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关节镜与传统开放手术治疗臀肌挛缩症的比较研究

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中国矫形外科杂志 2012年第17期20卷 1564-1567页

作者：詹远平广西北海市卫生学校附属医院外一科北海合浦536100

[目的]比较关节镜和传统开放手术治疗臀肌挛缩症的疗效及可行性。[方法]回顾分析116例双侧臀肌挛缩症患者的临床资料,观察组为关节镜手术组56例,对照组为传统开放手术组60例,根据蔡斌等[1]疗效标准评价疗效,并对两组切口长度、手术时间... 详细信息

[目的]比较关节镜和传统开放手术治疗臀肌挛缩症的疗效及可行性。[方法]回顾分析116例双侧臀肌挛缩症患者的临床资料,观察组为关节镜手术组56例,对照组为传统开放手术组60例,根据蔡斌等[1]疗效标准评价疗效,并对两组切口长度、手术时间、出血量、术后镇痛药物应用、下床活动时间、术后住院时间、手术并发症、复发率等进行比较。[结果]经术后6个月～11年的随访,两组疗效比较,差异无显著性(P>0.05),但关节镜组切口长度、术中出血、术后镇痛药物应用、下床活动时间、术后住院时间等5项指标明显优于切开手术组,差异有统计学意义(P0.05)。[结论]与开放手术相比,关节镜治疗臀肌挛缩症具有创伤小、出血少、术后并发症发生率低、恢复快、手术瘢痕小、可早期进行功能锻炼,有利于关节功能的恢复等优点,且疗效肯定,是一种值得推荐的手术方法。

关键词：臀肌挛缩症关节镜开放手术

Molecular beacon-assisted isothermal amplification combined with nucleic acid lateral flow technology for the detection of multiple bacterial contaminations in platelets

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Molecular beacon-assisted isothermal amplification combined ...

Protective role of Vδ2 γδ T cells in patients with chronic hepatitis B through regulating production of the Th17 cells

2012全国临床微生物与感染免疫学术研讨会

作者： Wang Xiaohui,Wang Jidong,Li yuan,zhan Linsheng Beijing Institute of Transfusion Medicine

Bacterial infections still pose a major risk for the safety of the blood supply,especially for the platelet concentrates(PCs),as they are stored at room temperature for 5-7 days.A lot of works based on culture method have been done to test the sterility of the PCs,but most of them have to take at least 24h which is too long when compare to the short shift time of the *** species of bacteria could contaminate the PCs,it is really hard to identify a kind of antigen or protein that conserved in all species of bacteria serologically if it is not impossible. So,more and more researchers tend to use molecular diagnostic technologies to solve these problems. A trend evident in disease diagnosis field in the past two decades is that the molecular diagnostic technologies such as polymerase chain reaction(PCR) are edging out the serological method,because they are rapid,specific and most importantly *** the requirement of the expensive equipment and skillful workers restricted this method to only be applied in medical center or research ***,several isothermal amplification methods had been invented since *** typical ones include Strand Displacement Amplification(SDA), Nucleic Acid Sequence Based Amplification(NASBA) and Loop-Mediated Isothermal Amplification(LAMP) etc. Without of the need of precision instrument and skillful worker,these methods could detect as low as one copy of target genes at isothermal condition in about 2 *** our knowledge,the 16S rDNA sequence exists usually in most types of bacteria and often provides general information for organism *** 16S rDNA-based realtime PCR method is also considered as a useful tool for rapid screening of bacterial contaminations in blood ***,we employed the conserved 24-base fragment in it as a detection *** the mentioned isothermal amplification methods are sensitive and easy to use,they also have some disadvantages of which the primer design is the mo

关键词： Beacon A mplification Bacterial contamination Detection Platelets

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Protective role of Vδ2 γδ T cells in patients with chroni...

第八届全国免疫学学术大会

作者： Xiaoli Wu Ji-yuan zhan Xuexiu zhang Fu-Sheng Wang Zhinan Yin Colege of Life Sciences Nankai University Research Center for Biological Therapy Institute of Translational Hepatology Beijing 302 Hospital

背景:Chronic hepatitis B continues to be a major health problem globally with disease progression from liver inflammation to cirrhosis and hepatocellular *** innate and adaptive immune cells involved in the liver ***, γδ T cells, especially Vδ2 T cells role in chronic hepatitis B virus infection remain unclear.目的:To determine the character of Vd2 T cells in CHB patients and the regulate role of them in CHB patients 方法:Here we characterized peripheral and intrahepatic γδ T cells, and analyzed their association with liver injury in a cohort of HBV-infected patients, including 64 immune-activated(IA) patients, 22 immune-tolerant(IT) carriers and 30 healthy controls(HC).To achieving this, flow cytometry was adopted.结果:We demonstrated that the number and percentage of peripheral and hepatic Vδ2 T cells were significantly lower in IA patients than HC and IT subjects, and the number of Vδ2 T cells was inversely correlated with liver injury, but not HBV DNA load.Vδ2 T cells in IA patients exhibited an impaired proliferative capacity due to abnormalities in the G2/M cell cycle phases, and a skewed chemotactic ability contributing to the lower number of these cells in ***, an in vitro co-culture assay showed that Vδ2 T cells significantly suppressed the production of the Th17-associated cytokines, interleukin(IL)-17 and IL-22, by CD4+ T cells in both cell contact-dependent and IFN-γ-dependent mechanisms.结论:The infection microenvironment in IA patients results in decreased numbers of Vδ2 T cells in peripheral blood and liver, which in turn impairs the suppression of Th17 cell function and reduces liver ***, adoptive transfer of Vδ2 T cells may provide a novel therapeutic approach for IA patients.

关键词： Liver damage Immune regulation Chemotaxis Proliferation Immune therapy

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北京市土地供应计划与土地市场交易现状分析

北京社会科学 2010年第1期 27-32页

作者：张占录张远索中国人民大学土地管理系北京100872 北京联合大学应用文理学院北京100083

编制土地年度供应计划有利于政府对房地产行业进行调控,土地市场交易现状既受制于土地供应计划又对其有反作用。本文基于北京市2008年全年及2009年(截至6月26日)最新土地市场交易数据,利用地理信息系统技术及统计分析方法,研究交易地块... 详细信息

编制土地年度供应计划有利于政府对房地产行业进行调控,土地市场交易现状既受制于土地供应计划又对其有反作用。本文基于北京市2008年全年及2009年(截至6月26日)最新土地市场交易数据,利用地理信息系统技术及统计分析方法,研究交易地块空间分布特征及平均成交地价、平均楼面地价、成交价与底价比值等变化趋势,发现空间上北京中东南部交易地块成交价与底价比值较大,时间上2008年初及2009年五六月份交易地块成交价与底价比值最大,规划用途上住宅用地交易地块成交价与底价比值最大。在金融危机大背景下,房地产行业极易出现泡沫,制定土地供应计划时应进一步加大保障性住房用地的供给。

关键词：北京市土地供应计划土地市场交易成交价/底价房价

Clinical and genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer families

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World Journal of Gastroenterology 2006年第25期12卷 4074-4077页

作者： Xu-Lin Wang Ying yuan Su-zhan zhang Shan-Rong Cai Yan-Qin Huang Qiang Jiang Shu Zheng Cancer Institute the 2nd Affiliated Hospital College of Medicine Zhejiang University 88 Jie-Fang Road Hangzhou 310009 Zhejiang Province China

AIM： To analyze the clinical characteristics of Chinese hereditary nonpolyposis colorectal cancer （HNPCC） families and to screen the germline mutations of human mismatch repair genes hMLH1 and hMSH2 in the probands. METHODS： Thirty-one independent Chinese HNPCC families were collected in Zhejiang Province. All of them met Chinese HNPCC criteria. Clinical data about patient gender, site of colorectal cancer, age of onset, history of multiple colorectal cancer, associated extracolonic cancer were recorded. PCR and denaturing high performance liquid chromatography （DHPLC） were employed to screen the mutations. Sequencing analysis was used to find out the exact mutation site and characteristics of the samples showing abnormal DHPLC profiles. RESULTS： One hundred and thirty-six malignant neoplasms were found in 107 patients including 14 multiple cancers. One hundred and six of the 136 neoplasms （77.9%） were diagnosed as colorectal cancer, with an average age of onset at 48.57 ±29.00 years. Gastric cancer was the most common extracolonic cancer （10.3%） in these families. Twenty-three different sequence variations in hMLHI and hMSH2 genes were detected in these 17 families. Fifteen sequence variations were located in the exons, including 5 SNPs, 3 silent mutations, 3 missense mutations, 2 nonsense mutations and 2 frameshift mutations. The latter seven mutations seemed to be pathogenic. CONCLUSION： Germline mutations of hMLH1 and hMSH2 genes are identified in about one-third HNPCC kindreds fulfilling Chinese HNPCC criteria. Chinese HNPCC families have some particular clinical characteristics, such as a left-sided predominance, less synchronous or metachronous colorectal cancer, and frequent occurrence of gastric cancer.

关键词： Colorectal cancer Hereditary nonpolyposis DNA mutation analysis High pressure liquid Chromatography Oncogenes

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灰色粒子群自适应卫星钟差预报方法

哈尔滨工业大学学报 2018年第4期50卷 71-77页

作者：李源战兴群梅浩刘宝玉上海交通大学航空航天学院上海200240

高精度卫星钟差预报是当前接收机实时精密单点定位技术(Real-time precise point positioning,RT-PPP)亟需解决的关键技术难题之一.为找到一种基于小样本钟差序列的快速高精度卫星钟差预报方法,在分析常规GM(1,1)灰色模型(grey model)... 详细信息

高精度卫星钟差预报是当前接收机实时精密单点定位技术(Real-time precise point positioning,RT-PPP)亟需解决的关键技术难题之一.为找到一种基于小样本钟差序列的快速高精度卫星钟差预报方法,在分析常规GM(1,1)灰色模型(grey model)缺点的基础上对其进行了改进,提出了PGM(1,1)模型(particle swarm optimization-grey model)及其算法.该模型利用最新量测值进行初始化,然后通过引入遗忘因子的最小二乘法对新旧信息进行加权处理;再引入优化因子对模型系数进行调节,以归一化的平均相对误差作为精度检验标准,采用粒子群算法对其自适应寻优.最后选取了5颗钟差变化典型的GPS(global positioning system)卫星原子钟进行1 d内的精密钟差预报实验.结果表明,相对于常规GM(1,1)灰色模型和常规二次项拟合模型,所提出的模型及其算法预报精度有显著提升,其平均预报残差达到了亚纳秒级,且所需训练样本小.因此,该预报模型可以应用于卫星钟差快速精准预报.

关键词：卫星钟差预报灰色理论遗忘因子粒子群寻优自适应

Research of Discriminating Driver Accident Proneness Based on Fuzzy Clustering

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Research of Discriminating Driver Accident Proneness Based o...

极值理论(EVT)方法用于受险价值(VaR)计算的实证比较与分析

第13届中国系统仿真技术及其应用学术年会

作者： Zhiye yuan,Renjun zhan Xi’an Engineering College of Armed Police Force,Xi’an,China,710086

For the facts that 70% of traffic accidents are accounted by the driver,and the most accidents are caused by part of the drivers with "accident proneness",this document proposes a new method about the evaluation of drivers’ psychological characteristics and skills characteristics,and establishes the drivers’ discriminate model by fuzzy clustering. Comparing with the equivalent number of accidents of the drivers,its credibility is high that the discriminate model is used to drivers’ accident proneness evaluation.

关键词： accident proneness discriminate model fuzzy Clustering evaluation

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系统工程理论与实践 2000年第10期20卷 27-35,57页

作者：田宏伟詹原瑞邱军天津大学管理学院天津300072

讨论了根据极值理论 ( EVT)计算受险价值 ( Va R)的两类不同的方法 :基于矩估计的“两次子样试算法”和极大似然估计法 ,并给出了各自理论推导过程和计算步骤 .同时 ,把这两类方法与正态分布和经验分布的结果进行了比较 .应用四种汇率... 详细信息

讨论了根据极值理论 ( EVT)计算受险价值 ( Va R)的两类不同的方法 :基于矩估计的“两次子样试算法”和极大似然估计法 ,并给出了各自理论推导过程和计算步骤 .同时 ,把这两类方法与正态分布和经验分布的结果进行了比较 .应用四种汇率历史数据进行的实证计算表明 ,在极端条件下 ,用极值理论方法估计 Va R具有很高的准确性 ,而矩估计法的结果又优于极大似然估计法 .

关键词：受险价值极值理论极大似然估计汇率

桶间距对四桶吸力式基础各单向承载力的影响及最优间距的确定

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岩土力学 2018年第10期39卷 3603-3611页

作者：肖忠王琰王元战刘莺天津大学水利工程仿真与安全国家重点实验室天津300072 天津大学天津市港口与海洋工程重点试验室天津300072

四桶吸力式基础由4个按正方形排列的吸力式桶形基础组成,并通过上部结构连成整体共同承受外部荷载,相比于单桶基础,四桶基础能承受更恶劣的海洋环境荷载,可作为海上风机和海洋平台等结构物的基础,具有广阔的应用前景。为探究饱和软土地... 详细信息

四桶吸力式基础由4个按正方形排列的吸力式桶形基础组成,并通过上部结构连成整体共同承受外部荷载,相比于单桶基础,四桶基础能承受更恶劣的海洋环境荷载,可作为海上风机和海洋平台等结构物的基础,具有广阔的应用前景。为探究饱和软土地基上四桶基础和单桶基础在承载力以及破坏模式方面的关系,优化四桶基础的设计,建立了大量的四桶和单桶基础的三维有限元模型,系统研究了不同基础埋深和土体剪切强度时桶间距对四桶基础各单向承载能力和对应的破坏模式的影响。结果表明,竖向承载力系数受桶间距影响较小,而水平承载力系数受其影响较大,力矩承载力系数受其影响尤为显著;在同一桶间距比时,四桶吸力式基础的各单向承载力系数随基础埋深比的增加逐渐增大,随土体剪切强度不均匀度指标的增大逐渐减小。通过分析四桶基础的各单向承载力、对应的破坏模式和群效应系数,定义了四桶基础的最优桶间距,可为四桶基础桶间距的优化设计提供依据。

关键词：四桶吸力式基础最优桶间距承载特性破坏模式软土地基