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Theoretical Study of the Sensitivity-Improvement Effect of Phosphoryl Group in Mass Spectrometry of Small Peptides

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Chinese Chemical Letters 2001年第9期12卷 807-808页

作者： Yang JIANG Bo TAN yu fen zhao The Key Laboratory of Bioorganic Phosphorus Chemistry Ministry of EducationDepartment of ChemistrySchool of Life Sciences and EngineeringTsinghua UniversityBeijing 100084

It was found that phosphorylation of small peptide could improve the sensitivity in mass spectrometry. Density functional theory calculations showed that the energy for the protonation of N-(O,O'-dimethyl) phosphoryl ... 详细信息

关键词： Phosphoryl group small peptide mass spectrometry relative energy

Convenient and Efficient Synthesis of L-Rhamnopyranosyl Phosphoramidates via H-Phosphonate

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Chinese Chemical Letters 2003年第7期14卷 685-688页

作者： Qi SUN Qiang XIAO Yong JU yu fen zhao The Key Laboratory of Bioorganic Phosphorus Chemistry of Education Ministry Department of ChemistrySchool of Life Sciences and EngineeringTsinghua UniversityBeijing 100084

The a-L-rhamnopyranosyl phosphomonoesters conjugated with L-amino acid methyl esters were stereoselectively synthesized in a convenient route by utilizing H-phosphonate intermediate.

关键词： H-Phosphonate L-rhamnose phosphoramidate.

A chitosan-mediated inhalable nanovaccine against SARS-CoV-2

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Nano Research 2022年第5期15卷 4191-4200页

作者： Shao-Hua Zhuo Jun-Jun Wu Lang zhao Wen-Hao Li yu-fen zhao Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Institute for Brain Disorders Beijing 100069China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Institute of Drug Discovery Technology Ningbo UniversityNingbo 315221China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),with several antigenic variants,has grown into a global challenge,and the rapid establishment of an immune barrier is crucial to achieving long-term control of the *** has led to a great demand for easy preparation and scalable vaccines,especially in low-income ***,we present an inhalable nanovaccine comprising chitosan and SARS-CoV-2 spike *** chitosan-mediated nanovaccine enabled a strong spike-specific antibody immune response and augmented local mucosal immunity in bronchoalveolar lavage and lungs,which might be capable of protecting the host from infection without systemic *** addition,the enhanced adaptive immunity stimulated by chitosan showed potential protection against ***,inhalation of the nanovaccine induced a comparable antibody response compared to intramuscular *** inhalable nanovaccine against SARS-CoV-2 offers a convenient and compliant strategy to reduce the use of needles and the need for medical staff.

关键词： severe acute respiratory syndrome coronavirus 2(SASR-CoV-2) inhalation nanovaccine chitosan

Polydentate cyclotriphosphazene ligands:Design,synthesis and bioactivity

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Chinese Chemical Letters 2009年第1期20卷 58-61页

作者： Le Wang Yong Ye Shang Bin Zhong yu fen zhao Key Laboratory of Chemical Biology and Organic Chemistry Department of Chemistry Zhengzhou University Zhengzhou 450052 China Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100084 China

Five multinuclear cyclotriphosphazene ligands were synthesized and tested for their cleavage activities to plasmid DNA. All of these new compounds were confirmed by MS, ^1H NMR, ^31P NMR, ^13C NMR and IR. Preliminary studies on the cleavage of pUC19 DNA in the presence of metal complexes were performed. The results revealed that these complexes could act as powerful catalysts under physiological conditions. The complexes 3b ＋ Cu can effectively cleave DNA to nicked form, giving hydrolysis rate constant of 0.08/h under physiological conditions. An acid-base catalyzed DNA phosphate-diester hydrolysis mechanism was also orooosed.

关键词： Cyclotriphosphazene Polydentate ligand DNA cleavage Hydrolysis

Improved Electrochemical Synthesis of Nitro-substituted 1-Aryl-2-pyrrolidinecarbonitriles

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Chinese Chemical Letters 2006年第6期17卷 736-738页

作者： Wei LIU yuan MA Ying Wu YIN yu fen zhao The Key Laboratory for Bioorganic Phosphorus Chemistry ＆ Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 Department of Chemistry Tsinghua UniversityBeijing 100084 Beijing TH-UNIS Insight Co.Ltd. Beijing 100084

In this paper, we described an improved electrochemical method for synthesis of some 1-aryl-2-pyrrolidinecarbonitrile derivatives bearing an electron-withdrawing group （NO2）. The electrochemical synthesis of titile ... 详细信息

关键词： Anodic cyanation nitrile pyrrolidine electrochemistry.

Synthesis and Biological Activities of N-Phosphoryl Branched Peptides

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Chinese Chemical Letters 2003年第4期14卷 343-346页

作者： Sheng Li CAO yu Yang JIANG yu Ping fenG Yan Ling NIU yu fen zhao Key Laboratory of Bioorganic Phosphorus Chemistry Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084 Department of Chemistry Capital Normal UniversityBeijing 100037

A series of N-phosphoryl branched peptides were synthesized by coupling of various N-phosphoryl amino acids to L-Lysine methyl ester, and their structures were confirmed by 31P NMR, 1H NMR, MS and elemental analysis. The results of cell biological tests indicated that compound 1d and 1e obviously inhibited the growth of both K562 and A2780 cells.

关键词： N-Phosphoryl branched peptide synthesis biological activity apoptosis.

Investigation of Spontaneous Condensation of an Amino Acid Based Amphiphile on Cast Film by in situ Transmission FT-IR Spectroscopy

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Chinese Chemical Letters 2005年第12期16卷 1637-1640页

作者： Hai Yan WANG Yan Mei LI Yi XIAO yu fen zhao The Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084

The spontaneous condensation of the amphiphilic N-（O,O-dihexadecyl）phosphorylalanine on the cast film was observed by in situ investigation of transmission infrared spectroscopy The particular orientation and ordered packing of the monomers within the multilayers of the cast film is concluded to attribute to the spontaneous condensation between the monomers.

关键词： Amphiphile cast film condensation FT-IR N-(O O-dihexadecyl)phosphoryl alanine

Oligouridylates Formation with N-(O,O'-Diisopropyl)-Phosphoryl Alanine in the presence of Poly(β-(N^7-Adeninyl)Ethyl Methacrylate)

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Chinese Chemical Letters 2001年第4期12卷 313-316页

作者： Hong Qi XIANG Jian Jun HU Yang JIANG yu fen zhao Bioorganic Phosphorus Laboratory Department of ChemistrySchool of Life Science and EngineeringTsinghua UniversityBeijing 100084

The oligouridylates formation with N-(O,O-diisopropyl)-phosphoryl alanine in the presence of poly((-(N7-adeninyl)ethyl methacrylate) was studied. An increased yield by the presence of the polymeric nucleic acid analo... 详细信息

关键词： N-phosphoryl amino acid nucleoside interaction polymeric nucleic acid analog.

Synthesis and thermal stability of a novel phosphorus-nitrogen containing intumescent flame retardant

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Chinese Chemical Letters 2008年第3期19卷 277-278页

作者： Zhi yu Ju Yong Ye Ru Yi Zou Xin Cheng Liao yu fen zhao Key Laboratory for Chemical Biology and Organic Chemistry of Henan Province Department of Chemistry Zhengzhou University Zhengzhou 450052 China Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084 China

A novel phosphorus-nitrogen containing intumescent flame retardant （P-N IFR） was prepared via the reaction of dichlor-opentate with N-methylaniline. The structure of the product was confirmed by ^1H NMR, ^31p NMR, M... 详细信息

关键词： Synthesis Thermal stability Intumescent flame retardant