The Schlager mouse as a model of altered retinal phenotype

作     者：Lakshini Y.Herat Aaron L.Magno Márcio G.Kiuchi Kristy L.Jackson Revathy Carnagarin Geoffrey A.Head Markus P.Schlaich Vance B.Matthews Lakshini Y. Herat;Aaron L. Magno;Márcio G. Kiuchi;Kristy L. Jackson;Revathy Carnagarin;Geoffrey A. Head;Markus P. Schlaich;Vance B. Matthews

作者机构：Dobney Hypertension CentreSchool of Biomedical Science-Royal Perth Hospital UnitUniversity of Western AustraliaPerthAustralia Research CentreRoyal Perth HospitalPerthAustralia Dobney Hypertension CentreSchool of Medicine-Royal Perth Hospital UnitUniversity of Western AustraliaPerthAustralia Neuropharmacology LaboratoryBaker Heart and Diabetes InstituteMelbourneAustralia Department of Cardiology and Department of NephrologyRoyal Perth HospitalPerthAustralia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第3期

页      面：512-518页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：generously funded by grants from the Royal Perth Hospital Medical Research Foundation(to VBM and MPS) 

主　　题：blood pressure eye hypertension mice neural regeneration retina Schlager mouse sympathetic nervous system 

摘      要：Hypertension is a risk factor for a large number of vision-threatening eye disorders.In this study,we investigated for the first time the retinal neural structure of the hypertensive BPH/2J mouse(Schlager mouse)and compared it to its control counterpart,the normotensive BPN/3J strain.The BPH/2J mouse is a selectively inbred mouse strain that develops chronic hypertension due to elevated sympathetic nervous system activity.When compared to the BPN/3J strain,the hypertensive BPH/2J mice showed a complete loss of outer layers of the neural retina at 21 weeks of age,which was indicative of a severe vision-threatening disease potentially caused by hypertension.To elucidate whether the retinal neural phenotype in the BPH/2J strain was attributed to increased BP,we investigated the neural retina of both BPN/3J and BPH/2J mice at 4 weeks of age.Our preliminary results showed for the first time that the BPH/2J strain develops severe retinal neural damage at a young age.Our findings suggest that the retinal phenotype in the BPH/2J mouse is possibly due to elevated blood pressure and may be contributed by an early onset spontaneous mutation which is yet to be identified or a congenital defect occurring in this strain.Further characterization of the BPH/2J mouse strain is likely to i)elucidate gene defects underlying retinal disease;ii)understand mechanisms leading to neural retinal disease and iii)permit testing of molecules for translational research to interfere with the progression of retinal disease.The animal experiments were performed with the approval of the Royal Perth Hospital Animal Ethics Committee(R535/17-18)on June 1,2017.