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Blending with transition metals improves bioresorbable zinc as better medical implants

生物活性材料(英文) 2023年第2期20卷 243-258页

作者： yingchao su Jiayin Fu Juncen Zhou Elias Georgas Shaokang Du Yi-Xian Qin Yadong Wang Yufeng Zheng Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityStony BrookNYUSA Nancy E.and Peter C.Meinig School of Biomedical Engineering Cornell UniversityIthacaNYUSA Department of Cardiology Sir Run Run Shaw HospitalZhejiang UniversityHangzhouZhejiangChina Academy for Advanced Interdisciplinary Studies Peking UniversityBeijingChina School of Materials Science and Engineering Peking UniversityBeijingChina

Zinc(Zn)is a new class of bioresorbable metal that has potential for cardiovascular stent material,orthopedic implants,wound closure devices,etc.However,pure Zn is not ideal for these applications due to its low mechanical strength and localized degradation behavior.Alloying is the most common/effective way to overcome this limitation.Still,the choice of alloying element is crucial to ensure the resulting alloy possesses sufficient mechanical strength,suitable degradation rate,and acceptable biocompatibility.Hereby,we proposed to blend selective transition metals(i.e.,vanadium-V,chromium-Cr,and zirconium-Zr)to improve Zn’s properties.These selected transition metals have similar properties to Zn and thus are beneficial for the metallurgy process and mechanical property.Furthermore,the biosafety of these elements is of less concern as they all have been used as regulatory approved medical implants or a component of an implant such as Ti6Al4V,CoCr,or Zr-based dental implants.Our study showed the first evidence that blending with transition metals V,Cr,or Zr can improve Zn’s properties as bioresorbable medical implants.In addition,three in vivo implantation models were explored in rats:subcutaneous,aorta,and femoral implantations,to target the potential clinical applications of bioresorbable Zn implants.

关键词： Degradation Cardiovascular Orthopedic subcutaneous Antibacterial

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Improved mechanical, degradation, and biological performances of Zn–Fe alloys as bioresorbable implants

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Bioactive Materials 2022年第11期7卷 334-343页

作者： yingchao su Jiayin Fu Wonsae Lee Shaokang Du Yi-Xian Qin Yufeng Zheng Yadong Wang Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityStony BrookNYUSA Nancy E.and Peter C.Meinig School of Biomedical Engineering Cornell UniversityIthacaNYUSA Department of Cardiology Sir Run Run Shaw HospitalZhejiang UniversityHangzhouZhejiangChina Academy for Advanced Interdisciplinary Studies Peking UniversityBeijingChina School of Materials Science and Engineering Peking UniversityBeijingChina

Zinc(Zn)is a promising bioresorbable implant material with more moderate degradation rate compared to magnesium(Mg)and iron(Fe).However,the low mechanical strength and localized degradation behavior of pure Zn limit its clinical applications.Alloying is one of the most effective ways to overcome these limitations.After screening the alloying element candidates regarding their potentials for improvement on the degradation and biocompatibility,we proposed Fe as the alloying element for Zn,and investigated the in vitro and in vivo performances of these alloys in both subcutaneous and femoral tissues.Results showed that the uniformly distributed secondary phase in Zn–Fe alloys significantly improved the mechanical property and facilitated uniform degradation,which thus enhanced their biocompatibility,especially the Zn-0.4Fe alloy.Moreover,these Zn–Fe alloys showed outstanding antibacterial property.Taken together,Zn–Fe alloys could be promising can-didates as bioresorbable medical implants for various cardiovascular,wound closure,and orthopedic applications.

关键词： Zinc Mechanical Degradation Biocompatibility Antibacterial

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supplemental mineral ions for bone regeneration and osteoporosis treatment

再生工程(英文)

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再生工程(英文) 2023年第2期4卷 170-182页

作者： yingchao su Matthew Cappock Stephanie Dobres Allan J.Kucine Wayne C.Waltzer Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Oral and Maxillofacial surgery Stony Brook UniversityStony BrookNY 11794USA Department of Urology Stony Brook UniversityStony BrookNY 11794USA

Mineral ions play a crucial role in various biological processes in the human body,particularly in bone repair and regeneration.supplementation with mineral ions offers several advantages over other therapies or treatments for bone repair and regeneration,such as higher biosafety,universal applicability,and compatibility with the immune system.Additionally,supplementation with mineral ions may avoid the need for invasive surgical procedures.The aim of this review is to provide a comprehensive overview of the functions of potentially beneficial mineral ions and their effects on bone regeneration and osteoporosis treatment.By examining previous studies,including in vitro cellular experiments,in vivo animal models,and clinical trials,this review compares the benefits and potential adverse effects of these mineral ions.Moreover,the review provides guidelines for suggested daily supplementation of these mineral ions to assist future preclinical and clinical studies in bone regeneration and osteoporosis treatment.

关键词： Mineral elements Metallic ions Dietary supplementation Bone repair Bone regeneration Osteoporosis

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Calcium phosphate coatings enhance biocompatibility and degradation resistance of magnesium alloy:Correlating in vitro and in vivo studies

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Bioactive Materials 2021年第5期6卷 1223-1229页

作者： Julia Gao yingchao su Yi-Xian Qin Department of Biomedical Engineering Stony Brook UniversityStony BrookNY11794United States

Magnesium(Mg)and its alloys are promising biodegradable materials for orthopedic applications.However,one of the major problems is their rapid degradation rate with quick evolution of hydrogen gas.To overcome this problem,calcium phosphate(CaP)coatings have been used to improve the degradation resistance and the biocompatibility of Mg materials.This study focuses on the comparison and correlation of the in vitro and in vivo degradation and biocompatibility behaviors of these materials.A CaP coating consisting of dicalcium phosphate dihydrate(DCPD)was deposited on an AZ60 Mg alloy by the chemical conversion method.Then,the in vitro degradation testing including electrochemical and immersion tests,and in vivo implantation of the CaP coated Mg alloy were conducted to compare the degradation behaviors.Next,the in vitro cell behavior and in vivo bone tissue response were also compared on both uncoated and CaP-coated Mg samples.Data showed that the CaP coating provided the Mg alloy with significantly better biodegradation behavior and biocompatibility.The in vitro and in vivo biocompatibility tests exhibited good consistency while not the case for biodegradation.Results showed that the in vitro electrochemical test could be a quick screening tool for the biodegradation rate,while the in vitro immersion degradation rate was often 2-4 folds faster than the in vivo degradation rate.

关键词： Magnesium implants Calcium phosphate Biodegradation Cytocompatibility Bone regeneration

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Biofunctionalization of metallic implants by calcium phosphate coatings

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Bioactive Materials 2019年第1期4卷 196-206页

作者： yingchao su Irsalan Cockerill Yufeng Zheng Liping Tang Yi-Xian Qin Donghui Zhu Department of Biomedical Engineering University of North TexasDentonTXUSA Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijingChina Department of Bioengineering University of Texas at ArlingtonArlingtonTXUSA Department of Biomedical Engineering Stony Brook UniversityStony BrookNYUSA

Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability.Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions.Calcium phosphates(CaPs)are the major inorganic component of bone tissues,and thus owning inherent biocompatibility and osseointegration properties.As such,they have been widely used in clinical orthopedics and dentistry.The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs.This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances,and then give insight into the representative biofunctions,i.***.osteointegration,corrosion resistance and biodegradation control,and antibacterial property,provided by CaP coatings for metallic implant materials.

关键词： Calcium phosphates Metallic implant materials surface biofunctionalization Osteointegration Biodegradation

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Bioactive glass coatings on metallic implants for biomedical applications

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Bioactive Materials 2019年第1期4卷 261-270页

作者： Joy-anne N.Oliver yingchao su Xiaonan Lu Po-Hsuen Kuo Jincheng Du Donghui Zhu Department of Materials Science and Engineering University of North TexasDentonTX76203USA Department of Biomedical Engineering University of North TexasDentonTX76203USA Department of Biomedical Engineering Stony Brook UniversityStony BrookNYUSA

Metallic implant materials possess adequate mechanical properties such as strength,elastic modulus,and ductility for long term support and stability in vivo.Traditional metallic biomaterials,including stainless steels,cobalt-chromium alloys,and titanium and its alloys,have been the gold standards for load-bearing implant materials in hard tissue applications in the past decades.Biodegradable metals including iron,magnesium,and zinc have also emerged as novel biodegradable implant materials with different in vivo degradation rates.However,they do not possess good bioactivity and other biological functions.Bioactive glasses have been widely used as coating materials on the metallic implants to improve their integration with the host tissue and overall biological performances.The present review provides a detailed overview of the benefits and issues of metal alloys when used as biomedical implants and how they are improved by bioactive glass-based coatings for biomedical applications.

关键词： Bioactive glass coating Metallic biomaterials Biodegradation Biocompatibility Bioactivity.contents

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绿豆枯萎病抗性种质创制与新品种选育

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作物杂志 2024年第2期 249-254页

作者：张志肖沈颖超范保杰王彦刘长友王珅曹志敏苏秋竹时会影田静河北省农林科学院粮油作物研究所/河北省作物遗传育种实验室河北石家庄050035

枯萎病是影响绿豆产量最严重的病害之一。枯萎病病原菌厚垣孢子抗逆性强,在土壤中存活时间长,农业及化学防治方法均难以控制,因此筛选和创制抗性种质和培育抗性品种是最经济有效的途径。本研究采用剪根浸根接种法,对杂交选育的81份绿豆... 详细信息

枯萎病是影响绿豆产量最严重的病害之一。枯萎病病原菌厚垣孢子抗逆性强,在土壤中存活时间长,农业及化学防治方法均难以控制,因此筛选和创制抗性种质和培育抗性品种是最经济有效的途径。本研究采用剪根浸根接种法,对杂交选育的81份绿豆高代品系进行了苗期枯萎病抗性鉴定。结果显示,品系间枯萎病抗性存在明显差异;通过初级产比试验、高级产比鉴定试验、省区域试验及生产试验,培育出抗枯萎病、高产稳产、优质的绿豆新品种冀绿23。

关键词：绿豆枯萎病抗性新品种

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绿豆新品种产量及主要农艺性状鉴定与评价

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作物杂志 2024年第3期 90-99页

作者：王珅范保杰刘长友王彦张志肖苏秋竹时会影沈颖超王学清田静河北省农林科学院粮油作物研究所/河北省作物遗传育种试验室河北石家庄050035 河北省农林科学院河北石家庄050035

为了筛选适合不同生态区域种植的高产优质绿豆新品种,以国家鉴定品种冀绿13号为对照,2019-2020年间对来源于15家育种单位的27个绿豆新品种在23个试验点进行了联合鉴定。结果表明,0802-4-2-1-2-1、保绿201323-3、保绿201322-3、白绿13号... 详细信息

为了筛选适合不同生态区域种植的高产优质绿豆新品种,以国家鉴定品种冀绿13号为对照,2019-2020年间对来源于15家育种单位的27个绿豆新品种在23个试验点进行了联合鉴定。结果表明,0802-4-2-1-2-1、保绿201323-3、保绿201322-3、白绿13号、皖科绿3号、渝绿9号和品绿2014-129共7个品种增产显著,较对照增产2.35%~11.55%。综合分析,0802-4-2-1-2-1、保绿201323-3、保绿201322-3和皖科绿3号的生态适应性较好。根据生育期、株高、主茎分枝数、单株荚数等表型性状及产量表现,分别筛选出适宜不同生态区种植的绿豆新品种,为品种推广应用提供了科学依据。

关键词：绿豆新品种产量适应性

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豇豆新品种冀豇1号的选育

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中国种业 2024年第5期 128-130页

作者：王彦张志肖王珅时会影沈颖超刘长友苏秋竹田静范保杰河北省农林科学院粮油作物研究所/河北省作物遗传育种实验室石家庄050035

冀豇1号(冀豇0903-1-1-2)是由河北省农林科学院粮油作物研究所以中国农业科学院育成品种中豇1号和从日本引进的罔山红豇豆为亲本,通过杂交、自交及定向选择选育而成。2020-2021年参加河北省豇豆新品种区域试验,2年试验试点间平均产量144... 详细信息

冀豇1号(冀豇0903-1-1-2)是由河北省农林科学院粮油作物研究所以中国农业科学院育成品种中豇1号和从日本引进的罔山红豇豆为亲本,通过杂交、自交及定向选择选育而成。2020-2021年参加河北省豇豆新品种区域试验,2年试验试点间平均产量144.79kg/667m^(2),比对照中豇1号平均增产41.31%,居参试品系第1位。2023年通过河北省种子总站认定,定名为冀豇1号,认定编号:冀认豆(2023)001,是河北省认定的第一个豇豆品种。该品种直立、抗倒,抗根腐病、病毒病,结荚集中,成熟一致,不炸荚,适于一次性机械化收获。籽粒蛋白质含量25.20g/100g、粗淀粉含量46.51%、粗脂肪含量0.87%。

关键词：豇豆粒用冀豇1号选育

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Strength and deformation behaviors of veined marble specimens after vacuum heat treatment under conventional triaxial compression

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Acta Mechanica Sinica 2017年第5期33卷 886-898页

作者： Haijian su Hongwen Jing Qian Yin Liyuan Yu yingchao Wang Xingjie Wu State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology

The mechanical behaviors of rocks affected by high temperature and stress are generally believed to be significant for the stability of certain projects involving rocks, such as nuclear waste storage and geothermal resource exploitation. In this paper, veined marble specimens were treated to high temperature treatment and then used in conventional triaxial compression tests to investigate the effect of temperature, confining pressure, and vein angle on strength and deformation behaviors. The results show that the strength and deformation parameters of the veined marble specimens changed with the temperature, presenting a critical temperature of 600 . The triaxial compression strength of a horizontal vein () is obviously larger than that of a vertical vein (). The triaxial compression strength, elasticity modulus, and secant modulus have an approximately linear relation to the confining pressure. Finally, Mohr-Coulomb and Hoek-Brown criteria were respectively used to analyze the effect of confining pressure on triaxial compression strength.

关键词： Veined marble Conventional triaxial compression High temperature Vein angle Hoek-Brown criterion

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