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Donhexocin,a New Non-tetrahydrofuran Acetogenin from Goniothalamus Donnaiensis

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Chinese Chemical Letters 1997年第3期8卷 233-234页

作者： Jiang, Z yu, dq CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

A novel bioactive Annonaceous acetogenin, donhexocin (1), has been isolated from the roots of Goniothalamus donnaiensis (Annonaceae). 1 is a new acetogenin lacking THF rings but bearing six hydroxyls including two vic-diol systems in the aliphatic chain. Its structure and stereochemistry has been elucidated by spectoscopic analysis and derivatization.

关键词： ANNONACEOUS ACETOGENINS

Absolute Configurations of Tonkinin A and B: Two New Acetogenins from Uvaria Tonkinensis

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Chinese Chemical Letters 1997年第9期8卷 789-790页

作者： Chen, Y yu, dq CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

The absolute stereochemistries of Annonaceous acetogenins, tonkinin A and B, have been established by the use of the convenient conversion to their formaldehyde acetal derivatives and the subsequent application of the... 详细信息

关键词： ANNONACEOUS ACETOGENINS DERIVATIVES

Total Synthesis of dl-Ligustiphenol

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Chinese Chemical Letters 1996年第10期7卷 896-897页

作者： Huang, YH yu, dq CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

----(-)S-Ligustiphenol is a new sesquiterpene compound with antiinflammatory and immunosuppressive activities. The total synthesis of its racemate was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m-cresol, protection of phenolic hydroxyl, Grignard reaction,aldol condensation, etc. The target compound was characterized by comparing its H-1 NMR,MS and IR spectra with natural (-) ligustiphenol.

关键词： Total Synthesis of dl-Ligustiphenol

Synthesis of 7-Epi-howiinol A

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Chinese Chemical Letters 1997年第10期8卷 863-864页

作者： Sun, SY yu, dq CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

7-Epi-howiinol A, an antitumor lactone, has been synthesized in nine steps starting from alpha-D-glucoheptonic gamma-lactone with an overall yield of 8.5%.

关键词： Cl Synthesis of 7-Epi-howiinol A HL

THE　STRUCTURAL　ELUCIDATION　AND　ABSOLUTE　CONFIGURATIONS　OF　TWO　NEW　POLYOXYGENATED　CYCLOHEXENES　FROM　UVARIA　GRANDIFLORA　ROXB．

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Chinese Chemical Letters 1996年第3期7卷 241-244页

作者： Pan, XP yu, dq Lee, KH BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA UNIV N CAROLINA SCH PHARMNAT PROD LABDIV MED CHEM & NAT PRODCHAPEL HILLNC 27599 CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA

Two new polyoxygenated cyclohexenes,named uvarigranol E (I) andF(VII),were isolated from the rhizome of Uvaria grandiflora. On the basis ofspectral analysis and chemical derivatizations, including preparation of Mosheresters,the structures of I and VII were established as IR-acetoxymethyl-l,2Sdihydroxy-3 R,6S-dibenzoyloxy-cyclohex-4-ene and IR-hydroxymethyl-l,2Sdihydroxy-3R,6S-dibenzoyloxy cyclohex-4-ene.

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A New Annonaceous Acetogenin from Goniothalamus Gardneri

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Chinese Chemical Letters 1997年第11期8卷 971-974页

作者： Chen, Y Chen, RY yu, dq Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

A new monotetrahydrofuran Annonaceous acetogenin, gardnerin (1) was isolated from the roots of Goniothalamus gardneri Hook. f. et. Thoms. This compound possesses five hydroxyl groups, with two hydroxyl groups at C-8 and C-10 positions. The absolute stereochemistry at 8-OH and 10-OH positions Nas determined by converting 1 to its ketolactone isomer, 2,4-cis/trans gardnerin. Bioactivities of this new compound against human tumor cell lines are reported. Five known acetogenin compounds gigantetrocin A and B, annonacin, goniothalamicin, isoannonacin were also found.

关键词： RELATIVE CONFIGURATION MURICATA DERIVATIVES LEAVES

UVARIGRANIN:A NEW ACETOGENIN FROM UVARIA GRANDIFLORA ROXB

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Chinese Chemical Letters 1995年第6期6卷 473-476页

作者： Pan, XP yu, dq Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Beijing Union Med Coll Beijing 100050 Peoples R China

A new Annonaceous acetogenin, named uvarigranin(I),was isolated from the ethanol extract of the roots of Uvaria grandiflora Roxb, together with the known isodesacetyluvaricin (II) Their plane structures and relative configurations were established on the basis of NMR and MS spectroscopic methods. Compound I belongs to a mono(-1)-trahydrofuran (THF) type acetogenin with an unusual acetoxy group at the adjacent carbon on the THF ring.

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STUDIES ON THE TOTAL SYNTHESIS OF CIMICIFUGAMIDEFROM CIMICIFUGA DAHURICA

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Chinese Chemical Letters 1996年第6期7卷 545-548页

作者： Ding, PY Zhu, XX Cai, MS yu, dq BEIJING MED UNIV SCH PHARMACEUT SCIDEPT ORGAN CHEMBEIJING 100083PEOPLES R CHINA CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA

Cimicifugamide, a new natural compound isolated from the roots of Cimicifuga dahurica, was totally synthesized by a reaction sequence of seven steps in an overall yield of 31 %. D-Galactose was used as starting material, trifluoroacetoxy was used as leaving group at C-1. The target product was characterized by IR, MS, H-1-NMR C-13-NMR and elemental analysis.

关键词： TOTAL STUDIES ON THE TOTAL SYNTHESIS OF CIMICIFUGAMIDEFROM CIMICIFUGA DAHURICA

Four New Steroidal Alkaloids from the Roots of Sarcococca Vagans

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Chinese Chemical Letters 1997年第6期8卷 511-514页

作者： yu, SS Zou, ZM Zen, J yu, dq Cong, PZ CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA

Four new steroidal alkaloids, named sarcovagine A-D, were isolated from the roots of Sarcococca vagans. Their structures were determined as 20 alpha-dimethylamino-2 beta,4 beta-dihydroxy-3 beta-tigloylamino-5 alpha-pregnane (sarcovagine A, 1), 20 alpha-dimethylamino-2 alpha-hydroxy-4 beta-acetoxy-3 beta-tigloylamino-5 alpha-pregnane (sarcovagine B, 2), 20 alpha-dimethylamino-4 beta-acetoxy-3 beta-tigloylamino-5 alpha-pregnane (sarcovagine C, 3), 20 alpha-dimethylamino-3-tigloylamino-5 alpha-pregn-2(3)-en-4-one (sarcovagine D, 4), respectively.

关键词： Four New Steroidal Alkaloids from the Roots of Sarcococca Vagans HNMR data NH EIMS ppm