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Atomically dispersed Ni electrocatalyst for superior urea-assisted water splitting

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Journal of Energy Chemistry 2024年第3期90卷 1-6,I0002页

作者： Fang Luo Shuyuan Pan yuhua Xie Chen Li yingjie yu Zehui Yang College of Materials Science and Engineering State Key Laboratory of New Textile Materials&Advanced Processing TechnologyWuhan Textile UniversityWuhan 430200China Hubei Hydrogen Energy Technology Innovation Center Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074HubeiChina

Urea oxidation reaction(UOR) has been selected as substitution for oxygen evolution reaction ascribing to its low thermodynamic voltage as well as utilization of nickel as ***,we report the formation of nickel single atoms(Ni-SAs) as exceptional bifunctional electrocatalyst toward UOR and hydrogen evolution reaction(HER) in urea-assisted water *** UOR catalysis,Ni-SAs perform a superior catalytic performance than Ni-NP/NC and Pt/C ascribing to the formation of HOO-Ni-N_(4) structure evidenced by in-situ Raman spectroscopy,corresponding to a boosted mass activity by 175-fold at 1.4 V *** than Ni-NP/***,Ni-SAs requires only 450 mV overpotential to obtain HER current density of 500 mA cm^(-2).136 mA cm^(-2) is achieved in urea-assisted water splitting at1.7 V for Ni-SAs,boosted by 5.7 times than Pt/C-IrO_(2) driven water splitting.

关键词： Urea oxidation reaction Hydrogen evolution reaction Nickel single atoms Water splitting

Sliding mode control of supercavitating vehicles in the vertical plane using guaranteed cost theory

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High Technology Letters 2011年第2期17卷 186-190页

作者：吕瑞 Wei yingjie Zhang Jiazhong yu Kaiping Wang Jinghua School of Astronautics Harbin Institute of Technology Harbin 150001 P.R. China

This paper focuses on robust control problems for supercavitating vehicles in the vertical plane. Firstly, for the mathematical model with mismatched uncertainties, the robust sliding mode function is designed based on the guaranteed cost theory, and a sufficient condition for the existence is given in terms of linear matrix inequality （LMI）. Secondly, a continuous sliding mode controller is proposed to handle the nonlinear, time - varying behavior of the vehicles. Simulation results demonstrate that the system responds rapidly and has good robust stability. Therefore, it provides theoretical references for further study on control problems of supercavitating vehicles.

关键词： supercavitating vehicles mismatched uncertainties guaranteed cost control linear matrix inequality (LMI) sliding mode control

Visible-light-irradiated tandem sulfonylation/cyclization of indole tethered alkenes for the synthesis of tetrahydrocarbazoles

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Chinese Chemical Letters 2022年第11期33卷 4886-4890页

作者： yingjie yu Aiyao Liu Jingrui He Chengting Wang Haibo Mei Jianlin Han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

A visible-light-mediated reaction of indole derivatives employing arylsulfonyl chlorides as sulfonyl surrogates has been developed,which proceeds via the sequence of reduction of sulfonyl chloride,sulfonylation,and intramolecular *** mild protocol transforms a diverse array of indole tethered alkenes and simple sulfonyl chlorides into highly valuable functionalized tetrahydrocarbazoles in good *** reaction is also suitable for gram-scale synthesis,which provides an efficient and green access to multi-substituted tetrahydrocarbazoles.

关键词： Visible-light-irradiation Sulfonylation Tetrahydrocarbazoles Indoles Tandem radical reaction Sulfonyl chlorides

Corrosion mechanism of CuAl-NiC abradable seal coating system——The influence of porosity,multiphase,and multilayer structure on the corrosion failure

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Journal of Materials Science & Technology 2021年第29期88卷 258-269页

作者： yumeng Ni Fan Zhang Demian I.Njoku yingjie yu Jinshan Pan Meijiang Meng Ying Li Corrosion and Protection Division Shenyang National Laboratory for Materials ScienceInstitute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Material Science and Technology University of Science and Technology of ChinaShenyang110016China Department of Engineering and Design School of Engineering and InformaticsUniversity of SussexBrightonBN19RHUnited Kingdom Division of Surface and Corrosion Science KTH Royal Institute of TechnologyDrottning Kristinas väg.51SE-10044StockholmSweden Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang110819China

In this study,the corrosion behavior of the CuAl-NiC abradable seal coating system in chloride solution was investigated to systematically research the effect of porosity,multiphase,and multilayer structure on the corrosion *** the composition and structure analysis,the corrosion process of the system was predicted and then verified with mercury intrusion porosimetry,cross-section SEM/EDS analysis,and electrochemical *** results demonstrated that the interphase selective corrosion caused the porosity of the top layer to decrease first and then increase during the corrosion *** interlayer galvanic corrosion,determined by the pore connectivity,is crucial for corrosion failure.

关键词： Abradable seal coating system Galvanic corrosion Multilayer Porosity

Antibody-platinum(IV)prodrugs conjugates for targeted treatment of cutaneous squamous cell carcinoma

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Journal of Pharmaceutical Analysis 2024年第3期14卷 389-400页

作者： Xiangye Yin yingjie Zhuang Haiqin Song yujian Xu Fan Zhang Jianxin Cui Lei Zhao yingjie yu Qixu Zhang Jun Ye Youbai Chen Yan Han Department of Plastic and Reconstructive Surgery The First Medical CenterChinese PLA General HospitalBeijing100853China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200023China State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Department of Plastic Surgery University of Texas MD Anderson Cancer CenterHoustonTX77030USA State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Antibody-drug conjugates(ADCs)are a new type of targeting antibodies that conjugate with highly toxic anticancer drugs via chemical linkers to exert high specificity and efficient killing of tumor cells,thereby attracting considerable attention in precise oncology ***(Cet)is a typical antibody that offers the benefits of good targeting and safety for individuals with advanced and inoperable cutaneous squamous cell carcinoma(cSCC);however,its anti-tumor activity is limited to a single ***(CisPt)shows good curative effects;however,its adverse effects and non-tumor-targeting ability are major *** this study,we designed and developed a new ADC based on a new cytotoxic platinum(IV)prodrug(C8Pt(IV))and *** so-called antibody-platinum(IV)prodrugs conjugates,named Cet-C8Pt(IV),showed excellent tumor targeting in ***,it accurately delivered C8Pt(IV)into tumor cells to exert the combined anti-tumor effect of Cet and ***,metabolomic analysis showed that Cet-C8Pt(IV)promoted cellular apoptosis and increased DNA damage in cSCC cells by affecting the vitamin B6 metabolic pathway in tumor cells,thereby further enhancing the tumor-killing ability and providing a new strategy for clinical cancer treatment using antibody-platinum(IV)prodrugs conjugates.

关键词： Antibody drug conjugate Cutaneous squamous cell carcinoma DNA damage Platinum drug Targeted therapy

Structure-activity relationship of defective electrocatalysts for nitrogen fixation

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Chinese Chemical Letters 2023年第7期34卷 87-101页

作者： yusheng Wang Nan Yang Xue Xin yingjie yu yuao Wei Baoli Zha Wenjing Liu Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China

Ammonia(NH_(3)), as an important chemical substance and clean energy carrier, plays an indispensable role in industrial and agricultural production. The electrocatalytic synthesis of NH+3 under mild conditions has attracted worldwide attention in the energy field due to its environmental friendliness and cost efficiency,but unsatisfactory NH_(3) yields and Faradaic efficiencies are restricting its development. The introduction of defect has been demonstrated as a feasible way to overcome the disadvantages of electrochemistry, as it can regulate the electronic structure and modulate coordination environment of electrocatalysts, which further create active sites and enhance nitrogen adsorption. In this regard, it is necessary to understand the effects of various types of defects on electrocatalysts based on the latest progress in the defect engineering for nitrogen reduction reaction(NRR). In this review, the concept, classifications, and characterization of defects as well as the approaches to create them in electrocatalysts are firstly ***, certain types of defects(vacancy, dopant, amorphism, edge/corner, and porousness) affecting the performances of various electrocatalysts are further described. Finally, the summary and challenges of electrocatalytic ammonia synthesis are proposed to design advanced electrocatalysts with high efficiency.

关键词： Nitrogen reduction reaction Defect Approaches to induce defects Electrochemistry

Electrical conductivities of two granite samples in southern Tibet and their geophysical implications

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Science China Earth Sciences 2017年第8期60卷 1522-1532页

作者： GUO YingXing WANG DuoJun ZHOU YongSheng LIU ZaiYang yu yingjie LI DanYang ZHANG DongNing ZHU Aiyu Institute of Geophysics China Earthquake Administration College of Earth Sciences University of Chinese Academy of Sciences The State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake Administration

There are clear differences in the electrical conductivities of the crustal granites of the Qinghai-Tibet *** these granites are among the major rock types on the Qinghai-Tibet Plateau, it is very important to detect the electrical conductivity of granites under high temperatures and pressures to study the electrical conductivity structure of this area. Using impedance spectroscopy at a frequency range of 10.1–106 Hz, the electrical conductivity of the muscovite-granite collected from Yadong was investigated at a confining pressure of 1.0 GPa and temperatures ranging from 577 to 996 K, while the electrical conductivity of the biotite-granite collected from Lhasa was investigated at a pressure of 1.0 GPa and temperatures ranging from587 to 1382 K. The calculated activation enthalpies of the Yadong muscovite-granite sample is 0.92 eV in the low-temperature range(577–919 K) and 2.16 eV in the high-temperature range(919–996 K). The activation enthalpies of the Lhasa biotite-granite sample is 0.48 eV in the low-temperature range(587–990 K) and 2.06 eV in the high-temperature range(990–1382 K). The change in the activation enthalpies of the granites at different temperature ranges may be associated with the dehydration of the two samples. The electrical conductivities of the granite samples obtained in the laboratory using impedance spectroscopy correspond well with field observations conducted near the sampling points, both in terms of the actual conductivity values and the observed variations between the low-temperature and high-temperature regimes. This correlation of laboratory and field conductivities indicates that the conductivities of the crustal rocks in the two regions closely correspond to granite *** calculated the electrical conductivities of muscovite-granite and biotite-granite samples using the effective medium and HS boundary models. When applied to the crustal rocks of southern Tibet, the results of the geophysical conductivity

关键词： Electrical conductivity High temperature and pressure Granite Southern Tibet Plateau

Fluorine-containing pharmaceuticals approved by the FDA in 2020:Synthesis and biological activity

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Chinese Chemical Letters 2021年第11期32卷 3342-3354页

作者： yingjie yu Aiyao Liu Gagan Dhawan Haibo Mei Wei Zhang Kunisuke Izawa Vadim A.Soloshonok Jianlin Han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Biomedical Science Acharya Narendra Dev CollegeUniversity of DelhiIndia Department of Chemistry University of Massachusetts Boston100 Morrissey BoulevardBostonMA 02125United States Hamari Chemical Ltd. 1-4-29 KunijimaHigashi-Yodogawa-kuOsaka 533-0024Japan Department of Organic Chemistry I Faculty of ChemistryUniversity of the Basque Country UPV/EHUPaseo Manuel Lardizabal 320018 San SebastianSpain IKERBASQUE Basque Foundation for ScienceMaría Díaz de Haro 3Plaza Bizkaia48013 BilbaoSpain

Thirteen new fluorine-containing drugs,which have been granted approval by the US Food and Drug Administration(FDA)in 2020,are profiled in this *** areas of these new fluorinated pharmaceuticals include medicines and diagnostic agents for Cushing's disease,neurofibromatosis,migraine,Alzheimer's disease,myelodysplastic syndromes,hereditary angioedema attacks,and various *** of these approved drugs feature aromatic fluorine(Ar-F)(11 compounds),aromatic Ar-CF_(3)(1),aliphatic CHF(1)and CF_(2)(1)*** each compound,we provide a spectrum of biological activity,medicinal chemistry discovery,and synthetic approaches.

关键词： Fluorine and compounds Blockbuster drugs Modern pharmaceuticals Synthesis Drug design and development Asymmetric synthesis

Racial disparity in colorectal cancer: Gut microbiome and cancer stem cells

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World Journal of Stem Cells 2016年第9期8卷 279-287页

作者： Sachin Goyal Pratima Nangia-Makke Lulu Farhana yingjie yu Adhip PN Majumdar Department of Internal Medicine John D Dingell VA Medical Center Detroit MI 48201 United States Department of Internal Medicine Wayne State University Detroit MI 48201 United States Karmanos Cancer Institute Wayne State University School of Medicine Detroit MI 48201 United States

Over the past two decades there has been remarkable progress in cancer diagnosis, treatment and screening. The basic mechanisms leading to pathogenesis of various types of cancers are also understood better and some patients, if diagnosed at a particular stage go on to lead a normal pre-diagnosis life. Despite these achievements, racial disparity in some cancers remains a mystery. The higher incidence, aggressiveness and mortality of breast, prostate and colorectal cancers(CRCs) in AfricanAmericans as compared to Caucasian-Americans are now well documented. The polyp-carcinoma sequence in CRC and easy access to colonic epithelia or colonic epithelial cells through colonoscopy/colonic effluent provides the opportunity to study colonic stem cells early in course of natural history of the disease. With the advent of metagenomic sequencing, uncultivable organisms can now be identified in stool and their numbers correlated with the effects on colonic epithelia. It would be expected that these techniques would revolutionize our understanding of the racial disparity in CRC and pave a way for the same in other cancers as well. Unfortunately, this has not happened. Our understanding of the underlying factors responsible in African-Americans for higher incidence and mortality from colorectal carcinoma remains minimal. In this review, we aim to summarize the available data on role of microbiome and cancer stem cells in racial disparity in CRC. This will provide a platform for further research on this topic.

关键词： Colorectal cancer Cancer stem cells Racial disparity Microbiome MiRNA