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Expression of adhesion molecules on mature cholangiocytes in canal of Hering and bile ductules in wedge biopsy samples of primary biliary cirrhosis

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World Journal of Gastroenterology 2005年第28期11卷 4382-4389页

作者： Hiroaki Yokomori Masaya Oda Mariko Ogi Go Wakabayashi Shigeyuki Kawachi Kazunori Yoshimura Toshihiro Nagai Masaki Kitajima Masahiko nomura Toshifumi Hibi Department of Internal Medicine Kitasato Institute Medical Center Hospital Saitama 364-8501Japan Organized Center of Clinical Medicine International University of Health and Welfare Tokyo 107-0052Japan Laboratory of Pathology Kitasato Institute Medical Center Hospital Saitama 364-8501Japan Department of Surgery School of Medicine Keio UniversityTokyo 160-0016Japan Physiology Saitama Medical School Saitama 350-0495Japan Electron Microscopy Laboratory School of Medicine Keio UniversityTokyo 160-0016Japan Department of Internal Medicine School of Medicine Keio UniversityTokyo 160-0016Japan

AIM：To examine the expression of intercellular adhesion molecule-1 （ICAM-1） and lymphocyte function-associated antigen-1（LFA-1）expression on canals of Hering （COH）and bile ductules associated with the autoimmune process of bile duct destruction in primary biliary cirrhosis（PBC）．METHODS：Ten wedged liver biopsies of PBC（five cases each of stages 2 and 3）were studied. The liver specimens were processed for transmission electron microscopy. Immunohistochemistry was performed using anti-ICAM-1 and anti-LFA-1 mouse *** situ hybridization was done to examine the messenger RNA expression of ICAM-1 in ***-embedded sections using peptide nucleic acid probes and the catalyzed signal amplification （CSA）***-silver staining for electron microscopy was Derrormed using anti-ICAM and anti-LFA-1 mouse *** immunogold particles on epithelial cells of bileductules and cholangiocytes of CoH cells were counted and analyzed *** blotting was performed to confirm ICAM-1 protein expression．RESULTS：In liver tissues of PBC ***-stochemistry showed aberrant ICAM-1 expression on the plasma membrane of epithelial cells lining bile ductules，and also on mature cholangiocytes but not on hepatocytes in ***-1-positive lymphocytes were closely associated with epithelial cells in bile ***-1 expression at protein level was confirmed by Western *** situ hybridization demonstrated ICAM-1 mRNA expression in bile ductules and LFA-1 mRNA in lymphocytes infiltrating the *** immunoelectron microscopy，ICAM-1 was demonstrated on the basal suface of epithelial cells in bile ductules and on the luminal surfaces of cholangiocytes in damaged *** with intermediate morphology resembling progenitor cells in Coil were not labeled with ICAM-1 and LFA-1．CONCLUSION：De novo expression of ICAM-1 both on mature cholangiocytes in COH and epithelial cells in bile ductules in PBC implies that lymphocyte-indu

关键词： Primary biliary cirrhosis Canal of Hedng Small bile ductile ICAM-1 LFA-1 Immunohistochemistry Western blot Immunogold electron microscopyPrimary biliary cirrhosis Canal of Hedng Small bile ductile ICAM-1 LFA-1 Immunohistochemistry Western blot Immunogold electron microscopy

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A Survey for Exploring Personality Traits of Excessive Online Game Users in Japan

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Computer Technology and Application 2012年第12期3卷 818-825页

作者： Tatsuya nomura Yuma Goto Department of Media Informatics Ryukoku University Otsu Shiga 520-2194 Japan MFK Ltd. Kobe Hyogo 651-1121 Japan

For the aim at exploring differences on personality traits between excessive online game users and non-excessive users in Japan, an online survey was conducted using psychological scales measuring addictive tendencies for online gaming, depressive tendencies, aggression, and self-concealment. The results revealed that excessive online game users having addictive tendencies in Japan had lack of self-esteem as one of depressive tendencies, high aggressive tendencies, and low tendency of self-disclosure, in contrast with non-excessive users. Moreover, it was suggested that these users had a confidence in the society based on contributive behaviors in multi-player groups of online gaming.

关键词： Online gaming addiction personality traits questionnaire survey.

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Recent trends in bone metastasis treatments:A historical comparison using the new Katagiri score system

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World Journal of Clinical Cases 2024年第15期12卷 2499-2505页

作者： Kenji Matsuda Kazuhiro Shimazu Hanae Shinozaki Koji Fukuda Taichi Yoshida Daiki Taguchi Kyoko nomura Hiroyuki Shibata Department of Clinical Oncology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Environmental Health Science and Public Health Akita University Graduate School of MedicineAkita 010-8543Japan Department of Comprehensive Cancer Control Akita University Graduate School of MedicineAkita 010-8543Japan

BACKGROUND Bone metastasis has various negative *** of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may *** is estimated that at least 5%cancer patients might be suffering from bone *** 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone *** then,the therapeutic outcomes for patients have gradually *** life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be *** To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone *** For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was *** association with survival was determined for each *** Data from 136 patients were *** 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was *** factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(P<0.001),bone modifying agents(P=0.0175)and immune checkpoint inhibitors(P=0.0128).In recent years,advances in various treatment methods have extended the survival period for patients with advanced *** is necessary not only to simply extend survival time,but also to maintain ADL and improve *** Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly *** and scoring system for p

关键词： Bone metastasis New Katagiri scoring system Prognosis Immune check point inhibitors Survival

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Use of electron microscopy on microstructure characterization of high chromium cast irons

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China Foundry 2007年第1期4卷 38-43页

作者： J.T.H. Pearce T. Chairuangsri A. Wiengmoon N. Poolthong H. nomura MTEC-National Metals and Materials Technology Centre Department of Industrial Chemistry Chiang Mai University Department of Physics Naresuan University Division of Materials Technology King Mongkut's University of Technology Thonburi Department of Materials Nagoya University

The physical metallurgy underlying the development of cast microstructures in abrasion resistant high chromium cast irons, and their structural modification by thermal treatments is relatively complex. Structural characterisation via electron microscopy therefore has a key role to play in furthering our understanding of the phase transformations that control the microstructures and hence the service performances of these irons as wear parts. This paper shows how both scanning and especially transmission electron microscopy can provide valuable information on the nature of eutectic and secondary carbides and on the matrix structures in these irons. Particular attention is given to current characterisation research on conventionally cast 30%Cr irons that are used for applications involving corrosive wear e.g. slurry pumps and on a semi-solid cast 27%Cr iron that has a potential for applications in industry.

关键词： high chromium cast iron electron microscopy microstructure characterization

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Successful treatment with rifampin for fulminant antibiotics-associated colitis in a patient with non-Hodgkin's lymphoma

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World Journal of Gastroenterology 2004年第5期10卷 765-766页

作者： Kenichi nomura Yosuke Matsumoto Naohisa Yoshida Sawako Taji Naoki Wakabayashi Shoji Mitsufuji Shigeo Horiike Masuji Morita Takeshi Okanoue Masafumi Taniwaki Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan School of Nursing Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Clinical Molecular Genetics and Laboratory Medicine Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan

A 74-year-old man was admitted to the hospital because of chemotherapy for relapsed non-Hodgkin's lymphoma (NHL).The patient became febrile and experienced diarrhea after chemotherapy. Although ceftazidime and amikacin sulfate were administered as empiric therapy, diarrhea was *** several days, stool cytotoxin assay for clostridium difficile (C. difficile) was positive and he was diagnosed as having antibiotics-associated colitis (AAC). Although antibiotics were discontinued and both oral vancomycin and metronidazole were administrated, disease was not improved. To rule out the presence of an additional cause of diarrhea, colon fiberoscopic examination was performed. It revealed multiple deep ulcerative lesions at right side colon, surface erosive and minute erosive lesions in all continuous *** were not seen. These findings are compatible with AAC without pseudomembranes. There are no reports that the rifampin is effective on refractory ***, we administered oral rifampin for the current *** reasons are 1) conventional antibiotics were not effective,2) rifampin has excellent in vitro activity against C. difficile,and 3) the efficacy of rifampin on relapsing colitis due to *** is established. After administration of rifampin, fever alleviated and diarrhea was improved. Because AAC may result in significant mortality, patients with refractory or fulminant AAC should be treated with oral rifampin from outset.

关键词：暴发性抗生素相关性大肠炎利福平非何杰金氏淋巴瘤抗药性羧形菌病例报告

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Detection of BCL2-IGHrearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma

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World Journal of Gastroenterology 2004年第17期10卷 2602-2604页

作者： Naohisa Yoshida Kenichi nomura Yosuke Matsumoto Kazuhiro Nishida Naoki Wakabayashi Hideyuki Konishi Shoji Mitsufuji Keisho Kataoka Takeshi Okanoue Masafumi Taniwaki Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan Clinical Molecular Genetics and Laboratory Medicine Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan

A 59-year-old woman was admitted to our hospital because of recurrent follicular lymphoma(FL).Colonoscopic examination revealed a rectal submucosal tumor(SMT)without any erosions and *** this patient,it was difficult to distinguish non-Hodgkin's lymphoma(NHL)invasion from other disorders of the colon including carcinoid tumor merely based on endoscopic *** and immunohistochemical studies on biopsy specimens showed an infiltration of atypical lymphocytes that were positive for CD20 and BCL2 but negative for *** in situ hybridization on paraffin-embedded tissue sections (T-FISH)identified a translocation of BCL2 with IGHgene. Based on these findings,the tumor was defined as an invasion of FL.T-FISH method is useful for the detection of a monoclonality of atypical lymphocytes in an SMT of the gastrointestinal tract,and particularly for the detection of chromosomal translocations specific to lymphoma subtypes.

关键词： Gene Rearrangement Biopsy Female Humans Immunoglobulin Heavy Chains In Situ Hybridization, Fluorescence Lymphoma, Follicular Middle Aged Neoplasm Recurrence, Local Paraffin Embedding Proto-Oncogene Proteins c-bcl-2 Rectal Neoplasms

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Time Course of Elevations in Plasma Olprinone Concentration during Pediatric Cardiac Surgery

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Open Journal of Anesthesiology 2013年第2期3卷 80-83页

作者： Satoshi Kurokawa Minoru nomura Department of Anesthesiology Faculty of Medicine Tokyo Women’s Medical University Tokyo Japan

Purpose: Little research has been reported to date on the usefulness of olprinone in pediatric cardiac surgery, and no standard pediatric infusion protocol is currently established. Our study sought to confirm that the regimen described herein rapidly achieves the requisite plasma olprinone concentrations. Methods: For the purposes of our study, we enrolled 13 patients: 7 biventricular repair candidates and 6 Fontan-type operation candidates. We administered a continuous infusion of olprinone to our study subjects at 0.3 μg/kg/min with no loading dose starting approximately 30 minutes (min) before weaning from cardiopulmonary bypass (CPB). We performed blood sampling at 15, 30, 45, 60, 90, and 120 min after the start of infusion and at the same elapsed intervals after separation from CPB. We measured plasma olprinone concentrations using ultra-fast liquid chromatography. Results: We observed effective plasma olpri-none concentrations (>20 ng/ml) at 30 min after weaning from CPB, or at 60 min after the start of infusion. Conclusion: We conclude that continuous olprinone infusion at 0.3 μg/kg/min without a loading dose initiated immediately after the release of aortic cross-clamping or immediately after the completion of all surgical procedures quickly and reliably achieves effective plasma concentrations.

关键词： Olprinone Phosphodiesterase-3 Inhibitor Plasma Concentration Pediatric Cardiac Surgery Weaning from Cardio-Pulmonary Bypass

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A case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection

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World Journal of Gastroenterology 2013年第37期19卷 6299-6303页

作者： Joji Tani Hisaaki Miyoshi Takako nomura Hirohito Yoneyama Hideki Kobara Hirohito Mori Asahiro Morishita Takashi Himoto Tsutomu Masaki Department of Gastroenterology and Neurology Kagawa University Faculty of Medicine Department of Integrated Medicine Kagawa University Faculty of Medicine

Plasmablastic lymphoma(PBL)is a very rare B-cell lymphoproliferative disorder was with an aggressive clinical behavior that recently characterized by the World Health *** PBL is most commonly observed in the oral cavity of human immunodeficiency virus(HIV)-positive patients,it can also be observed at extra-oral sites in HIV-negative ***-Barr virus(EBV)may be closely related the pathogenesis of *** shows different clinicopathological characteristics between HIV-positive and-negative ***,we report a case of PBL of the liver in a 79-yearold HIV-negative *** patient died approximately1.5 mo after examination and autopsy showed that the main lesion was a very large liver *** examination of the excised lesion showed large-cell lymphoma with plasmacytic differentiation diffusely infiltrating the liver and involving the surrounding *** neoplastic cells were diffusely positive for CD30,EBV,Bob-1,and *** autopsy findings suggested a diagnosis of *** our knowledge,the present case appears to be the first report of PBL with initial presentation of the liver in a patient without HIV infection.

关键词： Plasmablastic lymphoma Human immunodeficiency virus-negative Normal liver Pathogenesis Immunohistochemistry

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Morphological Change of Cocrystal Bis(8-Quinolinolato) Copper(II): 7,7,8,8-Tetracyanoquinodimethane Polymorphism

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Advances in Chemical Engineering and Science 2023年第1期13卷 1-6页

作者： Norihito Doki Minami nomura Masaaki Yokota Department of Chemistry and Bioengineering Faculty of Science and Engineering Iwate University Morioka Japan

We studied cocrystal of bis(8-quinolinolato) copper(II) (CuQ2) and 7,7,8,8-tetracyanoquinodimethane (TCNQ), which change dramatically crystal shape in a moment by adding press on crystal face. Single crystal was prepared by dissolving CuQ2 and TCNQ in chloroform by evaporation of the solution at ambient conditions. We investigated about crystal structure and morphological change properties. We proclaim that this phenomenon is solid phase transition to Form I from Form II, it is caused by pressure on the crystal face (001) of Form II and the crystal expansion direction is the side face (100). We take note of the common structure between polymorph and explain that this transition occurs by the structure like dominoes falling. We obtained a correlation between molecular level structure change and macroscopic shape changes.

关键词： Crystal Morphology Crystal Structure Organic Compounds

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夏热冬冷地区地下蓄热模拟分析

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太阳能学报 2020年第9期41卷 382-388页

作者：李勇李勇陈旭东 Shigetoshi Ipposhi Yasumitsu nomura 王如竹上海交通大学制冷与低温工程研究所上海200240 三菱电机公司先进技术研发中心日本

利用Fluent软件建立地下埋管换热器的三维土壤蓄热模型,实现气温和辐照影响下土壤长期蓄热的动态仿真。对夏热冬冷地区天气条件下8个月的长期蓄热进行模拟研究,得到土壤温度分布特征及各边界热流的变化情况。在蓄热一个月的条件下,采用... 详细信息

利用Fluent软件建立地下埋管换热器的三维土壤蓄热模型,实现气温和辐照影响下土壤长期蓄热的动态仿真。对夏热冬冷地区天气条件下8个月的长期蓄热进行模拟研究,得到土壤温度分布特征及各边界热流的变化情况。在蓄热一个月的条件下,采用正常蓄热、加倍时长和间隔运行3种不同控制策略,对比其蓄热效果。结果表明,地表热流受天气温度影响较大,蓄热体底部和侧面主要受整体温度的影响;随着蓄热体温度的升高,底部和侧面热量耗散逐渐增大;加倍时长后蓄热一个月得到的内能增量是正常蓄热的1.52倍,间隔加热是正常蓄热的1.12倍;对于3个月以上的入口温度恒定的长期蓄热,加倍时长和间隔加热2种方式的蓄热效率优势不明显。

关键词：地源热泵蓄热模拟模型温度分布热量耗散控制策略

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