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Neural Regeneration Research 2021年第3期16卷 506-507页

作者： Kazuyuki Hirooka Tohru Yamamoto yoshiaki kiuchi Department of Ophthalmology and Visual Science Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan Department of Molecular Neurobiology Kagawa University Faculty of MedicineKagawaJapan

Glaucoma and dysfunction of axonal transport:One of the leading causes of irreversible blindness worldwide is glaucoma,with increased intraocula r pressu re(IOP)being the most common risk ***,in some glaucoma patients it has been shown that the IOP does not differ from that of the normal *** Japan,normal-tension glaucoma(NTG),which accounts for 92%of primary open-angle glaucoma,has been shown to be more frequent in the population.

关键词： glaucoma axonal transport

Evaluation of rebound tonometer iCare IC200 as compared with IcarePRO and Goldmann applanation tonometer in patients with glaucoma

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Eye and Vision 2021年第1期8卷 244-252页

作者： Shunsuke Nakakura Ryo Asaoka Etsuko Terao Yuki Nagata Yasuko Fukuma Satomi Oogi Miku Shiraishi yoshiaki kiuchi Department of Ophthalmology Saneikai Tsukazaki Hospital68-1 Aboshi WakuHimeji 671-1227Japan Department of Ophthalmology Seirei Hamamatsu General HospitalHamamatsuShizuokaJapan Seirei Christopher University HamamatsuShizuokaJapan Department of Ophthalmology and Visual Sciences Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan

Background:This study investigated the agreement between a new rebound tonometer,IC200,and IcarePRO and Goldmann applanation tonometry(GAT).Methods:This was a prospective cross-sectional *** measured the intraocular pressure(IOP)in 145 eyes of 145 glaucoma patients in the sitting position using GAT,IcarePRO,and *** and IC200 measurements were also obtained in the supine ***200 measurement was performed using two modes:single six(IC200-single)and automatic(IC200-continuous)six-measurements ***:All tonometers provided high reproducibility in both positions(all intraclass correlation coefficients>0.90),although it was highest with GAT,followed by IC200-continuous and IC200-single and then *** the sitting position,the mean(±SD)IOPs of GAT,IcarePRO,IC200-single,and IC200-continuous were 14.5±2.9 mmHg,13.3±3.2 mmHg,11.6±3.2 mmHg,and 11.5±3.2 mmHg,*** measured with IcarePRO or IC200 were significantly lower than those with GAT,particularly in patients with low *** measured with all tonometers were significantly elevated in the supine position as compared with the sitting position,but this difference was significantly greater with IC200-single and IC200-continuous compared with *** elevation was significant in eyes without bleb versus those with bleb,but this finding was not observed when IOP was measured with *** IOPs of the single and continuous modes of IC200 were interchangeable in both ***:GAT,IcarePRO,and IC200 had sufficiently high reproducibility,but measurements with IcarePRO may not be accurate in the supine *** of IOP in the supine position,especially in eyes with bleb,was more sensitively captured with IC200 than with IcarePRO.

关键词： Glaucoma IC200 IcarePRO Rebound tonometer Goldmann applanation tonometer

Calculating the Crystallite Size of Microsorum scolopendria AgCl Nanoparticles and Their Biological Activities

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Journal of Biomaterials and Nanobiotechnology 2024年第2期15卷 25-37页

作者： Christian Nanga Chick Mohammed Mahdaly Phillippe Belle Ebanda Kedi kiuchi Sonoko Francois Eya’ane Meva Department of Materials and Life Sciences Faculty of Science and Technology Sophia University Tokyo Japan Laboratory of Innovative Nanostructured Material (NANO: C) Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Nanosciences African Network iThemba LABS-National Research Foundation Cape Town South Africa Department of Studies in Human Life Sciences Otsuma Womens University Tokyo Japan Institute for Inorganic Chemistry and Structural Chemistry Heinrich-Heine-University Dsseldorf Dsseldorf Germany

In this work, AgCl nanoparticles were synthesized from Microsorum scolopendria (MS) aqueous extract and AgNO3 solution. Preliminary confirmation was a color change from a light brown to a dark-colored solution and a UV-Vis spectra surface plasmon resonance peak at 427 nm. Measured vibrational frequencies at 1713 cm1 and 1030 cm1 for C-O stretching of carboxylic acid or aliphatic ketone, and 1547 cm1 for possibly N-O stretching of nitro compounds by Infrared (FTIR) analysis explain the possible biomaterial electronegative species or functional groups responsible for the reduction of Ag ( 1) to Ag (0) for the formation of MS-AgCl nanoparticles. XRD analysis studies revealed that these particles contained face-centered cubic crystallites of metallic AgCl of 100 % with an average calculated crystallite size range of 30.34 nm (SD = 5.10 nm) by Scherrers equation and a calculated crystallite size of 66.04 nm with a lattice strain of 0.00175 nm by Williamson Hall equation. The measured albumin denaturing activity of MS-AgCl nanoparticles gave an IC50 value of 26.70 g/mL and 1.35 g/mL for the positive control diclofenac. Additionally, the measured ability of phosphomolybdate complex formation, the antioxidant IC value of MS-AgCl nanoparticles was 35.29 g/mL, and positive control ascorbic acid was 13.91 g/mL. In all, using MS fern frond aqueous extracts, this preliminary work confirms MS-AgCl nanoparticles as potential therapeutic agents for oxidative stress, inflammatory problems, and related diseases.

关键词： Microsorum scolopendria SNPs IR UV-Vis Antioxidant

SIMULATION OF ROLL-FORMING PROCESSES OF WELDED PIPE

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Chinese Journal of Mechanical Engineering 1996年第1期9卷 32-37页

作者： Hua Jiang Manabu kiuchi Nanchang University University of Tokyo Japan

A multi- pumose simulation method for the roll- formign is proposed. The forming pro- cesses of welded pipes are systematically simulated by using the method. The three-dimensional cu rved surfaces of sheet metals in forming processes are mathema tically expressed by using the shape fonction S(X) which represents flow pattern of each part of sheet metal. Through optimis- ing t e parameter n in s(X), the best approximation of the deformation of sheet metal is derived and the minimum power of deformation is obtained. A mathematical procedure of this analysis is systematically foimulated. The simulation method can be applied to the analysis and simulation for various roll- forming processes of welded pipes observed in commercial production line.

关键词： Welded pipe Roll- forming Simulation

Search for invisible decays of the Higgs boson produced at the CEPC

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Chinese Physics C 2020年第12期44卷 1-8页

作者： Yuhang Tan Xin Shi Ryuta kiuchi Manqi Ruan Maoqiang Jing Dan Yu Kaili Zhang Xinchou Lou Xin Mo Gang Li Susmita Jyotishmati Institute of High Energy Physics Beijing 100049China School of Physical Sciences University of Chinese Academy of Science(UCAS)Beijing 100049China State Key Laboratory of Particle Detection and Electronics 19B Yuquan RoadShijingshan DistrictBeijing 100049China Department of Physics University of Texas at DallasTexas 75080-3021USA

The Circular Electron Positron Collider(CEPC),proposed as a future Higgs boson factory,will operate at a center-of-mass energy of 240 GeV and will accumulate 5.6 ab−1 of integrated luminosity in 7 *** this study,we estimate the upper limit of BR(H→inv)for three independent channels,including two leptonic channels and one hadronic channel,at the *** on the full simulation analysis,the upper limit of BR(H→inv)could reach 0.26%at the 95%confidence *** the Stand Model(SM),the Higgs boson can only decay invisibly via H→ZZ∗→νν¯νν¯,so any evidence of invisible Higgs decays that exceed BR(H→inv)of the SM will indicate a phenomenon that is beyond the SM(BSM).The invariant mass resolution of the visible hadronic decay system ZH(Z→qq,H→inv)is simulated,and the physics requirement at the CEPC detector for reaching this is given.

关键词： CEPC invisible Higgs decays upper limit bosonmass resolution

Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice

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World Journal of Gastroenterology 2020年第23期26卷 3225-3235页

作者： Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G kiuchi Markus P Schlaich Vance B Matthews School of Biomedical Sciences Dobney Hypertension CentreRoyal Perth Hospital UnitUniversity of Western AustraliaPerth 6000Australia Faculty of Health and Medical Sciences University of Western AustraliaCrawley 6009Australia Faculty of Health Sciences School of Public HealthCurtin UniversityBentley 6102Australia Research Centre Royal Perth HospitalPerth 6000Australia Department of Molecular Ophthalmology University of Western AustraliaCrawley 6009Australia Dobney Hypertension Centre School of MedicineRoyal Perth Hospital UnitUniversity of Western AustraliaPerth 6000Australia Department of Cardiology and Department of Nephrology Royal Perth HospitalPerth 6000Australia

BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated *** protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic *** To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse *** The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield *** Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba ***, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced

关键词： Sodium glucose co-transporter inhibitors Sodium glucose co-transporter 2 Diabetes Diabetic retinopathy Mouse Gut microbiota Empagliflozin Dapagliflozin Succinate Akimba

Successful treatment of hypovascular advanced hepatocellular carcinoma with lipiodol-targetting intervention radiology

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World Journal of Gastroenterology 2007年第32期13卷 4398-4400页

作者： Kazutaka Kurokohchi Akihiro Deguchi Tsutomu Masaki Takashi Himoto Hirohito Yoneyama Mitsuyoshi Kobayashi Tsuyoshi Maeta Takaaki kiuchi Fumikazu Kohi Hisaaki Miyoshi Tomohiko Taminato Shigeki Kuriyama Department of Gastroenterology and Neurology Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan Department of Laboratory MedicineKagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan Department of Gastroenterology and Neurology Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan Department of Gastroenterology KKR Takamatsu Hospital4-18 TenjinmaeTakamatsuKagawa 760-0018Japan Department of Radiology KKR Takamatsu Hospital4-18 TenjinmaeTakamatsuKagawa 760-0018Japan Department of Laboratory Medicine Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan

We report a case of hypovascular advanced hepa-tocellular carcinoma (HCC) successfully treated with a novel combination therapy of percutaneous ethanol-lipiodol injection (PELI) and intervention radiology (IVR),lipiodol-targetting IVR (Lipi-IVR). The present case had a hypovascular HCC (3 cm in diameter) located in the S6 region of the liver. Although the tumor was not detectable at all by both of early and late phase of helical dynamic computed tomography (CT),it could be detected by ultrasonography (US) as a low echoic space occupying lesion (SOL) beside the gallbladder and right kidney. Serum levels of alpha fetoprotein (AFP) and AFP-L3 were extremely high. Combination therapy of PELI,firstly reported in our department,and IVR (PELI and IVR,lipiodol-targetting IVR) was performed twice for the treatment. PELI could effectively visualize the location of the tumor for IVR treatment and show the presence of a thin blood vessel branching from the right hepatic artery flowing into the lipiodol deposit. After treatment,the serum levels of AFP and AFP-L3 were rapidly decreased to normal and maintained for more than eight months. Thus,this case expressing the tremendous effect might give us insight into the effectiveness of the novel combination therapy of PELI and IVR for the treatment of hypovascular HCC.

关键词： hepatocellular carcinoma Percutaneous ethanol-lipiodol injection therapy Intervention radiology

Extension of Client-Server Applications to the Internet

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Extension of Client-Server Applications to the Internet

The Schlager mouse as a model of altered retinal phenotype

2002年IEEE十区计算机、通信、控制和电机工程会议

作者： Yoshizumi Serizawa Mai kiuchi Central Research Institute of Electric Power Industry 2-11-1 Iwado Kita Komae-shi Tokyo 201-8511 Japan Central Research Institute of Electric Power Industry 2-11-1 Iwado Kita Komae-shi Tokyo 201-8511 Japan

The Rapid advance of network technologies leavesno doubt that client-server applications running over theInternet will in the future be one of the most prevalent types ofsoftware program. This extension of client-server applicationsto Internet is based on available technologies and outlines apreliminary framework for developing applications, whichextends a traditional client-server application to the Internetand allows the developers to follow a standard procedure andfocus on the implementation of application functions. AnInternet extended client-server application will take advantageof all currently available Internet technologies, such as opennetwork communication protocol, well-proven applicationmodels and flexible system architecture.

关键词： Client-Server Application Active Server Page (ASP) Hyper Text Markup Language (HTML) page Hyper Text Transfer Protocol (HTTP) Internet

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Neural Regeneration Research 2020年第3期15卷 512-518页

作者： Lakshini Y.Herat Aaron L.Magno Márcio G.kiuchi Kristy L.Jackson Revathy Carnagarin Geoffrey A.Head Markus P.Schlaich Vance B.Matthews Dobney Hypertension Centre School of Biomedical Science-Royal Perth Hospital UnitUniversity of Western AustraliaPerthAustralia Research Centre Royal Perth HospitalPerthAustralia Dobney Hypertension Centre School of Medicine-Royal Perth Hospital UnitUniversity of Western AustraliaPerthAustralia Neuropharmacology Laboratory Baker Heart and Diabetes InstituteMelbourneAustralia Department of Cardiology and Department of Nephrology Royal Perth HospitalPerthAustralia

Hypertension is a risk factor for a large number of vision-threatening eye *** this study,we investigated for the first time the retinal neural structure of the hypertensive BPH/2J mouse(Schlager mouse)and compared it to its control counterpart,the normotensive BPN/3J *** BPH/2J mouse is a selectively inbred mouse strain that develops chronic hypertension due to elevated sympathetic nervous system *** compared to the BPN/3J strain,the hypertensive BPH/2J mice showed a complete loss of outer layers of the neural retina at 21 weeks of age,which was indicative of a severe vision-threatening disease potentially caused by *** elucidate whether the retinal neural phenotype in the BPH/2J strain was attributed to increased BP,we investigated the neural retina of both BPN/3J and BPH/2J mice at 4 weeks of *** preliminary results showed for the first time that the BPH/2J strain develops severe retinal neural damage at a young *** findings suggest that the retinal phenotype in the BPH/2J mouse is possibly due to elevated blood pressure and may be contributed by an early onset spontaneous mutation which is yet to be identified or a congenital defect occurring in this *** characterization of the BPH/2J mouse strain is likely to i)elucidate gene defects underlying retinal disease;ii)understand mechanisms leading to neural retinal disease and iii)permit testing of molecules for translational research to interfere with the progression of retinal *** animal experiments were performed with the approval of the Royal Perth Hospital Animal Ethics Committee(R535/17-18)on June 1,2017.

关键词： blood pressure eye hypertension mice neural regeneration retina Schlager mouse sympathetic nervous system

Circulating microRNAs as a liquid biopsy: a next generation clinical biomarker for diagnosis of gastric cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 418-427页

作者： Shuhei Komatsu Jun kiuchi Taisuke Imamura Daisuke Ichikawa Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKawaramachihirokojiKamigyo-kuKyoto 602-8566Japan First Department of Surgery Faculty of MedicineUniversity of YamanashiChuoYamanashi 409-3898Japan

Accumulating evidence has suggested the potential clinical utility of novel body fluid biomarkers,or“liquid biopsy”,using circulating tumor cells and cell-free nucleic acids from cancer *** and reproducible,liquid biopsy could provide the basis for individualized therapeutic strategies by identifying genetic and epigenetic aberrations that are closely associated with cancer initiation and ***(miRNAs)are short noncoding RNAs that post-transcriptionally regulate gene *** also play important roles in various physiological and developmental processes as oncogenic or tumor-suppressive *** miRNA expression signatures have been identified in a number of human *** miRNAs have been detected in plasma and serum,and this in blood has attracted the attention of researchers for their potential as noninvasive *** miRNAs have emerged as tumor-associated biomarkers that reflect not only the existence of cancer,but also the dynamics,malignant potential,and drug resistance of ***,we review the recent biological and clinical research on the circulating miRNAs of gastric cancer and discuss future perspectives for their clinical applications as a liquid biopsy.

关键词： Liquid biopsy circulating nucleic acids circulating microRNA biomarker gastric cancer