Detection of BCL2-IGHrearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma
Detection of BCL2-IGHrearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma作者机构:Molecular Gastroenterology and HepatologyKyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan Molecular Hematology and OncologyKyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan Clinical Molecular Genetics and Laboratory MedicineKyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan
出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))
年 卷 期:2004年第10卷第17期
页 面:2602-2604页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:Gene Rearrangement Biopsy Female Humans Immunoglobulin Heavy Chains In Situ Hybridization, Fluorescence Lymphoma, Follicular Middle Aged Neoplasm Recurrence, Local Paraffin Embedding Proto-Oncogene Proteins c-bcl-2 Rectal Neoplasms
摘 要:A 59-year-old woman was admitted to our hospital because of recurrent follicular lymphoma(FL).Colonoscopic examination revealed a rectal submucosal tumor(SMT)without any erosions and *** this patient,it was difficult to distinguish non-Hodgkin s lymphoma(NHL)invasion from other disorders of the colon including carcinoid tumor merely based on endoscopic *** and immunohistochemical studies on biopsy specimens showed an infiltration of atypical lymphocytes that were positive for CD20 and BCL2 but negative for *** in situ hybridization on paraffin-embedded tissue sections (T-FISH)identified a translocation of BCL2 with IGHgene. Based on these findings,the tumor was defined as an invasion of FL.T-FISH method is useful for the detection of a monoclonality of atypical lymphocytes in an SMT of the gastrointestinal tract,and particularly for the detection of chromosomal translocations specific to lymphoma subtypes.