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Clinical efficacy of the topical application of tranexamic acid in tendon release in the hand:A randomized controlled trial

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Chinese Journal of Traumatology 2024年第3期27卷 163-167页

作者： Hao Liu jun Liu yong-Wei Wu Ming Zhou yong-jun Rui Suzhou Medical College of Soochow University Suzhou215000Jiangsu provinceChina Department of Traumatic Orthopedics Wuxi Ninth People's Hospital Affiliated to Soochow UniversityWuxi214000Jiangsu provinceChina

Purpose:To study the clinical effectiveness of the topical application of tranexamic acid in hand tendon ***:This was a randomized controlled trial conducted after receiving approval from the local ethics committee according to guidelines from the Helsinki *** patients who underwent hand tendon release operation in our hospital from January 2021 to December 2022 were included and randomly divided into 2 *** in the tranexamic acid group(40 cases)received intraoperative topical application of 2 g of tranexamic acid after tendon release,while patients in the conventional group(40 cases)did not receive topical application of tranexamic acid during *** operation time,perioperative hemoglobin changes,total blood loss,incidence of early postoperative complications,and total active movement(TAM)before surgery and 6 months after surgery were compared between the 2 *** continuous variable which follows normal distribution expressed by mean±SD and used t-test to compare between ***,categorical variables were used by Chi-square test,and a p<0.05 indicated that the differences were statistically ***:Both groups were followed up for 7-18 months,with a mean of 10.3 *** decrease in hemoglobin was significantly less in the tranexamic acid group than in the conventional group(t=7.611,p<0.001).The total blood loss in the tranexamic acid group(74.33±20.50)mL was less than that in the conventional group(83.05±17.73)mL,and the difference was statistically significant(p<0.05).Both groups showed improvement in thumb/finger flexion and extension range of motion after surgery,and the TAM improved compared with those before surgery,and the difference was statistically significant(p<0.001).The TAM improved more significantly in the tranexamic acid group(87.68°±10.44°)than in the conventional group(80.47°±10.93°)at 6 months after surgery,with a statistically significant difference(t=3.013,p<0.0

关键词： Tranexamic acid Tendon release Total active movement Tendon adhesion

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Tankyrase 2 promotes lung cancer cell malignancy

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World Journal of Clinical Oncology 2024年第6期15卷 755-764页

作者： Ying Wang yong-jun Zhang Department of Gynecological Oncology Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Integrated Traditional Chinese and Western Medicine Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina

BACKGROUND Tankyrase 2(TNKS2)is a potential candidate molecular target for the prognosis and treatment of non-small cell lung cancer(NSCLC),but its biological functions are *** To investigate the biological functions of TNKS2 in *** Using a lentiviral vector,we generated H647 model cells with TNKS2 knockdown by RNA interference and A549 model cells with TNKS2 overexpression by tran-sfection with a TNKS2 overexpressing *** and decreased exp-ression levels of TNKS2 in the two cell lines were verified using real-time reverse transcriptase-polymerase chain reaction and Western blot *** apopto-sis,proliferation,and migration were determined using flow cytometry,carbo-xyfluorescein succinimidyl ester staining,and scratch assay,***-munofluorescence staining was conducted to examine TNKS2 andβ-catenin ex-pression levels in the two transfected cell lines and the non-transfected *** TNKS2 mRNA and protein expression was significantly higher in the highly malignant NCI-H647 cells,while it remained at a low level in the less malignant A549 ***-mediated overexpression of TNKS2 in A549 cells resulted in a 3-fold increase in gene expression and a 1.7-fold increase in protein expression(P<0.01).Conversely,shRNA interference targeting TNKS2 Led to an 8-fold decrease in gene expression and a 3-fold decrease in protein expression(P<0.01)in NCI-H647 ***,the cell apoptosis rate was significantly reduced(50%)and cell migration rate was increased(35%)in the TNKS2 overexpression group than in the control group(P<0.05).In contrast,shTNKS2 promoted apoptosis by more than one fold and reduced migration by 60%(P<0.05).Immunofluorescence analysis revealed enhanced nuclear localization ofβ-catenin fluorescence signal associated with high TNKS2 expression *** blot analysis investigating TNKS2/β-catenin-related proteins indicated consistent changes between TNKS2 andβ-catenin expression in lung can

关键词： Apoptosis Migration Lung Cancer Proliferation Tankyrase 2

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Bioinformatic approaches of liquid–liquid phase separation in human disease

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中华医学杂志(英文版) 2024年第16期137卷 1912-1925页

作者： Sun jun Chen Yilong Bi Ruiye Yuan yong Yu Haopeng Department of Thoracic Surgery and West China Biomedical Big Data Center West China Hospital Sichuan University Chengdu Sichuan China Med-X Center for Informatics Sichuan University Chengdu Sichuan China Department of Orthognathic and TMJ Surgery State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China

Biomolecular aggregation within cellular environments via liquid–liquid phase separation (LLPS) spontaneously forms droplet-like structures, which play pivotal roles in diverse biological processes. These structures are closely associated with a range of diseases, including neurodegenerative disorders, cancer and infectious diseases, highlighting the significance of understanding LLPS mechanisms for elucidating disease pathogenesis, and exploring potential therapeutic interventions. In this review, we delineate recent advancements in LLPS research, emphasizing its pathological relevance, therapeutic considerations, and the pivotal role of bioinformatic tools and databases in facilitating LLPS investigations. Additionally, we undertook a comprehensive analysis of bioinformatic resources dedicated to LLPS research in order to elucidate their functionality and applicability. By providing comprehensive insights into current LLPS-related bioinformatics resources, this review highlights its implications for human health and disease.

关键词： Phase separation Liquid–liquid phase separation Disease Phase separation databases Bioinformatic tools

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Trans-PRK for recurrent epithelial corneal erosion induced by cooking oil accidentally after EVO ICL

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1953-1956页

作者： yong Ma Wan-Ru Shi Ling-Ling Niu Pei-jun Yao Xiao-Ying Wang Xing-Tao Zhou Jing Zhao Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China Key Laboratory of Myopia and Related Eye Diseases NHCShanghai 200031China Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical SciencesShanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care Shanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200031China

Dear Editor,We report a case with trans-photorefractive keratectomy(PRK)for recurrent epithelial corneal erosion caused by cooking oil after EVO-implantable contact lens(ICL)(EVO Visian ICL;STAAR Surgical AG,Switzerland),which should be distinguished from postoperative complications of *** corneal burns are classified as chemical and thermal burns,referring to direct contact injury to the cornea.

关键词： cooking erosion corneal

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C23 ameliorates carbon tetrachloride-induced liver fibrosis in mice

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World Journal of Hepatology 2024年第9期16卷 1278-1288页

作者： Rong-Xing Tang Xiao-jun Xie yong Xiong Su Li Chen Luo Yi-Gang Wang Department of Hepatopancreatobiliary Surgery Panzhihua Municipal Central HospitalPanzhihua 617000Sichuan ProvinceChina Department of Pathology Panzhihua Maternal and Children Health HospitalPanzhihua 617000Sichuan ProvinceChina

BACKGROUND C23,an oligo-peptide derived from cold-inducible RNA-binding protein(CIRP),has been reported to inhibit tissue inflammation,apoptosis and fibrosis by binding to the CIRP receptor;however,there are few reports on its role in liver fibrosis and the underlying mechanism is *** To explore whether C23 plays a significant role in carbon tetrachloride(CCl4)-induced liver *** CCl4 was injected for 6 weeks to induce liver fibrosis and C23 was used beginning in the second *** and Sirius red staining were used to examine changes in fiber *** factors in the liver were detected and changes inα-smooth muscle actin(α-SMA)and collagen I expression were detected via immu-nohistochemical staining to evaluate the activation of hematopoietic stellate cells(HSCs).Western blotting was used to detect the activation status of the trans-forming growth factor-beta(TGF-β)/Smad3 axis after C23 *** CCl4 successfully induced liver fibrosis in mice,while tumor necrosis factor-alpha(TNF-α),IL(interleukin)-1β,and IL-6 levels increased significantly and the IL-10 level decreased ***,C23 inhibited this *** the other hand,C23 significantly inhibited the activation of HSCs induced by CCl4,which inhibited the expression ofα-SMA and the synthesis of collagen *** terms of mechanism,C23 can block Smad3 phosphorylation significantly and inhibits INTRODUCTION At present there is no specific and effective drug for treating liver fibrosis caused by acute or chronic *** preclinical research has made breakthroughs,their suitability as clinical treatments is still *** activation of hepatic stellate cells(HSCs)caused by chronic inflammation is a key process in the development of liver fibrosis and activated HSCs expressα-smooth muscle actin(α-SMA)and transdifferentiate into myofibroblasts with proliferation,migration and secretion abilities,synthesizing the extracellular matrix to deposit in th

关键词： C23 oligo-peptide Carbon tetrachloride Liver fibrosis Transforming growth factor-beta/Smad3 axis

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Micro-power negative pressure wound technique reduces risk of incision infection following loop ileostomy closure

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 186-195页

作者： Deng-yong Xu Bing-jun Bai Lina Shan Hui-Yan Wei Deng-Feng Lin Ya Wang Da Wang Department of Colorectal Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Wound&Ostomy Care Clinic Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Hospital Infection Control Zhejiang Cancer HospitalHangzhou 310005Zhejiang ProvinceChina

BACKGROUND Prophylactic loop ileostomy is an effective way to reduce the clinical severity of anastomotic leakage following radical resection of rectal *** surgical site infection(SSI)is a common complication after ileostomy *** To evaluate the efficacy and safety of the micro-power negative pressure wound technique(MPNPWT)in preventing incisional *** This was a prospective,randomized controlled clinical trial conducted at a single center.A total of 101 consecutive patients who underwent ileostomy closure after rectal cancer surgery with a prophylactic ileostomy were enrolled from January 2019 to December *** were randomly allocated into an MPNPWT group and a control *** MPNPWT group underwent intermittent suturing of the surgical incision with 2-0 Prolene and was covered with a micro-power negative pressure *** surgical outcomes were compared between the MPNPWT(n=50)and control(n=51)*** factors for incisional SSI were identified using logistic *** There were no differences in baseline characteristics between the MPNPWT(n=50)and control groups(n=51).The incisional SSI rate was significantly higher in the control group than in the MPNPWT group(15.7%vs 2.0%,P=0.031).However,MPNPWT did not affect other surgical outcomes,including intra-abdominal complications,operative time,and blood *** hospital stay length and hospitalization costs did not differ significantly between the two groups(P=0.069 and 0.843,respectively).None of the patients experienced adverse effects of MPNPWT,including skin allergy,dermatitis,and *** also helped heal the infected *** study indicated that MPNPWT was an independent protective factor[odds ratio(OR)=0.005,P=0.025)]and diabetes was a risk factor(OR=26.575,P=0.029)for incisional *** MPNPWT is an effective and safe way to prevent incisional SSI after loop ileostomy closure.

关键词： Micro-power negative pressure technique Ileostomy closure Incisional surgical site infection Infection prevention Postoperative incision

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Quorum Sensing:An Emerging Role for Vibrio Infection and Host Defense

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Infectious Microbes & Diseases 2024年第2期6卷 47-55页

作者： Hao-Nan Lin Xian-Hui Huang Xin-jun Miao Wei-Lin Hu yong-Liang Lou Dan-Li Xie The School of Laboratory Medicine&Life Sciences Wenzhou Medical UniversityWenzhouChina Key Laboratory of Laboratory Medicine Ministry of Education of ChinaWenzhouChina Wenzhou Key Laboratory of Sanitary Microbiology WenzhouChina Department of Emergency Wenzhou Central HospitalWenzhouZhejiangChina Department of Microbiology School of MedicineZhejiang UniversityHangzhouChina Zhuji Institute of Biomedical Research School of PharmacyWenzhou Medical UniversityZhujiChina

Quorum sensing(QS)is a mechanism that allows bacteria to regulate various physiological and biochemical functions by secreting,sensing and responding to signaling molecules called autoinducers(AIs).In Vibrio species,QS plays a crucial role in modulating different biological *** can influence the formation of biofilms,which are communities of bacteria encased in a protective *** also controls flagella formation and motility,ensuring that Vibrio *** move efficiently in response to environmental ***ally,QS in Vibrio *** the production of different virulence factors based on cell *** enables the bacteria to adjust their virulence strategies accordingly,enhancing *** also influences the interaction between Vibrio *** their ***ing infection by Vibrio spp.,QS can affect the host immune response and colonization *** the role of QS in these interactions is crucial for unraveling the complex dynamics between Vibrio *** the *** summary,research on QS in Vibrio *** revealed its significance in regulating various biological phenotypes,controlling virulence factor production and affecting host de*** provides valuable insights into the intricate mechanisms underlying microbial behavior,host adaptation and Vibrio ***.

关键词： quorum sensing Vibrio species biological phenotype bacterial virulence host defense

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灰色欧拉优化模型及其应用

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控制与决策 2024年第6期39卷 2060-2068页

作者：王安党耀国王俊杰南京航空航天大学经济与管理学院南京211106 平顶山学院数学与统计学院河南平顶山467002

针对一类具有近似幂函数特征的序列建模预测问题,通过引入非齐次欧拉方程,提出一种优化的灰色欧拉模型.对该模型的建模机理、参数估计和时间响应式等进行研究,讨论以误差平方和最小为目标,对灰色欧拉模型的初始点进行优化,研究灰色欧拉... 详细信息

针对一类具有近似幂函数特征的序列建模预测问题,通过引入非齐次欧拉方程,提出一种优化的灰色欧拉模型.对该模型的建模机理、参数估计和时间响应式等进行研究,讨论以误差平方和最小为目标,对灰色欧拉模型的初始点进行优化,研究灰色欧拉模型的3种基本形式和3种优化形式.该模型能很好地拟合幂函数特征的序列,拓展灰色预测理论的体系,扩大灰色预测理论的应用范围.最后,利用中国能源消费量和幂函数拟合两个实例来测试模型的有效性,结果表明,所提出的新模型具有更好的拟合和预测精度.

关键词： GM(1 1)模型 GEM(1 1)模型 OSGEM(1 1)模型最小二乘法

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Artificial Water Channel Promoting Depolymerization of Actin Filaments to Trigger Cancer Cell Apoptosis

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Chinese Journal of Chemistry 2024年第12期42卷 1335-1340页

作者： Lei Zhang Yin-Gui Cao Ting Fan Jjiatong Zhao yong-Hong Fu Qi Xiao Zhan-Ting Li Yunfeng Wang Bo Xiao jun-Li Hou Department of Chemistry Fudan University220 Handan RoadShanghai 200433China State Key Laboratory of Silkworm Genome Biology Cllege of SericultureTextileand Biomass Sciences InstitutionSouthwest UniversityChongqing400715China ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital Fudan UniversityShanghai 200031 Fudan International School 325 Guoquan RoadShanghai 200433China

Actin filaments play important physiological functions,which have become potential targets of antitumor *** chemicals to intervene their polymerization-depolymerization dynamics would generate new strategies for designing antitumor *** this report,an artificial water channel appending acetazolamide moiety,a ligand that can selectively bind to carbonic anhydrase IX,has been prepared.

关键词： Artificial water channel Actin depolymerization Cell apoptosis Nanostructures Molecular recognition Supramolecular chemistry

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Meiotic transcriptional reprogramming mediated by cell-cell communications in humans and mice revealed by scATACseq and scRNA-seq

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Zoological Research 2024年第3期45卷 601-616页

作者： Hai-Quan Wang Xiao-Long Wu Jing Zhang Si-Ting Wang yong-Juan Sang Kang Li Chao-Fan Yang Fei Sun Chao-jun Li State Key Laboratory of Reproductive Medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Medical School Nanjing UniversityNanjingJiangsu 210093China Zhejiang University School of Medicine HangzhouZhejiang 310016China Department of Urology and Andrology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China Model Animal Research Center of Medical School Nanjing UniversityNanjingNanjingJiangsu 210093China Liangzhu Laboratory Zhejiang UniversityHangzhouZhejiang 311121China

Meiosis is a highly complex process significantly influenced by transcriptional ***,studies on the mechanisms that govern transcriptomic changes during meiosis,especially in prophase I,are ***,we performed single-cell ATAC-seq of human testis tissues and observed reprogramming during the transition from zygotene to pachytene *** event,conserved in mice,involved the deactivation of genes associated with meiosis after reprogramming and the activation of those related to spermatogenesis before their functional ***,we identified 282 transcriptional regulators(TRs)that underwent activation or deactivation subsequent to this *** suggested that physical contact signals from Sertoli cells may regulate these TRs in spermatocytes,while secreted ENHO signals may alter metabolic patterns in these *** results further indicated that defective transcriptional reprogramming may be associated with non-obstructive azoospermia(NOA).This study revealed the importance of both physical contact and secreted signals between Sertoli cells and germ cells in meiotic progression.

关键词： Single-cell RNA-seq Single-cell ATAC-seq Spermatogenesis Meiosis Transcriptional reprogramming Cell-cell communication

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