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A classification method of building structures based on multi-feature fusion of UAV remote sensing images

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Earthquake Research Advances 2021年第4期1卷 38-47页

作者： Haoguo Du Yanbo Cao Fanghao zhang Jiangli Lv Shurong Deng yongkun Lu Shifang He Yuanshuo zhang Qinkun Yu Yunnan Earthquake Agency Kunming650224YunnanChina

In order to improve the accuracy of building structure identification using remote sensing images,a building structure classification method based on multi-feature fusion of UAV remote sensing image is proposed in this *** identification approaches of remote sensing images are integrated in this method:object-oriented,texture feature,and digital elevation based on DSM and *** RGB threshold classification method is used to classify the identification *** accuracy of building structure classification based on each feature and the multi-feature fusion are compared and *** results show that the building structure classification method is feasible and can accurately identify the structures in large-area remote sensing images.

关键词： Remote sensing image Building structure classification Multi-feature fusion Object-oriented classification method Texture feature classification method DSM and DEM elevation classification method RGB threshold classification method

基于GPS秒脉冲向量信号同步技术的断路器速度特性无线测量装置研究

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电工技术 2024年第1期 133-135页

作者：李永昆徐静张博闻王笑宇白华颖国网河南省电力公司超高压公司河南郑州450000

针对目前断路器速度特性测试受限于测试线长度、强电磁干扰、无法三相同时测试费时费力等问题,研制一种基于GPS秒脉冲向量信号同步技术的断路器速度特性无线测量装置。该装置适用于500 kV、220 kV、66 kV等不同电压等级断路器三相分合... 详细信息

针对目前断路器速度特性测试受限于测试线长度、强电磁干扰、无法三相同时测试费时费力等问题,研制一种基于GPS秒脉冲向量信号同步技术的断路器速度特性无线测量装置。该装置适用于500 kV、220 kV、66 kV等不同电压等级断路器三相分合闸速度测试,实现了断路器速度特性行程曲线的无线化测量,缩短了现场测试时间,提高了速度特性测量效率。

关键词：速度特性 GPS秒脉冲无线同步

骨盆原发恶性肿瘤外科治疗疗效及预后影响因素分析

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中华肿瘤杂志 2024年第4期46卷 344-353页

作者：刘巍峰郝林李卓宇金韬孙扬杨勇昆李远杨发军鱼锋张清牛晓辉首都医科大学附属北京积水潭医院骨肿瘤科北京100035

目的探讨不同分期骨盆肿瘤预后因素及外科边界对预后的影响。方法回顾性收集2000年1月至2017年12月于北京积水潭医院接受整块切除手术治疗骨盆原发恶性肿瘤患者(208例)的临床病理资料。生存分析采用Kaplan-Meier法和Log rank检验,影响... 详细信息

目的探讨不同分期骨盆肿瘤预后因素及外科边界对预后的影响。方法回顾性收集2000年1月至2017年12月于北京积水潭医院接受整块切除手术治疗骨盆原发恶性肿瘤患者(208例)的临床病理资料。生存分析采用Kaplan-Meier法和Log rank检验,影响因素分析采用Cox比例风险回归模型。结果208例患者中,初次治疗183例,外院治疗后复发25例。根据Enneking分期,IB期110例,ⅡB期98例。Ⅰ区(髂骨)切除19例,Ⅱ区(髋臼周围)切除1例,Ⅲ区(耻、坐骨)切除15例,Ⅰ+Ⅱ区切除29例,Ⅱ+Ⅲ区切除71例,Ⅰ+Ⅳ区(骶髂关节)切除29例,Ⅰ+Ⅱ+Ⅲ区切除35例,Ⅰ+Ⅱ+Ⅳ区切除3例,Ⅰ+Ⅱ+Ⅲ+Ⅳ区切除6例。外科切缘为囊内7例,污染边缘21例,边缘67例,广泛113例。全组208例患者术后局部复发37例(17.8%),包括最终截肢12例,再次切除25例,5年无复发生存率为79.4%。边缘切除患者5年复发率(22.3%)高于广泛切除患者(4.3%),5年无复发生存率(77.7%)低于广泛切除患者(95.7%,均P<0.05);R0切除与R1切除患者的5年复发率(分别为11.1%和60.7%)及5年无复发生存率(分别为88.8%和39.3%)差异均有统计学意义(均P<0.05)。切除后未重建92例,重建116例。至随访结束,208例患者中死亡63例(30.3%),5、10和15年生存率分别为70.4%、66.8%和61.3%,其中ⅠB期患者5年生存率为90.4%,ⅡB期患者5年生存率为46.8%(P<0.05)。术后切口并发症29例,盆腔脏器损伤1例。最终功能可评价患者132例,肌肉骨骼肿瘤学会评分为(25.1±3.6)分。多因素分析显示,诊断分期(HR=3.135,95%CI:1.447~6.791,P=0.004)、外科R0/R1边界(HR=0.481,95%CI:0.252~0.920,P=0.027)、肿瘤转移(HR=6.172,95%CI:3.271~11.645,P<0.001)是骨盆肿瘤的独立预后因素。结论骨盆肿瘤整块切除安全外科边界是控制复发的关键因素;ⅡB期骨盆肿瘤生存率显著低于ⅠB期肿瘤;切口感染是最主要的术后并发症;外科分期、R0/R1边界、肿瘤转移是骨盆肿瘤的独立预后因素。

关键词：骨盆恶性肿瘤切除外科边界重建复发并发症

Nanobodies with cross-neutralizing activity provide prominent therapeutic efficacy in mild and severe COVID-19 rodent models

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Virologica Sinica 2023年第5期38卷 787-800页

作者： Qiuxue Han Shen Wang Zhenshan Wang Cheng zhang Xinyue Wang Na FengTiecheng Wang yongkun Zhao Hang Chi Feihu Yan Xianzhu Xia Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100021China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun132122China Jiangsu Co-innovation Centre for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou225009China

The weakened protective efficacy of COVID-19 vaccines and antibodies caused by SARS-CoV-2 variants presents a global health emergency,which underscores the urgent need for universal therapeutic antibody intervention for clinical ***,we screened three alpacas-derived nanobodies(Nbs)with neutralizing activity from twenty RBD-specific *** three Nbs were fused with the Fc domain of human IgG,namely aVHH-11-Fc,aVHH-13-Fc and aVHH-14-Fc,which could specifically bind RBD protein and competitively inhibit the binding of ACE2 receptor to *** effectively neutralized SARS-CoV-2 pseudoviruses D614G,Alpha,Beta,Gamma,Delta,and Omicron sub-lineages BA.1,BA.2,BA.4,and BA.5 and authentic SARS-CoV-2 prototype,Delta,and Omicron BA.1,BA.2 *** mice-adapted COVID-19 severe model,intranasal administration of aVHH-11-Fc,aVHH-13-Fc and aVHH-14-Fc effectively protected mice from lethal challenges and reduced viral loads in both the upper and lower respiratory *** the COVID-19 mild model,aVHH-13-Fc,which represents the optimal neutralizing activity among the above three Nbs,effectively protected hamsters from the challenge of SARS-CoV-2 prototype,Delta,Omicron BA.1 and BA.2 by significantly reducing viral replication and pathological alterations in the *** structural modeling of aVHH-13 and RBD,aVHH-13 binds to the receptor-binding motif region of RBD and interacts with some highly conserved *** together,our study illustrated that alpaca-derived Nbs offered a therapeutic countermeasure against SARS-CoV-2,including those Delta and Omicron variants which have evolved into global pandemic strains.

关键词： COVID-19 SARS-CoV-2 Nanobody Broad-spectrum Therapeutic Rodent models

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高水位运行条件下密云水库洪水防御对策分析

中国防汛抗旱 2024年第6期34卷 65-70页

作者：张冠宇卢亚静李永坤王泽勇褚旭樊敏北京市密云水库管理处北京101512 北京市水科学技术研究院北京100048

密云水库作为北京市重要的水资源战略储备基地的同时还承担着关键的防洪任务,近年来持续高水位运行使密云水库面临着“蓄泄”两难的实际问题,洪水防御压力不断增加。为分析密云水库现状防洪能力,从洪水监测预报预警、洪水调度和防洪抢... 详细信息

密云水库作为北京市重要的水资源战略储备基地的同时还承担着关键的防洪任务,近年来持续高水位运行使密云水库面临着“蓄泄”两难的实际问题,洪水防御压力不断增加。为分析密云水库现状防洪能力,从洪水监测预报预警、洪水调度和防洪抢险技术3个方面,围绕工程措施和非工程措施,开展密云水库洪水防御的对策分析。分析了密云水库建库以来历史洪水特征及预报预警现状,对中小洪水在不同控泄情景下进行调洪计算,提出中小洪水相机实施预报调度的措施建议,选取北京市、山西省、河南省典型降雨情景,开展极端降雨过程移置模拟,提出调度方案,为水库应对极端降雨提供参考。基于以上分析,提出了建设监测、预报、调度一体化的,具有预报、预警、预演、预案“四预”功能的智慧系统工作建议,以期为密云水库洪水调度优化和洪水防御技术提升提供参考。

关键词：密云水库高水位洪水防御洪水调度防洪抢险

Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions

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Science China(Physics,Mechanics & Astronomy) 2017年第5期60卷 1-35页

作者： LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing zhang YingJun Li Jie Liu Min Wang yongkun Ding WeiYan zhang Institute of Applied Physics and Computational Mathematics Beijing 100094China Center for Applied Physics and Technology HEDPSPeking UniversityBeijing 100871China IFSA Collaborative Innovation Center of MoE Shanghai Jiaotong UniversityShanghai 200240China Institute of Fusion Theory and Simulation Zhejiang UniversityHangzhou 310027China Graduate School China Academy of Engineering PhysicsBeijing 100088China Research Center of Laser Fusion China Academy of Engineering PhysicsMianyang 621900China Shanghai Institute of Laser Plasma Shanghai 201800China State Key Laboratory for GeoMechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China

Inertial fusion energy （IFE） has been considered a promising, nearly inexhaustible source of sustainable carbon-free power for the world＇s energy future. It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion （ICF） hot-spot ignition scheme. In this mini-review, we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade. In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF, we first decompose the problem into different stages according to the implosion physics processes. The decomposed essential physics pro- cesses that are associated with ICF implosions, such as Rayleigh-Taylor instability （RTI）, Richtmyer-Meshkov instability （RMI）, Kelvin-Helmholtz instability （KHI）, convergent geometry effects, as well as perturbation feed-through are reviewed. Analyti- cal models in planar, cylindrical, and spherical geometries have been established to study different physical aspects, including density-gradient, interface-coupling, geometry, and convergent effects. The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations. The KHI considering the ablation effect has been discussed in detail for the first time. A series of single-mode ablative RTI experiments has been performed on the Shenguang-II laser facility. The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths, and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions, which has directly supported the research of ICF ignition target design. The ICF hot-spot ignition implosion design that uses several controlling features, based on our current understanding of hydrodynamic instabilities, to address shell implosion stability, has been

关键词： hydrodynamic instabilities inertial-confinement fusion implosions Rayleigh-Taylor instability Richtmyer-Meshkov in-stability Kelvin-Helmholtz instability convergent geometry effects perturbation feed-through

基于激光雷达和多传感器数据融合的塔机防碰撞系统

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机械设计与制造工程 2024年第9期53卷 117-121页

作者：胡永坤殷晨波乔文华黄文武张子立陆志远南京工业大学机械与动力工程学院江苏南京211816 大汉科技股份有限公司山东济南250200 江苏天宙检测有限公司江苏南京211816

针对建筑工地施工作业密度增高导致的群塔碰撞事故频发的问题,提出了预碰撞点预警和激光雷达预警区预警双重判断的防碰撞方法,设计了基于激光雷达和多传感器数据融合的塔机防碰撞系统。该系统设计了雷达防碰撞、多传感器数据采集、数据... 详细信息

针对建筑工地施工作业密度增高导致的群塔碰撞事故频发的问题,提出了预碰撞点预警和激光雷达预警区预警双重判断的防碰撞方法,设计了基于激光雷达和多传感器数据融合的塔机防碰撞系统。该系统设计了雷达防碰撞、多传感器数据采集、数据通讯与传输等模块。现场测试表明,该系统运行稳定,数据采集准确,防碰撞功能符合实际塔机吊装过程使用要求,为塔机防碰撞领域提供了一种高效、可靠的智能解决方案。

关键词：塔式起重机防碰撞算法激光雷达数据融合无线通讯

维普期刊数据库博看期刊

密云水库流域蒸发量变化规律及不同蒸发皿转换系数分析

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北京水务 2024年第3期 55-61页

作者：樊敏卢亚静李永坤郝天奇王主张明阳褚旭李龙北京市密云水库管理处北京101512 北京市水科学技术研究院北京100048

为分析气候变化背景下密云水库流域蒸发量变化规律,采用气候倾向率、Mann-Kendall趋势检验法和Morlet小波变换法分析密云水库流域1960-2022年白河观测站蒸发皿蒸发量随时间的变化趋势;同时为建立不同型号水面蒸发皿之间的定量转换关系,... 详细信息

为分析气候变化背景下密云水库流域蒸发量变化规律,采用气候倾向率、Mann-Kendall趋势检验法和Morlet小波变换法分析密云水库流域1960-2022年白河观测站蒸发皿蒸发量随时间的变化趋势;同时为建立不同型号水面蒸发皿之间的定量转换关系,选择3个典型水文观测站2005-2022年E601型蒸发皿和20 cm口径蒸发皿的同步观测数据,进行流域年蒸发量计算,并开展不同蒸发皿转换系数的分析。结果表明:1960年以来,密云水库流域蒸发量呈不显著上升趋势,蒸发主要集中在春夏两季,占全年蒸发量的71.3%,四季蒸发量总体上呈现上升-上升-下降-上升的趋势;密云白河观测站蒸发量存在33 a时间尺度的“丰-枯”变化第一主周期及20 a时间尺度的“枯-丰”变化第二主周期。密云水库流域E601型和20 cm口径2种蒸发皿具有较好的相关性和同步性,白河站、张家坟水文站和下会水文站的蒸发同步观测值在冰期(11月至次年3月)的转换系数分别为0.56、0.52和0.53,非冰期(4-10月)的转换系数分别为0.71、0.70和0.64,全年蒸发皿的转换系数分别为0.68、0.66和0.62。结果对开展密云水库流域蒸发量的统计分析研究具有一定参考价值。

关键词：密云水库蒸发皿蒸发量变化特征气候倾向率 Mann-Kendall趋势检验法 Morlet小波分析转换系数

The substitution V379I in PA protein attenuates the pathogenicity of influenza A(H1N1)pdm09 viruses in mice

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Science China(Life Sciences) 2017年第9期60卷 1044-1046页

作者： yongkun Chen Wenfei Zhu Tian Bai Xiaohui Zou Siyu zhang Yan Sun Xiyan Li XingyYu Xiang Qinglong Zhao Chaoyang Huang Tao Chen Dayan Wang Yuelong Shu National Institute for Viral Disease Control and Prevention Collaboration Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionKey Laboratory for Medical VirologyNational Health and Family Planning CommissionBeifing 102206China Hunan Provincial Center for Disease Control and Prevention Changsha 410005China Changsha Central Hospital Changsha 410004China Jilin Provincial Center for Disease Control and Prevention Changchun 130062China

Dear Editor,Since August 2010,the world was in the post-pandemic period and the influenza A（H1N1）pdm09（pdmH1N1）virus co-circulated with H3N2 and B virus seasonally（WHO,2010）.The continuous surveillance on the pdmH1N1 virus in the post-pandemic period was recommended by *** order to detect unusual events that might indicate a shift in severity disease,or emergence of a new virus,we collected a total of 312 throat swabs of laboratory-confirmed pdmHlNl patients from Hunan and Jilin provinces in China during January to March, 2016. Amongst them, 212 were influenza-like illness （ILI） outpatients while the remaining 100 were hospitalized patients.

关键词： B病毒流感甲型致病性 A蛋白小鼠流行季节住院病人