检索结果-南通市图书馆

Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells

Cellular & Molecular Immunology 2015年第4期12卷 424-434页

作者： Jhih-Jia Jhang yu-Ting cheng cheng-Ying Ho Gow-chin Yen Department of Food Science and Biotechnology National Chung Hsing University Taichung Taiwan China and ZAgricultural Biotechnology CenterNational Chung Hsing University Taichung Taiwan China Correspondence: Professor GC Yen Department of Food Science and Biotechnology National Chung Hsing University 250 Kuokuang Road Taichung40227 Taiwan China.

Gouty arthritis is an inflammatory disease that is caused by an accumulation of monosodium urate （MSU） crystals in the joints. MSU is capable of activating the nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 （NLRP3） inflammasome, leading to interleukin-lβ （IL-lβ） secretion. Reactive oxygen species （ROS） are major mediators of the NLRP3/IL-lβ interaction. Although nuclear factor E2-related factor 2 （Nrf2） is recognized as a transcription factor that is involved in the response to oxidative stress, the effect of MSU on Nrf2 and on Nrf2-mediated antioxidant enzymes remains unclear. The treatment of THP-1 monocytes using phorbol 12-myristate 13-acetate （PMA） was shown to initiate inflammatory responses. Here, we showed that THP-1 cells, following treatment with MSU crystals, significantly increased IL-1β release, NLRP3 inflammasome activation and ROS production. MSU also promoted the nuclear translocation of Nrf2 and activated lysosomal destabilization. Moreover, the levels of heme oxygenase-1 （HO-1） in gene and protein expressions were upregulated by MSU. MSU-induced IL-lβ secretion and NLRP3 inflammasome activation were inhibited by the knockdown of Nrf2 and via the HO-1 inhibitor zinc （11） protoporphyrin IX （ZnPP）. In addition, HO-1 inhibition increased the level of superoxide anion production and the consumption of glutathione. These findings suggest that Nrf2 and HO-1 mediate redox homeostasis and interact with pro-inflammatory factors in MSU-challenged THP-1 cells, thereby providing new insight into how MSU-induced gouty inflammation is mediated by specific mechanisms that are involved in the Nrf2/Ho-1 antioxidant signaling pathway.

关键词： HO-1 monosodium urate NLRP3 inflammasome Nrf2 THP-1 cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

引用

World Journal of Stem Cells 2022年第1期14卷 76-91页

作者： Hsi-Lung Hsieh Ming-chin yu Li-ching cheng Ta-Sen Yeh Ming-Ming Tsai Department of Nursing Division of Basic Medical SciencesChang-Gung University of Science and TechnologyTaoyuan 333Taiwan Research Center for chinese Herbal Medicine College of Human EcologyChang Gung University of Science and TechnologyTaoyuan 333Taiwan Department of Neurology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of General Surgery Chang Gung Memorial Hospital at LinkouTaoyuan 333Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of General Surgery New Taipei Municipal TuCheng HospitalNew Taipei 236Taiwan Department of General Surgery Chang Gung Memorial HospitalChiayi 613Taiwan

Gastric cancer(GC)is a primary cause of cancer-related mortality worldwide,and even after therapeutic gastrectomy,survival rates remain poor.The presence of gastric cancer stem cells(GCSCs)is thought to be the major reason for resistance to anticancer treatment(chemotherapy or radiotherapy),and for the development of tumor recurrence,epithelial–mesenchymal transition,and metastases.Additionally,GCSCs have the capacity for self-renewal,differentiation,and tumor initiation.They also synthesize antiapoptotic factors,demonstrate higher performance of drug efflux pumps,and display cell plasticity abilities.Moreover,the tumor microenvironment(TME;tumor niche)that surrounds GCSCs contains secreted growth factors and supports angiogenesis and is thus responsible for the maintenance of the growing tumor.However,the genesis of GCSCs is unclear and exploration of the source of GCSCs is essential.In this review,we provide up-todate information about GCSC-surface/intracellular markers and GCSC-mediated pathways and their role in tumor development.This information will support improved diagnosis,novel therapeutic approaches,and better prognosis using GCSC-targeting agents as a potentially effective treatment choice following surgical resection or in combination with chemotherapy and radiotherapy.To date,most anti-GCSC blockers when used alone have been reported as unsatisfactory anticancer agents.However,when used in combination with adjuvant therapy,treatment can improve.By providing insights into the molecular mechanisms of GCSCs associated with tumors in GC,the aim is to optimize anti-GCSCs molecular approaches for GC therapy in combination with chemotherapy,radiotherapy,or other adjuvant treatment.

关键词： Gastric cancer stem cells Stem cell-surface markers Tumor niche Tumor microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis

引用

World Journal of Gastrointestinal Oncology 2019年第3期11卷 181-194页

作者： cheng-yu Hung Ta-Sen Yeh cheng-Kun Tsai Ren-chin Wu Ying-Chieh Lai Meng-Han Chiang Kuan-Ying Lu Chia-Ni Lin Mei-Ling cheng Gigin Lin Molecular Medicine Research Center Chang Gung University Clinical Metabolomics Core Lab Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Medical Imaging and Intervention Imaging Core Lab Institute for Radiological Research Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Surgery Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Pathology Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Laboratory Medicine Chang Gung Memorial Hospital at Linkou and Chang Gung University Department of Biomedical Science College of Medicine Chang Gung University

BACKGROUND Based on the breakthrough of genomics analysis, The Cancer Genome Atlas Research Group recently proposed an integrative genomic analysis, dividing gastric cancer(GC) into four subtypes, characterized by the chromosomal instability(CIN) status. However, the CIN status of GC is still vaguely characterized and lacking the valuable easy-to-use CIN markers to diagnosis in molecular and histological detection.AIM To explore the associations of CIN with downstream lipidomics profiles.METHODS We collected cancerous and noncancerous tissue samples from 18 patients with GC; the samples were divided into CIN and non-CIN types based on the system of The Cancer Genome Atlas Research Group and 409 sequenced oncogenes and tumor suppressor genes. We identified the lipidomics profiles of the GC samples and samples of their adjacent noncancerous tissues by using liquid chromatography–mass spectrometry. Furthermore, we selected leading metabolites based on variable importance in projection scores of > 1.0 and P <0.05.RESULTS Twelve men and six women participated in this study; the participants had a median age of 67.5 years(range, 52–87 years) and were divided into CIN(n = 9)and non-CIN(n = 9) groups. The GC samples exhibited distinct profiles of lysophosphocholine, phosphocholine, phosphatidylethanolamine,phosphatidylinositol, phosphoserine, sphingomyelin, ceramide, and triglycerides compared with their adjacent noncancerous tissues. The glycerophospholipid levels(phosphocholine, phosphatidylethanolamine, and phosphatidylinositol)were 1.4-to 2.3-times higher in the CIN group compared with the non-CIN group(P < 0.05). Alterations in the glycerolipid and glycerophospholipid pathways indicated progression of GC toward CIN.CONCLUSION The lipidomics profiles of GC samples were distinct from those of their adjacent noncancerous tissues. CIN status of GC is primarily associated with downstream lipidomics in the glycerophospholipid pathway.

关键词： Chromosomal instability Gastric cancer Glycerophospholipids Metabolomics Lipidomics profile

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

H■rmander's Multipliers for the Weighted Herz-type Hardy Spaces

引用

Acta Mathematica Sinica,English Series 2006年第5期22卷 1509-1518页

作者： Ming Yi LEE chin cheng LIN yu Tien LIN Institute of Mathematics Academia Sinica Taipei 115 China ( Taiwan) Department of Mathematics National Central University Chung-Li 320 China (Taiwan)

In this article, we apply the molecular characterization of the weighted Hardy space developed by the first two authors to show the boundedness of Hormander multiplier on the weighted Herz-type Hardy spaces HK^α,p 2... 详细信息

关键词： Ap weights Herz-type Hardy spaces Hormander＇s multipliers Weighted Hardy spaces

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical utility of hepatitis B surface antigen kinetics in treatment-na?ve chronic hepatitis B patients during longterm entecavir therapy

引用

World Journal of Gastroenterology 2018年第6期24卷 725-736页

作者： Tien-ching Lin Yen-cheng Chiu Hung-Chih Chiu Wen-Chun Liu Pin-Nan cheng Chiung-yu Chen Ting-Tsung Chang I-chin Wu Department of Internal Medicine National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan City70403Taiwan Infectious Disease and Signaling Research Center National Cheng Kung UniversityTainan 70403Taiwan

AIM To investigate the utility of hepatitis B surface antigen(HBsAg) kinetics in chronic hepatitis B patients during long-term entecavir treatment.METHODS This retrospective study included treatment-na?ve chronic hepatitis B patients who received at least 2 years of consecutive entecavir treatment. Patients were followed up at three to six month intervals with liver biochemistry, hepatitis B virus DNA, and abdominal sonography. In hepatitis B e antigen(HBeAg)-positive patients, HBeAg levels were assessed every three to six month until results became negative. Serum HBsAg levels were determined at the baseline, oneyear and five-year time points. Liver cirrhosis was diagnosed through liver biopsy, imaging examinations, or clinical findings of portal hypertension. Hepatocellular carcinoma was diagnosed by histological examination or dynamic image studies.RESULTS A total of 211 patients were enrolled. The median treatment time was 5.24(2.00-9.62) years. Multivariate analysis showed that lower baseline HBsAg levels were associated with an earlier virological response, earlier hepatitis B e antigen(HBeAg) seroconversion, and earlier biochemical response in HBeAg-positive patients(cut-off value: 4 log IU/mL) and an earlier virological response in HBeAg-negative non-cirrhotic patients(cut-off value: 2.4 log IU/mL). Although HBsAg levels decreased slowly during long-term entecavir treatment, higher HBsAg decrease rates were found in the first year for HBeAg-positive non-cirrhotic patients, and patients with higher baseline HBsAg levels. More favorable clinical outcomes were not observed by a rapid HBsAg decline per se, but depended on lower baseline HBsAg levels.CONCLUSION Baseline HBsAg can be used to predict treatment responses. HBsAg levels and decrease rates should be considered together according to disease status while interpreting HBsAg changes.

关键词： Chronic hepatitis B Entecavir Hepatitis B e antigen Hepatitis B surface antigen Kinetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice

引用

Food Science and Human Wellness 2019年第4期8卷 344-350页

作者： Jia-Ni Lin Pei-Sheng Lee Nai-Wen Mei An-chin cheng Roch-Chui yu Min-Hsiung Pan Institute of Food Science and Technology National Taiwan UniversityTaipeiTaiwanChina GINCARE Int’l Enterprises Co. Ltd.No.24Sec.3Chungyang Rd.Tu-Cheng Dist.New Taipei City23673TaiwanChina Department of Tourism Food and Beverage ManagementChang Jung Christian UniversityTainan 71101TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina Department of Health and Nutrition Biotechnology Asia UniversityTaichungTaiwanChina

Excess caloric intake increases the amount of adipose tissue and contributes to metabolic disorders in disrupted metabolic homeostasis.This study aimed to investigate the anti-obesity effects of ginseng and the alternation of gut microbiota composition in high-fat diet(HFD)-induced obesity.The results showed that HFD treatment influenced body weight gain,adipose tissue accumulation and biochemical parameter changes.Compared to the HFD group,ginseng supplementation of HFD-fed mice decreased body weight,adipose tissue mass,total cholesterol(T-CHO)and high-density lipoprotein(HDL)/low-density lipoprotein(LDL)ratio.To analysis the alterations of gut microbiota,ginseng in dietary supplements decreased Firmicutes abundance and increased Bacteroidetes abundance.Taken together,these findings suggest ginseng may modulate the energy storage and alter gut microbiota composition.

关键词： Ginseng High-fat diet Obesity Gut microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metabolomic alterations and chromosomal instability status in gastric cancer

引用

World Journal of Gastroenterology 2018年第33期24卷 3760-3769页

作者： cheng-Kun Tsai Ta-Sen Yeh Ren-chin Wu Ying-Chieh Lai Meng-Han Chiang Kuan-Ying Lu cheng-yu Hung Hung-Yao Ho Mei-Ling cheng Gigin Lin Clinical Metabolomics Core Lab Chang Gung Memorial Hospital at Linkou and Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Imaging and Intervention Imaging Core LabInstitute for Radiological ResearchChang Gung Memorial Hospital at Linkou and Chang Gung UniversityTaoyuan 333Taiwan Chang Gung Memorial Hospital at Linkou and Chang Gung University Taoyuan 333Taiwan Department of Pathology Chang Gung Memorial Hospital at Linkou and Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Biotechnology and Laboratory Science College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Biomedical Science College of MedicineChang Gung UniversityTaoyuan 333Taiwan

AIM To explore the correlation of metabolomics profiles ofgastric cancer(GC) with its chromosomal instability(CIN) status.METHODS Nineteen GC patients were classified as CIN and nonCIN type by The Cancer Genome Atlas Research Group system, based on 409 oncogenes and tumor suppressor genes sequenced. The aqueous metabolites of the GC tumor and its surrounding adjacent healthy tissues were identified through liquid chromatographymass spectrometry. Groups were compared by defining variable importance in projection score of > 1.2, a fold change value or its reciprocal of > 1.2, and a P value of < 0.05 as a significant difference.RESULTS In total,twelve men and seven women were enrolled, with a median age of 66 years(range, 47-87 years). The numbers of gene alterations in the CIN GC group were significantly higher than those in the non-CIN GC(32-218 vs 2-17; P < 0.0005). Compared with the adjacent healthy tissues, GC tumors demonstrated significantly higher aspartic acid, citicoline, glutamic acid, oxidized glutathione, succinyladenosine, and uridine diphosphate-Nacetylglucosamine levels, but significantly lower butyrylcarnitine, glutathione hydroxyhexanoycarnitine, inosinic acid, isovalerylcarnitine, and threonine levels(all P < 0.05). CIN tumors contained significantly higher phosphocholine and uridine 5'-monophosphate levels but significantly lower beta-citryl-L-glutamic acid levels than did non-CIN tumors(all P < 0.05). CIN GC tumors demonstrated additional altered pathways involving alanine, aspartate, and glutamate metabolism, glyoxylate and dicarboxylate metabolism, histidine metabolism, and phenylalanine, tyrosine, and tryptophan biosynthesis.CONCLUSION Metabolomic profiles of GC tumors and the adjacent healthy tissue are distinct, and the CIN status is associated with downstream metabolic alterations in GC.

关键词： Gastric cancer Metabolomics Oncogene Copy-number Chromosomal instability Liquid chromatography-mass spectrometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of Low-Power Double-Edge Triggered Flip-Flop

Design of Low-Power Double-Edge Triggered Flip-Flop

引用

2005 6th International Conference on ASIC

作者： yu Chien-cheng chin Ping-yuan Department of Electrical Engineering Hsiuping Institute of Technology Ta-Li city TaichungTaiwan Department of Electrical Engineering Oriental Institute of Technology Panchiao city TaipeiTaiwan

ISBN: (纸本)0780392108;9780780392106;0780392108;9780780392106

＜正＞A flip-flop is a bistable circuit which stores a selected logical state in response to a clock pulse and one or more data input signals.To reduce the complexity of circuit design, a large proportion of digital circuits are synchronous circuits;that is,they operate based on a clock signal.Among the more popular synchronous digital circuits are edge-triggered flip-flops.These flip-flops are desirable,especially in digital memories,registers,and caches,because they simplify circuit design,for example,by requiring stability of input data only during short intervals of time.Edge-triggered flipflop circuits may be classified into two types:single-edgetriggered （SET） flip-flops and double-edge-triggered（DET） flip-flops.The former type latches data on either the rising edge or falling edge of a clock signal.Because the latching occurs on only one of the rising and falling edges of a clock signal,data flow tends to be slow,i.e.,at only one half the clock edge frequency.Also,because of their single clockedge operation,SET flip-flops incur the power cost of operating at two clock edges per interval while using only one of the edges.The latter type of edge-triggered flip-flop operates on both the rising and falling edges of a clock signal. For a given clock signal,these flip-flops are faster than SET flip-flops,and consume about the same power as the SET flip flops.Therefore,it is desirable to provide a flip-flop which stores logical information at a rate faster than once per clock pulse.

关键词： Flip-flops Clocks Latches Multiplexing Cities and towns Circuit synthesis Digital circuits Bistable circuits Pulse circuits Registers

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients

引用

World Journal of Gastroenterology 2021年第42期27卷 7311-7323页

作者： yung-yu Hsieh Shui-Yi Tung Hung-yu Pan Te-Sheng Chang Kuo-Liang Wei Wei-Ming Chen Yi-Fang Deng Chung-Kuang Lu yu-Hsuan Lai cheng-Shyong Wu chin Li Department of Gastroenterology and Hepatology Chiayi Chang Gung Memorial HospitalChiayi 61301Taiwan College of Medicine Chang Gung UniversityTaoyuan 33302Taiwan Department of Applied Mathematics National Chiayi UniversityChiayi 60035Taiwan Department of Biomedical Sciences National Chung Cheng UniversityChiayi 62130Taiwan

BACKGROUND An increased amount of Fusobacterium nucleatum(F.nucleatum)is frequently detected in the gastric cancer-associated microbiota of the Taiwan Residents population.F.nucleatum is known to exert cytotoxic effects and play a role in the progression of colorectal cancer,though the impact of F.nucleatum colonization on gastric cancer cells and patient prognosis has not yet been examined.AIM To identify F.nucleatum-dependent molecular pathways in gastric cancer cells and to determine the impact of F.nucleatum on survival in gastric cancer.METHODS Coculture of F.nucleatum with a gastric cancer cell line was performed,and changes in gene expression were investigated.Genes with significant changes in expression were identified by RNA sequencing.Pathway analysis was carried out to determine deregulated cellular functions.A cohort of gastric cancer patients undergoing gastrectomy was recruited,and nested polymerase chain reaction was performed to detect the presence of F.nucleatum in resected cancer tissues.Statistical analysis was performed to determine whether F.nucleatum colonization affects patient survival.RESULTS RNA sequencing and subsequent pathway analysis revealed a drastic interferon response induced by a high colonization load.This response peaked within 24 h and subsided after 72 h of incubation.In contrast,deregulation of actin and its regulators was observed during prolonged incubation under a low colonization load,likely altering the mobility of gastric cancer cells.According to the clinical specimen analysis,approximately one-third of the gastric cancer patients were positive for F.nucleatum,and statistical analysis indicated that the risk for colonization increases in late-stage cancer patients.Survival analysis demonstrated that F.nucleatum colonization was associated with poorer outcomes among patients also positive for Helicobacter pylori(H.pylori).CONCLUSION F.nucleatum colonization leads to deregulation of actin dynamics and likely changes cancer cell mobility.Cohort analysis demonstrated tha

关键词： Fusobacterium nucleatum Helicobacter pylori Gastric cancer Survival Interferon Mobility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel electrospun poly(ε-caprolactone)/type Ⅰ collagen nanofiber conduits for repair of peripheral nerve injury

引用

Neural Regeneration Research 2019年第9期14卷 1617-1625页

作者： Chun-Ming Yen Chiung-Chyi Shen Yi-chin Yang Bai-Shuan Liu Hsu-Tung Lee Meei-Ling Sheu Meng-Hsiun Tsai Wen-yu cheng Department of Neurosurgery Neurological InstituteTaichung Veterans General HospitalTaichungTaiwanChina Ph.D.Program in Translational Medicine National Chung Hsing UniversityTaichungTaiwanChina Department of Physical Therapy Hungkuang UniversityTaichungTaiwanChina Basic Medical Education Center Central Taiwan University of Science and TechnologyTaichungTaiwanChina Department of Medical Imaging and Radiological Sciences Central Taiwan University of Science and TechnologyTaichungTaiwanChina Institute of Biomedical Sciences National Chung Hsing UniversityTaichungTaiwanChina Department of Medical Research Taichung Veterans General HospitalTaichungTaiwanChina Rong Hsing Research Center for Translational Medicine National Chung Hsing UniversityTaichungTaiwanChina Department of Management Information System National Chung Hsing UniversityTaichungTaiwanChina

Recent studies have shown the potential of artificially synthesized conduits in the repair of peripheral nerve injury.Natural biopolymers have received much attention because of their biocompatibility.To investigate the effects of novel electrospun absorbable poly(ε-caprolactone)/type I collagen nanofiber conduits(biopolymer nanofiber conduits)on the repair of peripheral nerve injury,we bridged 10-mm-long sciatic nerve defects with electrospun absorbable biopolymer nanofiber conduits,poly(ε-caprolactone)or silicone conduits in Sprague-Dawley rats.Rat neurologica1 function was weekly evaluated using sciatic function index within 8 weeks after repair.Eight weeks after repair,sciatic nerve myelin sheaths and axon morphology were observed by osmium tetroxide staining,hematoxylin-eosin staining,and transmission electron microscopy.S-100(Schwann cell marker)and CD4(inflammatory marker)immunoreactivities in sciatic nerve were detected by immunohistochemistry.In rats subjected to repair with electrospun absorbable biopolymer nanofiber conduits,no serious inflammatory reactions were observed in rat hind limbs,the morphology of myelin sheaths in the injured sciatic nerve was close to normal.CD4 immunoreactivity was obviously weaker in rats subjected to repair with electrospun absorbable biopolymer nanofiber conduits than in those subjected to repair with poly(ε-caprolactone)or silicone.Rats subjected to repair with electrospun absorbable biopolymer nanofiber conduits tended to have greater sciatic nerve function recovery than those receiving poly(ε-caprolactone)or silicone repair.These results suggest that electrospun absorbable poly(ε-caprolactone)/type I collagen nanofiber conduits have the potential of repairing sciatic nerve defects and exhibit good biocompatibility.All experimental procedures were approved by Institutional Animal Care and Use Committee of Taichung Veteran General Hospital,Taiwan,china(La-1031218)on October 2,2014.

关键词： poly(ε-caprolactone) type I collagen electrospinning sciatic nerve nerve conduit immunohistostaining walking track analysis peripheral nerve injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：