Fluorine-containing pharmaceuticals approved by the FDA in 2020:Synthesis and biological activity

作     者：Yingjie Yu Aiyao Liu Gagan Dhawan Haibo Mei Wei Zhang Kunisuke Izawa Vadim A.Soloshonok Jianlin Han Yingjie Yu;Aiyao Liu;Gagan Dhawan;Haibo Mei;Wei Zhang;Kunisuke Izawa;Vadim A.Soloshonok;Jianlin Han

作者机构：Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesInternational Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Biomedical ScienceAcharya Narendra Dev CollegeUniversity of DelhiIndia Department of ChemistryUniversity of Massachusetts Boston100 Morrissey BoulevardBostonMA 02125United States Hamari Chemical Ltd.1-4-29 KunijimaHigashi-Yodogawa-kuOsaka 533-0024Japan Department of Organic Chemistry IFaculty of ChemistryUniversity of the Basque Country UPV/EHUPaseo Manuel Lardizabal 320018 San SebastianSpain IKERBASQUEBasque Foundation for ScienceMaría Díaz de Haro 3Plaza Bizkaia48013 BilbaoSpain 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第11期

页      面：3342-3354页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：the financial support from the National Natural Science Foundation of China(No.21761132021) IKERBASQUE,Basque Foundation for Science 

主　　题：Fluorine and compounds Blockbuster drugs Modern pharmaceuticals Synthesis Drug design and development Asymmetric synthesis 

摘      要：Thirteen new fluorine-containing drugs,which have been granted approval by the US Food and Drug Administration(FDA)in 2020,are profiled in this *** areas of these new fluorinated pharmaceuticals include medicines and diagnostic agents for Cushing s disease,neurofibromatosis,migraine,Alzheimer s disease,myelodysplastic syndromes,hereditary angioedema attacks,and various *** of these approved drugs feature aromatic fluorine(Ar-F)(11 compounds),aromatic Ar-CF_(3)(1),aliphatic CHF(1)and CF_(2)(1)*** each compound,we provide a spectrum of biological activity,medicinal chemistry discovery,and synthetic approaches.