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Effect of Jinlong capsule on proliferation and apoptosis of human pancreatic cancer cells BxPC-3

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Journal of Traditional Chinese Medicine 2013年第2期33卷 205-210页

作者： Yaoyuan Li Jieqing Hu Hui Huang yonghe he Department of Oncology Guang'an men Hospital Affiliated to China Academy of Chinese Medical Sciences Department of Traditional Chinese Medicine Fengtai District Community Health Center Jiansheng Pharmaceutical Co. Ltd.

OBJECTIVE:To study the possible roles of Jinlong capsule(JLC) on the proliferation and apoptosis of human pancreatic cancer cells ***:The human pancreatic cancer cells BxPC-3 were treated with JLC at the concentration of 0.05-1.00 mg/mL for 24-120 *** inhibition rate of JLC on human pancreatic cancer cells BxPC-3 was detected by 3-(4,5-dimethiylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) *** cytometry was employed to measure cell apoptosis using Annexin V-FITC/Propidium iodide(AV-FITC/PI) *** cycles were determined by PI *** expression of S100 Calcium binding protein A4(S100A4) in cell matrix was measured by enzyme-linked immunosorbent assay(ELISA).The expression levels of apoptosis-related protein such as BCL2/adenovirus E1B 19 kDa interacting protein 3(BNIP3),B-cell lymphoma/leukemia-2(Bcl-2) and Cys-teinylaspartate specific proteinase 3(Caspase-3) were detected byWestern ***:JLC significantly inhibited the proliferation of human pancreatic cancer cells BxPC-3 in a dose-dependent and time-dependent *** promoted cell apoptosis and maintained cell cycle in S and G 2 /M phase rather than G 1 /G 0 *** expression of S100A4 in the cell matrix was *** expression of cell apoptotic protein BNIP3 was increased while Bcl-2 was ***:JLC can inhibit the proliferation of human pancreatic cancer cells BxPC-3 by stimulating cell apoptosis,arresting the cell cycle at S and G 2 /M phase which blocks the circulation of normal cell cycle and reducing the expression of S100A4 *** pro-apoptosis protein BNIP3 and lower anti-apoptosis protein Bcl-2 levels were found,which may be related to the apoptotic effects of JLC.

关键词：细胞凋亡癌细胞胰腺增殖酶联免疫吸附试验胶囊 Western印迹钙结合蛋白

Numerical simulation of flow field deposition and erosion characteristics around bridge-road transition section

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Journal of Mountain Science 2024年第5期21卷 1491-1508页

作者： ZHANG Kai WANG Zhenghui WANG Tao TIAN Jianjin ZHANG Hailong LIU yonghe College of Civil Engineering Lanzhou Jiaotong UniversityLanzhou 730000China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Wind-sand flow generates erosion and deposition around obstacles such as bridges and roadbeds, resulting in sand damage and endangering railway systems in sandy regions. Previous studies have mainly focused on the flow field around roadbeds, overlooking detailed examinations of sand particle erosion and deposition patterns near bridges and roadbeds. This study employs numerical simulations to analyze the influence of varying heights and wind speeds on sand deposition and erosion characteristics at different locations: the bridge-road transition section(side piers), middle piers, and roadbeds. The results show that the side piers, experience greater accumulation than the middle piers. Similarly, the leeward side of the roadbed witnesses more deposition compared to the windward side. Another finding reveals a reduced sand deposition length as the vertical profile, in alignment with the wind direction, moves further from the bridge abutments at the same clearance height. As wind speeds rise, there’s a decline in sand deposition and a marked increase in erosion around the side piers, middle piers and roadbeds. In conclusion, a bridge clearance that’s too low can cause intense sand damage near the side piers, while an extremely high roadbed may lead to extensive surface sand deposition. hence, railway bridges in areas prone to sandy winds should strike a balance in clearance height. This research provides valuable guidelines for determining the most suitable bridge and roadbed heights in regions affected by wind and sand.

关键词： Sandstorm Flow field Bridge-road transition section Sedimentation erosion Numerical simulation

新时代科学教师教育体系：内涵、现状与建设路径

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教师教育研究 2024年第4期36卷 27-33页

作者：杨杰何雨泽郑永和北京师范大学科学教育研究院

新时代科技创新人才的自主培养，依赖高质量科学教师。要实现高质量科学教师可持续供给就必须建立高质量的科学教师教育体系。科学教师教育体系是由实践体系、学术体系和保障体系所组成的“三位一体”有机整体，当前主要面临三重挑战：... 详细信息

新时代科技创新人才的自主培养，依赖高质量科学教师。要实现高质量科学教师可持续供给就必须建立高质量的科学教师教育体系。科学教师教育体系是由实践体系、学术体系和保障体系所组成的“三位一体”有机整体，当前主要面临三重挑战：科学教师教育实践体系不完善难以满足高质量科学教师队伍建设需求，科学教师教育学术体系不强健难以满足科学教师教育专业化需求，科学教师教育保障体系不健全难以支撑研究与实践的可持续发展。应当立足新时代科学教师队伍建设需求，通过建立认证、培养、培训一体化的科学教师培养模式，健全有顶层规划、有学科建制、有学术组织的学术新生态，建设多主体协同的科学教师教育保障体系等举措来建设高质量科学教师教育体系。

关键词：科学教育科学教师教师教育教育体系

The Magnaporthe oryzae effector Avr-PikD suppresses rice immunity by inhibiting an LSD1-like transcriptional activator

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The Crop Journal 2024年第2期12卷 482-492页

作者： Jiayuan Guo Yiling Wu Jianqiang Huang Kaihui Yu Meilian Chen Yijuan Han Zhenhui Zhong Guodong Lu yonghe Hong Zonghua Wang Xiaofeng Chen Fujian Universities Engineering Research Center of Marine Biology and Drugs Fuzhou Institute of OceanographyCollege of Geography and OceanographyMinjiang UniversityFuzhou 350108FujianChina Rice Research Institute Fujian Academy of Agricultural SciencesFuzhou 350018FujianChina Ministerial and Provincial Joint Innovation Center for Safety Production of Cross-Strait Crops Minjiang UniversityFuzhou 350108FujianChina State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Avirulence effectors(Avrs),encoded by plant pathogens,can be recognized by plants harboring the corresponding resistance proteins,thereby initiating effector-triggered immunity(ETI).In susceptible plants,however,Avrs can function as effectors,facilitating infection via effector-triggered susceptibility(ETS).Mechanisms of Avr-mediated ETS remain largely *** we report that the Magnaporthe oryzae effector Avr-PikD enters rice cells via the canonical cytoplasmic secretion pathway and suppresses rice basal ***-PikD interacts with an LSD1-like transcriptional activator AKIP30 of rice,and AKIP30 is also a positive regulator of rice immunity,whereas Avr-PikD impedes its nuclear localization and suppresses its transcriptional *** summary,*** delivers Avr-PikD into rice cells to facilitate ETS by inhibiting AKIP30-mediated transcriptional regulation of immune response against ***.

关键词： Magnaporthe oryzae Avirulence effector Avr-PikD Effector-triggered susceptibility Rice immunity Transcriptional activator

长三角地区城市密度对碳排放绩效的影响效应与机制

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生态学报 2024年第10期44卷 4092-4104页

作者：陈飞徐鹤李永贺上海应用技术大学城市建设与安全工程学院上海201418

城市密度是衡量城市各要素空间集聚程度的表征也是调控城市各要素资源分配效率的重要手段。过往主要围绕城市密度的物质形态测度来研究城市空间资源利用与环境问题,少有立足碳排放绩效的视角来研究城市密度的演变逻辑。立足生态效益中... 详细信息

城市密度是衡量城市各要素空间集聚程度的表征也是调控城市各要素资源分配效率的重要手段。过往主要围绕城市密度的物质形态测度来研究城市空间资源利用与环境问题,少有立足碳排放绩效的视角来研究城市密度的演变逻辑。立足生态效益中自然资源投入最小化与获得价值最大化的观点,从经济、社会、环境三个维度构建碳排放绩效综合评价指标,以长三角41个城市为例,基于标准差椭圆分析城市密度与碳排放绩效的时空演变及关联特征,采用地理加权回归模型与地理探测器相结合的方法,确定城市密度对碳排放绩效的影响效应及机制。结果表明:(1)城市密度与碳排放绩效均升高,城市密度增速减慢,而碳排放绩效增速加快;二者均呈东南—西北向发展且关联性不断增强。(2)城市密度分指标对碳排放绩效的影响效应存在时空差异,东南部多数城市各分指标影响系数增大且作用方向不变;西北部人口密度负向影响显著增强,经济密度的影响由负转正,而空间密度的影响由正转负。(3)城市密度与其他经济社会因素交互后对碳排放绩效产生影响,其中经济密度与产业结构协同作用对碳排放绩效的影响最大,且与因子独立作用相比,人口密度与其他影响因素的交互效应增幅最大。理清城市密度对碳排放绩效的影响效应及机制,可以为城市空间结构的合理优化提供依据。

关键词：碳排放绩效城市密度影响效应交互作用

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恶性肿瘤络病论

北京中医药大学学报 2005年第5期28卷 75-77页

作者：贺用和中国中医研究院广安门医院北京100053

恶性肿瘤是临床常见疾病,其发病率与死亡率逐年上升,成为导致人类死亡的主要疾病之一.古今中医学者从不同角度对肿瘤的病因病机、治则用药进行了深入的研究.叶天士提出积"著而不移,是为阴邪聚络",认为肿瘤乃痰浊、瘀血等有形之阴邪凝聚... 详细信息

恶性肿瘤是临床常见疾病,其发病率与死亡率逐年上升,成为导致人类死亡的主要疾病之一.古今中医学者从不同角度对肿瘤的病因病机、治则用药进行了深入的研究.叶天士提出积"著而不移,是为阴邪聚络",认为肿瘤乃痰浊、瘀血等有形之阴邪凝聚于络脉而成,提出了肿瘤的络病论.……

关键词：恶性肿瘤络病病机治则

A review on DFACS(I):System design and dynamics modeling

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Chinese Journal of Aeronautics 2024年第5期37卷 92-119页

作者： Bohan JIAO Qifan LIU Zhaohui DANG Xiaokui YUE yonghe ZHANG Yuanqing XIA Li DUAN Qinglei HU Chenglei YUE Pengcheng WANG Ming GUO Zhansheng DUAN Bing CUI Chu ZHANG Xiaodong SHAO School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 710699China School of Automation Beijing Institute of TechnologyBeijing 100081China Institute of Mechanics Chinese Academy of SciencesBeijing 710043China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

The Drag-Free and Attitude Control System(DFACS)is a critical platform for various space missions,including high precision satellite navigation,geoscience and gravity field measurement,and space scientific *** paper presents a comprehensive review of over sixty years of research on the design and dynamics model of ***,we examine the open literature on DFACS and its applications in Drag-Free missions,providing readers with necessary background information on the ***,we analyze the system configurations and main characteristics of different DFACSs,paying particular attention to the coupling mechanism between the system configuration and dynamics ***,we summarize the dynamics modeling methods and main dynamics models of DFACS from multiple perspectives,including common fundamentals and specific ***,we identify current challenges and technological difficulties in the system design and dynamics modeling of DFACS,while suggesting potential avenues for future *** paper aims to provide readers with a comprehensive understanding of the state-of-the-art in DFACS research,as well as the future prospects and challenges in this field.

关键词： Drag-Free DFACS System Design Dynamics Modeling Control design

A review on DFACS(II):Modeling and analysis of disturbances and noises

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Chinese Journal of Aeronautics 2024年第5期37卷 120-147页

作者： Chenglei YUE Bohan JIAO Zhaohui DANG Xiaokui YUE yonghe ZHANG Yuanqing XIA Li DUAN Qinglei HU Qifan LIU Pengcheng WANG Ming GUO Zhansheng DUAN Bing CUI Chu ZHANG Xiaodong SHAO School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 710699China School of Automation Beijing Institute of TechnologyBeijing 100081China Institute of Mechanics Chinese Academy of SciencesBeijing 710043China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

This paper presents Part II of a review on DFACS,which specifically focuses on the modeling and analysis of disturbances and noises in *** Part I,the system composition and dynamics model of the DFACS were *** this paper,we discuss the effects of disturbance forces and noises on the system,and summarize various analysis and modeling methods for these interferences,including the integral method,frequency domain analysis method,and magnitude evaluation *** analyzing the impact of disturbances and noises on the system,the paper also summarizes the system’s performance under slight ***,we highlight current research difficulties in the field of DFACS noise ***,this paper provides valuable insights into the modeling and analysis of disturbances and noises in DFACSs,and identifies key areas for future research.

关键词： Drag-free DFACS Disturbance Analysis Noise Analysis Frequency Domain Analysis Performance Evaluation

鄂尔多斯盆地及邻区中—晚二叠世构造-沉积环境与原型盆地演化

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岩性油气藏 2024年第1期36卷 32-44页

作者：翟咏荷何登发开百泽中国石油勘探开发研究院北京100083 中国地质大学(北京)能源学院北京100083 中国石油东方地球物理公司河北涿州072751

根据钻井、测井、野外露头及地球化学资料,参考盆地周缘构造环境、盆地构造沉降特征及沉积相展布,恢复了鄂尔多斯盆地中—晚二叠世不同时期构造-沉积环境,探讨了盆地性质及演化过程。研究结果表明:①中—晚二叠世鄂尔多斯盆地南缘和北... 详细信息

根据钻井、测井、野外露头及地球化学资料,参考盆地周缘构造环境、盆地构造沉降特征及沉积相展布,恢复了鄂尔多斯盆地中—晚二叠世不同时期构造-沉积环境,探讨了盆地性质及演化过程。研究结果表明:①中—晚二叠世鄂尔多斯盆地南缘和北缘经历了洋盆俯冲消减过程,以强烈的挤压构造环境为特征,上二叠统石千峰组沉积期盆地北缘古亚洲洋闭合进入陆陆碰撞阶段,盆地内构造沉降速度缓慢。②中—晚二叠世鄂尔多斯盆地为大型的克拉通内坳陷盆地,中二叠统石盒子组沉积期基准面呈下降趋势,盆地主体延续山西组沉积期南北高、中部低的古地理格局,南华北地区地势相对更低;周缘隆起区快速抬升且范围逐渐扩大,为坳陷盆地内提供物源,盆地内发育冲积扇、冲积平原、三角洲和浅湖相,向南发育残存潮坪—潟湖,呈南北向展布;晚二叠世基准面趋于稳定,湖相范围扩大,主要发育于盆地南部,潮坪—潟湖环境向南缩小。③研究区油气成藏受控于沉积环境,中二叠世发育的陆相三角洲沉积体系有利于形成储集层和盖层,且和下部煤系地层组成中二叠统良好的生-储-盖组合;上二叠统为氧化干旱的古气候,沉积水体较浅,形成的泥岩厚度小,生烃潜力有限,无法形成大规模气藏。

关键词：原型盆地恢复古亚洲洋闭合克拉通内坳陷盆地盆地演化构造-沉积环境三角洲沉积石盒子组石千峰组中—晚二叠世鄂尔多斯盆地