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Clinical features and treatment outcomes of major depressive disorder with genital symptoms

Chinese Medical Journal 2024年第5期137卷 622-624页

作者： Xiaohui Wu Yuncheng Zhu Ping Sun Shuo Wang Zhiguo Wu Jia Huang Lan Cao Yun Wang Yousong Su Zhijian Yao Zuowei Wang Fan Wang Yong Wang Daihui Peng Jun Chen yiru fang Department of Clinical Research Center&Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai 200083China Department of Psychiatry Nanjing Medical University Affiliated Brain HospitalNanjingJiangsu 210029China Department of Psychiatry&Affective Disorders Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 200118China

To the Editor:Major depressive disorder(MDD)is a mood disorder characterized by complex patterns of emotional,cognitive,and behavioral symptomology and deficits in daily functioning.Genital symptoms,including a reduction in libido and menstrual disturbances,have been considered to be a classic symptom of MDD for many decades.Previous evidence has reached a broad consensus that the incidence of genital symptoms is higher in patients with MDD than in the general population.A systematic review and meta-analysis found a bidirectional association between MDD and genital symptoms,with patients with MDD showing a 50–70%increased risk of developing genital symptoms,while individuals with genital symptoms had a 130–210%increased risk of developing MDD.^([1])As previously reported,50–70%of people with MDD experience sexual dysfunction.^([2])To date,few studies have focused on the comparison of clinical features between patients with MDD with and without genital symptoms,and the longitudinal prognosis.

关键词： symptoms Clinical features

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Synthesis of atomically dispersed cationic nickel-confined mesoporous ZSM-48(ANMZ-48)directed by metal complexes in amphiphilic molecules

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Science China Chemistry 2024年第1期67卷 343-350页

作者： Yu Chen Quanzheng Deng yiru Mao Yuxi fang Zhihua Cao Honggen Peng Shunai Che Lu Han School of Chemical Science and Engineering Tongji UniversityShanghai 200092China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Resources and Environment Nanchang UniversityNanchang 330031China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China

The synthesis of mesoporous zeolite-anchored atomically dispersed metal catalysts(ADCs)is a considerable challenge in chemistry and materials science.Here we report the synthesis of atomically dispersed cationic nickel-confined mesoporous ZSM-48(ANMZ-48)by in situ hydrothermal reaction employing a designed tri-functional metal complex template,by which the triquaternary ammonium groups in the hydrophilic region direct the formation of ZSM-48 zeolite;the aromatic groups in the hydrophobic tail generate the mesopores through π-π stacking;and the complexes formed by nickel ions coordinated with terpyridyl groups generate atomically dispersed Ni2+confined in zeolite frameworks due to the strong sintering resistance generated by the strong coordination interaction.The ANMZ-48 is consisting of stacking of sheet-like ZSM-48 domains connected by multiply crystal twinning sharing the common(011)plane,generating abundant of imbedded mesopores with the uniform thickness of~2.4 nm and with the width of 10-50 nm.The excellent catalytic activity and stability of ANMZ-48 were also reflected in the dry reforming of methane(DRM)reaction.

关键词： atomically dispersed catalyst mesoporous zeolite ZSM-48 in situ hydrothermal synthesis the dry reforming of methane reaction

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A Breakthrough in Understanding the Rapid Antidepressant Effect of Ketamine Based on Structural Analysis

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Neuroscience Bulletin 2022年第2期38卷 229-231页

作者： Hongmei Liu Xiaohui Wu Jun Chen yiru fang Clinical Research Center Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic disorders Shanghai 201108China

Major depressive disorder(MDD)is one of the most common and serious mental diseases.Its overall 12-month prevalence rate is〜6%,while the lifetime risk increases about twofold(15%-18%),which means almost one in five people will experience at least one depressive episode during their lifetime[1].MDD is characterized by sad emotion accompanied by anhedonia,lack of energy or appetite,sleep disturbance,and low self-evaluation.In severe cases,suicidal ideation/attemp^ehavior or self-injurious behavior may occur,which seriously affects patients'daily life and social function.In 2010,MDD was listed as the second greatest disease burden in the world,and is expected to rank first by 2030[2].

关键词： function lifetime listed

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Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications

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Neuroscience Bulletin 2021年第6期37卷 863-880页

作者： Zezhi Li Meihua Ruan Jun Chen yiru fang Clinical Research Center and Division of Mood Disorders of Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Department of Neurology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Shanghai Institute of Nutrition and Health Shanghai Information Center for Life SciencesChinese Academy of ScienceShanghai 200031China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of ScienceShanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108China

Major depressive disorder(MDD),also referred to as depression,is one of the most common psychiatric disorders with a high economic burden.The etiology of depression is still not clear,but it is generally believed that MDD is a multifactorial disease caused by the interaction of social,psychological,and biological aspects.Therefore,there is no exact pathological theory that can independently explain its pathogenesis,involving genetics,neurobiology,and neuroimaging.At present,there are many treatment measures for patients with depression,including drug therapy,psychotherapy,and neuromodulation technology.In recent years,great progress has been made in the development of new antidepressants,some of which have been applied in the clinic.This article mainly reviews the research progress,pathogenesis,and treatment of MDD.

关键词： Major depressive disorder Pathogenesis Treatment Progress

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Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review

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General Psychiatry 2020年第1期33卷 8-19页

作者： Yiming Chen Wu Hong yiru fang Clinical Research Center&Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology ShanghaiChina

Disturbance of biological rhythms contributes to the onset of bipolar disorders and is an important clinical feature of the condition.To further explore the role of biological rhythms in bipolar disorders,95 English articles published between 1968 and 2019 were retrieved from the PubMed database and analysed.We herein review the outcomes of studies on biological rhythm disturbance in bipolar disorders,including the epidemiology,aetiology,clinical features(eg,sleep,feeding and eating disorders)and treatment of the condition evaluated by patients*selfreport and biological indicators such as melatonin.Our report supports the characterisation of biological rhythm disturbance as a significant clinical feature affecting the onset and development of bipolar disorders and reviews classical and novel treatments,such as chronotherapy,that can be applied in the clinical practice.Our analysis indicates that a more comprehensive study of the pathophysiology,clinical phenomenology and treatment of biological rhythm disturbance is required.

关键词： epidemiology bipolar disturbance

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Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder

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Neuroscience Bulletin 2021年第8期37卷 1176-1187页

作者： Yuncheng Zhu Xiaohui Wu Rubai Zhou Oliver Sie Zhiang Niu fang Wang yiru fang Division of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai200083China Clinical Research Center Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai200030China Shanghai Medical College Fudan UniversityShanghai200032China Shanghai Yangpu Mental Health Center Shanghai200093China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai201108China

Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological changes.Glucocorticoid,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion disorders.In this review,we summarize the independent and interactive functions of these three axes in female MDD patients.The similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA.

关键词： Major depressive disorder Neurosecretory systems Sex steroid hormones

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Disturbances of affective cognition in mood disorders

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Science China(Life Sciences) 2021年第6期64卷 938-941页

作者： Jun Chen Zuowei Wang Zezhi Li Daihui Peng yiru fang Clinical Research Center&Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Guangzhou 510515China Hongkou District Mental Health Center of Shanghai Shanghai 200083China Ren Ji Hospital Shanghai Jiao Tong University School of MedicineShanghai 200127China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108China

Mood disorders,also known as affective disorders,result in a consistent disturbance in mood.There are two major subtypes of mood disorders,i.e.,major depressive disorder(MDD)and bipolar disorder(BD).Mood disorders affect hundreds of millions of people and are the most common mental disorders.According to China’s national survey in2009(Phillips et al.,2009),the weighted 12-month prevalence of mental disorders was 17.5%and 9.3%,respectively.Mood disorders were among the highest prevalence rate disorders related to disease’s increased burdens.

关键词： disorders prevalence al.

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Perspective on Etiology and Treatment of Bipolar Disorders in China: Clinical Implications and Future Directions

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Neuroscience Bulletin 2019年第4期35卷 608-612页

作者： Zuowei Wang Chen Jun Kerning Gao Haichen Yang yiru fang Division of Mood Disorders Hongkou District Mental Health Center Shanghai 200083 China Division of Mood Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China Case Western Reserve University School of Medicine Cleveland OH 44106 USA Mood and Anxiety Clinic in the Mood Disorders Program of the Department of Psychiatry University Hospital Cleveland Medical Center Cleveland OH 44106 USA Department of Mood Disorders Shenzhen Mental Health Centre Shenzhen 518003 China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031 China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108 China

Bipolar disorder (BD) is a chronic, recurrent, disabling disease, even when given currently-available pharmacological and psychological treatments. Currently, the etiology and pathogenesis of BD remain unclear. As a consequence, patients with BD are frequently unrecognized, misdiagnosed, and inappropriately treated, which often yields a low treatment response and poor outcome.

关键词： Perspective Future Directions Bipolar Disorders

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The Relationship Between Neuroimmunity and Bipolar Disorder:Mechanism and Translational Application

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Neuroscience Bulletin 2019年第4期35卷 595-607页

作者： Zhiang Niu Lu Yang Xiaohui Wu Yuncheng Zhu Jun Chen yiru fang Clinical Research Center Division of Mood Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031 China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108 China

Neuroimmune system may be involved in the pathological process of bipolar disorder(BD),but the essential association is not fully understood.Accumulating evidence has shown that BD involves the activation of immune cells and the release of inflammatory substances in the central nerve system(CNS).Meanwhile,neuroimmune responses also interact with other hypothesis of the etiology of BD that are widely recognized,such as neurotransmitter systems,neuroendocrine systems,neurotrophic factors,and oxidative stress.Simultaneously,related genes and immune changes in peripheral blood vary with it.Overall,neuroimmunity may play an important role in the pathogenesis of BD,and the inflammatory cytokines,especially interleukin-6 and tumor necrosis factor-alpha,have potential value for the clinical diagnosis and prognosis of BD,as well as predicting the therapeutic effects of drugs.Large-scale studies are needed to extend the evidence on neuroimmunity in BD,and to examine its clinical value for applications such as early prediction and treatment.

关键词： Neuroimmunity Inflammation Cytokines Bipolar disorder Translational application

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Early Diagnosis of Bipolar Disorder Coming Soon:Application of an Oxidative Stress Injury Biomarker(BIOS)Model

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Neuroscience Bulletin 2022年第9期38卷 979-991页

作者： Zhiang Niu Xiaohui Wu Yuncheng Zhu Lu Yang Yifan Shi Yun Wang Hong Qiu Wenjie Gu Yina Wu Xiangyun Long Zheng Lu Shaohua Hu Zhijian Yao Haichen Yang Tiebang Liu Yong Xia Zhiyu Chen Jun Chen yiru fang Clinical Research Center and Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai200030China Division of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai200083China Information and Statistics Department Shanghai Mental Health CenterShanghai200030China Department of Psychiatry Tongji HospitalTongji University School of MedicineShanghai200333China Department of Psychiatry First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Nanjing Brain Hospital The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing210029China Shenzhen Mental Health Center Shenzhen518003China Affiliated Mental Health Center Zhejiang University School of MedicineHangzhou Seventh People’s HospitalHangzhou310013China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai201108China

Early distinction of bipolar disorder(BD)from major depressive disorder(MDD)is difficult since no tools are available to estimate the risk of BD.In this study,we aimed to develop and validate a model of oxidative stress injury for predicting BD.Data were collected from 1252 BD and 1359 MDD patients,including 64 MDD patients identified as converting to BD from 2009 through 2018.30 variables from a randomly-selected subsample of 1827(70%)patients were used to develop the model,including age,sex,oxidative stress markers(uric acid,bilirubin,albumin,and prealbumin),sex hormones,cytokines,thyroid and liver function,and glycolipid metabolism.Univariate analyses and the Least Absolute Shrinkage and Selection Operator were applied for data dimension reduction and variable selection.Multivariable logistic regression was used to construct a model for predicting bipolar disorder by oxidative stress biomarkers(BIOS)on a nomogram.Internal validation was assessed in the remaining 784 patients(30%),and independent external validation was done with data from 3797 matched patients from five other hospitals in China.10 predictors,mainly oxidative stress markers,were shown on the nomogram.The BIOS model showed good discrimination in the training sample,with an AUC of 75.1%(95%CI:72.9%–77.3%),sensitivity of 0.66,and specificity of 0.73.The discrimination was good both in internal validation(AUC 72.1%,68.6%–75.6%)and external validation(AUC 65.7%,63.9%–67.5%).In this study,we developed a nomogram centered on oxidative stress injury,which could help in the individualized prediction of BD.For better real-world practice,a set of measurements,especially on oxidative stress markers,should be emphasized using big data in psychiatry.

关键词： Early recognition Bipolar disorder Big data Oxidative stress BIOS model

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