Tumor microenvironment of cancer stem cells:Perspectives on cancer stem cell targeting

作     者：Qianqian Guo Yi Zhou Tianyuan Xie Yin Yuan Huilong Li Wanjin Shi Lufeng Zheng Xiaoman Li Wenzhou Zhang Qianqian Guo;Yi Zhou;Tianyuan Xie;Yin Yuan;Huilong Li;Wanjin Shi;Lufeng Zheng;Xiaoman Li;Wenzhou Zhang

作者机构：Department of PharmacyThe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450003China Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia MedicaSchool of PharmacyNanjing University of Chinese MedicineNanjingJiangsu 210023China School of Life Science and TechnologyJiangsu Key Laboratory of Carcinogenesis and InterventionChina Pharmaceutical UniversityNanjingJiangsu 211198China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第3期

页      面：275-302页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.82173842,82204432) the Medical Science and Technology Research Project of Henan Province,China(No.SBGJ202003010) the Henan Province Science and Technology Research Project(No.222102310414) the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions(China) 

主　　题：Cancer stem cells Cancerstem-like cells Cellular factors Non-cellularfactors Tumor microenvironment 

摘      要：There are few tumor cell subpopulations with stem cell characteristics in tumor tis-sue,defined as cancer stem cells(CSCs)or cancer stem-like cells(CSLCs),which can recon-struct neoplasms with malignant biological behaviors such as invasiveness via self-renewal and unlimited *** microenvironment that CsCs depend on consists of various cellular components and corresponding medium *** these factors existing at a variety of levels and forms,cytokine networks and numerous signal pathways play an important role in signaling *** factors promote or maintain cancer cell stem-ness,and participate in cancer recurrence,metastasis,and *** review aims to summarize the recent molecular data concerning the multilayered relationship between CsCs and CsC-favorable *** also discuss the therapeutic implications of target-ing this synergistic interplay,hoping to give an insight into targeting cancer cell stemness for tumortherapyandprognosis.