Detection of BCL2-IGHrearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma

作     者：Naohisa Yoshida Kenichi Nomura Yosuke Matsumoto Kazuhiro Nishida Naoki Wakabayashi Hideyuki Konishi Shoji Mitsufuji Keisho Kataoka Takeshi Okanoue Masafumi Taniwaki 

作者机构：Molecular Gastroenterology and HepatologyKyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan Molecular Hematology and OncologyKyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan Clinical Molecular Genetics and Laboratory MedicineKyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第17期

页      面：2602-2604页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gene Rearrangement Biopsy Female Humans Immunoglobulin Heavy Chains In Situ Hybridization, Fluorescence Lymphoma, Follicular Middle Aged Neoplasm Recurrence, Local Paraffin Embedding Proto-Oncogene Proteins c-bcl-2 Rectal Neoplasms 

摘      要：A 59-year-old woman was admitted to our hospital because of recurrent follicular lymphoma(FL).Colonoscopic examination revealed a rectal submucosal tumor(SMT)without any erosions and *** this patient,it was difficult to distinguish non-Hodgkin s lymphoma(NHL)invasion from other disorders of the colon including carcinoid tumor merely based on endoscopic *** and immunohistochemical studies on biopsy specimens showed an infiltration of atypical lymphocytes that were positive for CD20 and BCL2 but negative for *** in situ hybridization on paraffin-embedded tissue sections (T-FISH)identified a translocation of BCL2 with IGHgene. Based on these findings,the tumor was defined as an invasion of FL.T-FISH method is useful for the detection of a monoclonality of atypical lymphocytes in an SMT of the gastrointestinal tract,and particularly for the detection of chromosomal translocations specific to lymphoma subtypes.