检索结果-南通市图书馆

World Journal of Pediatrics 2015年第2期11卷 181-184页

作者： yoshihiro Maruo Masafumi Suzaki Katsuyuki Matsui Yu Mimura Asami Mori Haruo Shintaku yoshihiro takeuchi Department of Pediatrics Shiga University of Medical ScienceTsukinowaSetaOtsuShiga 520-2192Japan Central Research Laboratory Shiga University of Medical ScienceTsukinowaSetaOtsuShiga 520-2192Japan Department of Pediatrics Osaka City University Graduate School of MedicineOsakaJapan

Background:Phenylketonuria(PKU)is caused by a defect in phenylalanine hydroxylase(PAH).More than 500 mutations have been reported for the gene encoding ***,approximately l%-5%of these include large deletions and large duplications that cannot be detected by conventional ***:In this report we tried to fully characterize a PAH-deficient *** patient was a 2-year-old Japanese boy who was diagnosed with classical PKU at the time of neonatal screening,which was confirmed by the tetrahydrobiopterin-loading ***-related direct sequencing and multiplex ligation-dependent probe amplification(MLPA)were used to analyze of the PAH of the ***:Using PCR-related direct sequencing method,we could detect only a heterozygous novel missense mutation:p.136G>C(p.G46R).A second mutation was detected by *** patient was heterozygous for a novel large deletion of exons 12 and 13:c.1200-?_1359+?del(EX12_13del).For genetic counseling,an accurate genetic diagnosis is often ***:Through a combination of MLPA and conventional methods,the success rate of PAH mutation identification can be close to 100%.

关键词： large deletion multiplex ligation-dependent probe amplification phenylalanine hydroxylase phenylketonuria

Drug-induced entero-colitis due to interleukin-17 inhibitor use;capsule endoscopic findings and pathological characteristics:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界胃肠病学杂志:英文版 2023年第32期29卷 4912-4919页

作者： Keita Saito Kiichiro Yoza Shinichiro Takeda yoshihiro Shimoyama Ken takeuchi Department of Gastroenterology Tsujinaka Hospital Kashiwano-HaKashiwa 277-0871Japan

BACKGROUND Interleukin-17(IL-17)inhibitors are known to cause exacerbation or new onset of inflammatory bowel disease upon ***,few reports have described characteristic endoscopic and histopathologic findings,and no small intestinal lesions have been reported so *** SUMMARY A woman in her 60s with psoriasis was administered ixekizumab(IXE),an anti-IL-17A antibody,for the treatment of *** months after commencing treatment,the patient visited our hospital because of persistent *** tests performed at the time of the visit revealed severe inflammation,and colonoscopy revealed multiple round ulcers throughout the colon.A tissue biopsy of the ulcer revealed infiltration of inflammatory cells and granuloma-like findings in the submucosal *** endoscopy revealed multiple jejunal *** the withdrawal of IXE,the symptoms gradually improved,and ulcer reduction and scarring of the colon were endoscopically *** To the best of our knowledge,17 reports have documented IL-17 inhibitorinduced entero-colitis with endoscopic images,endoscopic findings,and pathological characteristics,including the present *** of these cases showed diffuse loss of vascular pattern,coarse mucosa/ulcer formation in the left colon,and endoscopic findings similar to those of ulcerative *** the remaining eight cases,discontinuous erosions and ulcerations from the terminal ileum to the rectum were seen,with endoscopic findings similar to those of Crohn’s *** this case,the findings were confirmed by capsule endoscopy,which has not been previously reported.

关键词： Interleukin-17 inhibitor Ixekizumab Drug-induced entero-colitis Capsule endoscopy Case report

Expression analyses of stress‑responsive genes in the hermatypic coral Acropora tenuis and its symbiotic dinofagellates after exposure to the herbicide Diuron

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2023年第3期5卷 289-299页

作者： Hiroshi Ishibashi Seigo Minamide Ichiro takeuchi Graduate School of Agriculture Ehime UniversityMatsuyamaEhime 790-8566Japan Center of Advanced Technology for the Environment Graduate School of AgricultureEhime UniversityMatsuyamaEhime 790-8566Japan

Diuron is one of the most frequently applied herbicides in sugarcane farming in southern Japan,and *** addition,it is used as a booster substance in copper-based antifouling *** to these various uses,Diuron is released into the marine environment;however,little information is available on gene expression in corals and their symbiotic algae exposed to *** investigated the efects of Diuron on stress-responsive gene expression in the hermatypic coral Acropora tenuis and its symbiotic *** seven days of exposure to 1µg/L and 10µg/L Diuron,no signifcant changes in the body colour of corals were ***,quantitative reverse transcription-polymerase chain reaction analyses revealed that the expression levels of stress-responsive genes,such as heat shock protein 90(HSP90),HSP70,and calreticulin(CALR),were signifcantly downregulated in corals exposed to 10µg/L of Diuron for seven ***,aquaglyceroporin was signifcantly downregulated in corals exposed to environmentally relevant concentrations of 1µg/L *** contrast,no such efects were observed on the expression levels of other stress-responsive genes,such as oxidative stress-responsive proteins,methionine adenosyltransferase,and green/red fuorescent *** exposure had no signifcant efect on the expression levels of HSP90,HSP70,or HSP40 in the symbiotic *** results suggest that stress-responsive genes,such as HSPs,respond diferently to Diuron in corals and their symbiotic dinofagellates and that *** HSPs and CALRs may be useful molecular biomarkers for predicting stress responses induced by the herbicide Diuron.

关键词： Acropora tenuis Calreticulin Coral bleaching Diuron Heat shock protein

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Disseminated carcinomatosis of the bone marrow caused by granulocyte colony-stimulating factor:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第10期14卷 2077-2084页

作者： Kengo Fujita Ayaka Okubo Toshitsugu Nakamura Nobumichi takeuchi Department of Medical Oncology Ina Central HospitalNagano 396-8555Japan Department of Diagnostic Pathology Ina Central HospitalNagano 396-8555Japan

BACKGROUND Disseminated carcinomatosis of the bone marrow(DCBM)is a widespread metastasis with a hematologic disorder that is mainly caused by gastric *** it commonly occurs as a manifestation of recurrence long after curative treatment,the precise mechanism of relapse from dormant status remains *** colony-stimulating factor(G-CSF)can promote cancer progression and invasion in various ***,the potential of G-CSF to trigger recurrence from a cured malignancy has not been *** SUMMARY A 55-year-old Japanese woman was diagnosed with Ewing sarcoma localized on the fifth lumbar vertebrae 6 years after curative gastrectomy for T1 gastric *** palliative surgery to release nerve compression,pathological diagnosis of the resected specimen was followed by curative radiation and *** treatment,G-CSF was administered 32 times for severe neutropenia *** months after completing definitive treatment,she complained of severe back pain and was diagnosed as multiple bone metastases with DCBM from gastric *** palliative chemotherapy,she died of disseminated intravascular coagulation 13 d after the *** examination of the autopsied bone marrow confirmed a diffuse positive staining for the G-CSF receptor(G-CSFR)in the relapsed gastric cancer cell cytoplasm,whereas the primary lesion cancer cells showed negative staining for *** this case,G-CSF administration may have been the key trigger for the disseminated relapse of a dormant gastric *** administering G-CSF to cancer survivors,recurrence of a preceding cancer should be monitored even after curative treatment.

关键词： Disseminated bone marrow carcinomatosis Gastric cancer Granulocyte colony-stimulating factor Cancer survivor Immunostaining Case report

A Delayed HIV Infection Model with the Homeostatic Proliferation of CD4^(+)T Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2022年第2期38卷 441-462页

作者： Qiang-hui XU Ji-cai HUANG Yue-ping DONG Yasuhiro takeuchi School of Mathematics and Statistics and Hubei Key Laboratory of Mathematical Sciences Central China Normal UniversityWuhan 430079China College of Science and Engineering Aoyama Gakuin UniversityKanagawa 252-5258Japan

In this paper,we investigate a delayed HIV infection model that considers the homeostatic prolif-eration of CD4^(+)T *** existence and stability of uninfected equilibrium and infected equilibria(smaller and larger ones)are studied by analyzing the characteristic equation of the *** intracellular delay does not affect the stability of uninfected equilibrium,but it can change the stability of larger positive equilibrium and Hopf bifurcation appears inducing stable limit ***,direction and stability of Hopf bifur-cation are well investigated by using the central manifold theorem and the normal form *** numerical simulation results show that the stability region of larger positive equilibrium becomes smaller as the increase of time ***,when the maximum homeostatic growth rate is very small,the larger positive equilibrium is always *** the contrary,when the rate of supply of T cells is very small,the larger positive equilibrium is always unstable.

关键词： HIV infection and persistence T cell homeostatic proliferation delayed model dynamics analysis Hopf bifurcation

Finite-difference time-domain simulation of partial discharges in a gas insulated switchgear

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High Voltage 2016年第1期1卷 52-56页

作者： Hiroki Tanaka Daiki Tanahashi yoshihiro Baba Naoto Nagaoka Naoki Okada Hideto Ohki Masayasu takeuchi Department of Electrical Engineering Doshisha UniversityKyotanabeKyoto 610-0321Japan Nissin Electric Co. LtdUkyokuKyoto 615-8686Japan

It is important to estimate the current magnitude and charge amount of a partial discharge (PD) in a gasinsulatedswitchgear (GIS). In this study, electromagnetic fields generated by a PD in an 84 kV-class three-phase GIS fortesting have been measured with a voltage probe installed on the outer surface of an insulation spacer of the GIS tank,and the corresponding simulations have been carried out using the three-dimensional finite-difference time-domain(FDTD) method. FDTD-computed time-domain voltages across spacers agree reasonably well with the correspondingmeasured ones, and the current magnitude of PD and its charge amount have been estimated.

关键词： magnitude difference insulation

Moving computational multi-domain method for modelling the flow interaction of multiple moving objects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Aerodynamics 2022年第1期4卷 78-95页

作者： Momoha Nishimura Masashi Yamakawa Shinichi Asao Seiichi takeuchi Mehdi Badri Ghomizad Department of Mechanical and System Engineering Kyoto Institute of TechnologyKyotoJapan Department of Mechanical Engineering College of Industrial TechnologyHyogoJapan

This study proposes a method for modelling the flow interaction of multiple moving objects where the flow field variables are communicated between multiple separate moving computational *** of using the conventional approach with a single fixed computational domain covering the whole flow field,this method advances the moving computational domain(MCD)method in which the computational domain itself moves in line with the motions of an object *** computational domains created around each object move independently,and the flow fields of each domain interact where the flows *** eliminates the spatial restriction for simulating multiple moving ***,a shock tube test verifies that the overset implementation and grid movement do not adversely affect the results and that there is communication between the grids.A second test case is conducted in which two spheres are crossed,and the forces exerted on one object due to the other’s crossing at a short distance are *** results verify the reliability of this method and show that it is applicable to the flow interaction of multiple moving objects.

关键词： Crossing Moving boundary problems Compressible flow Moving mesh method

Machine learning super-resolution of laboratory CT images in all-solid-state batteries using synchrotron radiation CT as training data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy and AI 2023年第4期14卷 612-619页

作者： M.Kodama A.takeuchi M.Uesugi S.Hirai Tokyo Institute of Technology 2-12-1 OokayamaMeguro-kuTokyo 152-8550Japan Japan Synchrotron Radiation Research Institute(JASRI/SPring-8) 1-1-1 KoutoSayoHyogo 679-5198Japan

High-performance all-solid-state lithium-ion batteries require observation,control,and optimization of the electrode structure.X-ray computational tomography(CT)is an effective nondestructive method for observing the electrode structure in three ***,the limited availability of synchrotron radiation CT,which offers high-resolution imaging with a high signal-to-noise ratio,makes it difficult to conduct experiments and restricts the use of X-ray CT in battery ***,laboratory CT systems are widely available,but they use X-rays emitted from a metal target,resulting in lower image quality and resolution compared with synchrotron radiation *** study explores a method for achieving comparable resolution in laboratory CT images of all-solid-state batteries to that of synchrotron radiation *** method involves using the synchrotron radiation CT images as training data for machine learning *** results demonstrate that,by employing an appropriate machine learning algorithm and activation function,along with a sufficiently deep network,the image quality of laboratory CT becomes equivalent to that of synchrotron radiation CT.

关键词： All-solid-state lithium-ion battery X-ray CT Laboratory CT Synchrotron radiation CT Super-resolution Machine learning

Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2022年第1期14卷 46-55页

作者： Masashi takeuchi Hirofumi Kawakubo Satoru Matsuda Shuhei Mayanagi Tomoyuki Irino Jun Okui Kazumasa Fukuda Rieko Nakamura Norihito Wada Hiroya takeuchi Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Preventive Medicine and Public Health Keio University School of MedicineTokyo 160-8582Japan Department of Surgery Hamamatsu University School of MedicineShizuoka 431-3192Japan

BACKGROUND Despite improvements in surgical procedures and peri-operative patients management,the postoperative complications in esophagogastric junction(EGJ)cancer remain high because of technical *** studies have indicated the negative influence of postoperative infectious complications on long-term survival after gastrointestinal ***,no study has shown the association between postoperative complications and long-term survival of patients with EGJ *** To elucidate influence of postoperative complications on the long-term outcomes of patients with EGJ *** A total of 122 patients who underwent surgery for EGJ cancer at the Keio University were included in this *** examined the association between complications and long-term oncologic *** In all patients,the 3-year overall survival(OS)rate was 71.9%,and the recurrencefree survival(RFS)rate was 67.5%.Compared with patients without anastomotic leakage,those with anastomotic leakage had poor median OS(8 mo vs not reached,P=0.028)and median RFS(5 mo vs not reached,P=0.055).Among patients with cervical anastomosis,there were not significant differences between patients with and without anastomotic ***,among patients who underwent intrathoracic anastomosis,patients with anastomotic leakage had significantly worse OS(P=0.002)and RFS(P=0.005).CONCLUSION Anastomotic leakage was significantly associated with long-term oncologic outcomes of patients with EGJ cancer,especially those who underwent intrathoracic *** anastomosis with subtotal esophagectomy may be an option for the patients who are at high risk for anastomotic leakage.

关键词： Esophagogastric junction cancer Complication Long-term outcome