检索结果-南通市图书馆

同方期刊数据库

软坚止痛膏对于骨癌痛大鼠的镇痛作用及机制研究

在线全文

学校读者我要写书评

暂无评论

辽宁中医杂志 2025年第2期52卷 190-193页

作者：易丹杜梦楠张欣张莹贾英杰天津中医药大学第一附属医院天津300380 国家中医针灸临床医学研究中心天津300380 天津中医药大学第二附属医院天津300143 天津市中医康复中心天津300143

目的探索软坚止痛膏对于骨癌痛大鼠的镇痛作用及机制。方法将40只SD大鼠分为空白组、模型组、软坚止痛膏组以及扶他林组,每组10只,除空白组外其余3组采用大鼠乳腺癌Walker 256混悬液(4×104 mL)4μL注射右后胫骨骨髓腔内建立骨转移癌痛... 详细信息

目的探索软坚止痛膏对于骨癌痛大鼠的镇痛作用及机制。方法将40只SD大鼠分为空白组、模型组、软坚止痛膏组以及扶他林组,每组10只,除空白组外其余3组采用大鼠乳腺癌Walker 256混悬液(4×104 mL)4μL注射右后胫骨骨髓腔内建立骨转移癌痛模型,观察各组大鼠疼痛缩足反射潜伏期(paw withdrawal latency,PWL)与疼痛缩足反射阈值(paw withdrawal threshold,PWT),并使用X光射线观察注射部位骨质破坏情况,造模成功后给药,软坚止痛膏组与扶他林组使用药物外涂,空白组与模型组不做干预,并使用蛋白印记法(Western Blot,WB)检测大鼠脊髓核因子激活的B细胞的κ-轻链增强(NF-κB)以及酶联免疫吸附剂测定(enzyme linked immunosorbent assay,ELISA)肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)、白细胞介素1β(interleukin-1β,IL-1β)、白细胞介素6(interleukin-6,IL-6)表达情况。结果相比较空白组,模型组、软坚止痛膏组、扶他林组PWL与PWT较前降低(P<0.05),且X光显示骨质不同程度破坏,证实骨癌痛模型造模成功,给药后软坚止痛膏组、扶他林组较模型组PWL与PWT较前上升明显(P<0.05),证实软坚止痛膏与扶他林的镇痛作用,且相比较扶他林组,软坚止痛膏组NF-κB及TNF-α、IL-1β、IL-6表达水平较模型组下降明显(P<0.05)。结论软坚止痛膏可缓解骨癌痛,可能与抑制NF-κB通路激活,下调TNF-α、IL-1β、IL-6表达相关。

关键词：软坚止痛膏骨癌痛机制中医外治法

Optimal output regulation for PMSM speed servo system using approximate dynamic programming

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2023年第7期66卷 75-76页

作者： Zhaowu PING yingjie jia Bangguo XIONG Hongwei ZHANG Jun-Guo LU School of Electrical Engineering and Automation Hefei University of Technology School of Mechanical Engineering and Automation Harbin Institute of Technology Department of Automation Shanghai Jiao Tong University

In recent decades, the output regulation problem has received considerable attention from researchers in the control community because it simultaneously addresses reference signal tracking, disturbance rejection, and robustness [1].Furthermore, when transient performance is considered by solving an optimization problem with a prescribed cost function, this output regulation problem is called an optimal output regulation(OOR) problem.

关键词：

Traditional Chinese medicines for non-small cell lung cancer: Therapies and mechanisms

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2023年第4期15卷 509-515页

作者： Fanming Kong Chaoran Wang Linlin Zhao Dongying Liao Xiaoqun Wang Binxu Sun Peiying Yang yingjie jia Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China

The most common subtype of lung cancer is non-small cell lung cancer(NSCLC), which has a poor prognosis and seriously threatens the health of human beings. The multidisciplinary comprehensive treatment model has gradually become the mainstream of NSCLC treatment. Traditional Chinese medicine(TCM) can be used effectively either as an adjunctive therapy or alone throughout the NSCLC therapy,which has a significant impact on survival, quality of life, and reduction of toxicity. Therefore, this paper reviewed the theoretical basis, the latest clinical application, and combined treatment mechanisms in order to explore the advantage stage of TCM treatment and the synergistic therapeutic mechanisms.

关键词： advantage stage clinical application mechanisms non-small cell lung cancer synergistic therapeutic theoretical basis traditional Chinese medicines treatment model

Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2023年第4期15卷 485-495页

作者： Fanming Kong Chaoran Wang Jing Zhang Xiaoqun Wang Binxu Sun Xian Xiao Haojian Zhang Yanqi Song yingjie jia Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Traditional Chinese Medicine Tianjin Medical University General HospitalTianjin 300052China

Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue,and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines(CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in Pub Med, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance,and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR,EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application.

关键词： Chinese herbal medicines clinical practice experimental research prostate cancer review

Attitude control of flexible satellite via three-dimensional magnetically suspended wheel

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第3期46卷 555-572页

作者： J.TAYEBI yingjie CHEN Ti CHEN Shiyuan jia State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and Astronautics School of Intelligent Engineering and Automation Beijing University of Posts and Telecommunications

This paper proposes an attitude control strategy for a flexible satellite equipped with an orthogonal cluster of three-dimensional(3D) magnetically suspended wheels(MSWs). The mathematical model for the satellite incorporating flexible appendages and an orthogonal cluster of magnetically suspended reaction wheel actuators is initially developed. After that, an adaptive attitude controller is designed with a switching surface of variable structure, an adaptive law for estimating inertia matrix uncertainty,and a fuzzy disturbance observer for estimating disturbance torques. Additionally, a Moore-Penrose-based steering law is proposed to derive the tilt angle commands of the orthogonal configuration of the 3D MSW to follow the designed control signal. Finally,numerical simulations are presented to validate the effectiveness of the proposed control strategy.

关键词： adaptive control attitude control disturbance observer flexible satellite three-dimensional (3D) magnetically suspended wheel (MSW) V412.4 V448.2

Two common genetic polymorphisms of xeroderma pigmentosum group D gene and susceptibility to prostate cancer: a meta-analysis of 4,297 cases and 5,307 controls

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

TMR Clinical Research 2019年第2期2卷 64-73页

作者： Shanqi Guo Xingkang jiang Xiaojiang Li Yuanyuan Wang yingjie jia Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China Department of Urology the Second Hospital of Tianjin Medical University Tianjin Institute of Urology Tianjin China

DNA repair gene are important in maintaining genome stability and integrity. Xeroderma pigmentosum group D (XPD) polymorphisms have been reported with prostate cancer (PCa) risk, but the conclusion remained controversial. The aim of this study was to derive a more precise estimation of the associations of two common XPD polymorphisms with the susceptibility of PCa. The pooled odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated to assess the association between XPD polymorphisms and PCa risk. A total of ten trials including 3,991 cases and 4,814 controls who were evaluated of XPD rs13181 genotype and PCa risk, but no statistical relationship was found both overall four genetic model and subgroup analyses. In addition, seven studies were identified with a total 7,642 participants to assess association between rs1799793 genetic polymorphism and PCa susceptibility. There were a slight association between PCa risk and XPD rs1799793 genetic polymorphism (CC versus TT, OR=0.52, 95% CI 0.25-1.06, P=0.07;Dominant model, OR=0.56, 95% CI 0.30-1.06, P=0.08 and recessive model, OR=0.74, 95% CI 0.53-1.03, P=0.08). Moreover, subgroup analysis stratified by ethnicity found the protective effect of rs1799793 polymorphism against PCa risk upon Asian population (CC versus TT, OR=0.48, 95% CI 0.32-0.72, P=0.00;Dominant model, OR=0.52, 95% CI 0.28-0.95, P=0.03 and recessive model, OR=0.67, 95% CI 0.50-0.89, P=0.01). Taken together, the existing evidence indicates XPD rs1799793 polymorphism should be viewed as a protective effect against PCa risk under CC versus TT, Dominant and Recessive model. For rs13181 polymorphism, no associations were found between this variant and the susceptibility of PCa.

关键词： DNA repair meta-analysis prostatic neoplasms polymorphism XPD

Clinical Efficacy of Ultrasonic Medicinal Penetration in the Removal of Blood Stasis and Alleviation of Zhuyu Juanbi Formula in the Treatment of Peripheral Neuropathy Induced by Paclitaxel

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proceedings of Anticancer Research 2024年第3期8卷 7-17页

作者： Ying Zhang Huixin Chen Qirong Zhang yingjie jia Dan Yi The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381China National Clinical Research Center of Acupuncture and Moxibustion Tianjin 300381China Tianjin University of Traditional Chinese Medicine Tianjin 301617China

Objective: To observe the clinical efficacy and differences of the Zhuyu Juanbi formula delivered through ultrasound at Zusanli on patients with chemotherapy-induced peripheral neuropathy (CIPN) due to paclitaxel injection. Methods: A total of 72 breast cancer patients with CIPN were randomly divided into two groups. The treatment group (36 cases) was treated with oral methylcobalamin plus ultrasonic medicine permeating Zhuyu Juanbi formulae, while the control group (36 cases) was treated with oral methylcobalamin alone. Following two 2 cycles of continuous treatment, the efficacy of peripheral neurotoxicity, TCM syndrome score, FACT/GOG-Ntx score, total neuropathy score, and safety indicators of gynecological cancer patients were observed in the two groups. Result: In the treatment of CIPN, the addition of ultrasonic medicine permeating Zhuyu Juanbi formulae was more effective than oral methylcobalamin alone in reducing peripheral neurotoxicity and improving the quality of life of patients. The difference between the two groups was statistically significant (P < 0.05), and ultrasound drug penetration Zhuyu Juanbi formulae significantly reduced the FACT/ GOG-Ntx score and TNS score in the treatment group. In terms of drug safety, it rarely caused adverse reactions such as grade 3 and 4 leukopenia, and the safety profile was therefore good. Conclusion: The combination of ultrasonic medicine permeating Zhuyu Juanbi formulae and methylcobalamin has been demonstrated to be an effective treatment for peripheral neurotoxicity in patients with PIPN. It has been shown to significantly improve the clinical symptoms of PIPN patients, improve the quality of life of patients, and have a good safety profile.

关键词： Chemotherapy-induced peripheral neuropathy(CIPN) Paclitaxel-induced peripheral neuropathy Zhuyu Juanbi formulae Ultrasonic drug delivery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

密肋复合板结构与装配式大板结构的体系比较

北京交通大学学报 2012年第1期36卷 77-81,86页

作者：苏力贾英杰北京交通大学土木建筑工程学院北京100044

密肋复合板结构是一种以密肋复合墙板为主要构件,集承重、节能、保温、维护为一体的新型装配整体式结构体系,拥有独特的结构构造、良好的耗能及保温隔热性能.通过与传统大板结构在地震作用下破坏机理与抗震设防措施的对比,分析其在结构... 详细信息

密肋复合板结构是一种以密肋复合墙板为主要构件,集承重、节能、保温、维护为一体的新型装配整体式结构体系,拥有独特的结构构造、良好的耗能及保温隔热性能.通过与传统大板结构在地震作用下破坏机理与抗震设防措施的对比,分析其在结构安全性、适用高度等方面与传统大板结构的不同.证明了密肋复合板结构体系有着优秀的结构性能及先进的设计理念,符合我国新时期对住宅结构发展的要求.

关键词：密肋复合板结构装配式大板结构耗能性能破坏机理

在线全文

学校读者我要写书评

暂无评论

液质联用技术在蜂蜜兽药残留检测中的应用

食品工业 2019年第7期40卷 284-286页

作者：贾英杰上海冠生园蜂制品有限公司上海201419

近年来,中国蜂产品行业的快速发展,蜂蜜作为十分常见的天然动物源性食品之一,国内外消费群体对蜂蜜中兽药残留的问题越来越关注。国家监管机构也加大对此类问题的监督,由于蜂蜜基质复杂,兽药残留多处于痕量水平,因此需要较高的技术水平... 详细信息

近年来,中国蜂产品行业的快速发展,蜂蜜作为十分常见的天然动物源性食品之一,国内外消费群体对蜂蜜中兽药残留的问题越来越关注。国家监管机构也加大对此类问题的监督,由于蜂蜜基质复杂,兽药残留多处于痕量水平,因此需要较高的技术水平和仪器设备对蜂蜜中的兽药残留进行检测,高效液相色谱-串联质谱技术因其高检测精度、高灵敏度、高通量使其成为在蜂蜜中应用最广泛的技术之一,结合蜂蜜中兽药残留现状,对液相色谱-串联质谱技术在蜂蜜中兽药残留检测方法上进行阐述,并对兽药残留检测技术的发展方向进行展望。

关键词：蜂蜜液相色谱-质谱兽药残留