Total Synthesis of dl-Ligustiphenol

作     者：Huang, YH Yu, DQ 

作者机构：CHINESE ACAD MED SCIINST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLLBEIJING 100050PEOPLES R CHINA 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：1996年第7卷第10期

页      面：896-897页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Total Synthesis of dl Ligustiphenol 

摘      要：----(-)S-Ligustiphenol is a new sesquiterpene compound with antiinflammatory and immunosuppressive activities. The total synthesis of its racemate was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m-cresol, protection of phenolic hydroxyl, Grignard reaction,aldol condensation, etc. The target compound was characterized by comparing its H-1 NMR,MS and IR spectra with natural (-) ligustiphenol.