Improved mechanical, degradation, and biological performances of Zn–Fe alloys as bioresorbable implants

作     者：Yingchao Su Jiayin Fu Wonsae Lee Shaokang Du Yi-Xian Qin Yufeng Zheng Yadong Wang Donghui Zhu 

作者机构：Department of Biomedical EngineeringStony Brook UniversityStony BrookNYUSA Nancy E.and Peter C.Meinig School of Biomedical EngineeringCornell UniversityIthacaNYUSA Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhouZhejiangChina Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina School of Materials Science and EngineeringPeking UniversityBeijingChina 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第11期

页      面：334-343页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was supported by the National Institutes of Health[R01HL140562] 

主　　题：Zinc Mechanical Degradation Biocompatibility Antibacterial 

摘      要：Zinc(Zn)is a promising bioresorbable implant material with more moderate degradation rate compared to magnesium(Mg)and iron(Fe).However,the low mechanical strength and localized degradation behavior of pure Zn limit its clinical *** is one of the most effective ways to overcome these *** screening the alloying element candidates regarding their potentials for improvement on the degradation and biocompatibility,we proposed Fe as the alloying element for Zn,and investigated the in vitro and in vivo performances of these alloys in both subcutaneous and femoral *** showed that the uniformly distributed secondary phase in Zn–Fe alloys significantly improved the mechanical property and facilitated uniform degradation,which thus enhanced their biocompatibility,especially the Zn-0.4Fe ***,these Zn–Fe alloys showed outstanding antibacterial *** together,Zn–Fe alloys could be promising can-didates as bioresorbable medical implants for various cardiovascular,wound closure,and orthopedic applications.