A case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection

作     者：Joji Tani Hisaaki Miyoshi Takako Nomura Hirohito Yoneyama Hideki Kobara Hirohito Mori Asahiro Morishita Takashi Himoto Tsutomu Masaki 

作者机构：Department of Gastroenterology and NeurologyKagawa University Faculty of Medicine Department of Integrated MedicineKagawa University Faculty of Medicine 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第37期

页      面：6299-6303页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Plasmablastic lymphoma Human immunodeficiency virus-negative Normal liver Pathogenesis Immunohistochemistry 

摘      要：Plasmablastic lymphoma(PBL)is a very rare B-cell lymphoproliferative disorder was with an aggressive clinical behavior that recently characterized by the World Health *** PBL is most commonly observed in the oral cavity of human immunodeficiency virus(HIV)-positive patients,it can also be observed at extra-oral sites in HIV-negative ***-Barr virus(EBV)may be closely related the pathogenesis of *** shows different clinicopathological characteristics between HIV-positive and-negative ***,we report a case of PBL of the liver in a 79-yearold HIV-negative *** patient died approximately1.5 mo after examination and autopsy showed that the main lesion was a very large liver *** examination of the excised lesion showed large-cell lymphoma with plasmacytic differentiation diffusely infiltrating the liver and involving the surrounding *** neoplastic cells were diffusely positive for CD30,EBV,Bob-1,and *** autopsy findings suggested a diagnosis of *** our knowledge,the present case appears to be the first report of PBL with initial presentation of the liver in a patient without HIV infection.