Synthesis and Biological Activities of N-Phosphoryl Branched Peptides

作     者：Sheng Li CAO Yu Yang JIANG Yu Ping FENG Yan Ling NIU Yu Fen ZHAO 

作者机构：Key Laboratory of Bioorganic Phosphorus ChemistryMinistry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084 Department of ChemistryCapital Normal UniversityBeijing 100037 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2003年第14卷第4期

页      面：343-346页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work is supported by Natural Science Foundation of Beijing City (7002006). Elemental analyses were performed by Institute of Chemistry Chinese Academy of Science 

主　　题：N-Phosphoryl branched peptide synthesis biological activity apoptosis. 

摘      要：A series of N-phosphoryl branched peptides were synthesized by coupling of various N-phosphoryl amino acids to L-Lysine methyl ester, and their structures were confirmed by 31P NMR, 1H NMR, MS and elemental analysis. The results of cell biological tests indicated that compound 1d and 1e obviously inhibited the growth of both K562 and A2780 cells.