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An Advanced Image Processing Technique for Backscatter-Electron Data by Scanning Electron Microscopy for Microscale Rock Exploration

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Journal of Earth Science 2024年第1期35卷 301-305页

作者： Zhaoliang Hou Kunfeng Qiu tong Zhou yiwei Cai Frontiers Science Center for Deep-time Digital Earth China University of GeosciencesBeijing 100083China Department of Geology University of ViennaVienna 1090Austria State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChinaUniversity of GeosciencesBeijing 100083China

Backscatter electron analysis from scanning electron microscopes(BSE-SEM)produces high-resolution image data of both rock samples and thin-sections,showing detailed structural and geochemical(mineralogical)*** allows an in-depth exploration of the rock microstructures and the coupled chemical characteristics in the BSE-SEM image to be made using image processing *** image processing is a powerful tool for revealing the more subtle data“hidden”in a picture,it is not a commonly employed method in geoscientific microstructural ***,we briefly introduce the general principles of image processing,and further discuss its application in studying rock microstructures using BSE-SEM image data.

关键词： Image processing rock microstructures electron-based imaging data mining

Single-cell atlas reveals a distinct immune profile fostered by T cell-B cell crosstalk in triple negative breast cancer

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Cancer Communications 2023年第6期43卷 661-684页

作者： Shuning Ding Niu Qiao Qingchen Zhu yiwei tong Shengyue Wang Xiaosong Chen Qiang Tian Yichuan Xiao Kunwei Shen Department of General Surgery Comprehensive Breast Health CenterRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiP.R.China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China Chinese Academy of Sciences Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghaiP.R.China

Background:Characterizing the unique immune microenvironment of each tumor is of great importance for better predicting prognosis and guiding cancer ***,the unique features of the immune microenvironment of triple negative breast cancer(TNBC)compared with other subtypes of breast cancer remain ***,we aimed to depict and compare the immune landscape among TNBC,human epidermal growth factor receptor 2-positive(HER2^(+))breast cancer,and luminal-like breast ***:Single-cell RNA sequencing(scRNA-seq)was performed on CD45^(+)immune cells isolated from human normal breast tissues and primary breast tumors of various *** analyzing the scRNA-seq data,immune cell clusters were identified and their proportions as well as transcriptome features were compared among TNBC,human HER2^(+)breast cancer,and luminal-like breast *** and cell-cell communication analyses were also conducted to characterize the immune ***:ScRNA-seq data of 117,958 immune cells were obtained and 31 immune clusters were identified.A unique immunosuppressive microenvironment in TNBC was decoded as compared to that in HER2^(+)or luminal-like breast cancer,which was characterized by higher proportions of regulatory T cells(Tregs)and exhausted CD8+T cells and accompanied by more abundant plasma *** and exhausted CD8+T cells in TNBC exhibited increased immunosuppression signature and dysfunctional *** analyses showed that B cells tended to differentiate to plasma cells in ***-cell communication analyses indicated that these unique features are fostered by the diversified T cell-B cell crosstalk in *** on the T cell-B cell crosstalk,a prognostic signaturewas established that could effectively predict the prognosis status for patients with ***,it was found that TNBC had a higher proportion of cytotoxic natural killer(NK)cells,whereas HER2^(+)or luminal-like breast cancer lost this f

关键词： breast cancer prognostic signature single-cell RNA sequencing T cell-B cell crosstalk triplenegative breast cancer tumor immune microenvironment

Estimating Multiple Socioeconomic Attributes via Home Location-A Case Study in China

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Journal of Social Computing 2021年第1期2卷 71-88页

作者： Shichang Ding Xin Gao Yufan Dong yiwei tong Xiaoming Fu State Key Laboratory of Mathematical Engineering and Advanced Computing Zhengzhou 276800China Department of Sociology Tsinghua UniversityBeijing 100085China Institute of Computer Science University of GottingenGottingen 37077Germany Shanghai Hejin Information Technology Company Shanghai 200100China

Inferring people’s Socioeconomic Attributes(SEAs),including income,occupation,and education level,is an important problem for both social sciences and many networked applications like targeted advertising and personalized *** works mainly focus on estimating SEAs from peoples’cyberspace behaviors and relationships,such as the content of tweets or the social networks between online *** cyberspace data,alternative data sources about users’physical behavior,like their home location,may offer new *** specifically,in this paper,we study how to predict a person’s income level,family income level,occupation type,and education level from his/her home *** a case study,we collect people’s home locations and socioeconomic attributes through a survey involving 9 provinces and 85 cities in *** further enrich home location with the knowledge from real estate websites,government statistics websites,online map services,*** learn a shared representation from input features as well as attribute-specific representations for different SEAs,we propose H2SEA,a factorization machine-based multi-task learning method with attention *** experiment results show that:(1)Home location can clearly improve the estimation accuracy for all SEA prediction tasks(e.g.,80.2%improvement in terms of F1-score in estimating personal income level);(2)The proposed H2SEA model outperforms alternative models for SEA inference in terms of various evaluation metrics,such as Area Under Curve(AUC),F-measure,and specificity;(3)The performance of specific SEA prediction tasks(e.g.,personal income)can be further improved if H2SEA only focuses on cities or villages due to urban-rural gap in China;(4)Compared with online crawled housing price data,the area-level average income and Points Of Interest(POI)are more important features for SEA inferences in China.

关键词： personal income family income occupation education multi-task learning

Combination losartan with hyaluronic acid modified diethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis

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Chinese Chemical Letters 2024年第3期35卷 406-414页

作者： Haili Hu Weiwei Zhang Lei Lei Fan tong Huilin Zhang yiwei Zhang Wenqin Yang Yilu Tang Ruyi Lin Xue Xia Jiamei Li Shiyong Song Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Pharmacy Henan UniversityKaifeng 475004China Department of Public Health Chengdu Medical CollegeChengdu 610500China

The application of photothermal therapy(PTT)is greatly limited by the low accumulation of photothermal agents,uneven photothermal distribution,and heat endurance of cancer *** still,despite PTT enhances immunogenicity,the anti-tumor immune efficacy is still unsatisfactory due to the inefficient immunogenic cell death(ICD)induction and poor infiltration of immune *** solve the above problems of PTT,we developed hyaluronic acid(HA)modified hollow copper sulfide nanoparticles encapsulating diethyldithiocarbamate(DDTC)to construct a breast tumor targeting and near infrared(NIR)photo-responsive drug delivery system(D-HCuS@HA),which further combined with losartan to improve the accumulation and penetration in the tumor *** irradiation,D-HCuS@HA realized enhanced PTT and released cytotoxic Cu(DDTC)_(2)to eliminate heat endurance tumor cells,thereby enhancing antitumor effect and inducing effective ***,the combination with losartan could remodel the tumor microenvironment,allowing more T cells to infiltrate into the tumor,and significantly inhibiting the occurrence and development of metastatic *** vitro/vivo results revealed the great potential of D-HCuS@HA combined with losartan,which provides a new paradigm for anti-tumor and anti-metastases.

关键词： Targeted drug delivery system Hollow copper sulfide nanoparticles Photothermal therapy Hyaluronic acid Breast cancer Anti-metastasis

330 kV变电站快速转供电的模块化技术研究

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电力勘测设计 2023年第11期 1-6,78页

作者：童亦崴康乐中国能源建设集团陕西省电力设计院有限公司陕西西安710054

随着社会经济的不断发展,电网发展越来越快。330 kV超高压变电站内设备重要性高,布置复杂,停电困难,在事故、基建、技改、抢修和自然灾害等情况下,站内有大量转供电需求,但实施难度较大、周期较长。本文结合模块化设计思路,从方案设计... 详细信息

随着社会经济的不断发展,电网发展越来越快。330 kV超高压变电站内设备重要性高,布置复杂,停电困难,在事故、基建、技改、抢修和自然灾害等情况下,站内有大量转供电需求,但实施难度较大、周期较长。本文结合模块化设计思路,从方案设计、绝缘特性及快速运输三个方面阐述330 kV变电站快速转供电方案。该方案的实施可迅速替代站内常规变压器,有效降低转供电实施难度,缩减停电时间,减少全寿命周期的投资费用。该方案可为提高电网安全稳定过渡及抵御风险发挥重要作用,具有良好的社会效益和经济效益。

关键词： 330 kV变电站模块化技术应急供电快速转供电

基于长波段雷达卫星的供水管网探漏技术及实践

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给水排水 2023年第2期49卷 131-137页

作者：佟怿维尹宁郭晨张晓虎崔言沈涛杨光靳林北京市自来水集团有限责任公司管网管理分公司北京100089 北京博宇智图信息技术有限公司北京100102

城市供水管道的泄漏,不仅造成严重的水资源浪费,而且对供水管网系统安全和居民的生产、生活用水安全保障带来严重的影响。基于长波段雷达卫星的城市地下管道漏水检测技术,通过提取介电常数,获取地下土壤中的水分信息,进而可检测出漏水区... 详细信息

城市供水管道的泄漏,不仅造成严重的水资源浪费,而且对供水管网系统安全和居民的生产、生活用水安全保障带来严重的影响。基于长波段雷达卫星的城市地下管道漏水检测技术,通过提取介电常数,获取地下土壤中的水分信息,进而可检测出漏水区域,确定漏水点位置。利用卫星探漏技术对北京五环内的管线进行定期检测,近五年的应用实践证明其确实能够全面、快速、高效地检测出供水管道的漏水点,极大地提高了主动检漏效率,且该技术不受天气、管材、管径、埋深的限制,具有较好的适用性。

关键词：卫星探漏供水管网漏损控制雷达卫星

腋窝临床淋巴结阳性超声特征与乳腺癌淋巴结转移负荷及预后的相关性研究

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中国癌症防治杂志 2022年第4期14卷 393-399页

作者：李卓璇童一苇陈小松沈坤炜上海交通大学医学院附属瑞金医院普外科乳腺疾病诊治中心上海200025

目的分析腋窝临床淋巴结阳性乳腺癌患者的腋窝淋巴结超声特征,探索超声特征与腋窝淋巴结转移负荷及患者预后的相关性。方法研究入组2009年1月至2020年12月于本中心接受腋窝淋巴结清扫术的临床淋巴结阳性乳腺癌患者,分析可预测腋窝淋巴... 详细信息

目的分析腋窝临床淋巴结阳性乳腺癌患者的腋窝淋巴结超声特征,探索超声特征与腋窝淋巴结转移负荷及患者预后的相关性。方法研究入组2009年1月至2020年12月于本中心接受腋窝淋巴结清扫术的临床淋巴结阳性乳腺癌患者,分析可预测腋窝淋巴结转移负荷的临床病理指标和超声指标。利用多因素Cox回归分析影响患者预后的超声指标。结果共纳入1055例乳腺癌患者,其中低淋巴结负荷(1-2枚淋巴结转移)398例(37.7%),高淋巴结负荷(≥3枚淋巴结转移)657例(62.3%)。多因素分析显示,患者年龄≥55岁(OR=1.56,95%CI:1.20-2.02,P=0.001),超声肿瘤大小<20.0 mm(OR=1.54,95%CI:1.14-2.09,P=0.005)、超声淋巴结长径<20.0 mm(OR=2.03,95%CI:1.48-2.79,P<0.001)、超声淋巴结短径<8.6 mm(OR=1.41,95%CI:1.06-1.89,P=0.019)和超声可疑淋巴枚数1-2枚(OR=2.74,95%CI:1.63-4.61,P<0.001)与低淋巴结负荷独立相关。孕激素受体和淋巴结长径是DFS(HR=2.06,95%CI:1.21-3.50,P=0.008;HR=1.66,95%CI:1.15-2.40,P=0.007)和OS(HR=4.53,95%CI:2.18-9.59,P<0.001;HR=3.49,95%CI:1.96-6.20,P<0.001)的独立预测因素。结论超声特征有助于预测腋窝临床淋巴结阳性乳腺癌患者的淋巴结转移负荷及预后,指导后续个体化治疗。

关键词：乳腺癌临床淋巴结阳性淋巴结转移负荷超声特征前哨淋巴结预后

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SOD3免疫调节作用的研究进展

中国科学：生命科学 2024年第7期54卷 1197-1210页

作者：刘童李其龙吕坤荧张义伟陈启军沈阳农业大学动物科学与医学学院重要家畜疫病研究教育部重点实验室沈阳110866 农业农村部反刍动物重大疫病防控重点实验室(东部) 沈阳110866

超氧化物歧化酶3(superoxide dismutase 3,SOD3)是一种作用于细胞外的抗氧化酶,其主要功能是催化超氧化物转化为过氧化氢和氧.最近有研究表明,SOD3还参与多种疾病的免疫调节过程.在宿主体内,宿主来源的SOD3直接参与调控氧化应激、免疫... 详细信息

超氧化物歧化酶3(superoxide dismutase 3,SOD3)是一种作用于细胞外的抗氧化酶,其主要功能是催化超氧化物转化为过氧化氢和氧.最近有研究表明,SOD3还参与多种疾病的免疫调节过程.在宿主体内,宿主来源的SOD3直接参与调控氧化应激、免疫细胞的成熟、增殖和分化及炎症反应等免疫调节过程.此外,病原体也可以高表达SOD3逃避宿主免疫防御,并通过抑制宿主的细胞反应以完成入侵过程.SOD3表达水平也与多种免疫相关疾病进展密切相关.因此,SOD3有望成为免疫治疗的关键靶点.本文对SOD3免疫调节作用的研究进展进行了综述.

关键词：超氧化物歧化酶3 免疫调节免疫功能障碍寄生虫疾病

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北方某城市供水管道破损分析及预防措施研究

给水排水 2023年第5期49卷 150-155页

作者：郭金鹏齐轶昆刘彦辉王敏杨海燕佟怿维尚毅峰北京市自来水集团有限责任公司北京100032 北京建筑大学环境与能源工程学院北京100044

从市政供水管道破损事故发生的角度出发,全面分析了北方某城市2011年至2020年供水管道破损事故的相关数据,发现管道破损事故类型较多的是腐蚀性漏眼和环状断裂;镀锌管、钢塑复合管和铸铁管是发生破损事故较多的管材;易发生破损事故的管... 详细信息

从市政供水管道破损事故发生的角度出发,全面分析了北方某城市2011年至2020年供水管道破损事故的相关数据,发现管道破损事故类型较多的是腐蚀性漏眼和环状断裂;镀锌管、钢塑复合管和铸铁管是发生破损事故较多的管材;易发生破损事故的管道管龄和管径分别为10年~19年和DN15~DN50;单位管道长度破损事故发生频次最高的管材为镀锌管。根据管道破损事故相关信息,深入剖析了破损事故发生的可能原因,并从技术和管理角度提出了预防管道破损事故的有效措施。

关键词：市政供水管道破损事故管材类型原因分析预防措施