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Sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogel for synergistic combination therapy of pancreatic cancer

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Nano Research 2019年第6期12卷 1389-1399页

作者： Kun shi Bingxin xue Yanpeng Jia Liping yuan Ruxia Han Fan Yang Jinrong Peng Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China

Pancreatic cancer is one of the most devastating cancers with poor prognosis and no significant change in the survival rate over the past *** targeted drug delivery through interventional endoscopic ultrasonography-guided fine-needle injection (EUS-FNI) is an attractive and minimally invasive strategy for inoperable pancreatic *** injectable in-situ formed long-lasting drug delivery system is a promising alternative for the localized treatment of pancreatic cancer via ***,a biodegradable thermo-sensitive copolymer hydrogel for the co-delivery of anticancer agents gemcitabine (GEM) and cis-platinum (DDP) was *** hydrogel is a free flowable liquid at room temperature that changes into a semi-solid hydrogel following injection in response to the physiological *** in vitro and in vivo drug release behaviors indicate sustained drug release of this delivery *** cellular proliferation inhibition and desirable apoptosis promotion have been found when pancreatic cancer Bxpc-3 cells were co-cultured with this GEM-DDP/hydrogel *** a single intratumoral injection,the dual-drug loaded hydrogel formulation exhibited superior anti-tumor efficacy and minimized systemic side effect on pancreatic cancer xenograft mouse model in comparison to the intravenously injected free GEM and DDP *** addition,a strong synergistic therapeutic effect of the GEM-DDP/hydrogel system against pancreatic cancer has been found in vitro and in vivo compared to the single-drug loaded hydrogel *** obtained findings suggest this developed thermo-sensitive copolymer hydrogel system as a potential universal carrier for the localized targeted delivery of multi-drugs,for use in a variety of inoperable solid tumors.

关键词： localized drug delivery sustained release thermo-sensitive hydrogel combination therapy pancreatic cancer

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A meta-analysis of heavy metals pollution in farmland and urban soils in China over the past 20 years

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Journal of Environmental Sciences 2021年第3期33卷 217-226页

作者： xuehong yuan Nandong xue Zhiguang Han State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Technical Center for Soil Agricultural and Rural Ecology and EnvironmentMinistry of Ecology and Environment of the People’s Republic ChinaBeijing 100012China

A total of 713 research papers about field monitor experiments of heavy metals in farmland and urban soils in China,published from 2000 to 2019,were obtained.A meta-analysis was conducted to evaluate the level of China's heavy metal pollution in soils,mainly focusing on eight heavy *** was found that the average concentrations of cadmium(Cd),lead(Pb),zinc(Zn),copper(Cu),mercury(Hg),chromium(Cr),nickel(Ni),and arsenic(As)in China were 0.19,30.74,85.86,25.81,0.074,67.37,27.77 and 8.89 mg/kg,*** with the background value(0.097 mg/kg),the Cd content showed a twofold(0.19 mg/kg)rise in farmland soils and a threefold(0.29 mg/kg)rise in urban *** decreasing order of the mean Igeo was Cd(1.77)>Pb(0.62)>Zn(0.60)>Cu(0.58)>Hg(0.57)>Cr(0.54)>Ni(0.47)>As(0.28).Nearly 33.54%and 44.65%of sites in farmland and urban soils were polluted with *** average concentrations of eight heavy metals were not sensitive change in recent two decades in farmland and urban *** average P_n values for urban(2.52)and farmland(2.15)soils showed that heavy metal pollution in urban soils was more serious than that in farmland,and the middle Yangtze River regions,where industrial activity dominates,were the most *** meta-analysis comprehensively evaluated the current pollution situation of soil heavy metal,and provided important basis for soil management and environment prevention in China.

关键词： Heavy metals Farmland soils Urban soils Pollution assessment Meta-analysis

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Signal modeling and impulse response shaping for semiconductor detectors

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Nuclear Science and Techniques 2022年第4期33卷 72-82页

作者： xue-yuan Wang Jian-Bin Zhou ming Wang Huai-Ping Wang Xu Hong Yi Liu Ping Huang College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyErxian BridgeNo.1 East 3 RoadChenghua DistrictChengdu 610059China Jiangxi Engineering Technology Research Center of Nuclear Geoscience Data Science and System East China University of TechnologyNanchang 330013China China Testing Technology Co. LtdChengdu 610021China

The output-signal models and impulse response shaping(IRS)functions of semiconductor detectors are important for establishing high-precision measurement *** this paper,an output-signal model for semiconductor detector systems is *** to the proposed model,a multistage cascade deconvolution IRS algorithm was developed using the C-R inverse system,R-C inverse system,and differentiator *** silicon drift detector signals acquired from the analog-to-digital converter were *** experimental results indicated that the shaped pulses obtained using the proposed model had no undershoot,and the average peak base width of the output shaped pulses was reduced by 36%compared with that for a simple model proposed in a previous work[1].Offline processing results indicated that compared with the traditional IRS algorithm,the average peak base width of the output shaped pulses obtained using the proposed algorithm was reduced by 11%,and the total elapsed time required for pulse shaping was reduced by 26%.The proposed algorithm avoids recursive *** the sampling frequency of the digital system reaches 100 MHz,the proposed algorithm can be simplified to integer *** proposed IRS algorithm can be applied to high-resolution energy spectrum analysis,highcounting rate energy spectrum correction,and coincidence and anti-coincidence measurements.

关键词： Output-signal model Impulse response shaping C-R inverse system R-C inverse system Integer arithmetic

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Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

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Chinese Journal of Integrative Medicine 2020年第1期26卷 72-80页

作者： LUO Ting-ting LU yuan YAN shi-kai XIAO xue RONG Xiang-lu GUO Jiao Institute of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangzhou 510006China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China

Chinese medicine(CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years, which is identified suitable for the study of CM formula. In this review, we summarized the methodology of network pharmacology, including network construction, network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets, and then find out and validate the key nodes via network analysis and network verification. Besides, we reviewed the application in CM formula research, mainly including targets discovery, bioactive compounds screening, toxicity evaluation, mechanism research and quality control research. Finally, we proposed prospective in the future and limitations of network pharmacology, expecting to provide new strategy and thinking on study for CM formula.

关键词： network pharmacology Chinese medicine formula targets discovery mechanism research quality control research

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Anomalous Temperature Effects of the Entanglement of Two Coupled Qubits in Independent Environments

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Chinese Physics Letters 2012年第4期29卷 7-10页

作者： SHAN Chuan-Jia CAO Shuai xue Zheng-yuan ZHU shi-Liang Laboratory of Quantum Information Technology and SPTE South China Normal UniversityGuangzhou 510006 College of Physics and Electronic Science Hubei Normal UniversityHuangshi 435002

We investigate the entanglement dynamical behavior of two coupled qubits via a Heisenberg XX interaction,which are connected with two independent finite temperature heat *** numerical simulations of the quantum master equation,it is found that the interesting phenomena of entanglement sudden death (ESD) as well as sudden birth (ESB) appear during the evolution process for particular initial *** also show that two critical temperatures T1 (determining that the quantum state is entangled or separable) and T2 (where maximal stationary entanglement can be observed) exist,and stationary entanglement exhibits a non-monotonic behavior as a function of the finite temperature noise *** results enlarge the domain of the reasonable experimental temperature where stationary entanglement can be observable.

关键词： stationary quantum Independent

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Preparation and Rheological Characterization of Long Chain Branching Polyglycolide

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Chinese Journal of Polymer Science 2024年第8期42卷 1177-1184页

作者： Wei-Lin Liu ming-Fu Lyu Heng-yuan Zhang Jian-Ye Liu shi-Jun Zhang Beijing University of Chemical Technology Beijing 100029China SINOPEC(Beijing)Research Institute of Chemical Industry Co. Ltd.Beijing 100013China

The long chain branching(LCB)polyglycolide(PGA)was successfully prepared by the successive reactions of the terminal hydroxyl groups of PGA with triglycidyl isocyanurate(TGIC)and pyromellitic dianhydride(PMDA).The influence of LCB produced by functional group reaction on rheological and crystallization behavior was studied and discussed through linear rheology,uniaxial elongation and DSC(differential scanning calorimetry).The much higher viscosity and the more notable strain hardening behavior of modified PGA indicates the LCB with high degree of entanglements are *** melt strength of PGA is finally improved greatly and can make su re that the supercritical CO_(2)foaming can be carried out successfully.

关键词： Polyglycolide(PGA) Long chain branching(LCB) Rheology

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Deriving a minimum set of viewpoints for maximum coverage over any given digital elevation model data

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International Journal of Digital Earth 2016年第12期9卷 1153-1167页

作者： Xuan shi Bowei xue Department of Geoscience University of ArkansasFayettevilleARUSA

This paper introduces how to automatically derive a minimum set of viewpoints for maximum coverage over a large scale of digital terrain *** is a typical data and computation-intensive research covering a series of geocomputation tasks that have not been implemented efficiently or optimally in prior *** paper introduces a three-step computational solution to resolve the *** any given digital elevation model(DEM)data,automatic generation of control viewpoints is the first step through map algebra calculation and hydrological modeling *** each viewpoint,the viewshed calculation then has to be *** combined viewshed derived from the viewshed of all viewpoints establishes the maximum viewshed coverage of the given ***,detecting the minimum set of viewpoints for the maximum coverage is a Non-deterministic Polynomial-time hard *** outcome of the computation has broader societal impacts since the research questions and solutions can be adapted into realworld application and decision-making practice,such as the distribution,optimization and management of telecommunication infrastructure and wildfire observation towers,and military tactics and operations dependent upon landscape and terrain features.

关键词： Minimum set maximum coverage viewshed digital terrain optimization

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Preparation of Zinc-nickel-cobalt Ternary Oxide Nanosheets as Electrodes in Supercapacitors

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Chemical Research in Chinese Universities 2017年第6期33卷 939-945页

作者： shi xue ZHOU Guowei Key Laboratory of Fine Chemicals in Universities of Shandong School of Chemistry and PharmaceutIcal Engineering Qilu University of Technology Jinan 250353 P. R. China

Novel zinc-nickel-cobalt ternary oxide nanosheets were successfully synthesized via an easy solvothermal method followed by calcination and were tailored to have different numbers of wrinkles by controlling the vohtrne ratio of the components in the mixed solvent. Nanosheets with more wrinkles yielded a large specific surface area（111.61 m2/g）, which improved their electrochemical properties. The resulting products were characterized using a three-electrode system in 6 mol/L KOH electrolyte solution. With unique structures, the nanosheets with more wrinkles displayed a good capacitive behavior and an excellent specific capacitance retention of 97.18% after 2000 continuous charge-discharge cycles. Considering their high electrochemical performance and simple fabrication, we proposed that these unique zinc-nickel-cobalt oxide nanosheets are promising supercapacitor electrodes for energy storage applications.

关键词： Zinc-nickel-cobalt Ternary oxide Nanosheet Wrinkle Supercapacitor

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Direct Reduction Experiment on Iron-Bearing Waste Slag

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Journal of Iron and Steel Research International 2013年第3期20卷 24-29,35页

作者： CHENG Xiang-li ZHAO Kai QI yuan-hong shi xue-feng ZHEN Chang-liang State Key Laboratory of Advanced Steel Process and Products Central Iron and Steel Research Institute

A lot of iron-bearing slags were produced,and whose grade is much more than that of industrial iron ore *** analysis and phase identification shows that the iron-bearing slag is amorphous,has fayalite main phase,iron grade is 36.10%,and is difficult to recover iron from the *** calculation indicates that CO cannot reduce fayalite at high temperature and carbon direct reduction can be ***,the reaction begins at 770 ℃ and the temperature can be reduced down to 500℃ when CaO is *** this basis,a method is put forward to making direct enrichment of iron by taking carbon contained pellets to realize the rapid reduction of fayalite,and the direct reduction process were studied in this *** show that xC/xO should be less than 1.5 for the need of reduction and carburization,and CaO and Al2O3 can spur the reduction of *** conditions that xC/xO is 1.2,metallization rate can be 77% when temperature is 1 250 ℃ and only carbon is added,and metallization rate can be 74% when temperature is 1 200 ℃ and only CaO is *** the addition of Al2O3 can get a higher metallization rate（10% or so） than usual as R is between 0.4 and *** the optimized condition of R equals to 0.6,temperature of 1 250 ℃,slag melting point of 1 320 ℃,and time of 30 min,the metallization rate can reach 88.43%.

关键词： iron-bearing slag fayalite metallization rate basicity

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Parallelizing maximum likelihood classification on computer cluster and graphics processing unit for supervised image classification

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International Journal of Digital Earth 2017年第7期10卷 737-748页

作者： Xuan shi Bowei xue Department of Geosciences University of ArkansasFayettevilleARUSA

Supervised image classification has been widely utilized in a variety of remote sensing *** large volume of satellite imagery data and aerial photos are increasingly available,high-performance image processing solutions are required to handle large scale of *** paper introduces how maximum likelihood classification approach is parallelized for implementation on a computer cluster and a graphics processing unit to achieve high performance when processing big imagery *** solution is scalable and satisfies the need of change detection,object identification,and exploratory analysis on large-scale high-resolution imagery data in remote sensing applications.

关键词： Maximum likelihood classification supervised classification parallel computing graphics processing unit

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