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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑young kim Yang Li Guozhen Shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-young kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Tribological properties of multilayer tetrahedral amorphous carbon coatings deposited by filtered cathodic vacuum arc deposition

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Friction 2021年第5期9卷 1292-1302页

作者： young-Jun JANG Jae-il kim Wooyoung LEE Jongkuk kim Department of Extreme Environmental Coatings Surface Technology DivisionKorea Institute of Materials Science(KIMS)Gyeongnam-do 51508Republic of Korea Department of Mechanical Science and Engineering Graduate School of EngineeringNagoya UniversityNagoya 464-8603Japan

Tetrahedral amorphous carbon(ta‐C)has emerged as an excellent coating material for improving the reliability of application components under high normal ***,we present the results of our investigations regarding the mechanical and tribological properties of a 2‐μm‐thick multilayer ta‐C coating on high‐speed steel *** composed of alternating soft and hard layers are fabricated using filtered a cathodic vacuum arc with alternating substrate bias voltages(0 and 100 V or 0 and 150 V).The thickness ratio is discovered to be 1:3 for the sp2‐rich and sp3‐rich *** results show that the hardness and elastic modulus of the multilayer ta‐C coatings increase with the sp3 content of the hard *** hardness reached approximately 37 GPa,whereas an improved toughness and a higher adhesion strength(>29 N)are *** friction performance(μ=0.07)of the multilayer coating is similar to that of the single layer ta‐C thick coating,but the wear rate(0.13×10^(–6) mm^(3)/(N∙m))improved under a high load of 30 *** further demonstrate the importance of the multilayer structure in suppressing crack propagation and increasing the resistance to plastic deformation(H3/E2)ratio.

关键词： tetrahedral amorphous carbon(ta‐C) filtered cathodic vacuum arc deposition multilayer coatings alternating substrate bias voltage wear resistance plastic deformation resistance

Nonlinear Finite Element Analysis of Ocean Cables

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海洋工程：英文版 2004年第4期18卷 537-550页

作者： Nam-il kim Sang-Soo JEON Moon-young kim Department of Civil-Environmental Engineering SungKyunKwan University Jangan-Gu Suwon Kyongki-Do 440-746 S. Korea Highway and Transportation Technology Institute Korea Highway Corporation San 28-1 Sancheok-Ri Dongtan-Myeon Hwaseong City S. Korea Department of Civil-Environmental Engineering SungKyunKwan University Jangan-Gu Suwon Kyongki-Do 440-746 S. Korea

This study has focused on developing numerical procedures for the dynamic nonlinear analysis of cable structures subjected to wave forces and ground motions in the ocean. A geometrically nonlinear finite element procedure using the isoparametric curved cable element based on the Lagrangian formulation is briefly summarized. A simple and accurate method to determine the initial equilibrium state of cable systems associated with self-weights, buoyancy and the motion of end points is presented using the load incremental method combined with penalty method. Also the Newmark method is used for dynamic nonlinear analysis of ocean cables. Numerical examples are presented to validate the present numerical method.

关键词： nonlinear cable wave finite element analysis

Surface properties of Al-doped ZnO thin film before and after CF_4/Ar plasma etching

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Plasma Science and Technology 2022年第7期24卷 194-200页

作者： young-Hee JOO Gwan-Ha kim Doo-Seung UM Chang-il kim School of Electrical and Electronics Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Semiconductor Materials and Applications Korea PolytechnicSeongnam 13122Republic of Korea Department of Electrical Engineering Sejong UniversitySeoul 05006Republic of Korea

Al-doped ZnO(AZO) is considered as an alternative to transparent conductive oxide *** and achieving a stable surface are important challenges in the development and optimization of dry etching processes, which must be overcome for the application of AZO in various devices. Therefore, in this study, the etch rate and surface properties of an AZO thin film after plasma etching using the adaptive coupled plasma system were investigated. The fastest etch rate was achieved with a CF_(4)/Ar ratio of 50:50 sccm. Regardless of the ratio of CF_(4) to Ar,the transmittance of the film in the visible region exceeded 80%. X-ray photoelectron spectroscopy analysis of the AZO thin film confirmed that metal-F bonding persists on the surface after plasma etching. It was also shown that F eliminates O vacancies. Consequently, the work function and bandgap energy increased as the ratio of CF-4 increased. This study not only provides information on the effect of plasma on AZO thin film, but identifies the cause of changes in the device characteristics during device fabrication.

关键词： Al-doped ZnO plasma etching F-based plasma surface characteristics X-ray photoelectron spectroscopy ultraviolet photoelectron spectroscopy

Deposition and Characterization of (Ba, Sr)RuO3 Oxide Electrode Using TMHD-Based Single Cocktail Source

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Journal of Rare Earths 2004年第z2期22卷 8-12页

作者： Hyun Chul kim Kyung il Hong young Bae kim Duck Kyun Choi Department of Ceramic Engineering Hanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea

(Ba, Sr)RuO3 has been paid an attention as a promising electrode for (Ba, Sr)TiO3 dielectric material due to its similarity in structure and chemical composition with BST. In this study, (Ba, Sr)RuO3 conductive oxide film was deposited on a 4 inch p-type Si wafer by metal organic chemical vapor deposition (MOCVD) using single cocktail source for the practical device application. Ba(TMHD)2, Sr(TMHD)2, Ru(TMHD)3 precursors and solvent [1-EtylePiPerdine (C7H15 N) ] as starting materials were mixed together for single cocktail source. A liquid delivery system (LDS) and a vaporization cell were utilized for the delivery and vaporization of single cocktail source, respectively. The source feeding rate was controlled by a liquid mass flow controller (LMFC). Deposition parameters, such as the oxygen flow and the source flow rate,were sensitive to phase formation, resistivity and the composition ratio of (Ba, Sr)RuO3 films. Highly (110)-textured (Ba,Sr)RuO3 film was obtained vhen the Ar/O2 ratio was 200/140 sccm at a source flow rate of 0.05 sccm. The process window of stoichiometric composition of BSR film was observed with varying the source flow rate from 0.05 sccm to 0.1 sccm.

关键词： (Ba, Sr)RuO3 (Ba, Sr)TiO3 MOCVD liquid delivery system(LDS) nozzle type injector

Effect of Palladium Nanoparticles on Photocatalytic Characteristics of N doped Titania Catalyst

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Journal of Materials Science & Technology 2015年第6期31卷 664-669页

作者： Jong-Ho Lee Jeong-il Youn young-Jig kim Han-Jun Oh Department of Chemistry Hanseo University School of Advanced Materials Engineering Sungkyunkwan University Department of Materials Science Hanseo University

To improve the photocatalytic efficiency of TiO2nanotubular catalyst,N doped and Pd decorated titania nanotubes was successfully synthesized via anodizing,hydrazine hydrate treatment and photoreduction of Pd *** small Pd nanoparticles were precipitated on TiO2nanotubes through photoreduction of Pd ions,and its distribution is relatively *** X-ray photoelectron spectrometry（XPS） result,the N 1s spectrum represents two peaks with binding energy at 399.7 and 400.7 eV,which suggests that the nitrogen elements doped by hydrazine hydrate treatment are located in interstitial sites of the TiO2crystalline *** N doped TiO2nanotubes with Pd particles,a high photocurrent was detected due to increase of interface charge carrier separation ***,N doped and Pd decorated TiO2nanotubes exhibited much higher dye destruction efficiency and rate constant due to the synergistic effect of the N dopant and the Pd deposition on TiO2nanotubes.

关键词： Pd nanoparticle Titania nanotube Anodizing Dye dec

Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy

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World Journal of Gastroenterology 2013年第47期19卷 8867-8872页

作者： il Han Song So Mi kim young Kwang Choo Division of Hepatology Department of Internal MedicineDankook University College of MedicineCheonan 330-715South Korea Department of Internal Medicine Jeju National University School of MedicineJeju 690-767South Korea

Hepatocellular carcinoma(HCC)is a grave primary liver cancer that has a limited therapeutic option because it is generally diagnosed later in an advanced stage due to its aggressive biologic *** early detection of HCC has a great impact on the treatment efficacy and survival of patients at high risk for *** host,environmental,and virus-related risk factors have been *** B virus(HBV)is a major cause of end-stage liver diseases such as liver cirrhosis or HCC in endemic areas,and its serologic or virologic status is considered an important risk *** risk prediction derived from the identification of major risk factors is necessary for providing adequate screening/surveillance strategies to high-risk *** risk prediction models for HBV-related HCC have been presented recently with simple,efficient,and readily available to use parameters applicable to average-or unknown-risk populations as well as high-risk *** scoring systems of risk estimation to assess HCC development can provide the way to an evidence-based clinical approach for cost-and effort-effective outcomes,capable of inducing a personalized surveillance program according to risk *** this review,the concepts and perspectives of the risk prediction of HCC are discussed through the analysis of several risk prediction models of HBV-related HCC.

关键词： Hepatocellular carcinoma Hepatitis B virus Chronic hepatitis B Risk prediction Risk factors