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Clinical features and prognostic factors of duodenal neuroendocrine tumours:A comparative study of ampullary and nonampullary regions

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 907-918页

作者： Sa Fang yu-Peng shi Lu Wang Shuang Han Yong-Quan shi Department of Gastroenterology Honghui HospitalXi’an Jiaotong UniversityXi'an 710054Shanxi ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710032Shaanxi ProvinceChina Department of Gastroenterology Xijing Hospital Affiliated to Air Force Medical UniversityXi'an 710032Shaanxi ProvinceChina

BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare ***,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic ***,there is no consensus regarding the ideal treatment of *** there are few studies on the clinical features and survival analysis of *** To analyze the clinical characteristics and prognostic factors of patients with duodenal neuroendocrine *** The clinical data of DNETs diagnosed in the First Affiliated Hospital of Air Force Military Medical University from June 2011 to July 2022 were ***-docrine tumours located in the ampulla area of the duodenum were divided into the ampullary region group;neuroendocrine tumours in any part of the duo-denum outside the ampullary area were divided into the nonampullary region *** a retrospective study,the clinical characteristics of the two groups and risk factors affecting the survival of DNET patients were *** Twenty-nine DNET patients were *** male to female ratio was 1:1.9,and females comprised the *** ampullary region group accounted for 24.1%(7/29),while the nonampullary region group accounted for 75.9%(22/29).When diagnosed,the clinical symptoms of the ampullary region group were mainly abdominal pain(85.7%),while those of the nonampullary region groups were mainly abdominal distension(59.1%).There were differences in the composition of staging of tumours between the two groups(Fisher's exact probability method,P=0.001),with nonampullary stage II tumours(68.2%)being the main stage(P<0.05).After the diagnosis of DNETs,the survival rate of the ampullary region group was 14.3%(1/7),which was lower than that of 72.7%(16/22)in the nonampullary region group(Fisher's exact probability method,P=0.011).The survival time of the ampullary region group was shorter than that of the nonampullary region group(P<0.000).The median survival time of the ampullary

关键词： Duodenum Neuroendocrine Tumour Ampullary Nonampullary Clinical features Prognostic

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Intermittent sliding-lock-knot suture for limbal conjunctival autograft fixation in pterygium surgery:a technique note

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 838-844页

作者： Ling Zhang Run-Hua Lyu Jing-Ru Wang Wen-Jian shi Feng Zheng ying-ying Gao Department of Ophthalmology the Second Affiliated HospitalFujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Neurosurgery the Second Affiliated HospitalFujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

AIM:To report a technique used with intermittent slidinglock-knot(ISLK)fixation for limbal conjunctival autografts in pterygium surgery and compared with those of routine intermittent(RI)***:Consecutive patients with primary pterygium who had undergone pterygium excision combined with limbal conjunctival autograft transplantation between March 2021 and March 2022 at our institute were retrospectively *** outcome measures were mean duration of surgery and suture removal,degree of conjunctival hyperemia on postoperative day 1,pain score at suture removal,postoperative symptoms at 6mo,including conjunctival hyperemia,foreign body sensation,and graft ***:Ninety-eight patients underwent monocular surgery and were divided into ISLK(51 eyes)and RI(47 eyes)groups according to the type of conjunctiva autograft fixation method *** was no significant difference in mean duration of surgery between the two groups(18.59±2.39min vs 18.15±2.20min,P=0.417);however,compared to the RI group,shorter suture removal times were observed in the ISLK group[0.58min(0.42-0.87)vs 3.00min(2.21-4.15),P<0.001].The degree of conjunctival hyperemia on postoperative day 1 was milder in the ISLK group(P<0.001).Pain scores at suture removal were lower in the ISLK group than in RI group[1(0-3)vs 2(1-4),P<0.001].Postoperative symptoms at 6mo were comparable between the groups(P=0.487),with no ***:ISLK is an innovative method for limbal conjunctival autograft fixation after pterygium *** to RI fixation,ISLK facilitates suture removal and reduces discomfort,with comparable surgery duration and less conjunctival hyperemia.

关键词： intermittent sliding-lock-knot fixation pterygium suture removal

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Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第10期30卷 1393-1404页

作者： Ming-Hui Zeng Qi-yu shi Liang Xu yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Gastroenterology Cangzhou People’s HospitalCangzhou 061000Hebei ProvinceChina Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Tianjin Research Institute of Liver Diseases Tianjin 300192China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,affecting about 1/4th of the global population and causing a huge global economic *** date,no drugs have been approved for the treatment of NAFLD,making the correction of unhealthy lifestyles the principle method of *** patients with poor adherence to lifestyle correction and attempting to improve their adherence are therefore very *** To develop and validate a scale that can rapidly assess the adherence of patients with NAFLD to lifestyle *** The Exercise and Diet Adherence Scale(EDAS)was designed based on com-pilation using the Delphi method,and its reliability was subsequently *** and laboratory indicators were measured,and patients completed the EDAS questionnaire at baseline and after 6 *** efficacy of the EDAS was evaluated in the initial ***,the efficacy of the EDAS was internally verified in a validation *** The EDAS consisted of 33 items in six dimensions,with a total of 165 *** EDAS score correlated significantly with daily number of exercise and daily reduction in calorie intake(P500 kacl/d),(sensitivity/specificity was 100.0%/75.8%),while patients score below 97 could nearly rule out the possibility of daily exercise(sensitivity/specificity was 89.5%/44.4%).Total EDAS scores≥116,97-115,and<97 points were indicative of good,average,and poor adherence,respectively,to diet and exercise *** The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.

关键词： Fatty liver Lifestyle intervention Behavioral change Patient adherence Compliance

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Effect of TiO_(2) addition on microstructures and properties of Mgo-Cao refractory aggregates

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Journal of Iron and Steel Research(International) 2024年第6期31卷 1547-1554页

作者： Shuai Zhang Jing-ran Wang yuan-gao Li Feng-you Li Wen Yan Hui-ying shi The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Joint International Research Laboratory of Refractories and Metallurgy Wuhan 430081HubeiChina Shanxi Luweibao Taigang Refractory Co. Ltd.Taiyuan 030003ShanxiChina

MgO-CaO(40 wt.%CaO)refractory aggregates were prepared using the calcined dolomite and light-burned magnesia fine powder as raw materials and TiO_(2) as *** effect of TiO_(2) on their phase composition,microstructures and properties was investigated by X-ray diffraction and scanning electron *** properties such as bulk density,apparent porosity,relative aggregate tube strength and hydration resistance were also *** results showed that the CaTiO_(3) generated by the reaction between CaO and TiO_(2) was distributed around the CaO grain boundaries and intermittently distributed with MgO,which formed an isolation layer around CaO and greatly improved the hydration ***,the introduction of TiO_(2) promoted sintering and increased the grain size,further improving the strengths and hydration resistance of the *** addition,the most significant enhancement in the hydration resistance and strengths of the samples was achieved when 1.0-2.0 wt.%TiO_(2) was *** this case,the relative strength of aggregate increased from 33.3% to 37.3%-43.1%,and the mass gain after the hydration test decreased from 3.13% to 1.26%-1.45%.

关键词： MgO-CaO refractory aggregate TiO_(2)addition Phase composition Microstructure Hydration resistance

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Neighbor Product Distinguishing Total Coloring via Combinatorial Nullstellensatz

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Acta Mathematicae Applicatae Sinica 2024年

作者： Meng-ying shi Li ZHANG School of Mathematical Sciences Tongji University

Let G =(V, E) be a simple graph and φ : V(G) ∪ E(G) → {1, 2, · · ·, k} be a proper total-k-coloring of G. Let f(v) = φ(v)Π(uv∈E(G))φ(uv). The coloring φ is neighbor product distinguishing if f(u) ≠ f(v) for each edge uv ∈ E(G). The neighbor product distinguishing total chromatic number of G, denoted by χΠ’’(G),is the smallest integer k such that G admits a k-neighbor product distinguishing total coloring. Li et al. conjectured that χΠ’’(G) ≤ △(G) + 3 for any graph with at least two vertices and confirmed the conjecture for K4-minor free graph. In this paper, we prove that for a graph G with at least two vertices,(1) if mad(G) <(60)/(17),then χΠ’’(G) ≤ max{△ + 2, 8};(2) if mad(G) <8/3, then χΠ’’(G) ≤ max{△ + 2, 6}. Furthermore, by using the Combinatorial Nullstellensatz, we simplify their proof and show that χΠ’’(G) ≤ max{△(G) + 2, 6} for any K4-minor free graph.

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Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying shi Li-ping ZHU Jun-long BAI Ren-ren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

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Biomarkers for neuromyelitis optica:a visual analysis of emerging research trends

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Neural Regeneration Research 2024年第12期19卷 2735-2749页

作者： Xiangjun Li Jiandong Zhang Siqi Zhang Shengling shi Yi’an Lu ying Leng Chunyan Li Department of Ophthalmology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina Department of Ophthalmology Changchun Bright Eye HospitalChangchunJilin ProvinceChina Departemt of Endocrinology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple *** the past 20 years,the search for biomarke rs for neuromyelitis optica has been ***,we used a bibliometric approach to analyze the main research focus in the field of biomarkers for neuromyelitis *** in this area is consistently increasing,with China and the United States leading the way on the number of studies *** Mayo Clinic is a highly reputable institution in the United States,and was identified as the most authoritative institution in this ***,Professor Wingerchuk from the Mayo Clinic was the most authoritative expe rt in this *** analysis revealed that the terms "neuro myelitis optica"(261 times), "multiple sclerosis"(220 times), "neuromyelitis optica spectrum disorder"(132 times), "aquaporin4"(99 times),and "optical neuritis"(87 times) were the most frequently used keywords in literature related to this *** analysis of the classical literature showed that the majority of publications provide conclusive research evidence supporting the use of aquaporin-4-IgG and neuromyelitis optica-IgG to effectively diagnose and differentiate neuromyelitis optica from multiple ***,aquaporin-4-IgG has emerged as a highly specific diagnostic biomarker for neuromyelitis optica spectrum *** oligodendrocyte glycoprotein-IgG is a diagnostic biomarke r for myelin oligodendrocyte glycoprotein antibody-associated *** biomarkers for neuromyelitis optica in clude cerebrospinal fluid immunological biomarkers such as glial fibrillary acidic protein,serum astrocyte damage biomarkers like FAM19A5,serum albumin,and gammaaminobutyric *** latest prospective clinical trials are exploring the potential of these *** results indicate that glial fibrillary acidic protein is emerging as a promising candidate biomarker for neuromyelit

关键词： aquaporin-4 autoantibody multiple sclerosis myelin oligodendrocyte glycoprotein antibody-associated disease neuromyelitis optica neuromyelitis optica spectrum disorder optical coherence tomography

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A new fabrication method for enhancing the yield of linear micromirror arrays assisted by temporary anchors

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Microsystems & Nanoengineering 2024年第3期10卷 169-180页

作者： Xingchen Xiao Ting Mao yingchao shi Kui Zhou Jia Hao Yiting yu Ningbo Institute of Northwestern Polytechnical University College of Mechanical EngineeringNorthwestern Polytechnical University710072 Xi’anChina Key Laboratory of Micro/Nano Systems for Aerospace(Ministry of Education) Shaanxi Province Key Laboratory of Micro and Nanoelectromechanical SystemsNorthwestern Polytechnical University710072 Xi’anChina

As one of the most common spatial light modulators,linear micromirror arrays(MMAs)based on microelectromechanical system(MEMS)processes are currently utilized in many ***,two crucial challenges exist in the fabrication of such devices:the adhesion of silicon microstructures caused by anodic bonding and the destruction of the suspended silicon film due to residual *** solve these issues,an innovative processing method assisted by temporary anchors is *** approach effectively reduces the span of silicon microstructures and improves the Euler buckling limit of the silicon ***,these temporary anchors are strategically placed within the primary etching areas,enabling easy removal without additional processing *** a result,we successfully achieved wafer-level,high-yield manufacturing of linear MMAs with a filling factor as high as 95.1%.Demonstrating superior capabilities to those of original MMAs,our enhanced version boasts a total of 60 linear micromirror elements,each featuring a length-to-width ratio of 52.6,and the entire optical aperture measures 5 mm×6 *** linear MMA exhibits an optical deflection angle of 20.4°at 110 Vdc while maintaining exceptional deflection flatness and *** study offers a viable approach for the design and fabrication of thin-film MEMS devices with high yields,and the proposed MMA is promising as a replacement for digital micromirror devices(DMDs,by TI Corp.)in fields such as spectral imaging and optical communication.

关键词： mirror exceptional anodic

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Molecular investigation into the transformation of recalcitrant dissolved organic sulfur in refinery sour water during stripping process

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Petroleum Science 2024年第3期21卷 2112-2119页

作者： yu-Guo Li Chen He Chun-Mao Chen Fan Liu Quan shi State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China State Key Laboratory of Coal Mining and Clean Utilization Beijing 100013China PetroChina Ningxia Petrochemical Company Yinchuan 750021NingxiaChina

Refinery sour water primarily originates from the tops of towers in various units and coker condensate,and cannot be discharged directly to a wastewater treatment plant due to high levels of chemical oxygen demand(COD)and organic sulfur *** after the recovery of H_(2)S from the sour water by the stripping process,the effluent still contains a high concentration of dissolved organic sulfur(DOS),which can have a huge bad *** chemical composition of dissolved organic matter(DOM)in refinery wastewater has been extensively studied,the investigation of recalcitrant DOS from sour waters remains *** the present study,chemical composition of sour water DOMs(especially DOS)was investigated using fluorescence spectroscopy(excitation-emission matrix,EEM)and mass spectrometry,including gas chromatography-mass spectrometry(GC-MS)and high-resolution Orbitrap *** GC-MS and EEM results showed that volatile and low-aromaticity compounds were effectively removed during the stripping process,while compounds with high hydrophilicity and humification degree were found to be more *** Orbitrap MS results showed that weak-polar oxygenated sulfur compounds were easier to be removed than oxygenated ***,the effluent still contained significant amounts of sulfur-containing compounds with multiple sulfur atoms,particularly in the form of highly unsaturated and aromatic *** Orbitrap MS/MS results of CHOS-containing compounds from the effluent indicate that the sulfur atoms may exist as sulfonates,disulfide bonds,*** the composition and structure of sour water DOS is crucial for the development of effective treatment processes that can target polysulfide compounds and minimize their impact on the environment.

关键词： Molecular transformation Dissolved organic sulfur Stripping process Refinery sourwater Orbitrap MS

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Conformations and adsorption behavior of poly(allylamine hydrochloride) studied by single molecule force spectroscopy

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Chinese Science Bulletin 2008年第1期53卷 22-26页

作者： yu ying WANG Fang shi WeiQing WANG LiYan WANG WenBin SHEN JiaCong Key Lab of Supramolecular Structure and Materials Jilin University Changchun 130012 China

Poly(allylamine hydrochloride) (PAH), which is frequently used in fabricating polyelectrolyte multilayer films, was studied by single molecule force spectroscopy (SMFS). Plenty of force-extension curves with a long plateau were obtained in water, indicating that train-like structure was predominant when PAH was adsorbed on the substrate. It was found that the peak-type force-extension curves of PAH in water were not able to be fitted by the modified freely-jointed chain model. Additionally, there was a flat region in the derivative of force-extension curves. Thus, it was inferred that PAH chain in water was in a special conformation and underwent a "conformational transition" under the stretching of an external force. This phenomenon did not appear in the SMFS experiment in 1 mol/L urea solution, which indi-cated that urea was able to break the special conformation.

关键词：光谱学单分子吸附丙烯胺

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