interactive mode.

关键词： Somatosensory game human-computer interaction Kinect equipment

Anti-apoptotic effect of Shudipingchan granule in the substantia nigra of rat models of Parkinson＇s disease

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Neural Regeneration Research 2016年第10期11卷 1625-1632页

作者： qing Ye Xiao-lei yuan Jing He Jie Zhou Can-xingyuan Xu-ming Yang Department of Neurology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China College of Acupuncture and Manipulation Shanghai University of Traditional Chinese Medicine Shanghai China

Levodopa is the gold-standard treatment for Parkinson＇s disease. However, although it alleviates the clinical symptoms, it cannot delay the progressive apoptosis of dopaminergic neurons or prevent motor complications in the long term. In the present study, we investigated the effect of Shudipingchan granule on neuronal apoptosis in a rat model of Parkinson＇s disease, established by injecting 6-hydroxydopamine into the substantia nigra pars compacta and ventral tegmental area. We then administered levodopa （20 mg/kg intraperitoneally, twice daily） with or without Shudipingchan granule （7.5 mL/kg intragastrically, twice daily）, for 4 weeks. The long-term use of levodopa accel- erated apoptosis of nigral cells and worsened behavioral symptoms by activating the extracellular signal-regulated kinase pathway and downstream apoptotic factors. However, administration of Shudipingchan granule with levodopa reduced expression of phosphorylated extracellular signal-regulated kinase 1/2 and Bax, increased tyrosine hydroxylase and Bcl-2, reduced apoptosis in the substantia nigra, and markedly improved dyskinesia. These findings suggest that Shudipingchan granule suppresses neuronal apoptosis by inhibiting the hyper- phosphorylation of extracellular signal-regulated kinase and downregulating expression of anti-apoptotic genes. Shudipingchan granule, used in combination with levodopa, can effectively reduce the symptoms of Parkinson＇s disease.

关键词： nerve regeneration Parkinson's disease levodopa substantia nigra apoptosis Shudipingchan granule extracellular signal-regulatedkinase pathway behavior neural rege,eration