The substitution V379I in PA protein attenuates the pathogenicity of influenza A(H1N1)pdm09 viruses in mice

作     者：Yongkun Chen Wenfei Zhu Tian Bai Xiaohui Zou Siyu Zhang Yan Sun Xiyan Li XingyYu Xiang Qinglong Zhao Chaoyang Huang Tao Chen Dayan Wang Yuelong Shu 

作者机构：National Institute for Viral Disease Control and PreventionCollaboration Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionKey Laboratory for Medical VirologyNational Health and Family Planning CommissionBeifing 102206China Hunan Provincial Center for Disease Control and PreventionChangsha 410005China Changsha Central HospitalChangsha 410004China Jilin Provincial Center for Disease Control and PreventionChangchun 130062China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2017年第60卷第9期

页      面：1044-1046页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the National Mega-projects for Infectious Diseases(2014ZX10004002-002 to Yuelong Shu) the National Key Research and Development Program of China(2016YFC1200201 to Yuelong Shu) the National Nature Science Foundation of China(81601758 to Wenfei Zhu) 

主　　题：B病毒 流感 甲型 致病性 A蛋白 小鼠 流行季节 住院病人 

摘      要：Dear Editor,Since August 2010,the world was in the post-pandemic period and the influenza A（H1N1）pdm09（pdmH1N1）virus co-circulated with H3N2 and B virus seasonally（WHO,2010）.The continuous surveillance on the pdmH1N1 virus in the post-pandemic period was recommended by *** order to detect unusual events that might indicate a shift in severity disease,or emergence of a new virus,we collected a total of 312 throat swabs of laboratory-confirmed pdmHlNl patients from Hunan and Jilin provinces in China during January to March, 2016. Amongst them, 212 were influenza-like illness （ILI） outpatients while the remaining 100 were hospitalized patients.