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Genome-wide transcriptome analysis of porcine epidemic diarrhea virus virulent or avirulent strain-infected porcine small intestinal epithelial cells

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Virologica Sinica 2022年第1期37卷 70-81页

作者： Ouyang Peng xiaona Wei Usama Ashraf Fangyu Hu yongbo xia Qiuping Xu Guangli Hu Chunyi Xue Yongchang Cao Hao Zhang State Key Laboratory of Biocontrol Life Sciences SchoolSun Yat-sen UniversityGuangzhou510006China Wen's Group Academy Wen's Foodstuffs Group CoLtdXinxingGuangdong527400China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan430070China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

Porcine epidemic diarrhea virus(PEDV)is the main cause of diarrhea,vomiting,and mortality in pigs,which results in devastating economic loss to the pig industry around the *** recent years,the advent of RNAsequencing technologies has led to delineate host responses at late stages of PEDV infection;however,the comparative analysis of host responses to early-stage infection of virulent and avirulent PEDV strains is currently ***,using the BGI DNBSEQ RNA-sequencing,we performed global gene expression profiles of pig intestinal epithelial cells infected with virulent(GDS01)or avirulent(HX)PEDV strains for 3,6,and 12 *** was observed that over half of all significantly dysregulated genes in both infection groups exhibited a down-regulated expression *** enrichment analyses indicated that the differentially expressed genes(DEGs)in the GDS01 group were predominantly related to autophagy and apoptosis,whereas the genes showing the differential expression in the HX group were strongly enriched in immune responses/*** the DEGs,the functional association of TLR3 and IFIT2 genes with the HX and GDS01 strains replication was experimentally validated by TLR3 inhibition and IFIT2 overexpression systems in cultured ***3 expression was found to inhibit HX strain,but not GDS01 strain,replication by enhancing the IFIT2 expression in infected *** conclusion,our study highlights similarities and differences in gene expression patterns and cellular processes/pathways altered at the early-stage infection of PEDV virulent and avirulent *** findings may provide a foundation for establishing novel therapies to control PEDV infection.

关键词： Coronavirus Porcine epidemic diarrhea virus(PEDV) Virulence Transcriptome Apoptosis Autophagy Immunity

Two families of Niho sequences having four-valued cross correlation with m-sequences Dedicated to Professor Yingbo Zhang on the Occasion of His 70th Birthday

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Science China Mathematics 2017年第12期60卷 2377-2390页

作者： FAN JinMei XU YunGe xia yongbo ZENG xiangYong Faculty of Mathematics and Statistics Hubei Key Laboratory of Applied MathematicsHubei University College of Science Guilin University of Technology Department of Mathematics and Statistics South-Central University for Nationalities

For two odd integers m and s with 1≤s < m and gcd(m, s) = 1, let h satisfy h(2~s-1) ≡1(mod 2~m+ 1) and d =(h + 1)(2~m-1) + 1. The cross correlation function between a binary m-sequence of period 22~m-1 and its d-decimation sequence is proved to take four values, and the correlation distribution is completely determined. Let n be an even integer and k be an integer with 1≤k≤n/2. For an odd prime p and a p-ary m-sequence {s(t)} of period p^n-1, define u(t) =∑(p^k-1)/2 i=0 s(d_it), where d_i = ip^(n/2) + p^k-i and i = 0, 1,...,(p^k-1)/2. It is proved that the cross correlation function between {u(t)} and {s(t)} is three-valued or four-valued depending on whether k is equal to n/2 or not, and the distribution is also determined.

关键词： m-sequence decimation sequence correlation distribution Niho exponent exponential sum

GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease

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Neuroscience Bulletin 2024年第4期40卷 451-465页

作者： Huiqin Li xiang Cao Xinya Gu Mengqi Dong Lili Huang Chenglu Mao Shengnan xia Haiyan Yang Xinyu Bao yongbo Yang Yun Xu Department of Neurology and Neurosurgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower HospitalState Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical DiseasesNanjing UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Jiangsu Provincial Key Discipline of Neurology Nanjing210008China Nanjing Neurology Medical Center Nanjing210008China

Moyamoya disease(MMD)is a chronic occlusive cerebrovascular disease with the development of a network of abnormal *** inflammation is associated with the occurrence and development of ***,the mechanisms underlying the formation of the abnormal vascular network remain ***-eight patients with MMD,26 ischemic stroke patients,and 26 unrelated healthy volunteers were enrolled in this study The data showed that the levels of granulocyte-macrophage colony-stimulating factor(GM-CSF)were higher in MMD patients than in healthy controls(P<0.01),and GM-CSF was mainly from Th1 and Th17 cells in *** found that increased GM-CSF drove monocytes to secrete a series of cytokines associated with angiogenesis,inflammation,and *** summary,our findings demonstrate for the first time the important involvement of GM-CSF in MMD and that GM-CSF is an important factor in the formation of abnormal vascular networks in MMD.

关键词： Moyamoya disease Vascular endothelial cells GM-CSF VEGF

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一类低差分均匀度幂函数的差分谱

中南民族大学学报（自然科学版） 2024年第1期43卷 126-132页

作者：夏永波包福荣彭丽娜中南民族大学数学与统计学学院武汉430074

刻画了有限域Fpn上一类低差分均匀度幂函数f(x)=x 2的差分谱,其中p和n满足pn≡3(mod 4)和pn≠27.通过研究函数f(x)的差分方程,找到了使得差分方程f(x+1)-f(x)=b有两个解的充要条件并计算了Fpn中满足条件的b的个数,从而计算出了该函数的... 详细信息

刻画了有限域Fpn上一类低差分均匀度幂函数f(x)=x 2的差分谱,其中p和n满足pn≡3(mod 4)和pn≠27.通过研究函数f(x)的差分方程,找到了使得差分方程f(x+1)-f(x)=b有两个解的充要条件并计算了Fpn中满足条件的b的个数,从而计算出了该函数的差分谱.

关键词：有限域差分均匀度差分谱差分方程

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一类新的具有大集合容量的p元低相关序列集

中国科学技术大学学报 2011年第7期41卷 636-641页

作者：夏永波中南民族大学数学与统计学学院湖北武汉430074

设p是奇素数,正整数n≥3,gcd(k,n)=1,利用有限域Fpn上的一类二次型,构造了一类新的周期为pn-1的p元序列集Fn,k.新构造的序列集的容量为p2n,最大非平凡相关值为pn/2+1+1,其相关值分布也被确定.同其他低相关序列集相比,所得的序列集Fn,k... 详细信息

设p是奇素数,正整数n≥3,gcd(k,n)=1,利用有限域Fpn上的一类二次型,构造了一类新的周期为pn-1的p元序列集Fn,k.新构造的序列集的容量为p2n,最大非平凡相关值为pn/2+1+1,其相关值分布也被确定.同其他低相关序列集相比,所得的序列集Fn,k不仅具有低的相关特性,同时还具有更大的集合容量.

关键词：二次型指数和 p元序列有限域

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p元m序列与其采样序列之间的互相关性

计算机工程与应用 2011年第35期47卷 1-3,10页

作者：夏永波中南民族大学数学与统计学学院武汉430074

设p是奇素数,n为一正偶数,且满足gcd(n-1,p+1)=1。令d=(pn-1+1)/(p+1),α是有限域Fpn的本原元,研究了周期为pn-1的p元m序列{tr1n(αt)}与其采样序列{tr1n(αdt)}之间的互相关性,确定了相关函数Cd(τ)的所有可能取值,并得到了|Cd(τ)+1|... 详细信息

设p是奇素数,n为一正偶数,且满足gcd(n-1,p+1)=1。令d=(pn-1+1)/(p+1),α是有限域Fpn的本原元,研究了周期为pn-1的p元m序列{tr1n(αt)}与其采样序列{tr1n(αdt)}之间的互相关性,确定了相关函数Cd(τ)的所有可能取值,并得到了|Cd(τ)+1|￡pn/2+1的概率。当n充分大时,该概率接近1。

关键词：相关函数指数和 p元m序列有限域

有限域上二次型序列与几何序列的互相关性(英文)

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Applied Mathematics(A Journal of Chinese Universities) 2006年第2期21卷 223-233页

作者：夏永波彭丽 School of Mathematics and Compute Science of Hubei University Wuhan 430062China

For all types of quadratic forms,the cross-correlations between geometric sequences and the newly defined quadratic form sequences are determined to extend the results presented by Klapper in 1993 and *** technique for computing cross-correlations is based on counting the number of solutions for a system of equations that consists of a quadratic form and a linear function.

关键词：有限域二次型序列几何序列互相关性

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一类新的二元序列集及其相关分布（英文）

中南民族大学学报（自然科学版） 2016年第1期35卷 145-150页

作者：夏永波上官晓天中南民族大学数学与统计学学院武汉430074

对于奇整数m≥5,构造了一类新的周期为2m-1的二元序列集,并完全确定了衡量新序列集性能的一个重要指m+3标——相关分布.新序列集的最大相关值为22+1,集合容量为22m+2m+1,和著名的Rothaus序列具有类似的相关性质,能适用于无线通信系统如C... 详细信息

对于奇整数m≥5,构造了一类新的周期为2m-1的二元序列集,并完全确定了衡量新序列集性能的一个重要指m+3标——相关分布.新序列集的最大相关值为22+1,集合容量为22m+2m+1,和著名的Rothaus序列具有类似的相关性质,能适用于无线通信系统如CDMA通信系统.

关键词： Rothaus序列序列族相关函数相关分布 BCH码

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一类二值差分函数的密码学性质及其应用

中南民族大学学报（自然科学版） 2022年第1期41卷 109-115页

作者：杜俊雨夏永波中南民族大学数学与统计学学院武汉430074

研究了有限域F_(2^(n))上回旋镖均匀度为4的密码函数F(x)=x^(2^(t)+2)+γx的性质,其中n≡2(mod4),t=n/2且ord(γ^(2^(t)-1))=3.通过研究差分方程解的数目,确定了F(x)的差分谱,结果表明该函数是二值差分的.利用二次型理论,计算了F(x)的Wa... 详细信息

研究了有限域F_(2^(n))上回旋镖均匀度为4的密码函数F(x)=x^(2^(t)+2)+γx的性质,其中n≡2(mod4),t=n/2且ord(γ^(2^(t)-1))=3.通过研究差分方程解的数目,确定了F(x)的差分谱,结果表明该函数是二值差分的.利用二次型理论,计算了F(x)的Walsh谱,进而确定了其非线性度.作为应用,利用F(x)构造一类二元线性码,确定了该线性码的重量分布.最后通过二值差分函数和2-设计之间的关系,利用该函数构造了一个2-设计.

关键词：差分谱二值差分函数线性码重量分布 2-设计

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