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Chinese Physics Letters 2009年第5期26卷 214-216页

作者：徐章程张雅婷 Jφrn M. Hvam yoshiji horikoshi Nno-photonics Group Key Laboratory of Weak-Light Nonlinear Photonics Materials (MOE) TEDA College Nankai University Tianjin 300457 Department of Communications Optics and Materials and Nano.DTU Technical University of Denmark DK-2800 Lynby Denmark School of Science & Engineering Waseda University Sinjuku-Ku Tokyo 169-8555 Japan

The inter-layer energy transfer in a bi-layer InGaAs/GaAs quantum dot structure with a thick GaAs barrier is studied using temperature-dependent photoluminescence. The abnormal enhancement of the photoluminescence of the QDs in the layer with a larger amount of coverage considering the resonant Forster energy transfer between the at 110K is observed, which can be explained by wetting layer states at elevated temperatures.

关键词： gamma-ray bursts gamma-rays relativity

液相外延生长高质量多层(AlGa)As-GaAs的新方法

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微纳电子技术 1979年第4期 75-80页

作者： yoshiji horikoshi 章征龙

为生长多层半导体,如AlxGa1-xAs-GaAs双异质结构层,研究了一种新的液相外延生长方法。这种方法有两个特点:一是附加GaAl蒸气到生长气氛中;另一是用新舟结构使多层液相外延生长能在不摩擦生长熔体的情况下进行。用这种方法生长的双异质... 详细信息

为生长多层半导体,如AlxGa1-xAs-GaAs双异质结构层,研究了一种新的液相外延生长方法。这种方法有两个特点:一是附加GaAl蒸气到生长气氛中;另一是用新舟结构使多层液相外延生长能在不摩擦生长熔体的情况下进行。用这种方法生长的双异质结片在整个片子上（10×12毫米）都是十分均匀的,这意味着它的每一部分都适于制作长寿命的激光器。由同一片子制作的激光器起始电流分散程度不超过±10％。

关键词：液相外延生长照片热损伤液相外延物理性损伤生长气氛光致发光 AlGa)As-GaAs 熔体电器构件 As 双异质结构电子器件激光器光激射器面缺陷堆垛层错层错衬底基片质量

用点缺陷产生模型估计InGaAsP-InP和GaAlAs-GaAsDH激光器的寿命

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半导体光电 1980年第3期 67-74页

作者： yoshiji horikoshi Takeshi KOBAYASHI Yoshitaka FURUKAWA 贾洪均日本电报电话公司武藏野电气通信研究所日本电报电话公司武藏野电气通信研究所日本电报电话公司武藏野电气通信研究所

本文是将远距离结异质结激光器的缺陷模型进行扩展,用它来解释普通双异质结激光器的老化特性。认为激光器的退化主要取决于两种因素:其一是老化前保持在限制层内的可动缺陷在老化过程中朝p-n结运动并积聚在那里,第二是由于注入载流子的... 详细信息

本文是将远距离结异质结激光器的缺陷模型进行扩展,用它来解释普通双异质结激光器的老化特性。认为激光器的退化主要取决于两种因素:其一是老化前保持在限制层内的可动缺陷在老化过程中朝p-n结运动并积聚在那里,第二是由于注入载流子的非辐射复合在有源区产生了可动缺陷。我们利用这种模型,首次得出InGaAsP-InP激光器的极限寿命比AlGaAs—GaAs激光器长得多。

关键词：激光器限制非辐射复合光激射器电子器件 InGaAsP-InP 有源区

Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease

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World Journal of Gastroenterology 2024年第28期30卷 3428-3446页

作者： Aritoshi Koizumi Kosuke Kaji Norihisa Nishimura Shohei Asada Takuya Matsuda Misako Tanaka Nobuyuki Yorioka Yuki Tsuji Koh Kitagawa Shinya Sato Tadashi Namisaki Takemi Akahane Hitoshi yoshiji Department of Gastroenterology Nara Medical UniversityKashihara 634-8521Japan

BACKGROUND Alcohol-associated liver disease(ALD)is a leading cause of liver-related morbidity and mortality,but there are no therapeutic targets and modalities to prevent ALD-related liver *** proliferator activated receptor(PPAR)α and δ play a key role in lipid metabolism and intestinal barrier homeostasis,which are major contributors to the pathological progression of ***,elafibranor(EFN),which is a dual PPARαand PPARδagonist,has reached a phase III clinical trial for the treatment of metabolic dysfunctionassociated steatotic liver disease and primary biliary ***,the benefits of EFN for ALD treatment is *** To evaluate the inhibitory effects of EFN on liver fibrosis and gut-intestinal barrier dysfunction in an ALD mouse *** ALD-related liver fibrosis was induced in female C57BL/6J mice by feeding a 2.5% ethanol(EtOH)-containing Lieber-DeCarli liquid diet and intraperitoneally injecting carbon tetrachloride thrice weekly(1 mL/kg)for 8 ***(3 and 10 mg/kg/day)was orally administered during the experimental *** and molecular analyses were performed to assess the effect of EFN on steatohepatitis,fibrosis,and intestinal barrier *** EFN effects on HepG2 lipotoxicity and Caco-2 barrier function were evaluated by cell-based *** The hepatic steatosis,apoptosis,and fibrosis in the ALD mice model were significantly attenuated by EFN *** promoted lipolysis and β-oxidation and enhanced autophagic and antioxidant capacities in EtOH-stimulated HepG2 cells,primarily through PPARα***,EFN inhibited the Kupffer cell-mediated inflammatory response,with blunted hepatic exposure to lipopolysaccharide(LPS)and toll like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)*** improved intestinal hyperpermeability by restoring tight junction proteins and autophagy and by inhibiting apoptosis and proinflammatory *** protective effect on intestinal bar

关键词： Liver fibrosis Ethanol Gut barrier function Apoptosis Autophagy Peroxisome proliferator activated receptor

MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury

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Neural Regeneration Research 2023年第2期18卷 311-312页

作者： Tetsu Kimura Yuta horikoshi Department of Anesthesia and Intensive Care Medicine Akita University Graduate School of MedicineAkitaJapan

Spinal cord injury(SCI)is one of the leading causes of disability and is a devastating condition that requires long-term care,reduces social productivity,and gives an immense emotional burden on patients and their fa *** frequently occurs due to traffic accidents,falls,slips,violence,sports,and medical accidents in today's *** initial mechanical damage triggers a secondary injury cascade that induces more intractable damage(Silva et al.,2014).Secondary injury mechanisms have been postulated,including neuronal apoptosis,inflammation,oxidative stress,and excitotoxicity.

关键词： damage injury emotional

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Adsorption of urea,creatinine,and uric acid from three solution types using spherical activated carbon and its recyclability

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Chinese Journal of Chemical Engineering 2020年第12期28卷 2993-3001页

作者： Tomohito Kameda Kazuya horikoshi Shogo Kumagai Yuko Saito Toshiaki Yoshioka Graduate School of Environmental Studies Tohoku University6-6-07 AobaAramakiAoba-kuSendai 980-8579Japan

In this paper,we propose that the urinary toxins from the wastewater be adsorbed on an adsorbent such as spherical activated carbon and the latter be regenerated by subjecting it to high temperatures to recycle activated carbon and also to recycle the water used in *** studied the adsorption of artificial waste dialysate,which is a mixed solution of urea,creatinine,and uric acid,and the separate solutions for each of these and found that their extents of adsorption onto the spherical activated carbon material were nearly *** amount of adsorption was approximately 1.4 mg·g^−1 for urea,18 mg·g^−1 for creatinine,and 20 mg·g^−1 for uric *** urea,creatinine,and uric acid adsorbed onto the spherical activated carbon decomposed on heat treatment at 500℃,and the adsorption capacity of the spherical activated carbon was *** study successfully demonstrated that the spherical activated carbon can be recycled in the waste dialysate treatment process.

关键词： Adsorption Dialysate Spherical activated carbon Recycling

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海螺桑拿房

城市环境设计 2024年第1期147卷 192-197页

作者：隈太一堀越圭晋 SS

本项目坐落于直岛一个小海湾的豪华露营设施“SANA MANE”的中心，是一座由有机木材建造而成的桑拿房，名为“SAZAE”（海螺）。设计中最大的挑战在于其木制结构—项目由150层数控机床加工的28毫米厚胶合板堆叠而成。实木桑拿房的平均...

本项目坐落于直岛一个小海湾的豪华露营设施“SANA MANE”的中心，是一座由有机木材建造而成的桑拿房，名为“SAZAE”（海螺）。设计中最大的挑战在于其木制结构—项目由150层数控机床加工的28毫米厚胶合板堆叠而成。实木桑拿房的平均壁厚为450毫米，从而保证了建筑的隔热保温性能。从外观上看，建筑宛如贝壳一般，表面呈现出无数细小的褶皱，在阳光的照射下投下阴影，令人印象深刻。而从室内来看，褶皱呈现出舒缓的节奏，宛如人体的曲线，带来舒适的闲坐体验。阳光从建筑顶部的天窗照射进室内，营造出冥想的氛围与宁静的体验。

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Immunotherapy for nonalcoholic steatohepatitis using the multiple cytokine production modulator Y-40138

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World Journal of Gastroenterology 2009年第44期15卷 5533-5540页

作者： Tatsuhiro Tsujimoto Hideto Kawaratani Toshiyuki Kitazawa Hitoshi yoshiji Masao Fujimoto Masahito Uemura Hiroshi Fukui Third Department of Internal Medicine Nara Medical University840 Shijo-choKashiharaNara 634-8522Japan

AIM:To investigate the possible use of the multiple cytokine production modulator,Y-40138,as a novel immunotherapy in the rat nonalcoholic steatohepatitis (NASH) model. METHODS:We allocated 6-wk-old male F344 rats to choline-supplemented,L-amino acid-defined (CSAA) diet (control group),CSAA diet + Y-40138 (control + Y-40138 group),choline-def icient,L-amino acid-def ined (CDAA) diet (NASH group),or CDAA diet + Y-40138 (NASH + Y-40138 group). In each group,we measured the plasma alanine aminotransferase (ALT) levels,and the plasma and liver levels of tumor necrosis factor-α (TNF-α),interferon-γ (IFN-γ),and interleukin-10 (IL-10). Tissue specimens of phosphate buffered saline-perfused liver were subjected to hematoxylin and eosin staining,Azan staining,Sirius red staining,and immunohistochemical staining (for Kupffer cells and TNF-α). We then extracted Kupffer cells from the collagenase-perfused livers using the Percoll gradient centrifugation method,and measured the TNF-α levels in the supernatant (in vitro TNF-α production by Kupffer cells) using an enzyme-linked immunosorbent assay ***:In comparison to the NASH group,serumALT elevation was mild,production of serum and liver TNF-α and IFN-γ was inhibited,and IL-10 production was increased in the NASH + Y-40138 group. Amelioration of liver histology was also noted in the NASH + Y-40138 group. Kupffer cell immunohistochemical staining revealed no differences between groups,whereas TNF-α immunohistochemical staining showed fewer stained cells in the NASH + Y-40138 group than in the NASH group. The TNF-α levels in the in-vitro Kupffer cell culture supernatant were lower in the NASH + Y-40138 group than in the NASH ***:Administration of Y-40138 to NASH model rats reduced hepatic inflammation and suppressed fibrosis. These results indicate that the multiple cytokine production modulator,Y-40138,is promising as a novel treatment for NASH.

关键词： Nonalcoholic steatohepatitis Y-40138 Tumor necrosis factor α Interferon γ Interleukin-10 Kupffer cell Innate immunity

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南三陆311纪念馆

城市环境设计 2024年第1期147卷 132-137页

作者：名城俊树田中浩介今井博康堀越圭晋·中尾孝佑堀越圭晋中尾孝佑 SS

自2013年以来，我一直参与南三陆町的重建计划，该地在2011年3月11日的东日本大地震中遭受了严重破坏。我们为抬高了10米的人造地面制定了一个总体规划，包括三个概念：（1）将城镇与大海重新连接起来，（2）将山脉与神社重新连接起来...

自2013年以来，我一直参与南三陆町的重建计划，该地在2011年3月11日的东日本大地震中遭受了严重破坏。我们为抬高了10米的人造地面制定了一个总体规划，包括三个概念：（1）将城镇与大海重新连接起来，（2）将山脉与神社重新连接起来，以及（3）创建一条可步行的、赏心悦目的街道。我们设计了三个设施，都是重建计划的核心：太阳购物村（2017年）、中桥大桥（2020年）和311纪念馆（2022年）。311纪念馆代表了重建计划的高潮，成为衔接海洋、山脉和城镇（街道）的枢纽，同时也是连接过去和未来记忆的一种方式。

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Analysis of Ship Evacuation during Tsunami Using AIS （Automatic Identification System） Data

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Journal of Earth Science and Engineering 2012年第7期2卷 412-417页

作者： Masao Furusho yoshiji Yano Graduate School of Maritime Sciences Kobe University Hyogo 658-0022 Japan

External forces of marine weather, such as waves, currents and wind flows, affect the course and speed of a ship under way. As a result, marine accidents, such as collisions or grounding, may occur, particularly in inshore areas. On coasts where earthquakes and tsunamis occur frequently, such as the Japanese coast, a tsunami that advances into a bay from the open sea is influenced by the submarine topography. It grows into a huge wave that could cause tremendous damage to ships under way and at anchorage. A massive earthquake occurred in the Tohoku and Kanto regions of Japan on March 11,2011. In response, a tsunami alert, a tsunami warning and an advisory were issued for the entire Pacific coast region. This research investigates the evacuation behaviour of ships by AIS （automatic identification system） data in Tokyo Bay after the tsunami warning was issued. The unusual behaviour observed was attributed to the emergency evacuation of ships.

关键词： Great east Japan earthquake Tsunami AIS ship evacuation.