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Bioactive chemical constituents from the marine-derived fungus Cladosporium ***-5

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Journal of Oceanology and Limnology 2024年第3期42卷 905-914页

作者： Luting DAI Qingyi xie Jiaocen GUO Qingyun MA Li YANG Jingzhe yuan Haofu DAI Zhifang YU Youxing ZHAO College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Hainan Academy of Tropical Agricultural ResourceHaikou 571101China

A new isochromanone,cladosporinisochromanone(1),accompanied by 15 known compounds(2–16)were obtained from secondary metabolites produced by marine-derived fungus Cladosporium *** and HRESIMS spectra elucidation determined the planar structure of *** electronic circular dichroism(ECD)experiment assigned the absolute configuration of *** 1,2,4–6,and 10 displayed different degrees of neuroprotective activities on human neuroblastoma cells *** compounds(1,3–5,and 13)emerged resistance to protein tyrosine phosphatase 1B(PTP1B),further kinetic analysis and molecular docking study indicated that the most potent compound 13(IC50value of 10.74±0.61μmol/L)was found as a noncompetitive inhibitor for *** plasmon resonance(SPR)and molecular docking studies also demonstrated the interaction between compound 12 and Niemann-Pick C1 Like 1(NPC1L1),which has been identified as significant therapeutic target for *** addition,compounds 3,6,and 14 showed attractive inhibitory activity against the phytopathogenic fungi:Colletotrichum ***,library of Cladosporium metabolites is enriched and new active uses of known compounds are explored.

关键词： Cladosporium sp. marine-derived fungus neuroprotective effects protein tyrosine phosphatase 1B(PTP1B) Niemann-Pick C1 Like 1(NPC1L1) antifungal activity

Bioinspired anti-freezing 3D-printable conductive hydrogel microfibers for highly-sensitive and wide-range detection of ultralow and high strains

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Green Chemical Engineering 2024年第1期5卷 132-143页

作者： Yi-Min Yang Ting-yuan Hu Haidong Fan Lu Shi Shi-yuan Zhang Zhuang Liu Xiao-Jie Ju Rui xie Wei Wang Liang-Yin Chu School of Chemical Engineering Sichuan UniversityChengdu610065China Department of Mechanics Sichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China

Soft strain sensors that can transduce stretch stimuli into electrical readouts are promising as sustainable wearable ***,most strain sensors cannot achieve highly-sensitive and wide-range detection of ultralow and high *** by bamboo structures,anti-freezing microfibers made of conductive poly(vinyl alcohol)hydrogel with poly(3,4-ethylenedioxythiphene)-poly(styrenesulfonate)are developed via continuous microfluidic *** microfibers provide unique bamboo-like structures with enhanced local stress to improve both their length change and resistance change upon stretching for efficient signal *** microfibers allow highlysensitive(detection limit:0.05%strain)and wide-range(0%-400%strain)detection of ultralow and high strains,as well as features of good stretchability(485%strain)and anti-freezing property(freezing temperature:-41.1°C),fast response(200 ms),and good *** experimental results,together with theoretical foundation analysis and finite element analysis,prove their enhanced length and resistance changes upon stretching for efficient signal *** integrating microfluidic spinning with 3D-printing technique,the textiles of the microfibers can be flexibly *** microfibers and their 3D-printed textiles enable highperformance monitoring of human motions including finger bending and throat vibrating during *** work provides an efficient and general strategy for developing advanced conductive hydrogel microfibers as highperformance wearable strain sensors.

关键词： Conductive hydrogel microfibers Microfluidics Sensitive detection Wide detection range Anti-freezing

Analyzing the surface passivity effect of germanium oxynitride:a comprehensive approach through first principles simulation and interface state density

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Nuclear Science and Techniques 2024年第5期35卷 74-84页

作者： sheng-Jie Du Xiu-Xia Li Yang Tian yuan-yuan Liu Ke Jia Zhong-Zheng Tang Jian-Ping Cheng Zhi Deng Yu-Lan Li Zheng-Cao Li Sha-Sha Lv College of Nuclear Science and Technology Joint Laboratory of Jinping Ultra‑Low Radiation Background Measurement of Ministry of Ecology and Environment Key Laboratory of Beam Technology of Ministry of Education Beijing Normal UniversityBeijing Normal UniversityBeijing 100875China Joint Research Center Nuctech Company LimitedBeijing 100084China Department of Engineering Physics Key Laboratory of Particle&Radiation Imaging of Ministry of EducationTsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

High-purity germanium(HPGe)detectors,which are used for direct dark matter detection,have the advantages of a low threshold and excellent energy *** surface passivation of HPGe has become crucial for achieving an extremely low energy *** this study,first-principles simulations,passivation film preparation,and metal oxide semiconductor(MOS)capacitor characterization were combined to study surface *** calculations of the energy band structure of the -H,-OH,and -NH_(2) passivation groups on the surface of Ge were performed,and the interface state density and potential with five different passivation groups with N/O atomic ratios were accurately analyzed to obtain a stable surface *** on the theoretical calculation results,the surface passivation layers of the Ge_(2)ON_(2) film were prepared via magnetron sputtering in accordance with the optimum atomic ratio *** microstructure,C-V,and I-V electrical properties of the layers,and the passivation effect of the Al/Ge_(2)ON_(2)/Ge MOS were characterized to test the interface state *** mean interface state density obtained by the Terman method was 8.4×10^(11) cm^(-2) eV^(-1).The processing of germanium oxynitrogen passivation films is expected to be used in direct dark matter detection of the HPGe detector surface passivation technology to reduce the detector leakage currents.

关键词： Surface passivation High purity germanium detector Germanium nitrogen oxide Interface state density

Event-triggered finite-time command-filtered tracking control for nonlinear time-delay cyber physical systems against cyber attacks

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 225-236页

作者： Yajing MA yuan WANG Zhanjie LI Xiangpeng xie School of Internet of Things Nanjing University of Posts and TelecommunicationsNanjing210003China Institute of Advanced Technology for Carbon NeutralityNanjing University of Posts and TelecommunicationsNanjing210023China

This article addresses the secure finite-time tracking problem via event-triggered command-filtered control for nonlinear time-delay cyber physical systems(CPSs)subject to cyber *** the attack circumstance,the output and state information of CPSs is unavailable for the feedback design,and the classical coordinate conversion of the iterative process is incompetent in relation to the tracking *** solve this,a new coordinate conversion is proposed by considering the attack gains and the reference signal *** employing the transformed variables,a modified fractional-order command-filtered signal is incorporated to overcome the complexity explosion issue,and the Nussbaum function is used to tackle the varying attack *** systematically constructing the Lyapunov-Krasovskii functional,an adaptive event-triggered mechanism is presented in detail,with which the communication resources are greatly saved,and the finite-time tracking of CPSs under cyber attacks is ***,an example demonstrates the effectiveness.

关键词： Cyber physical systems Finite-time tracking Event-triggered Command-filtered control Attacks

Tuning hot carrier transfer dynamics by perovskite surface modification

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Chinese Chemical Letters 2024年第10期35卷 483-486页

作者： Chenghao Ge Peng Wang Pei yuan Tai Wu Rongjun Zhao Rong Huang Lin xie Yong Hua School of Materials and Energy Yunnan University Department of Physics Center for Optoelectronics Engineering Research Yunnan University

Understanding the role of perovskite surface passivators in hot carriers transfer dynamics is important to develop highly efficient perovskite solar cells(PSCs). In this work, we have designed and synthesized a naphthalimide-based organic small molecule(NCN) for perovskite surface defect passivator. We reveal that the introduction of NCN not only reduces the density of perovskite defect-state, but also promotes hot carriers(HCs) cooling in perovskite through the transient absorption spectroscopy measurements. Fast HCs cooling permits HCs transfer from perovskite layer into NCN layer, thus resulting in the decreased charge-carrier recombination in NCN-treated device. As expected, the power conversion efficiency(PCE)of PSCs with NCN is enhanced to 22.02% from 19.95% for the control device. The findings are relevant for developing highly efficient PSCs.

关键词： Charge recombination Hot carrier Interface passivation Naphthalimide Perovskite solar cells Stability

Dynamic mechanical characteristics of deep Jinping marble in complex stress environments

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 630-644页

作者： Chendi Lou Heping xie Ru Zhang Hai Ren Hao Luo Kun Xiao yuan Peng Qiang Tan Li Ren Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu610207China College of Water Resource&Hydropower Sichuan UniversityChengdu610065China MOE Key Laboratory of Deep Earth Science&Engineering Sichuan UniversityChengdu610065China Yalong River Hydropower Development Company Ltd.Chengdu610051China (Chongqing)International Engineering Technology Company Ltd.Chongqing401121China

To reveal the dynamic mechanical characteristics of deep rocks,a series of impact tests under triaxial static stress states corresponding to depths of 300-2400 m were *** results showed that both the strain rates and the stress environments in depth significantly affect the mechanical characteristics of *** sensitivity of strain rate to the dynamic strength and deformation modulus shows a negative correlation with depth,indicating that producing penetrative cracks in deep environments is more difficult when damage *** dynamic strength shows a tendency to decrease and then increase slightly,but decreases sharply *** demonstrates a similar trend as that of strength,whereas reflectivity indicates the opposite ***,two critical depths with high dynamically induced hazard possibilities based on the China Jinping Underground Laboratory(CJPL)were proposed for deep *** first critical depth is 600-900 m,beyond which the sensitivity of rock dynamic characteristics to the strain rate and restraint of circumferential stress decrease,causing instability of surrounding rocks under axial stress *** second one lies at 1500-1800 m,where the wave impedance and dynamic strength of deep surrounding rocks drop sharply,and the dissipation energy presents a negative *** suggests that the dynamic instability of deep surrounding rocks can be divided into dynamic load dominant and dynamic load induced types,depending on the second critical depth.

关键词： Rock mechanics Split-Hopkinson pressure bar Coupled static‒dynamic loading Different depths Holmquist-Johnson-Cook(HJC)model

A deep learning model based on contrast-enhanced computed tomography for differential diagnosis of gallbladder carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 376-384页

作者： Fei Xiang Qing-Tao Meng Jing-Jing Deng Jie Wang Xiao-yuan Liang Xing-Yu Liu sheng Yan Department of Hepatobiliary Pancreatic Surgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Radiology Affiliated Chuzhou First People’s HospitalAnhui Medical UniversityChuzhou 239000China

Background:Gallbladder carcinoma(GBC)is highly malignant,and its early diagnosis remains *** study aimed to develop a deep learning model based on contrast-enhanced computed tomography(CT)images to assist radiologists in identifying ***:We retrospectively enrolled 278 patients with gallbladder lesions(>10 mm)who underwent contrast-enhanced CT and cholecystectomy and divided them into the training(n=194)and validation(n=84)*** deep learning model was developed based on ResNet50 *** and clinical models were built based on support vector machine(SVM)*** comprehensively compared the performance of deep learning,radiomics,clinical models,and three ***:Three radiomics features including LoG_3.0 gray-level size zone matrix zone variance,HHL firstorder kurtosis,and LHL gray-level co-occurrence matrix dependence variance were significantly different between benign gallbladder lesions and GBC,and were selected for developing radiomics *** regression analysis revealed that age≥65 years[odds ratios(OR)=4.4,95%confidence interval(CI):2.1-9.1,P37 U/mL(OR=4.0,95%CI:1.6-10.0,P=0.003)were significant clinical risk factors of *** deep learning model achieved the area under the receiver operating characteristic curve(AUC)values of 0.864(95%CI:0.814-0.915)and 0.857(95%CI:0.773-0.942)in the training and validation datasets,which were comparable with radiomics,clinical models and three *** sensitivity of deep learning model was the highest both in the training[90%(95%CI:82%-96%)]and validation[85%(95%CI:68%-95%)]***:The deep learning model may be a useful tool for radiologists to distinguish between GBC and benign gallbladder lesions.

关键词： Gallbladder carcinoma Computed tomography Deep learning Radiomics

Cardiac Piezo1 Exacerbates Lethal Ventricular Arrhythmogenesis by Linking Mechanical Stress with Ca^(2+) Handling After Myocardial Infarction

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Research 2024年第1期2023卷 583-594页

作者： sheng-an Su Yuhao Zhang Wudi Li Yutao Xi Yunrui Lu Jian Shen yuankun Ma Yaping Wang Yimin Shen Lan xie Hong Ma Yao xie Meixiang Xiang Department of Cardiology Cardiovascular Key Laboratory of Zhejiang ProvinceThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Endocrinology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Texas Heart Institute HoustonTX 77030USA

Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial infarction(MI).Accumulating data show that ischemia,sympathetic activation,and inflammation contribute to ***,the role and mechanisms of abnormal mechanical stress in ventricular arrhythmia following MI remain *** aimed to examine the impact of increased mechanical stress and identify the role of the key sensor Piezo1 in ventricular arrhythmogenesis in *** with increased ventricular pressure,Piezo1,as a newly recognized mechano-sensitive cation channel,was the most up-regulated mechanosensor in the myocardium of patients with advanced heart ***1 was mainly located at the intercalated discs and T-tubules of cardiomyocytes,which are responsible for intracellular calcium homeostasis and intercellular communication.

关键词： ventricular homeostasis Ventricular

Asymmetry in circulation system and cardiovascular diseases

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Medicine in Novel Technology and Devices 2024年第1期21卷 1-9页

作者： Chang Liu sheng xie Yangchen Li Da Zhang Deyu Li Chi Zhang Key Laboratory of Biomechanics and Mechanobiology Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China Department of Radiology China-Japan Friendship HospitalBeijing100029China Children’s Hospital Capital Institute of Pediatrics Beijing100020China Department of Physics Sichuan Cancer HospitalChengdu610041China State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing100191China

Asymmetries in the human vascular system and cardiovascular disease are *** physiological asymmetry can manifest in the morphological structure and blood flow state,whereas pathological asymmetry can reflect differences in the occurrence and cure of bilateral vascular *** causes associated with these asymmetrical differences may be demand-driven or due to vascular grading or asymmetries in other physiological *** article aims to review the asymmetry of several typical arteries,including cerebral,cervical,and limb arteries,and lists possible causes to emphasize the necessity of considering asymmetric factors in the prevention,treatment,and rehabilitation of vascular *** research on asymmetries in the vascular system may improve the risk assessment and personalized treatment of vascular diseases.

关键词： Vascular morphology Hemodynamics Cardiovasculardiseases Asymmetry