Circulating microRNAs as a liquid biopsy: a next generation clinical biomarker for diagnosis of gastric cancer
Circulating microRNAs as a liquid biopsy: a next-generation clinical biomarker for diagnosis of gastric cancer作者机构：Division of Digestive SurgeryDepartment of SurgeryKyoto Prefectural University of MedicineKawaramachihirokojiKamigyo-kuKyoto 602-8566Japan First Department of SurgeryFaculty of MedicineUniversity of YamanashiChuoYamanashi 409-3898Japan
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2018年第4卷第1期
页 面：418-427页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Liquid biopsy circulating nucleic acids circulating microRNA biomarker gastric cancer
摘 要：Accumulating evidence has suggested the potential clinical utility of novel body fluid biomarkers,or“liquid biopsy,using circulating tumor cells and cell-free nucleic acids from cancer *** and reproducible,liquid biopsy could provide the basis for individualized therapeutic strategies by identifying genetic and epigenetic aberrations that are closely associated with cancer initiation and ***(miRNAs)are short noncoding RNAs that post-transcriptionally regulate gene *** also play important roles in various physiological and developmental processes as oncogenic or tumor-suppressive *** miRNA expression signatures have been identified in a number of human *** miRNAs have been detected in plasma and serum,and this in blood has attracted the attention of researchers for their potential as noninvasive *** miRNAs have emerged as tumor-associated biomarkers that reflect not only the existence of cancer,but also the dynamics,malignant potential,and drug resistance of ***,we review the recent biological and clinical research on the circulating miRNAs of gastric cancer and discuss future perspectives for their clinical applications as a liquid biopsy.
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