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Gastrointestinal dysfunction is associated with mortality in severe burn patients:a 10-year retrospective observational study from South China

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Military Medical Research 2023年第3期10卷 299-312页

作者： Qiu-Lan He Shao-Wei Gao ying Qin Run-Cheng Huang Cai-Yun Chen Fei zhou Hong-Cheng Lin Wen-Qi Huang Department of Anesthesiology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Anesthesiology Zhongshan People's HospitalZhongshan 528400GuangdongChina Department of Anesthesiology Dongguan People's HospitalDongguan 523059GuangdongChina Department of Burn Surgery the First Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Colorectal Surgery the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510655China

Background:Data on severe and extensive burns in China are limited,as is data on the prevalence of a range of related gastrointestinal(GI)disorders[such as stress ulcers,delayed defecation,opioid-related bowel immotility,and abdominal compartment syndrome(ACS)].We present a multicentre analysis of coincident GI dysfunction and its effect on burn-related ***:This retrospective analysis was conducted on patients with severe[≥20%total burn surface area(TBSA)]and extensive(>50%TBSA or>25%full-thickness TBSA)burns admitted to three university teaching institutions in China between January 1,2011 and December 31,*** 30-and 90-day mortality were assessed by collating demographic data,burn causes,admission TBSA,%full-thickness TBSA,Baux score,Abbreviated Burn Severity Index(ABSI)score,and Sequential Organ Failure Assessment(SOFA)score,shock at admission and the presence of an inhalation *** dysfunction included abdominal distension,nausea/vomiting,diarrhoea/constipation,GI ulcer/haemorrhage,paralytic ileus,feeding intolerance and ***,length of intensive care unit(ICU)stay,pain control[in morphine milligram equivalents(MME)]and overall length of hospital stay(LOHS)were ***:We analyzed 328 patients[75.6%male,mean age:(41.6±13.6)years]with a median TBSA of 62.0%(41.0%–80.0%);256(78.0%)patients presented with extensive *** 90-day mortality was 23.2%(76/328),with 64(84.2%)of these deaths occurring within 30 d and 25(32.9%)occurring within 7 *** dysfunction was experienced by 45.4%of patients and had a significant effect on 90-day mortality[odds ratio(OR)=14.070,95%confidence interval(CI)5.886–38.290,P<0.001].Multivariate analysis showed that GI dysfunction was associated with admission SOFA score and%full-thickness ***,88.2%(67/76)of deceased patients had GI dysfunction[hazard ratio(HR)for death of GI dysfunction=5.951],with a survival advantage for functional disorders(diarrhoea,constipation,or nausea/vomiting)ove

关键词： Severe burn Gastrointestinal dysfunction Mortality Sepsis Gastrointestinal haemorrhage Continuous analgesia

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影响儿童隐睾术后睾丸发育的因素研究进展

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赣南医学院学报 2024年第5期44卷 526-531页

作者：孙艳平吴文进周碧莹曾勇刘海金赣南医科大学第一临床医学院赣南医科大学第一附属医院小儿外科江西赣州341000

儿童隐睾是小儿泌尿生殖系统常见的先天性畸形,近年来发病率呈上升趋势,是引起不育、睾丸扭转、睾丸恶变的高危因素,并且可能对患儿身心健康造成影响,因此需积极进行治疗。目前主要采用睾丸下降固定术治疗,且可取得较好的疗效,但仍有部... 详细信息

儿童隐睾是小儿泌尿生殖系统常见的先天性畸形,近年来发病率呈上升趋势,是引起不育、睾丸扭转、睾丸恶变的高危因素,并且可能对患儿身心健康造成影响,因此需积极进行治疗。目前主要采用睾丸下降固定术治疗,且可取得较好的疗效,但仍有部分隐睾患儿术后存在睾丸发育较差的情况,甚至出现睾丸萎缩。本文对影响儿童隐睾术后睾丸发育的相关因素进行综述,以期为小儿隐睾临床规范化诊疗提供一定参考。

关键词：儿童隐睾手术治疗睾丸发育影响因素

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全固态连续拉曼激光器谐振腔结构的设计分析

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电子器件 2024年第4期47卷 968-974页

作者：周爱文孙雪纯王颖岳艺凡向柯赟沈君樊莉扬州大学物理科学与技术学院光电信息科学与工程系江苏扬州225009

谐振腔结构参数的选择对激光器性能提升尤为重要。采用ABCD传输矩阵法对连续波全固态拉曼激光器谐振腔的结构设计进行理论分析,详细研究了直线腔和折叠腔两种腔结构中晶体热透镜效应以及腔镜曲率半径、腔长等参数对腔内振荡激光腔模参... 详细信息

谐振腔结构参数的选择对激光器性能提升尤为重要。采用ABCD传输矩阵法对连续波全固态拉曼激光器谐振腔的结构设计进行理论分析,详细研究了直线腔和折叠腔两种腔结构中晶体热透镜效应以及腔镜曲率半径、腔长等参数对腔内振荡激光腔模参数的影响。在研究实现振荡基频激光与抽运光斑良好模式匹配的同时,减小拉曼介质中基频激光光斑尺寸,以获得高效率的拉曼转换,提高拉曼激光的输出功率和光束质量。所得研究结果将为优化设计拉曼激光器谐振腔的结构提供参考。

关键词：拉曼激光器全固态连续波谐振腔结构设计 ABCD传输矩阵

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Liposomal codelivery of inflammation inhibitor and collagen protector to the plaque for effective anti-atherosclerosis

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Chinese Chemical Letters 2023年第1期34卷 239-244页

作者： Xiaotong Li Jiayi Gu Qingqing Xiao ying Liu Ping zhou Lifang Fan Xiulian Zhang Xiang Lu Jun Wu Zhengxia Liu Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Department of Geriatrics The Second Affiliated HospitalNanjing Medical UniversityNanjing 210011China Key Laboratory for Aging&Disease Nanjing Medical UniversityNanjing 210011China Jiangsu Aosaikang Pharmaceutical Co. Ltd.Nanjing 211112China Department of Respiratory Disease Baoshan BranchShuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of GeriatricsThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Geriatrics The Affiliated Sir Run Run Hospital of Nanjing Medical UniversityNanjing 211166China

Plaque plays a central role in atherosclerosis(AS)progression,whereas inflammation and destruction of the plaque microenvironment contribute to plaque *** a result,a therapy regime,which combines anti-inflammation and inhibition-degradation of plaque matrix,appears to be a promising strategy to combat ***,we report a p H-sensitive liposome co-loading with the anti-inflammatory agent(oridonin,ORD)and plaque-collagen protector(marimastat)for anti-AS *** was first conjugated with hyaluronic acid(HA)to target the inflammation contributor,pro-inflammatory ***,the conjugate assembled onto the MATT-loaded *** co-loaded system(150 nm)significantly improved pharmacokinetics over the liposomes without anchoring the conjugate and accumulated effectively in the *** preparation administration allowed efficient anti-AS activities in high-fat diet(HFD)-Apoe-/-mice by decreasing the pro-inflammatory cytokine expression in the serum,lessening the lesion area,alleviating the plaque collagen degradation,promoting macrophage polarization from phenotypic M1 to M2,reducing T helper(Th)17 cells(Th17)/T regulatory cells(Tregs)and Th1/Th2 ratio,***,the serum determination in AS patients demonstrated high expression of the inflammatory cytokines,indicating our finding may offer a potential guideline for clinical practice.

关键词： Atherosclerosis Plaque Inflammation Collagen Macrophages Co-delivery Liposomes

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基于网络药理学和实验验证探究栀子豉汤治疗抑郁症的配伍机制

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沈阳药科大学学报 2024年第5期41卷 557-570页

作者：叶莹何镜刘筱婧高玉烨周婷婷高晓霞广东药科大学药学院广东广州510006 中国人民解放军海军军医大学药学系上海200433

目的基于网络药理学和体内外实验验证探究栀子豉汤治疗抑郁症的配伍机制。方法采用UPLC-QE-MS技术分析栀子豉汤及其组方药材栀子、淡豆豉中化学成分,结合网络药理学预测栀子、淡豆豉、栀子豉汤治疗抑郁症的相关靶点和信号通路;通过体内... 详细信息

目的基于网络药理学和体内外实验验证探究栀子豉汤治疗抑郁症的配伍机制。方法采用UPLC-QE-MS技术分析栀子豉汤及其组方药材栀子、淡豆豉中化学成分,结合网络药理学预测栀子、淡豆豉、栀子豉汤治疗抑郁症的相关靶点和信号通路;通过体内外实验对预测结果进行验证:采用抗生素鸡尾酒疗法建立伪无菌大鼠模型,寻找栀子、淡豆豉和栀子豉汤在体内肠道菌群影响下的入血成分及其代谢物的差异;利用谷氨酸诱导的PC12细胞模型评价栀子、淡豆豉和栀子豉汤含药血清以及入血成分基于神经保护的抗抑郁作用。结果分别在栀子、淡豆豉、栀子豉汤中鉴定出37、7和43种化学成分,确定了栀子、淡豆豉、栀子豉汤治疗抑郁症的187、146和196个潜在靶点,从而进一步发现栀子和栀子豉汤治疗抑郁症的9个共同核心靶点;富集分析结果显示,栀子、栀子豉汤主要通过神经活性配体-受体通路、MAPK信号通路和IL-17信号通路等多条信号通路发挥抗抑郁作用。对栀子、淡豆豉、栀子豉汤体内入血成分进行分析,栀子豉汤给药正常大鼠后可鉴定出18种入血成分及其代谢物,而栀子、淡豆豉给药正常大鼠,栀子豉汤给药伪无菌大鼠分别鉴定出9、3和12种入血成分及其代谢物,说明栀子在没有淡豆豉配伍或无体内肠道菌群调控下,其体内代谢会发生改变;体外细胞实验表明各组含药血清及部分入血成分具有神经保护作用,其中栀子豉汤含药血清以及栀子新苷的神经保护作用最显著,各含药血清均可下调谷氨酸诱导的PC12细胞中促炎细胞因子IL-1β、TNF-α和IL-6水平升高。结论淡豆豉具有一定的神经保护作用,与栀子配伍后能够调控体内肠道菌群,影响栀子的体内代谢,栀子豉汤的抗抑郁作用可能与其抑制炎症反应有关。

关键词：栀子豉汤栀子淡豆豉抑郁症肠道菌群

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奥沙利铂对人结肠癌细胞转录表达谱的分析

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环境与健康杂志 2024年第3期41卷 195-201页

作者：张书婧周庆红刘英华张静钱智勇天津市疾病预防控制中心毒理室天津300011

目的探讨奥沙利铂(oxaliplatin,OXA)对人结肠癌(SW620)细胞转录表达谱的影响。方法采用CCK-8试验观察终浓度为0(对照)、4、8、16、32、64、100、128 mg/L OXA暴露24 h对SW620细胞的增殖抑制作用,计算半抑制浓度(IC_(50))值(64 mg/L)作... 详细信息

目的探讨奥沙利铂(oxaliplatin,OXA)对人结肠癌(SW620)细胞转录表达谱的影响。方法采用CCK-8试验观察终浓度为0(对照)、4、8、16、32、64、100、128 mg/L OXA暴露24 h对SW620细胞的增殖抑制作用,计算半抑制浓度(IC_(50))值(64 mg/L)作为转录组测序的剂量浓度。采用RNA-seq方法进行转录组测序,筛选差异表达基因,进行GO富集分析、KEEG富集分析、PPI网络构建,探讨OXA的肿瘤增殖抑制作用可能涉及的差异基因、信号通路和生物学过程。结果与对照组比较,16、32、64、100、128 mg/L OXA暴露组SW620细胞的存活率均下降,差异有统计学意义(P<0.05);且随着OXA暴露浓度的升高,SW620细胞存活率呈现下降趋势。与对照组比较,OXA组差异表达基因8187个,其中上调基因2114个,下调基因6073个。GO富集分析结果显示,差异表达基因主要富集在Wnt信号通路、蛋白质丝氨酸-苏氨酸激酶活力、蛋白激酶活力、蛋白质磷酸化等过程。KEEG富集分析结果显示,差异表达基因主要富集在黏着连接、胞吞作用、癌症中的蛋白聚糖、癌症途径、Wnt信号通路等途径。通过PPI网络构建,MCODE和CytoHubba算法筛选出10个hub基因,分别为UQCRQ、NDUFA1、ATP5IF1、UQCR11、COX6A1、COX7A2、COX7B、NDUFA6、NDUFA4、COX8A。结论OXA对人结肠癌细胞SW620的增殖抑制作用可能与其调节细胞线粒体呼吸链及氧化磷酸化相关。

关键词：结肠癌奥沙利铂 RNA-seq 生物信息学

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Preparation of coated sand for selective laser sintering and optimization of baking process of sand moulds

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China Foundry 2023年第6期20卷 519-525页

作者： Peng-wei Wang Rui-long Yu Rui Tan Yan Wang ying-wei zhou Yue-ting Ma Yan-hai Li Jia-jun Liu Shao-kui Yin Shenyang Research Institute of Foundry Co. Ltd.CAMShenyang 110022China National Key Laboratory of Advanced Casting Technologies Shenyang 110022China

A cold method was used to prepare coated sand for application in the selective laser sintering(SLS)*** strength,loss on ignition,gas evolution,and accuracy of the SLS samples were tested and analyzed,and the baking process was thoroughly *** with coated sand prepared by the hot method,the cold method yields a more uniform and complete resin film on the sand's surface,resulting in enhanced tensile strength and ***,the cold method requires a lower binder content to meet the same strength requirements,thereby minimizing gas evolution,reducing porosity defects,and ultimately improving casting *** coated sand samples prepared through the cold method exhibit superior accuracy,with a size error of within±0.4 *** contrast,the coated sand samples prepared by the hot method display a lower accuracy,with an average negative error of 2.1993 *** highest tensile strength could be attained by controlling the baking temperature within a suitable range(180-190°C),which can effectively reduce the generation of gas,thus contributing to improved overall performance.

关键词： selective laser sintering(SLS) coated sand cold method hot method baking

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Protein Disulfide Isomerase A2 Is Correlated with Immune Infiltrates and Is a Novel Prognostic Biomarker in Glioma Patients

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Current Medical Science 2023年第6期43卷 1107-1115页

作者： Zhi-gang MA ying-xue LIU Ning ZOU Zhe HUANG Ming WANG Tao LI Jie zhou Li-gang CHEN Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Sichuan Clinical Medical Research Center for Neurosurgery Luzhou646000China School of Clinical Medicine Southwest Medical UniversityLuzhou646000China Department of Laboratory People’s Hospital of Deyang CityDeyang618000China Laboratory of Mitochondria and Metabolism Department of AnesthesiologyNational Clinical Research Center for GeriatricsWest China Hospital of Sichuan UniversityChengdu610041China Neurological Diseases and Brain Function Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Academician(Expert)Workstation of Sichuan Province The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China

Objective Protein disulfide isomerase A2(PDIA2),a member of the protein disulfide isomerase family,plays a key role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds,together with enzymes such as thiol isomerase,oxidase,and *** study investigated the clinical significance and potential functions of PDIA2 in *** The expression of PDIA2 in gliomas was explored using The Cancer Genome Atlas and Gene Expression Omnibus *** analyzed the clinical characteristics of glioma patients and the prognostic and diagnostic value of PDIA2 ***-Meier and Cox regression analyses were used to examine the effect of PDIA2 expression on overall survival,progression-free interval,and disease-specific ***,we performed Gene Set Enrichment Analysis and immune infiltration analysis to investigate the functions of ***2 mRNA and protein expression was evaluated in cell lines and glioma *** PDIA2 was expressed at low levels in glioma ***-Meier survival analysis showed that glioma patients with low PDIA2 levels had a worse prognosis than those with high PDIA2 *** operating characteristic curve analysis indicated the diagnostic and prognostic ability of PDIA2(area under the curve=0.918).Pathways associated with PD1,PI3K/AKT,cancer immunotherapy via PD1 blockade,Fceri-mediated NF-kB activation,FOXM1,and DNA repair were enriched in glioma patients with low levels of ***2 expression levels were negatively correlated with immune cell infiltrate *** PDIA2 levels are significantly downregulated in ***2 expression may be a potential biomarker for the diagnosis and prognosis of glioma patients.

关键词： glioma protein disulfide isomerase A2 bioinformatics diagnosis prognosis

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what drives progressive motor deficits in patients with acute pontine infarction?

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Neural Regeneration Research 2015年第3期10卷 501-504页

作者： Jue-bao Li Rui-dong Cheng Liang zhou Wan-shun Wen Gen-ying Zhu Liang Tian Xiang-ming Ye Department of Rehabilitation Medicine Zhejiang Provincial People’s Hospital

Progressive motor deficits are relatively common in acute pontine infarction and frequently associated with increased functional disability. However, the factors that affect the progression of clinical motor weakness are largely unknown. Previous studies have suggested that pontine infarctions are caused mainly by basilar artery stenosis and penetrating artery disease. Recently, lower pons lesions in patients with acute pontine infarctions have been reported to be related to progressive motor deficits, and ensuing that damage to the corticospinal tracts may be respon- sible for the worsening of neurological symptoms. Here, we review studies on motor weakness progression in pontine infarction and discuss the mechanisms that may underlie the neurologic worsening.

关键词： nerve regeneration pontine infarction progressive motor deficits basilar artery pene-trating artery corticospinal tract Wallerian degeneration review neural regeneration

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Mining favorable alleles for five agronomic traits from the elite rapeseed cultivar Zhongshuang 11 by QTL mapping and integration

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The Crop Journal 2021年第6期9卷 1449-1459页

作者： Xianming zhou Lihong Dai Pengfei Wang ying Liu Zhaoqi Xie Haiyan Zhang Qiang Xin Lili Wan Liyong Yang Guangsheng Yang Dengfeng Hong National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina Institute of Crops Wuhan Academy of Agricultural SciencesWuhan 430065HubeiChina shanghai Academy of Agricultural Sciences Shanghai 201403China

Zhongshuang 11(ZS11) is an elite inbred rapeseed(Brassica napus L.) cultivar widely planted in the Yangtze River basin for its favorable characteristics including high seed oil content(SOC), low seed glucosinolate content(SGC), long siliques, and stable yield. To transfer the ideal traits from ZS11 into 195-14 A, a Polima(pol)-type cytoplasmic male sterile line with high general combining ability, a doubled haploid population derived from the cross of ZS11 and 195-14 A was developed. Based on this population,a high-density genetic linkage map covering 2553 c M with an average marker interval of 0.81 c M, was constructed using the Brassica 60 K SNP array and simple sequence repeats. In seven environments, 64,29, 35, 37, and 33 QTL were identified for silique length, seeds per silique, seed density per silique,SOC, and SGC, respectively. Most favorable alleles were from ZS11. Seventy-one consensus QTL were identified by a QTL meta-analysis, eight of which(cqSL–A9–2, cqSL–C7, cqSGC–C2, cqSOC–A5–2, cqSOC–A5–3, cqSPS–A6–2, cqSPS–A7–2, and cqSDPS–A9–2) were assigned as major QTL. Comparative genomics and expression analysis predicted 72 candidate genes underlying the 21 consensus QTL for the five *** findings suggest the genetic basis of the superior performance of ZS11 and suggest favorable alleles for development of cultivars with improved yield and quality. These results will assist in cloning these promising alleles in the future.

关键词： Rapeseed ZS11 QTL Five agronomic traits Candidate genes

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